Uso de plantas para el tratamiento del acné vulgar: revisión sistemática de la literatura

ilustraciones, diagramas

Autores:
Guarín García, Juan David
Tipo de recurso:
Fecha de publicación:
2023
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/84634
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/84634
https://repositorio.unal.edu.co/
Palabra clave:
Plantas medicinales
Plants, Medicinal
Análisis documenatl
Análisis de información
Document analysis
Information analysis
Acné Vulgar
Plantas
Terapéutica
Rights
openAccess
License
Atribución-NoComercial-CompartirIgual 4.0 Internacional
id UNACIONAL2_ee71c5fa904d0984ee00270015d2d6cf
oai_identifier_str oai:repositorio.unal.edu.co:unal/84634
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Uso de plantas para el tratamiento del acné vulgar: revisión sistemática de la literatura
dc.title.translated.none.fl_str_mv Use of plants for the treatment of acne vulgaris: systematic review of the literature
title Uso de plantas para el tratamiento del acné vulgar: revisión sistemática de la literatura
spellingShingle Uso de plantas para el tratamiento del acné vulgar: revisión sistemática de la literatura
Plantas medicinales
Plants, Medicinal
Análisis documenatl
Análisis de información
Document analysis
Information analysis
Acné Vulgar
Plantas
Terapéutica
title_short Uso de plantas para el tratamiento del acné vulgar: revisión sistemática de la literatura
title_full Uso de plantas para el tratamiento del acné vulgar: revisión sistemática de la literatura
title_fullStr Uso de plantas para el tratamiento del acné vulgar: revisión sistemática de la literatura
title_full_unstemmed Uso de plantas para el tratamiento del acné vulgar: revisión sistemática de la literatura
title_sort Uso de plantas para el tratamiento del acné vulgar: revisión sistemática de la literatura
dc.creator.fl_str_mv Guarín García, Juan David
dc.contributor.advisor.none.fl_str_mv Amaris Peña, Oscar Ernesto
Vásquez Londoño, Carlos Alberto
dc.contributor.author.none.fl_str_mv Guarín García, Juan David
dc.subject.decs.spa.fl_str_mv Plantas medicinales
topic Plantas medicinales
Plants, Medicinal
Análisis documenatl
Análisis de información
Document analysis
Information analysis
Acné Vulgar
Plantas
Terapéutica
dc.subject.decs.eng.fl_str_mv Plants, Medicinal
dc.subject.lemb.spa.fl_str_mv Análisis documenatl
Análisis de información
dc.subject.lemb.eng.fl_str_mv Document analysis
Information analysis
dc.subject.proposal.spa.fl_str_mv Acné Vulgar
Plantas
Terapéutica
description ilustraciones, diagramas
publishDate 2023
dc.date.accessioned.none.fl_str_mv 2023-09-04T14:32:53Z
dc.date.available.none.fl_str_mv 2023-09-04T14:32:53Z
dc.date.issued.none.fl_str_mv 2023-09-03
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/84634
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/84634
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.references.spa.fl_str_mv Abozeid, D., Fawzy, G., Issa, M., Abdeltawab, N., & Soliman, F. (2023). Medicinal Plants and their Constituents in the Treatment of Acne vulgaris. Biointerface Research in Applied Chemistry, 13(2), 1–24. https://doi.org/10.33263/BRIAC132.189
Agnew, T., Leach, M., & Segal, L. (2014). The clinical impact and cost-effectiveness of essential oils and aromatherapy for the treatment of acne vulgaris: A protocol for a randomized controlled trial. Journal of Alternative and Complementary Medicine, 20(5), 399–405. https://doi.org/10.1089/acm.2013.0137
Ajjoun, M., Kharchoufa, L., Alami Merrouni, I., & Elachouri, M. (2022). Moroccan medicinal plants traditionally used for the treatment of skin diseases: From ethnobotany to clinical trials. Journal of Ethnopharmacology, 297, 1–60. https://doi.org/10.1016/j.jep.2022.115532
Alebiosu, C. O., Ogunledun, A., Ogunleye, D. S., Pharm, B., & Sagamu, N. (2003). A REPORT OF CLINICAL TRIAL CONDUCTED ON TOTO OINTMENT AND SOAP PRODUCTS.
Ansari, M., Nasreen, J., Abid, A., & Tanzeel, A. (2019). A systematic review of clinical trials examining the effectiveness of Unani drugs on skin diseases. Journal of Herbal Drugs, 9(4), 233–241. https://journals.iau.ir/article_671247_31db4f01a5c06eeebf7a47690f208628.pdf
Appiah, S., Lawley, B., Vu, M., Bell, C., & Jones, H. (2017). Evaluation of the effectiveness of Eladi Keram for the treatment of Acne vulgaris: a randomised controlled pilot study. European Journal of Integrative Medicine, 12, 38–43. https://doi.org/10.1016/j.eujim.2017.04.004
Armijos, C., Ramírez, J., & Vidari, G. (2022). Poorly Investigated Ecuadorian Medicinal Plants. Plants, 11(12), 1–33. https://doi.org/10.3390/plants11121590
Atif, A., & Naveed, A. (2015). The safety and efficacy of 3% Cannabis seeds extract cream for reduction of human cheek skin sebum and erythema content. Pakistan Journal of Pharmaceutical Sciences, 28(4), 1389–1395. https://www.researchgate.net/publication/279807247
Ayan, R. (2022). Ryyan. RAYYAN.
Basset, I., Pannowitz, D., & Barnetson, R. (1990). A comparative study of tea-tree oil versus benzoylperoxide in the treatment of acne. THE MEDICAL JOURNAL OF AUSTRALIA, 153, 455–458.
Benedetti, J. (2019). Descripción de las lesiones cutáneas. Manual MSD Versión para profesionales.
Bernal, R., Galeano, G., Rodríguez, Á., Sarmiento, H., & Gutierrez, M. (2017). Nombres comunes de las plantas de Colombia. Universidad Nacional de Colombia.
Bernal, R., Gradstein, R., & Celis, M. (2014). Catálogo de plantas y líquenes de Colombia. Universidad Nacional de Colombia.
Beverly, J. S. (2017). AMSTAR-2: herramienta de evaluación crítica de revisiones sistemáticas de estudios de intervenciones en salud. EVIDENCIA, 21(1), 6–15. www.evidencia.org.ar
Bucciarelli, A., Moreno, M., & Skliar, M. (2014). Efectos adversos de plantas medicinales y sus implicancias en salud. Adelantos en medicina, 1(4), 26–32.
Cao H, Wang, Y. G., Jp, L., Ca, S., & Liu, L. H. (2015). Complementary therapies for acne vulgaris (Review). The Cochrane Collaboration, 1–143. http://www.thecochranelibrary.com
Capitanio, B., Sinagra, J. L., Weller, R. B., Brown, C., & Berardesca, E. (2012). Randomized controlled study of a cosmetic treatment for mild acne. Clinical and Experimental Dermatology, 37(4), 346–349. https://doi.org/10.1111/j.1365-2230.2011.04317.x
Vásquez, C. (2014). Avances en la investigación sobre plantas medicinales. Instituto Alexander von Humboldt. http://reporte.humboldt.org.co/biodiversidad/2014/cap1/104/#seccion1
Carvajal-Yañez, N., Canaviri, D., Callejas, M., & Carrasco, P. (2011). Efecto Terapéutico en el Tratamiento del Acné Vulgar usando principios activos de MELISSA OFFICINALIS L. y PLANTAGO LANCEOLATA. Revista Científica Ciencia Médica, 14(2), 24–27.
Chilicka, K., Rogowska, A. M., Rusztowicz, M., Szyguła, R., Yanakieva, A., Asanova, B., & Wilczyński, S. (2022). The Effects of Green Tea (Camellia sinensis), Bamboo Extract (Bambusa vulgaris) and Lactic Acid on Sebum Production in Young Women with Acne Vulgaris Using Sonophoresis Treatment. Healthcare (Switzerland), 10(4), 1–14. https://doi.org/10.3390/healthcare10040684
Cochrane Bias Method Group. (2022). ROBINS-I tool. Risk of Bias info. https://sites.google.com/site/riskofbiastool/welcome/home?authuser=0
Dewi, N. K., Putra, I. B., & Jusuf, N. K. (2020). Passion fruit purple variant (Passiflora edulis Sims var. edulis) seeds extract 10% cream in acne vulgaris treatment: an open-label pilot study. International Journal of Dermatology, 59(12), 1506–1512. https://doi.org/10.1111/ijd.15178
Deyno, S., Mtewa, A. G., Abebe, A., Hymete, A., Makonnen, E., Bazira, J., & Alele, P. E. (2019). Essential oils as topical anti-infective agents: A systematic review and meta-analysis. Complementary Therapies in Medicine, 47, 1–22. https://doi.org/10.1016/j.ctim.2019.102224
Doni, M., Patel, M. I., Khalid, M., Husain, N., Khan, M. Q., & Ayesha, B. (2022). Therapeutic evaluation of herbal formulation in acne vulgaris and its influence on quality of life—A single-arm clinical trial. Journal of Herbal Medicine, 34, 1–7. https://doi.org/10.1016/j.hermed.2022.100577
Elsaie, M. L., Abdelhamid, M. F., Elsaaiee, L., & Emam, H. (2009). The Efficacy of Topical 2% Green Tea Lotion in Mild-to-Moderate Acne Vulgaris. Journal of Drugs in Dermatology, 8(4), 358–364. https://www.researchgate.net/publication/24275151
Fernández, R., & Pérez, N. (2020). Acné vulgaris: actualizaciones en fisiopatología y tratamiento. Revista Ciencia & Salud, 4(4), 53–66.
Fisk, W. A., Lev-Tov, H. A., & Sivamani, R. K. (2014). Botanical and Phytochemical Therapy of Acne: A Systematic Review. Phytotherapy Research, 28(8), 1137–1152. https://doi.org/10.1002/ptr.5125
Forest, J. M., & Rafikhah, N. (2014). Aloe vera Juice and Acne Vulgaris: A Placebo-Controlled Study. Asian Journal of Clinical Nutrition, 6(2), 29–34.
Fouladi, R. F. (2012). Aqueous Extract of Dried Fruit of Berberis vulgaris L. in Acne Vulgaris, a Clinical Trial. Journal of Dietary Supplements, 9(4), 253–261. https://doi.org/10.3109/19390211.2012.726702
García, H. (2008). Vademécum Colombiano de Plantas Medicinales (1a ed.). Ministerio de Protección Social de la República de Colombia.
Ghovvati, M., Afshari, G. K., Nasrollahi, S. A., Firooz, A., Samadi, A., Karimi, M., Talebi, Z., Kolahdooz, S., & Vazirian, M. (2019). Efficacy of topical cinnamon gel for the treatment of facial acne vulgaris: A preliminary study. Biomedical Research and Therapy, 6(1), 2958–2965. https://doi.org/10.15419/bmrat.v6i1.515
Gomes da Silva, A., de Freitas Puziol, P., Nunes Leitao, R., Gomes, R., Scherer, R., Lopes Martins, M. L., Saade Cavalcanti, A. S., & Cavalcanti, L. C. (2012). Application of the Essential Oil from Copaiba (Copaifera langsdorffii Desf.) for Acne Vulgaris: a Double-Blind, Placebo Controlled Clinical Trialinéégalitéés. Alternative Medicine Review, 17(1), 69–75.
Hajheydari, Z., Saeedi, M., Morteza-Semnani, K., & Soltani, A. (2014). Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: A randomized, double-blind, prospective trial. Journal of Dermatological Treatment, 25(2), 123–129. https://doi.org/10.3109/09546634.2013.768328
Hammer, K. A. (2015). Treatment of acne with tea tree oil (melaleuca) products: A review of efficacy, tolerability and potential modes of action. International Journal of Antimicrobial Agents, 45(2), 106–110. https://doi.org/10.1016/j.ijantimicag.2014.10.011
Heinrich, M., Barnes, J., Gibbons, S., & Williamson, E. M. (2012). Fundamentals of Pharmacognosy and Phytotherapy. En Fundamentals of Pharmacognosy and Phytotherapy (2a ed.). Elsevier.
Higgins, J., Savovic, J., Page, M., & Sterne, J. (2019). Revised Cochrane risk-of-bias tool for randomized trials (RoB 2).
Hwang, J. R., Cartron, A. M., & Khachemoune, A. (2021). A review of Nigella sativa plant-based therapy in dermatology. International Journal of Dermatology, 60(12), e493–e499. https://doi.org/10.1111/ijd.15615
Ito, K., Masaki, S., Hamada, M., Tokunaga, T., Kokuba, H., Tashiro, K., Yano, I., Yasumoto, S., & Imafuku, S. (2018). Efficacy and Safety of the Traditional Japanese Medicine Keigairengyoto in the Treatment of Acne Vulgaris. Dermatology Research and Practice, 2018, 1–8. https://doi.org/10.1155/2018/4127303
Jaturapisanukul, K., Udompataikul, M., Kanokrungsee, S., Rojhirunsakool, S., Kamanamool, N., Rachpirom, M., & Puttarak, P. (2021). Efficacy and safety of a novel water-soluble herbal patch for acne vulgaris treatment: A randomized, assessor-blinds controlled, intra-individual split-face comparative study. Dermatologic Therapy, 34(3), 1–8. https://doi.org/10.1111/dth.14925
Johnson, M., & Rafikhah, N. (2014). Berberis vulgaris Juice and Acne Vulgaris: A Placebo-Controlled Study. Asian Journal of Clinical Nutrition, 6(2), 47–52.
Jones, V. A., Patel, P. M., Wilson, C., Wang, H., & Ashack, K. A. (2021). Complementary and alternative medicine treatments for common skin diseases: A systematic review and meta-analysis. JAAD International, 2, 76–93. https://doi.org/10.1016/j.jdin.2020.11.001
Khan, B. A., & Akhtar, N. (2014). Clinical and sebumetric evaluation of topical emulsions in the treatment of acne vulgaris. Postepy Dermatologii i Alergologii, 31(4), 229–234. https://doi.org/10.5114/pdia.2014.40934
Kwon, H. H., Yoon, J. Y., Park, S. Y., Min, S., & Suh, D. H. (2014). Comparison of Clinical and Histological Effects between Lactobacillus-Fermented Chamaecyparis obtusa and Tea Tree Oil for the Treatment of Acne: An Eight-Week Double-Blind Randomized Controlled Split-Face Study. Dermatology, 229, 102–109.
Llanes Torres, H. M., Parra Ofarril, L., Martínez Gutiérrez, L., & Ruíz Alvarez, J. (2019). Tratamiento combinado de peloides y terapia floral en el acné juvenil. Revista Electrónica Medimay, 26(2), 145–156.
Lores, D., & Lazo, Y. (2011). Caracterización de las sospechas de reacciones adversas a medicamentos herbolarios notificadas a la Unidad Coordinadora Provincial de Farmacovigilancia Santiago de Cuba. Revista Mexicana de Ciencias Farmacéuticas, 1(42), 37–44.
Lu, P. H., & Hsu, C. H. (2016). Does supplementation with green tea extract improve acne in post-adolescent women? A randomized, double-blind, and placebo-controlled clinical trial. Complementary Therapies in Medicine, 25, 159–163. https://doi.org/10.1016/j.ctim.2016.03.004
Lubtikulthum, P., Kamanamool, N., & Udompataikul, M. (2019). A comparative study on the effectiveness of herbal extracts vs 2.5% benzoyl peroxide in the treatment of mild to moderate acne vulgaris. Journal of Cosmetic Dermatology, 18(6), 1767–1775. https://doi.org/10.1111/jocd.12962
Mansu, S. S. Y., Coyle, M., Wang, K., May, B., Zhang, A. L., & Xue, C. C. L. (2018). Herbal medicine Eriobotrya japonica formula for acne vulgaris: A systematic review. Journal of Herbal Medicine, 11, 12–23. https://doi.org/10.1016/j.hermed.2017.09.001
Martín, J. (1986). Introducción a la Fitoterapia. Natura Medicatrix, 12, 11–16.
Masoud, F., Badali, P., Isa, M. A., Alamdari, H. A., Asnaashari, S., Shokri, J., & Javadzadeh, Y. (2022). The novel topical herbal gel might be an alternative treatment in patients with acne vulgaris: A randomized, double-blind controlled study. Phytomedicine Plus, 2(2), 1–6. https://doi.org/10.1016/j.phyplu.2022.100232
Matiz, G., Osorio, M., Camacho, F., Atencia, M., & Herazo, J. (2012). Diseño y evaluación in vivo de fórmulas para acné basadas en aceites esenciales de naranja (Citrus sinensis), albahaca (Ocimum basilicum L) y ácido acético. Biomédica, 32, 125–133.
Mazzarello, V., Donadu, M. G., Ferrari, M., Piga, G., Usai, D., Zanetti, S., & Sotgiu, M. A. (2018). Treatment of acne with a combination of propolis, tea tree oil, and aloe vera compared to erythromycin cream: Two double-blind investigations. Clinical Pharmacology: Advances and Applications, 10, 175–181. https://doi.org/10.2147/CPAA.S180474
Microsoft. (2021). Microsoft Excel (2021). Microsoft.
Miglani, A., & Manchanda, R. K. (2014a). Observational study of Arctium lappa in the treatment of acne vulgaris. Homeopathy, 103(3), 203–207. https://doi.org/10.1016/j.homp.2013.12.002
Miglani, A., & Manchanda, R. K. (2014b). Prospective, non-randomised, open-label study of homeopathic Zingiber officinale (ginger) in the treatment of acne vulgaris. Focus on Alternative and Complementary Therapies, 19(4), 191–197. https://doi.org/10.1111/fct.12140
Mohebbipour, A., Sadeghi-Bazargani, H., & Mansouri, M. (2015). Sunflower Seed and Acne Vulgaris. Iranian Red Crescent Medical Journal, 17(9), 1–5. https://doi.org/10.5812/ircmj.16544
Nandgaonkar, P., Khobragade, P., Kuchewar, V., Pargaonkar, A., Nandgaonkar, P., & Gandhi, M. (2020). Comparative Study of Efficacy of Hemidesmus Indicus (L.) R. Br. and Decalepis Hamiltonii Wight & Arn. in Acne Vulgaris (Mukhadushika). Indian Journal of Forensic Medicine & Toxicology, 14(4), 6565–6571.
Nasri, H., Bahmani, M., Shahinfard, N., Nafchi, A. M., Saberianpour, S., & Kopaei, M. R. (2015). Medicinal plants for the treatment of acne vulgaris: A review of recent evidences. Jundishapur Journal of Microbiology, 8(11), 1–9. https://doi.org/10.5812/jjm.25580
NICE. (2021). Acne vulgaris: management NICE guideline. www.nice.org.uk/guidance/ng198
Orafidiya, L. O., Agbani, E. O., Oyedele, A. O., Babalola, O. O., Onayemi, O., & Aiyedun, F. F. (2004). The effect of aloe vera gel on the anti-acne properties of the essential oil of Ocimum gratissimum Linn leaf - A preliminary clinical investigation. International Journal of Aromatherapy, 14(1), 15–21. https://doi.org/10.1016/j.ijat.2003.12.005
Orozco, B., Elena Campo, M., Adriana Anaya, L., Atuesta, J., Janeth Ávila, M., Fernando Balcázar, L., Isabel Barona, M., María Becerra, M., Fernando Cárdenas, L., Concha, C., Cruz, A., Danies, M., Díaz-Granados, T., Helena Díaz, L., Espinosa, D., Gaita, A., García, G., García, L., Huyke, B., … Velásquez, N. (2011). Guías colombianas para el manejo del acné: una revisión basada en la evidencia por el Grupo Colombiano de Estudio en Acné. 129–158. www.revistasocolderma.com
Page, M., McKenzie, J., Bossuyt, P., Boutron, I., Hoffman, T., & Mulrow, C. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. https://doi.org/10.1136/bmj.n71
Palacios, S., Moncayo, L., Díaz, A., Montenegro, G., Mancheno, A., Salazar, P., Proaño, A., Fuertes, X., Arévalo, D., Boschetti, D., Cabezas, J., Alzate, M., Torres, G., Torres, M., & Solis, V. (2016). Diagnóstico y tratamiento del acné. https://www.salud.gob.ec/wp-content/uploads/2017/02/DIAGN%C3%93STICO-Y-TRATAMIENTO-DEL-ACN%C3%89_16012017.pdf
Paranjpe, P., & Kulkarni, P. H. (1995). Comparative efficacy of four Ayurvedic formulations in the treatment of acne vulgaris: a double-blind randomised placebo-controlled clinical evaluation. Journal of Ethnopharrnacology, 49, 127.
Pazyar, N., Yaghoobi, R., Bagherani, N., & Kazerouni, A. (2013). A review of applications of tea tree oil in dermatology. International Journal of Dermatology, 52(7), 784–790. https://doi.org/10.1111/j.1365-4632.2012.05654.x
Ping, L. (2011). Orígenes e historia de la medicina china.
Proença, A. C., Luís, Â., & Duarte, A. P. (2022). The Role of Herbal Medicine in the Treatment of Acne Vulgaris: A Systematic Review of Clinical Trials. Evidence-based Complementary and Alternative Medicine, 2022, 1–22. https://doi.org/10.1155/2022/2011945
Rajaiah Yogesh, H., Gajjar, T., Patel, N., & Kumawat, R. (2022). Clinical study to assess efficacy and safety of Purifying Neem Face Wash in prevention and reduction of acne in healthy adults. Journal of Cosmetic Dermatology, 21(7), 2849–2858. https://doi.org/10.1111/jocd.14486
Ramírez, L. (2005). USO DE PLANTAS MEDICINALES EN EL TRATAMIENTO DE ENFERMEDADES EN LA POBLACIÓN DE SANTA MARTA (COLOMBIA). Pontifica Universidad Javeriana.
Ramón, J., Rodríguez, E., Echegaray González, P., Mosquera Fernández, A., & Gerrikaetxebarria Peña, J. (2011). FITOTERAPIA Y SUS APLICACIONES. Revista Española de Podología, 258–267.
Reina, I. (2002). La FITOTERAPIA de la “A” a la “Z”.
Restrepo, R. (2010). Anatomía microscópica del folículo piloso. Rev. Asoc Colomb Dermatol, 18, 123–161. www.revistasocolderma.com
Reuter, J., Merfort, I., & Schempp, C. M. (2010). Botanicals in Dermatology An Evidence-Based Review. American Journal of Clinical Dermatology, 11(4), 247–267.
Rinaldi, F., Marotta, L., Mascolo, A., Amoruso, A., Pane, M., Giuliani, G., & Pinto, D. (2022). Facial Acne: A Randomized, Double-Blind, Placebo-Controlled Study on the Clinical Efficacy of a Symbiotic Dietary Supplement. Dermatology and Therapy, 12(2), 577–589. https://doi.org/10.1007/s13555-021-00664-z
Rodríguez, B., Vásquez, M., & Hernández, Á. (2018). Acné vulgar. algoritmos.aepap.org
Salmanian, M., Shirbeigi, L., Hashem-Dabaghian, F., Mansouri, P., Azizkhani, M., Alavi, S., & Ghobadi, A. (2021). The effects of myrtle (myrtus communis) and clindamycin topical solution in the treatment of mild to moderate acne vulgaris: A comparative split-face study. Journal of Pharmacopuncture, 23(4), 220–229. https://doi.org/10.3831/KPI.2020.23.4.220
Sánchez, I., Quesada, A., & Cedeño, M. (2010). Lesiones elementales en Dermatología. Revista médica de Costa Rica y Centroamérica, 67(594), 345–348.
Saric, S., Notay, M., & Sivamani, R. K. (2017). Green tea and other tea polyphenols: Effects on sebum production and acne vulgaris. Antioxidants, 6(1), 1–16. https://doi.org/10.3390/antiox6010002
Saviuc, C., Ciubucă, B., Dincă, G., Bleotu, C., Drumea, V., Chifiriuc, M. C., Popa, M., Pircalabioru, G. G., Marutescu, L., & Lazăr, V. (2017). Development and sequential analysis of a new multi-agent, anti-acne formulation based on plant-derived antimicrobial and anti-inflammatory compounds. International Journal of Molecular Sciences, 18(1), 1–11. https://doi.org/10.3390/ijms18010175
Sepaskhah, M., Mohammadi, A., Nabavizadeh, S. S., Faridi, P., & Babael, A. H. (2019). Comparison of the efficacy of oral fenugreek seed extract and azithromycin in the treatment of acne vulgaris: a randomized, triple-blind controlled pilot clinical trial. Iran Journal of Dermatology, 58–64.
Shakiba, R., Nilforoushzadeh, M. A., Hashem-Dabaghian, F., Minaii Zangii, B., Ghobadi, A., Shirbeigi, L., Aliasl, J., Shakiba, M., & Ghods, R. (2021). Effect of Cedar (Ziziphus spina-christi) topical solution in mild to moderate acne vulgaris: a randomized clinical study. Journal of Dermatological Treatment, 32(2), 197–202. https://doi.org/10.1080/09546634.2019.1692125
Sinha, P., Srivastava, S., Mishra, N., & Yadav, N. P. (2014). New Perspectives on Antiacne Plant Drugs: Contribution to Modern Therapeutics. En BioMed Research International (Vol. 2014, pp. 1–19). Hindawi Publishing Corporation. https://doi.org/10.1155/2014/301304
Soleymani, S., Zargaran, A., Farzaei, M. H., Iranpanah, A., Heydarpour, F., Najafi, F., & Rahimi, R. (2020). The effect of a hydrogel made by Nigella sativa L. on acne vulgaris: A randomized double-blind clinical trial. Phytotherapy Research, 34(11), 3052–3062. https://doi.org/10.1002/ptr.6739
Sung, S. H., Choi, G. H., Lee, N. W., & Shin, B. C. (2020). External application of herbal medicines for acne vulgaris: A systematic review and meta analysis. Journal of Pharmacopuncture, 23(1), 8–17. https://doi.org/10.3831/KPI.2020.23.002
Sutono, T. (2013). Efficacy of Garcinia mangostana L. (mangosteen rind extract) to reduce acne severity. Medical Journal of Indonesia, 22(3), 167–172. https://doi.org/10.13181/mji.v22i3.586
Tabasum, H., Ahmad, T., Anjum, F., & Rehman, H. (2014). The effect of Unani antiacne formulation (Zimade Muhasa) on acne vulgaris: A single-blind, randomized, controlled clinical trial. Journal of Pakistan Association of Dermatologists, 24(4), 319–326.
Thappa, D. M., & Dogra, J. (1994). Nodulocystic Acne: Oral Gugulipid versus Tetracycline. The journal of Dermatology, 21, 729–731.
Universidad Industrial de Santander. (2019). PROCESO UNIDAD ESPECIALIZADA DE SALUD “UISALUD” SUBPROCESO PRESTACIÓN DE SERVICIOS ASISTENCIALES. http://gpc.minsalud.gov.co/gpc/SitePages/buscador_gpc.aspx
Vogler, B. K., & Ernst, E. (1999). Aloe vera: a systematic review of its clinical effectiveness. British Journal of General Practice, 49, 823–828.
Waranuch, N., Phimnuan, P., Yakaew, S., Nakyai, W., Grandmottet, F., Onlom, C., Srivilai, J., & Viyoch, J. (2019). Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, garcinia mangostana peel extract, and Camellia sinensis leaf extract. Clinical, Cosmetic and Investigational Dermatology, 12, 383–391. https://doi.org/10.2147/CCID.S200564
Wunnoo, S., Bilhman, S., Amnuaikit, T., Ontong, J. C., Singh, S., Auepemkiate, S., & Voravuthikunchai, S. P. (2021). Rhodomyrtone as a new natural antibiotic isolated from rhodomyrtus tomentosa leaf extract: A clinical application in the management of acne vulgaris. Antibiotics, 10(2), 1–12. https://doi.org/10.3390/antibiotics10020108
Yang, J. H., Hwang, E. J., Moon, J., Yoon, J. Y., Kim, J. W., Choi, S., Cho, S. I., & Suh, D. H. (2021). Clinical efficacy of herbal extracts in treatment of mild to moderate acne vulgaris: an 8-week, double-blinded, randomized, controlled trial. Journal of Dermatological Treatment, 32(3), 297–301. https://doi.org/10.1080/09546634.2019.1657792
Zhong, H., Li, X., Zhang, W., Shen, X., Lu, Y., & Li, H. (2021). Efficacy of a New Non-drug Acne Therapy: Aloe Vera Gel Combined With Ultrasound and Soft Mask for the Treatment of Mild to Severe Facial Acne. Frontiers in Medicine, 8, 1–9. https://doi.org/10.3389/fmed.2021.662640
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dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá
institution Universidad Nacional de Colombia
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spelling Atribución-NoComercial-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Amaris Peña, Oscar Ernestofa93d6479d4f233df5a7fbc9fd8a58d8Vásquez Londoño, Carlos Alberto641216f12b5c456374da81aa9d2011e4Guarín García, Juan David4f8afbb43bdb733ba3dd6bf8d0ba58882023-09-04T14:32:53Z2023-09-04T14:32:53Z2023-09-03https://repositorio.unal.edu.co/handle/unal/84634Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasIntroducción: El acné vulgar es una enfermedad inflamatoria crónica de la piel que puede generar secuelas como hiperpigmentación y cicatrices. Los antibióticos son el principal tratamiento, sin embargo, el aumento en la resistencia antimicrobiana y los efectos secundarios han despertado el interés en la búsqueda de otras alternativas para su manejo. las plantas medicinales han sido objeto de estudio como alternativa terapéutica por sus efectos antiinflamatorio, antimicrobiano y antioxidante, por lo cual, se han realizado diversas investigaciones explorando su uso. A pesar de esto, es necesario un documento reciente que sintetice los resultados obtenidos en los estudios y evalúe su calidad metodológica, para guiar futuras investigaciones, y de manera preliminar, esta terapéutica. Metodología: Se realizaron búsquedas de estudios que utilizan plantas medicinales para el tratamiento del acné vulgar en diversas bases de datos hasta agosto de 2022. Se incluyeron 38 artículos con un total de 4.539 participantes y 167 especies diferentes de hierbas medicinales. Resultados: Las plantas medicinales son efectivas en el tratamiento del acné vulgar, en comparación con el tratamiento estándar o el placebo, con algunas excepciones. Su perfil de seguridad es adecuado, generando únicamente eventos adversos leves. Conclusión: Plantas o fórmulas herbales como Melaleuca alternifolia, Rosmarinus officinalis, entre otros, son de manera preliminar una terapia alternativa o complementaria efectiva y segura para el manejo del acné vulgar de gravedad leve o moderada. (Texto tomado de la fuente)Introduction: Acne vulgaris is a chronic inflammatory skin disease that can cause aftereffects such as hyperpigmentation and scars. Antibiotics are the main treatment, however, the increase in antimicrobial resistance and side effects have aroused interest in the search for other alternatives for its management. Medicinal plants have been studied as a therapeutic alternative for their anti-inflammatory, antimicrobial and antioxidant effects, which is why many investigations have been carried out exploring their use. Despite this, a recent document is needed that synthesizes the results obtained in the studies and evaluates their methodological quality, to guide future research, and in a preliminary way, this therapy. Methodology: Many databases were searched for studies using medicinal plants for the treatment of acne vulgaris up to August 2022. 38 articles with a total of 4.539 participants and 167 different species of medicinal herbs were included. Results: Medicinal plants are effective in the treatment of acne vulgaris, compared to standard treatment or placebo, with some exceptions. Its safety profile is adequate, producing only mild adverse events. Conclusion: Plants or herbal formulas such as Melaleuca alternifolia, Rosmarinus officinalis, among others, are preliminarily an effective and safe alternative or complementary therapy for the management of acne vulgaris of mild or moderate severity.MaestríaRevisión sistemática de la literaturaxiv, 89 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Maestría en Medicina AlternativaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede BogotáUso de plantas para el tratamiento del acné vulgar: revisión sistemática de la literaturaUse of plants for the treatment of acne vulgaris: systematic review of the literatureTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMAbozeid, D., Fawzy, G., Issa, M., Abdeltawab, N., & Soliman, F. (2023). Medicinal Plants and their Constituents in the Treatment of Acne vulgaris. Biointerface Research in Applied Chemistry, 13(2), 1–24. https://doi.org/10.33263/BRIAC132.189Agnew, T., Leach, M., & Segal, L. (2014). The clinical impact and cost-effectiveness of essential oils and aromatherapy for the treatment of acne vulgaris: A protocol for a randomized controlled trial. Journal of Alternative and Complementary Medicine, 20(5), 399–405. https://doi.org/10.1089/acm.2013.0137Ajjoun, M., Kharchoufa, L., Alami Merrouni, I., & Elachouri, M. (2022). Moroccan medicinal plants traditionally used for the treatment of skin diseases: From ethnobotany to clinical trials. Journal of Ethnopharmacology, 297, 1–60. https://doi.org/10.1016/j.jep.2022.115532Alebiosu, C. O., Ogunledun, A., Ogunleye, D. S., Pharm, B., & Sagamu, N. (2003). A REPORT OF CLINICAL TRIAL CONDUCTED ON TOTO OINTMENT AND SOAP PRODUCTS.Ansari, M., Nasreen, J., Abid, A., & Tanzeel, A. (2019). A systematic review of clinical trials examining the effectiveness of Unani drugs on skin diseases. Journal of Herbal Drugs, 9(4), 233–241. https://journals.iau.ir/article_671247_31db4f01a5c06eeebf7a47690f208628.pdfAppiah, S., Lawley, B., Vu, M., Bell, C., & Jones, H. (2017). Evaluation of the effectiveness of Eladi Keram for the treatment of Acne vulgaris: a randomised controlled pilot study. European Journal of Integrative Medicine, 12, 38–43. https://doi.org/10.1016/j.eujim.2017.04.004Armijos, C., Ramírez, J., & Vidari, G. (2022). Poorly Investigated Ecuadorian Medicinal Plants. Plants, 11(12), 1–33. https://doi.org/10.3390/plants11121590Atif, A., & Naveed, A. (2015). The safety and efficacy of 3% Cannabis seeds extract cream for reduction of human cheek skin sebum and erythema content. Pakistan Journal of Pharmaceutical Sciences, 28(4), 1389–1395. https://www.researchgate.net/publication/279807247Ayan, R. (2022). Ryyan. RAYYAN.Basset, I., Pannowitz, D., & Barnetson, R. (1990). A comparative study of tea-tree oil versus benzoylperoxide in the treatment of acne. THE MEDICAL JOURNAL OF AUSTRALIA, 153, 455–458.Benedetti, J. (2019). Descripción de las lesiones cutáneas. Manual MSD Versión para profesionales.Bernal, R., Galeano, G., Rodríguez, Á., Sarmiento, H., & Gutierrez, M. (2017). Nombres comunes de las plantas de Colombia. Universidad Nacional de Colombia.Bernal, R., Gradstein, R., & Celis, M. (2014). Catálogo de plantas y líquenes de Colombia. Universidad Nacional de Colombia.Beverly, J. S. (2017). AMSTAR-2: herramienta de evaluación crítica de revisiones sistemáticas de estudios de intervenciones en salud. EVIDENCIA, 21(1), 6–15. www.evidencia.org.arBucciarelli, A., Moreno, M., & Skliar, M. (2014). Efectos adversos de plantas medicinales y sus implicancias en salud. Adelantos en medicina, 1(4), 26–32.Cao H, Wang, Y. G., Jp, L., Ca, S., & Liu, L. H. (2015). Complementary therapies for acne vulgaris (Review). The Cochrane Collaboration, 1–143. http://www.thecochranelibrary.comCapitanio, B., Sinagra, J. L., Weller, R. B., Brown, C., & Berardesca, E. (2012). Randomized controlled study of a cosmetic treatment for mild acne. Clinical and Experimental Dermatology, 37(4), 346–349. https://doi.org/10.1111/j.1365-2230.2011.04317.xVásquez, C. (2014). Avances en la investigación sobre plantas medicinales. Instituto Alexander von Humboldt. http://reporte.humboldt.org.co/biodiversidad/2014/cap1/104/#seccion1Carvajal-Yañez, N., Canaviri, D., Callejas, M., & Carrasco, P. (2011). Efecto Terapéutico en el Tratamiento del Acné Vulgar usando principios activos de MELISSA OFFICINALIS L. y PLANTAGO LANCEOLATA. Revista Científica Ciencia Médica, 14(2), 24–27.Chilicka, K., Rogowska, A. M., Rusztowicz, M., Szyguła, R., Yanakieva, A., Asanova, B., & Wilczyński, S. (2022). The Effects of Green Tea (Camellia sinensis), Bamboo Extract (Bambusa vulgaris) and Lactic Acid on Sebum Production in Young Women with Acne Vulgaris Using Sonophoresis Treatment. Healthcare (Switzerland), 10(4), 1–14. https://doi.org/10.3390/healthcare10040684Cochrane Bias Method Group. (2022). ROBINS-I tool. Risk of Bias info. https://sites.google.com/site/riskofbiastool/welcome/home?authuser=0Dewi, N. K., Putra, I. B., & Jusuf, N. K. (2020). Passion fruit purple variant (Passiflora edulis Sims var. edulis) seeds extract 10% cream in acne vulgaris treatment: an open-label pilot study. International Journal of Dermatology, 59(12), 1506–1512. https://doi.org/10.1111/ijd.15178Deyno, S., Mtewa, A. G., Abebe, A., Hymete, A., Makonnen, E., Bazira, J., & Alele, P. E. (2019). Essential oils as topical anti-infective agents: A systematic review and meta-analysis. Complementary Therapies in Medicine, 47, 1–22. https://doi.org/10.1016/j.ctim.2019.102224Doni, M., Patel, M. I., Khalid, M., Husain, N., Khan, M. Q., & Ayesha, B. (2022). Therapeutic evaluation of herbal formulation in acne vulgaris and its influence on quality of life—A single-arm clinical trial. Journal of Herbal Medicine, 34, 1–7. https://doi.org/10.1016/j.hermed.2022.100577Elsaie, M. L., Abdelhamid, M. F., Elsaaiee, L., & Emam, H. (2009). The Efficacy of Topical 2% Green Tea Lotion in Mild-to-Moderate Acne Vulgaris. Journal of Drugs in Dermatology, 8(4), 358–364. https://www.researchgate.net/publication/24275151Fernández, R., & Pérez, N. (2020). Acné vulgaris: actualizaciones en fisiopatología y tratamiento. Revista Ciencia & Salud, 4(4), 53–66.Fisk, W. A., Lev-Tov, H. A., & Sivamani, R. K. (2014). Botanical and Phytochemical Therapy of Acne: A Systematic Review. Phytotherapy Research, 28(8), 1137–1152. https://doi.org/10.1002/ptr.5125Forest, J. M., & Rafikhah, N. (2014). Aloe vera Juice and Acne Vulgaris: A Placebo-Controlled Study. Asian Journal of Clinical Nutrition, 6(2), 29–34.Fouladi, R. F. (2012). Aqueous Extract of Dried Fruit of Berberis vulgaris L. in Acne Vulgaris, a Clinical Trial. Journal of Dietary Supplements, 9(4), 253–261. https://doi.org/10.3109/19390211.2012.726702García, H. (2008). Vademécum Colombiano de Plantas Medicinales (1a ed.). Ministerio de Protección Social de la República de Colombia.Ghovvati, M., Afshari, G. K., Nasrollahi, S. A., Firooz, A., Samadi, A., Karimi, M., Talebi, Z., Kolahdooz, S., & Vazirian, M. (2019). Efficacy of topical cinnamon gel for the treatment of facial acne vulgaris: A preliminary study. Biomedical Research and Therapy, 6(1), 2958–2965. https://doi.org/10.15419/bmrat.v6i1.515Gomes da Silva, A., de Freitas Puziol, P., Nunes Leitao, R., Gomes, R., Scherer, R., Lopes Martins, M. L., Saade Cavalcanti, A. S., & Cavalcanti, L. C. (2012). Application of the Essential Oil from Copaiba (Copaifera langsdorffii Desf.) for Acne Vulgaris: a Double-Blind, Placebo Controlled Clinical Trialinéégalitéés. Alternative Medicine Review, 17(1), 69–75.Hajheydari, Z., Saeedi, M., Morteza-Semnani, K., & Soltani, A. (2014). Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: A randomized, double-blind, prospective trial. Journal of Dermatological Treatment, 25(2), 123–129. https://doi.org/10.3109/09546634.2013.768328Hammer, K. A. (2015). Treatment of acne with tea tree oil (melaleuca) products: A review of efficacy, tolerability and potential modes of action. International Journal of Antimicrobial Agents, 45(2), 106–110. https://doi.org/10.1016/j.ijantimicag.2014.10.011Heinrich, M., Barnes, J., Gibbons, S., & Williamson, E. M. (2012). Fundamentals of Pharmacognosy and Phytotherapy. En Fundamentals of Pharmacognosy and Phytotherapy (2a ed.). Elsevier.Higgins, J., Savovic, J., Page, M., & Sterne, J. (2019). Revised Cochrane risk-of-bias tool for randomized trials (RoB 2).Hwang, J. R., Cartron, A. M., & Khachemoune, A. (2021). A review of Nigella sativa plant-based therapy in dermatology. International Journal of Dermatology, 60(12), e493–e499. https://doi.org/10.1111/ijd.15615Ito, K., Masaki, S., Hamada, M., Tokunaga, T., Kokuba, H., Tashiro, K., Yano, I., Yasumoto, S., & Imafuku, S. (2018). Efficacy and Safety of the Traditional Japanese Medicine Keigairengyoto in the Treatment of Acne Vulgaris. Dermatology Research and Practice, 2018, 1–8. https://doi.org/10.1155/2018/4127303Jaturapisanukul, K., Udompataikul, M., Kanokrungsee, S., Rojhirunsakool, S., Kamanamool, N., Rachpirom, M., & Puttarak, P. (2021). Efficacy and safety of a novel water-soluble herbal patch for acne vulgaris treatment: A randomized, assessor-blinds controlled, intra-individual split-face comparative study. Dermatologic Therapy, 34(3), 1–8. https://doi.org/10.1111/dth.14925Johnson, M., & Rafikhah, N. (2014). Berberis vulgaris Juice and Acne Vulgaris: A Placebo-Controlled Study. Asian Journal of Clinical Nutrition, 6(2), 47–52.Jones, V. A., Patel, P. M., Wilson, C., Wang, H., & Ashack, K. A. (2021). Complementary and alternative medicine treatments for common skin diseases: A systematic review and meta-analysis. JAAD International, 2, 76–93. https://doi.org/10.1016/j.jdin.2020.11.001Khan, B. A., & Akhtar, N. (2014). Clinical and sebumetric evaluation of topical emulsions in the treatment of acne vulgaris. Postepy Dermatologii i Alergologii, 31(4), 229–234. https://doi.org/10.5114/pdia.2014.40934Kwon, H. H., Yoon, J. Y., Park, S. Y., Min, S., & Suh, D. H. (2014). Comparison of Clinical and Histological Effects between Lactobacillus-Fermented Chamaecyparis obtusa and Tea Tree Oil for the Treatment of Acne: An Eight-Week Double-Blind Randomized Controlled Split-Face Study. Dermatology, 229, 102–109.Llanes Torres, H. M., Parra Ofarril, L., Martínez Gutiérrez, L., & Ruíz Alvarez, J. (2019). Tratamiento combinado de peloides y terapia floral en el acné juvenil. Revista Electrónica Medimay, 26(2), 145–156.Lores, D., & Lazo, Y. (2011). Caracterización de las sospechas de reacciones adversas a medicamentos herbolarios notificadas a la Unidad Coordinadora Provincial de Farmacovigilancia Santiago de Cuba. Revista Mexicana de Ciencias Farmacéuticas, 1(42), 37–44.Lu, P. H., & Hsu, C. H. (2016). Does supplementation with green tea extract improve acne in post-adolescent women? A randomized, double-blind, and placebo-controlled clinical trial. Complementary Therapies in Medicine, 25, 159–163. https://doi.org/10.1016/j.ctim.2016.03.004Lubtikulthum, P., Kamanamool, N., & Udompataikul, M. (2019). A comparative study on the effectiveness of herbal extracts vs 2.5% benzoyl peroxide in the treatment of mild to moderate acne vulgaris. Journal of Cosmetic Dermatology, 18(6), 1767–1775. https://doi.org/10.1111/jocd.12962Mansu, S. S. Y., Coyle, M., Wang, K., May, B., Zhang, A. L., & Xue, C. C. L. (2018). Herbal medicine Eriobotrya japonica formula for acne vulgaris: A systematic review. Journal of Herbal Medicine, 11, 12–23. https://doi.org/10.1016/j.hermed.2017.09.001Martín, J. (1986). Introducción a la Fitoterapia. Natura Medicatrix, 12, 11–16.Masoud, F., Badali, P., Isa, M. A., Alamdari, H. A., Asnaashari, S., Shokri, J., & Javadzadeh, Y. (2022). The novel topical herbal gel might be an alternative treatment in patients with acne vulgaris: A randomized, double-blind controlled study. Phytomedicine Plus, 2(2), 1–6. https://doi.org/10.1016/j.phyplu.2022.100232Matiz, G., Osorio, M., Camacho, F., Atencia, M., & Herazo, J. (2012). Diseño y evaluación in vivo de fórmulas para acné basadas en aceites esenciales de naranja (Citrus sinensis), albahaca (Ocimum basilicum L) y ácido acético. Biomédica, 32, 125–133.Mazzarello, V., Donadu, M. G., Ferrari, M., Piga, G., Usai, D., Zanetti, S., & Sotgiu, M. A. (2018). Treatment of acne with a combination of propolis, tea tree oil, and aloe vera compared to erythromycin cream: Two double-blind investigations. Clinical Pharmacology: Advances and Applications, 10, 175–181. https://doi.org/10.2147/CPAA.S180474Microsoft. (2021). Microsoft Excel (2021). Microsoft.Miglani, A., & Manchanda, R. K. (2014a). Observational study of Arctium lappa in the treatment of acne vulgaris. Homeopathy, 103(3), 203–207. https://doi.org/10.1016/j.homp.2013.12.002Miglani, A., & Manchanda, R. K. (2014b). Prospective, non-randomised, open-label study of homeopathic Zingiber officinale (ginger) in the treatment of acne vulgaris. Focus on Alternative and Complementary Therapies, 19(4), 191–197. https://doi.org/10.1111/fct.12140Mohebbipour, A., Sadeghi-Bazargani, H., & Mansouri, M. (2015). Sunflower Seed and Acne Vulgaris. Iranian Red Crescent Medical Journal, 17(9), 1–5. https://doi.org/10.5812/ircmj.16544Nandgaonkar, P., Khobragade, P., Kuchewar, V., Pargaonkar, A., Nandgaonkar, P., & Gandhi, M. (2020). Comparative Study of Efficacy of Hemidesmus Indicus (L.) R. Br. and Decalepis Hamiltonii Wight & Arn. in Acne Vulgaris (Mukhadushika). Indian Journal of Forensic Medicine & Toxicology, 14(4), 6565–6571.Nasri, H., Bahmani, M., Shahinfard, N., Nafchi, A. M., Saberianpour, S., & Kopaei, M. R. (2015). Medicinal plants for the treatment of acne vulgaris: A review of recent evidences. Jundishapur Journal of Microbiology, 8(11), 1–9. https://doi.org/10.5812/jjm.25580NICE. (2021). Acne vulgaris: management NICE guideline. www.nice.org.uk/guidance/ng198Orafidiya, L. O., Agbani, E. O., Oyedele, A. O., Babalola, O. O., Onayemi, O., & Aiyedun, F. F. (2004). The effect of aloe vera gel on the anti-acne properties of the essential oil of Ocimum gratissimum Linn leaf - A preliminary clinical investigation. International Journal of Aromatherapy, 14(1), 15–21. https://doi.org/10.1016/j.ijat.2003.12.005Orozco, B., Elena Campo, M., Adriana Anaya, L., Atuesta, J., Janeth Ávila, M., Fernando Balcázar, L., Isabel Barona, M., María Becerra, M., Fernando Cárdenas, L., Concha, C., Cruz, A., Danies, M., Díaz-Granados, T., Helena Díaz, L., Espinosa, D., Gaita, A., García, G., García, L., Huyke, B., … Velásquez, N. (2011). Guías colombianas para el manejo del acné: una revisión basada en la evidencia por el Grupo Colombiano de Estudio en Acné. 129–158. www.revistasocolderma.comPage, M., McKenzie, J., Bossuyt, P., Boutron, I., Hoffman, T., & Mulrow, C. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. https://doi.org/10.1136/bmj.n71Palacios, S., Moncayo, L., Díaz, A., Montenegro, G., Mancheno, A., Salazar, P., Proaño, A., Fuertes, X., Arévalo, D., Boschetti, D., Cabezas, J., Alzate, M., Torres, G., Torres, M., & Solis, V. (2016). Diagnóstico y tratamiento del acné. https://www.salud.gob.ec/wp-content/uploads/2017/02/DIAGN%C3%93STICO-Y-TRATAMIENTO-DEL-ACN%C3%89_16012017.pdfParanjpe, P., & Kulkarni, P. H. (1995). Comparative efficacy of four Ayurvedic formulations in the treatment of acne vulgaris: a double-blind randomised placebo-controlled clinical evaluation. Journal of Ethnopharrnacology, 49, 127.Pazyar, N., Yaghoobi, R., Bagherani, N., & Kazerouni, A. (2013). A review of applications of tea tree oil in dermatology. International Journal of Dermatology, 52(7), 784–790. https://doi.org/10.1111/j.1365-4632.2012.05654.xPing, L. (2011). Orígenes e historia de la medicina china.Proença, A. C., Luís, Â., & Duarte, A. P. (2022). The Role of Herbal Medicine in the Treatment of Acne Vulgaris: A Systematic Review of Clinical Trials. Evidence-based Complementary and Alternative Medicine, 2022, 1–22. https://doi.org/10.1155/2022/2011945Rajaiah Yogesh, H., Gajjar, T., Patel, N., & Kumawat, R. (2022). Clinical study to assess efficacy and safety of Purifying Neem Face Wash in prevention and reduction of acne in healthy adults. Journal of Cosmetic Dermatology, 21(7), 2849–2858. https://doi.org/10.1111/jocd.14486Ramírez, L. (2005). USO DE PLANTAS MEDICINALES EN EL TRATAMIENTO DE ENFERMEDADES EN LA POBLACIÓN DE SANTA MARTA (COLOMBIA). Pontifica Universidad Javeriana.Ramón, J., Rodríguez, E., Echegaray González, P., Mosquera Fernández, A., & Gerrikaetxebarria Peña, J. (2011). FITOTERAPIA Y SUS APLICACIONES. Revista Española de Podología, 258–267.Reina, I. (2002). La FITOTERAPIA de la “A” a la “Z”.Restrepo, R. (2010). Anatomía microscópica del folículo piloso. Rev. Asoc Colomb Dermatol, 18, 123–161. www.revistasocolderma.comReuter, J., Merfort, I., & Schempp, C. M. (2010). Botanicals in Dermatology An Evidence-Based Review. American Journal of Clinical Dermatology, 11(4), 247–267.Rinaldi, F., Marotta, L., Mascolo, A., Amoruso, A., Pane, M., Giuliani, G., & Pinto, D. (2022). Facial Acne: A Randomized, Double-Blind, Placebo-Controlled Study on the Clinical Efficacy of a Symbiotic Dietary Supplement. Dermatology and Therapy, 12(2), 577–589. https://doi.org/10.1007/s13555-021-00664-zRodríguez, B., Vásquez, M., & Hernández, Á. (2018). Acné vulgar. algoritmos.aepap.orgSalmanian, M., Shirbeigi, L., Hashem-Dabaghian, F., Mansouri, P., Azizkhani, M., Alavi, S., & Ghobadi, A. (2021). The effects of myrtle (myrtus communis) and clindamycin topical solution in the treatment of mild to moderate acne vulgaris: A comparative split-face study. Journal of Pharmacopuncture, 23(4), 220–229. https://doi.org/10.3831/KPI.2020.23.4.220Sánchez, I., Quesada, A., & Cedeño, M. (2010). Lesiones elementales en Dermatología. Revista médica de Costa Rica y Centroamérica, 67(594), 345–348.Saric, S., Notay, M., & Sivamani, R. K. (2017). Green tea and other tea polyphenols: Effects on sebum production and acne vulgaris. Antioxidants, 6(1), 1–16. https://doi.org/10.3390/antiox6010002Saviuc, C., Ciubucă, B., Dincă, G., Bleotu, C., Drumea, V., Chifiriuc, M. C., Popa, M., Pircalabioru, G. G., Marutescu, L., & Lazăr, V. (2017). Development and sequential analysis of a new multi-agent, anti-acne formulation based on plant-derived antimicrobial and anti-inflammatory compounds. International Journal of Molecular Sciences, 18(1), 1–11. https://doi.org/10.3390/ijms18010175Sepaskhah, M., Mohammadi, A., Nabavizadeh, S. S., Faridi, P., & Babael, A. H. (2019). Comparison of the efficacy of oral fenugreek seed extract and azithromycin in the treatment of acne vulgaris: a randomized, triple-blind controlled pilot clinical trial. Iran Journal of Dermatology, 58–64.Shakiba, R., Nilforoushzadeh, M. A., Hashem-Dabaghian, F., Minaii Zangii, B., Ghobadi, A., Shirbeigi, L., Aliasl, J., Shakiba, M., & Ghods, R. (2021). Effect of Cedar (Ziziphus spina-christi) topical solution in mild to moderate acne vulgaris: a randomized clinical study. Journal of Dermatological Treatment, 32(2), 197–202. https://doi.org/10.1080/09546634.2019.1692125Sinha, P., Srivastava, S., Mishra, N., & Yadav, N. P. (2014). New Perspectives on Antiacne Plant Drugs: Contribution to Modern Therapeutics. En BioMed Research International (Vol. 2014, pp. 1–19). Hindawi Publishing Corporation. https://doi.org/10.1155/2014/301304Soleymani, S., Zargaran, A., Farzaei, M. H., Iranpanah, A., Heydarpour, F., Najafi, F., & Rahimi, R. (2020). The effect of a hydrogel made by Nigella sativa L. on acne vulgaris: A randomized double-blind clinical trial. Phytotherapy Research, 34(11), 3052–3062. https://doi.org/10.1002/ptr.6739Sung, S. H., Choi, G. H., Lee, N. W., & Shin, B. C. (2020). External application of herbal medicines for acne vulgaris: A systematic review and meta analysis. Journal of Pharmacopuncture, 23(1), 8–17. https://doi.org/10.3831/KPI.2020.23.002Sutono, T. (2013). Efficacy of Garcinia mangostana L. (mangosteen rind extract) to reduce acne severity. Medical Journal of Indonesia, 22(3), 167–172. https://doi.org/10.13181/mji.v22i3.586Tabasum, H., Ahmad, T., Anjum, F., & Rehman, H. (2014). The effect of Unani antiacne formulation (Zimade Muhasa) on acne vulgaris: A single-blind, randomized, controlled clinical trial. Journal of Pakistan Association of Dermatologists, 24(4), 319–326.Thappa, D. M., & Dogra, J. (1994). Nodulocystic Acne: Oral Gugulipid versus Tetracycline. The journal of Dermatology, 21, 729–731.Universidad Industrial de Santander. (2019). PROCESO UNIDAD ESPECIALIZADA DE SALUD “UISALUD” SUBPROCESO PRESTACIÓN DE SERVICIOS ASISTENCIALES. http://gpc.minsalud.gov.co/gpc/SitePages/buscador_gpc.aspxVogler, B. K., & Ernst, E. (1999). Aloe vera: a systematic review of its clinical effectiveness. British Journal of General Practice, 49, 823–828.Waranuch, N., Phimnuan, P., Yakaew, S., Nakyai, W., Grandmottet, F., Onlom, C., Srivilai, J., & Viyoch, J. (2019). Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, garcinia mangostana peel extract, and Camellia sinensis leaf extract. Clinical, Cosmetic and Investigational Dermatology, 12, 383–391. https://doi.org/10.2147/CCID.S200564Wunnoo, S., Bilhman, S., Amnuaikit, T., Ontong, J. C., Singh, S., Auepemkiate, S., & Voravuthikunchai, S. P. (2021). Rhodomyrtone as a new natural antibiotic isolated from rhodomyrtus tomentosa leaf extract: A clinical application in the management of acne vulgaris. Antibiotics, 10(2), 1–12. https://doi.org/10.3390/antibiotics10020108Yang, J. H., Hwang, E. J., Moon, J., Yoon, J. Y., Kim, J. W., Choi, S., Cho, S. I., & Suh, D. H. (2021). Clinical efficacy of herbal extracts in treatment of mild to moderate acne vulgaris: an 8-week, double-blinded, randomized, controlled trial. Journal of Dermatological Treatment, 32(3), 297–301. https://doi.org/10.1080/09546634.2019.1657792Zhong, H., Li, X., Zhang, W., Shen, X., Lu, Y., & Li, H. (2021). Efficacy of a New Non-drug Acne Therapy: Aloe Vera Gel Combined With Ultrasound and Soft Mask for the Treatment of Mild to Severe Facial Acne. Frontiers in Medicine, 8, 1–9. https://doi.org/10.3389/fmed.2021.662640Plantas medicinalesPlants, MedicinalAnálisis documenatlAnálisis de informaciónDocument analysisInformation analysisAcné VulgarPlantasTerapéuticaEstudiantesInvestigadoresMaestrosPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/84634/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1015457433.2023.pdf1015457433.2023.pdfTesis de Maestría en Medicina Alternativaapplication/pdf2726261https://repositorio.unal.edu.co/bitstream/unal/84634/2/1015457433.2023.pdf542237f82adbbbaaf5b7e5293a3e47fbMD52THUMBNAIL1015457433.2023.pdf.jpg1015457433.2023.pdf.jpgGenerated Thumbnailimage/jpeg5062https://repositorio.unal.edu.co/bitstream/unal/84634/3/1015457433.2023.pdf.jpge62d3b259bc290f09bd4a0d45358236eMD53unal/84634oai:repositorio.unal.edu.co:unal/846342024-08-17 00:01:38.825Repositorio Institucional Universidad Nacional de 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