Efectividad clínica y seguridad de las intervenciones farmacológicas y psicológicas para el tratamiento del trastorno de ansiedad social en adolescentes: Revisión sistemática de la literatura con metaanálisis en red

ilustraciones, diagramas

Autores:
Samacá, Daniel Felipe
Tipo de recurso:
Fecha de publicación:
2023
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/84388
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/84388
https://repositorio.unal.edu.co/
Palabra clave:
150 - Psicología::158 - Psicología aplicada
610 - Medicina y salud
Phobia, Social
Fobia Social
Trastorno de ansiedad social
Adolescentes
Revisión sistemática
Meta-análisis en red
Social anxiety disorder
Adolescent
Systematic review
Network meta-analysis
Rights
openAccess
License
Atribución-NoComercial-SinDerivadas 4.0 Internacional
id UNACIONAL2_eb982094c56a926084dfb746cdf83ff1
oai_identifier_str oai:repositorio.unal.edu.co:unal/84388
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Efectividad clínica y seguridad de las intervenciones farmacológicas y psicológicas para el tratamiento del trastorno de ansiedad social en adolescentes: Revisión sistemática de la literatura con metaanálisis en red
dc.title.translated.eng.fl_str_mv Effectiveness and safety of pharmacological and psychological interventions for treating social anxiety disorder in adolescents: A systematic literature review and network meta-analysis
title Efectividad clínica y seguridad de las intervenciones farmacológicas y psicológicas para el tratamiento del trastorno de ansiedad social en adolescentes: Revisión sistemática de la literatura con metaanálisis en red
spellingShingle Efectividad clínica y seguridad de las intervenciones farmacológicas y psicológicas para el tratamiento del trastorno de ansiedad social en adolescentes: Revisión sistemática de la literatura con metaanálisis en red
150 - Psicología::158 - Psicología aplicada
610 - Medicina y salud
Phobia, Social
Fobia Social
Trastorno de ansiedad social
Adolescentes
Revisión sistemática
Meta-análisis en red
Social anxiety disorder
Adolescent
Systematic review
Network meta-analysis
title_short Efectividad clínica y seguridad de las intervenciones farmacológicas y psicológicas para el tratamiento del trastorno de ansiedad social en adolescentes: Revisión sistemática de la literatura con metaanálisis en red
title_full Efectividad clínica y seguridad de las intervenciones farmacológicas y psicológicas para el tratamiento del trastorno de ansiedad social en adolescentes: Revisión sistemática de la literatura con metaanálisis en red
title_fullStr Efectividad clínica y seguridad de las intervenciones farmacológicas y psicológicas para el tratamiento del trastorno de ansiedad social en adolescentes: Revisión sistemática de la literatura con metaanálisis en red
title_full_unstemmed Efectividad clínica y seguridad de las intervenciones farmacológicas y psicológicas para el tratamiento del trastorno de ansiedad social en adolescentes: Revisión sistemática de la literatura con metaanálisis en red
title_sort Efectividad clínica y seguridad de las intervenciones farmacológicas y psicológicas para el tratamiento del trastorno de ansiedad social en adolescentes: Revisión sistemática de la literatura con metaanálisis en red
dc.creator.fl_str_mv Samacá, Daniel Felipe
dc.contributor.advisor.none.fl_str_mv Eslava-Schmalbach, Javier Hernando
Calvo, José Manuel
dc.contributor.author.none.fl_str_mv Samacá, Daniel Felipe
dc.contributor.researchgroup.spa.fl_str_mv Grupo de Equidad en Salud
dc.contributor.orcid.spa.fl_str_mv Daniel Samacá-Samacá [0000000207824315]
dc.contributor.googlescholar.spa.fl_str_mv Daniel Samacá-Samacá [ceUA22cAAAAJ&hl=es&oi=ao]
dc.subject.ddc.spa.fl_str_mv 150 - Psicología::158 - Psicología aplicada
610 - Medicina y salud
topic 150 - Psicología::158 - Psicología aplicada
610 - Medicina y salud
Phobia, Social
Fobia Social
Trastorno de ansiedad social
Adolescentes
Revisión sistemática
Meta-análisis en red
Social anxiety disorder
Adolescent
Systematic review
Network meta-analysis
dc.subject.decs.eng.fl_str_mv Phobia, Social
dc.subject.decs.spa.fl_str_mv Fobia Social
dc.subject.proposal.spa.fl_str_mv Trastorno de ansiedad social
Adolescentes
Revisión sistemática
Meta-análisis en red
dc.subject.proposal.eng.fl_str_mv Social anxiety disorder
Adolescent
Systematic review
Network meta-analysis
description ilustraciones, diagramas
publishDate 2023
dc.date.accessioned.none.fl_str_mv 2023-08-01T15:40:21Z
dc.date.available.none.fl_str_mv 2023-08-01T15:40:21Z
dc.date.issued.none.fl_str_mv 2023-07-31
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/84388
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/84388
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.references.spa.fl_str_mv Walter HJ, Bukstein OG, Abright AR, Keable H, Ramtekkar U, Ripperger-Suhler J, et al. Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents With Anxiety Disorders. Vol. 59, Journal of the American Academy of Child and Adolescent Psychiatry. United States; 2020. p. 1107–24.
World Health Organization. Adolescent health [Internet]. 2022 [cited 2023 May 27]. Available from: https://www.who.int/health-topics/adolescent-health#tab=tab_1
Connolly SD, Bernstein GA. Practice parameter for the assessment and treatment of children and adolescents with anxiety disorders. J Am Acad Child Adolesc Psychiatry. 2007;46(2):267–83.
Salzer S, Stefini A, Kronmüller KT, Leibing E, Leichsenring F, Henningsen P, et al. Cognitive-behavioral and psychodynamic therapy in adolescents with social anxiety disorder: A multicenter randomized controlled trial. Psychother Psychosom. 2018;87(4):223–33.
Carlton CN, Sullivan-Toole H, Strege M V., Ollendick TH, Richey JA. Mindfulness-Based Interventions for Adolescent Social Anxiety: A Unique Convergence of Factors. Front Psychol. 2020;11(July).
Andrews G, Bell C, Boyce P, Gale C, Lampe L, Marwat O, et al. Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the treatment of panic disorder, social anxiety disorder and generalised anxiety disorder. Australian and New Zealand Journal of Psychiatry. 2018;52(12):1109–72.
Katzman MA, Bleau P, Blier P, Chokka P, Kjernisted K, Van Ameringen M, et al. Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders. BMC Psychiatry. 2014;14(SUPPL.1):1–83.
Hunger C, Hilzinger R, Klewinghaus L, Deusser L, Sander A, Mander J, et al. Comparing Cognitive Behavioral Therapy and Systemic Therapy for Social Anxiety Disorder: Randomized Controlled Pilot Trial (SOPHO-CBT/ST). Fam Process. 2020;59(4):1389–406.
Ameringen M Van, Turna J, Patterson B, Lau C. Pharmacotherapy for Adolescent Social Phobia. Social Anxiety and Phobia in Adolescents. 2015;301–22.
Centers for Disease Control and Prevention. Anxiety and Depression in Children | CDC. Centers for Disease Control and Prevention. 2020.
Agency for Healthcare Research and Quality. Anxiety in Children. Anxiety in Children: Comparative Effectiveness Review. 2020;(192):1–222.
Wang Z, Whiteside SPH, Sim L, Farah W, Morrow AS, Alsawas M, et al. Comparative effectiveness and safety of cognitive behavioral therapy and pharmacotherapy for childhood anxiety disorders: A systematic review and meta-analysis. JAMA Pediatr. 2017;171(11):1049–56.
Nordh M, Wahlund T, Jolstedt M, Sahlin H, Bjureberg J, Ahlen J, et al. Therapist-Guided Internet-Delivered Cognitive Behavioral Therapy vs Internet-Delivered Supportive Therapy for Children and Adolescents with Social Anxiety Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2021;78(7):705–13.
Harrer M, Cuijpers P, Furukawa TA, Ebert DD. Doing meta-analysis with R: a hands-on guide. Chapman and Hall/CRC; 2021.
Asociación Americana de Psiquiatría. Guía de consulta criterios diagnósticos de los del DSM-5. 2013.
Center for Behavioral Health Statistics and Quality. DSM-5 Changes: Implications for Child Serious Emotional Disturbance (unpublished internal documentation). 2016;(June):66.
Kalalo B, Marlietama CA, Cristabel G. Validity of the Liebowitz Social Anxiety Scale (LSAS) Measurement Tool. JPPP-Jurnal Penelitian dan Pengukuran Psikologi. 2021;10(1):18–26.
Morrison J. Guía para el diagnóstico clínico. The Guilford Press. 2013. 5–664 p.
Grupo de Gestión Integrada para la Salud Mental. Boletín de salud mental Salud mental en niños, niñas y adolescentes. Ministerio De Salud. 2017;1–24.
Nordahl HM, Vogel PA, Morken G, Stiles TC, Sandvik P, Wells A. Paroxetine, cognitive therapy or their combination in the treatment of social anxiety disorder with and without avoidant personality disorder: A randomized clinical trial. Psychother Psychosom. 2016;85(6):346–56.
National Collaborating Centre for Mental Health. Social anxiety disorder: recognition, assessment and treatment. In British Psychological Society; 2013.
American Academy of Child & Adolescent Psychiatry. Psychotherapy for Children and Adolescents: Different Types. 2019.
Strawn JR, Sakolsky DJ, Rynn MA. Psychopharmacologic Treatment of Children and Adolescents with Anxiety Disorders. Child Adolesc Psychiatr Clin N Am. 2012;21(3):527–39.
Gordon D, Wong J, Heimberg RG. Cognitive-behavioral therapy for social anxiety disorder: The state of the science. 2014;
Pharmacotherapy for anxiety disorders in children and adolescents.
Patel DR, Feucht C, Brown K, Ramsay J. Pharmacological treatment of anxiety disorders in children and adolescents: A review for practitioners. Transl Pediatr. 2018;7(1):23–35.
Pelligrino L, Pierce C, Walkup JT. Pharmacological management of childhood and adolescent anxiety disorders. Anxiety Disorders in Children and Adolescents, Second edition. 2011;367–91.
Patel DR, Feucht C, Brown K, Ramsay J. Pharmacological treatment of anxiety disorders in children and adolescents: A review for practitioners. Transl Pediatr. 2018;7(1):23–35.
Quah SKL, McIver L, Roberts AC, Santangelo AM. Trait anxiety mediated by amygdala serotonin transporter in the common marmoset. Journal of Neuroscience. 2020;40(24):4739–49.
Pharmacotherapy for anxiety disorders in children and adolescents.
Medina J, García de León M. Efectos secundarios de los antidepresivos. Vigilia sueño. 2004;48–57.
Da Prada M, Kettler R, Keller HH, Burkard WP, Muggli-Maniglio D, Haefely WE. Neurochemical profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type A. Journal of Pharmacology and Experimental Therapeutics. 1989 Jan 1;248(1):400 LP – 414.
Baker HJ, Lawrence PJ, Karalus J, Creswell C, Waite P. The Effectiveness of Psychological Therapies for Anxiety Disorders in Adolescents: A Meta-Analysis. Clin Child Fam Psychol Rev. 2021;24(4):765–82.
Zhou X, Zhang Y, Furukawa TA, Cuijpers P, Pu J, Weisz JR, et al. Different Types and Acceptability of Psychotherapies for Acute Anxiety Disorders in Children and Adolescents: A Network Meta-analysis. JAMA Psychiatry. 2019;76(1):41–50.
Cervin M, Lundgren T. Technology-delivered cognitive-behavioral therapy for pediatric anxiety disorders: a meta-analysis of remission, posttreatment anxiety, and functioning. J Child Psychol Psychiatry. 2022;63(1):7–18.
Carpenter JK, Andrews LA, Witcraft SM, Powers MB, Smits JAJ, Hofmann SG. Cognitive behavioral therapy for anxiety and related disorders: A meta‐analysis of randomized placebo‐controlled trials. Depress Anxiety. 2018;35(6):502–14.
Mayo-Wilson E, Dias S, Mavranezouli I, Kew K, Clark DM, Ades AE, et al. Psychological and pharmacological interventions for social anxiety disorder in adults: A systematic review and network meta-analysis. Lancet Psychiatry. 2014;1(5):368–76.
Dobson E, Bloch M, Strawn JR. Efficacy and tolerability of pharmacotherapy for pediatric anxiety disorders. Journal of Clinical Psychiatry. 2019;
Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page M, et al. Cochrane Handbook for Systematic Reviews of Interventions. The Cochrane Collaboration. 2019. 1–39 p.
Administration FD. What is a Serious Adverse Event? Http://Www.Fda.Gov/Safety/Medwatch/Howtoreport/Ucm053087.Htm. 2011. p. 1–2.
Grupo de Gestión Integrada para la Salud Mental. Boletín de salud mental Salud mental en niños, niñas y adolescentes. Ministerio De Salud. 2017;1–24.
Song F. What is indirect comparison. Hayward Medical Communications. 2009;1–6.
Catalá-López F, Tobías A, Roqué M. Conceptos básicos del metaanálisis en red. Aten Primaria. 2014;46(10):573–81.
Schwarzer G, Carpenter JR, Rücker G. Meta-analysis with R. Springer, editor. 2015.
Schwarzer G, Carpenter JR, Rücker G. Meta-analysis with R. Springer, editor. 2015.
Salanti G. Indirect and mixed‐treatment comparison, network, or multiple‐treatments meta‐analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool. Res Synth Methods. 2012;3(2):80–97.
Catalá-López F, Tobías A, Roqué M. Conceptos básicos del metaanálisis en red. Aten Primaria. 2014;46(10):573–81.
Rücker G, Krahn U, König J, Efthimiou O, Schwarzer G. Netmeta: network meta-analysis using frequentist methods. R package version. 2019;1.
Schwarzer G, Schwarzer MG. Package ‘meta’. The R foundation for statistical computing. 2012
Dias S, Welton NJ, Sutton AJ, Ades AE. NICE DSU technical support document 2: a generalised linear modelling framework for pairwise and network meta-analysis of randomised controlled trials. 2011
Cohen J. Statistical power analysis. Current Directions in Psychological Sciences, 1, 98-101. 1992.
Nikolakopoulou A, Higgins JPT, Papakonstantinou T, Chaimani A, Giovane C Del, Egger M, et al. Cinema: An approach for assessing confidence in the results of a network meta-analysis. PLoS Med. 2020 Apr 3;17(4):e1003082.
Öst LG, Cederlund R, Reuterskiöld L. Behavioral treatment of social phobia in youth: Does parent education training improve the outcome? Behaviour Research and Therapy. 2015 Apr 1;67:19–29.
Leigh E, Clark DM. Internet-delivered therapist-assisted cognitive therapy for adolescent social anxiety disorder (OSCA): a randomised controlled trial addressing preliminary efficacy and mechanisms of action. J Child Psychol Psychiatry. 2022
Beidel DC, Turner SM, Morris TL. Behavioral treatment of childhood social phobia. J Consult Clin Psychol. 2000;68(6):1072–80
Masia Warner C, Colognori D, Brice C, Herzig K, Mufson L, Lynch C, et al. Can school counselors deliver cognitive-behavioral treatment for social anxiety effectively? A randomized controlled trial. J Child Psychol Psychiatry. 2016 Nov 1;57(11):1229–38.
Warner CM, Fisher PH, Shrout PE, Rathor S, Klein RG. Treating adolescents with social anxiety disorder in school: An attention control trial. J Child Psychol Psychiatry. 2007 Jul;48(7):676–86.
Herbert JD, Gaudiano BA, Rheingold AA, Moitra E, Myers VH, Dalrymple KL, et al. Cognitive behavior therapy for generalized social anxiety disorder in adolescents: A randomized controlled trial. J Anxiety Disord. 2009 Mar;23(2):167–77.
Melfsen S, Kühnemund M, Schwieger J, Warnke A, Stadler C, Poustka F, et al. Cognitive behavioral therapy of socially phobic children focusing on cognition: A randomised wait-list control study. Child Adolesc Psychiatry Ment Health. 2011 Feb 28;5.
Salzer S, Stefini A, Kronmüller KT, Leibing E, Leichsenring F, Henningsen P, et al. Cognitive-behavioral and psychodynamic therapy in adolescents with social anxiety disorder: A multicenter randomized controlled trial. Psychother Psychosom. 2018 Aug 1;87(4):223–33.
Gil-Bernal F, Hernández-Guzmán L. Tratamiento cognitivo-conductual para niños mexicanos con fobia social Tratamiento cognitivo-conductual para niños mexicanos con fobia social *. Vol. 40. 2009.
Olivares J, Olivares-Olivares PJ, Rosa-Alcázar AI, Montesinos L, Macià D. Contribución de la competencia del terapeuta en el tratamiento de adolescentes con fobia social generalizada. Psicothema. 2014;26(4):483–9.
Olivares-Olivares P, Rosa-Alcázar AI, Olivares-Rodríguez J. Does individual attention improve the effect of group treatment of adolescents with social phobia? International Journal of Clinical and Health Psychology [Internet]. 2008;8(2):465–81. Available from: http://www.redalyc.org/articulo.oa?id=33712001008
Sánchez-García R, Olivares J. Effectiveness of a program for early detection/intervention in children/adolescents with generalized social phobia [Internet]. Vol. 25. 2009. Available from: http://revistas.um.es/analesps
Rosa-Alcázar AI, Olivares-Rodríguez J, Olivares-Olivares P, Olivares J. El Papel de la Planifi cación de la Interacción en el Tratamiento de Adolescentes con Fobia Social Generalizada* The Role of Planned Interaction in the Treatment of Generalized Social Phobia of Personality, Assessment and Psychological Treatment. 2007;25:205–12.
Asbrand J, Heinrichs N, Schmidtendorf S, Nitschke K, Tuschen-Caffier B. Experience Versus Report: Where Are Changes Seen After Exposure-Based Cognitive-Behavioral Therapy? A Randomized Controlled Group Treatment of Childhood Social Anxiety Disorder. Child Psychiatry Hum Dev. 2020 Jun 1;51(3):427–41.
Spence SH, Donovan CL, March S, Kenardy JA, Hearn CS. Generic versus disorder specific cognitive behavior therapy for social anxiety disorder in youth: A randomized controlled trial using internet delivery. Behaviour Research and Therapy. 2017 Mar 1;90:41–57.
Dineen Wagner K, Berard R, Stein MB, Wetherhold E, Carpenter DJ, Perera P, et al. A Multicenter, Randomized, Double-blind, Placebo-Controlled Trial of Paroxetine in Children and Adolescents With Social Anxiety Disorder. 2004.
Olivares J, Rosa-Alcázar AI, Olivares-Olivares PJ. Transmisión de información cualificada frente a tratamiento psicológico estructurado de adolescentes con fobia social generalizada. Int J Clin Health Psychol. 2009;9(2):241–58.
Ingul JM, Aune T, Nordahl HM. A randomized controlled trial of individual cognitive therapy, group cognitive behaviour therapy and attentional placebo for adolescent social phobia. Psychother Psychosom. 2013 Dec;83(1):54–61.
March JS, Entusah AR, Rynn M, Albano AM, Tourian KA. A Randomized Controlled Trial of Venlafaxine ER Versus Placebo in Pediatric Social Anxiety Disorder. Biol Psychiatry. 2007 Nov 15;62(10):1149–54.
Tillfors M, Andersson G, Ekselius L, Furmark T, Lewenhaupt S, Karlsson A, et al. A randomized trial of internet-delivered treatment for social anxiety disorder in high school students. Cogn Behav Ther. 2011;40(2):147–57.
Olivares-Olivares PJ, Ortiz-González PF, Olivares J. Role of social skills training in adolescents with social anxiety disorder. International Journal of Clinical and Health Psychology. 2019 Jan 1;19(1):41–8.
Amorós-Boix M, Rosa-Alcázar AI, Olivares-Olivares PJ. Papel de la focalización de la atención en el tratamiento de la fobia social generalizada en adolescentes [Internet]. Vol. 27, anales de psicología. 2011. Available from: http://revistas.um.es/analesps
Beidel DC, Turner SM, Sallee FR, Ammerman RT, Crosby LA, Pathak S. SET-C versus fluoxetine in the treatment of childhood social phobia. J Am Acad Child Adolesc Psychiatry. 2007;46(12):1622–32.
Nordh M, Wahlund T, Jolstedt M, Sahlin H, Bjureberg J, Ahlen J, et al. Therapist-Guided Internet-Delivered Cognitive Behavioral Therapy vs Internet-Delivered Supportive Therapy for Children and Adolescents with Social Anxiety Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2021 Jul 1;78(7):705–13.
Spence SH, Donovan C, Brechman-Toussaint M. The Treatment of Childhood Social Phobia : The Effectiveness of a Social Skills Training-based, Cognitive-behavioural Intervention, with and without Parental Involvement. Vol. 41, J. Child Psychol. Psychiat. 2000
Bandelow B, Michaelis S, Wedekind D. Treatment of anxiety disorders. Dialogues Clin Neurosci. 2022
Agency for Healthcare Research, Quality. Anxiety in Children. Anxiety in Children: Comparative Effectiveness Review. 2020;(192):1–222.
Wang Z, Whiteside SPH, Sim L, Farah W, Morrow AS, Alsawas M, et al. Comparative effectiveness and safety of cognitive behavioral therapy and pharmacotherapy for childhood anxiety disorders: A systematic review and meta-analysis. JAMA Pediatr. 2017;171(11):1049–56.
Cervin M, Lundgren T. Technology-delivered cognitive-behavioral therapy for pediatric anxiety disorders: a meta-analysis of remission, posttreatment anxiety, and functioning. J Child Psychol Psychiatry. 2022;63(1):7–18.
Christ C, Schouten MJE, Blankers M, van Schaik DJF, Beekman ATF, Wisman MA, et al. Internet and computer-based cognitive behavioral therapy for anxiety and depression in adolescents and young adults: Systematic review and meta-analysis. Vol. 22, Journal of Medical Internet Research. JMIR Publications Inc.; 2020.
Zhou X, Zhang Y, Furukawa TA, Cuijpers P, Pu J, Weisz JR, et al. Different Types and Acceptability of Psychotherapies for Acute Anxiety Disorders in Children and Adolescents: A Network Meta-analysis. JAMA Psychiatry. 2019;76(1):41–50.
Spadoni C. Pediatric Drug Development: Challenges and Opportunities. Curr Ther Res Clin Exp [Internet]. 2018 Dec 28;90:119–22. Available from: https://pubmed.ncbi.nlm.nih.gov/31388366
Auby P. Pharmaceutical research in paediatric populations and the new EU Paediatric Legislation: an industry perspective. Child Adolesc Psychiatry Ment Health [Internet]. 2008 Dec 8;2(1):38. Available from: https://pubmed.ncbi.nlm.nih.gov/19063723
Nordh M, Wahlund T, Jolstedt M, Sahlin H, Bjureberg J, Ahlen J, et al. Therapist-Guided Internet-Delivered Cognitive Behavioral Therapy vs Internet-Delivered Supportive Therapy for Children and Adolescents with Social Anxiety Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2021;78(7):705–13.
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.license.spa.fl_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rights.uri.spa.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial-SinDerivadas 4.0 Internacional
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dc.format.extent.spa.fl_str_mv xv, 248 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv Bogotá - Medicina - Maestría en Epidemiología Clínica
dc.publisher.faculty.spa.fl_str_mv Facultad de Medicina
dc.publisher.place.spa.fl_str_mv Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá
institution Universidad Nacional de Colombia
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spelling Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Eslava-Schmalbach, Javier Hernandoe23e4adcaa27a47ab5b481e75250ab4c600Calvo, José Manuel79bccdf638c368bb9c95d749842960f9600Samacá, Daniel Felipe2199db69334226fdf7ef39185a782777600Grupo de Equidad en SaludDaniel Samacá-Samacá [0000000207824315]Daniel Samacá-Samacá [ceUA22cAAAAJ&hl=es&oi=ao]2023-08-01T15:40:21Z2023-08-01T15:40:21Z2023-07-31https://repositorio.unal.edu.co/handle/unal/84388Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasObjetivo: Evaluar la efectividad clínica y la seguridad de las intervenciones farmacológicas y psicológicas utilizadas para el tratamiento del trastorno de ansiedad social en adolescentes. Metodología: Se realizó una revisión sistemática de la literatura con metaanálisis en red, implementando un modelo frecuentista de efectos aleatorios. La reducción de los síntomas de ansiedad social se evaluó como la diferencia estandarizada de medias entre el cambio del puntaje en la línea de base hasta la evaluación de seguimiento. La remisión parcial y completa se evaluaron como desenlace dicotómico a partir del riesgo relativo en la frecuencia del evento. La certeza de la evidencia se evaluó con el enfoque CINeMA. Resultados: Tras la identificación de 9309 referencias en bases de datos y fuentes complementarias se incluyeron 25 ensayos clínicos aleatorizados. La mayoría de los estudios evaluaron diferentes modalidades de la terapia cognitivo-conductual, incluyendo aplicaciones individuales, grupales, virtuales, autodirigidos, entre otros. Entre los tratamientos farmacológicos se identificó el uso de la venlafaxina ER, la fluoxetina y la paroxetina, sin embargo, estos estudios incluyeron población de niños y niñas, y presentaron alto riesgo de sesgo, por lo cual sus resultados fueron limitados. La certeza de la evidencia fue baja para la mayoría de las comparaciones de interés. Los resultados mostraron poca o ninguna diferencia en la reducción de síntomas de ansiedad social y la remisión parcial o completa para adolescentes con trastorno de ansiedad social. Conclusión: Se requiere la generación de más evidencia científica, con mayor rigor metodológico, para determinar las mejores opciones de tratamiento para adolescentes con ansiedad social. (Texto tomado de la fuente)Objective: To evaluate the clinical effectiveness and safety of pharmacological and psychological interventions used to treat social anxiety disorder in adolescents. Methodology: A systematic literature review with network meta-analysis was performed, implementing a random-effects frequency model. Reduction in social anxiety symptom severity was assessed as the standardized mean difference between the change in the score at baseline to follow-up assessment. Partial and complete remission were assessed as dichotomous outcomes from relative risk in event frequency. The certainty of the evidence was assessed using the CINeMA approach. Results: After identifying 9309 references in databases and complementary sources, 25 randomized clinical trials were included. Most studies evaluated different modalities of cognitive-behavioral therapy, including individual, group, virtual, and self-directed. Among the pharmacological treatments, the use of venlafaxine ER, fluoxetine and paroxetine was identified; however, these studies included a population of children and presented a high risk of bias, so their results were limited. The certainty of the evidence was low for most of the comparisons of interest. The results showed little or no difference in the reduction of social anxiety symptoms and partial or complete remission for adolescents with social anxiety disorder. Conclusion: More scientific evidence, with greater methodological rigor, is required to determine the best treatment options for adolescents with social anxiety.MaestríaMagíster en epidemiología clínicaSe realizó una revisión sistemática de la literatura con metaanálisis en red, implementando un modelo frecuentista de efectos aleatorios. La reducción de los síntomas de ansiedad social se evaluó como la diferencia estandarizada de medias entre el cambio del puntaje en la línea de base hasta la evaluación de seguimiento. La remisión parcial y completa se evaluaron como desenlace dicotómico a partir del riesgo relativo en la frecuencia del evento. La certeza de la evidencia se evaluó con el enfoque CINeMA.Salud materna, Neurociencia cognitiva y de comunicaciónxv, 248 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Maestría en Epidemiología ClínicaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá150 - Psicología::158 - Psicología aplicada610 - Medicina y saludPhobia, SocialFobia SocialTrastorno de ansiedad socialAdolescentesRevisión sistemáticaMeta-análisis en redSocial anxiety disorderAdolescentSystematic reviewNetwork meta-analysisEfectividad clínica y seguridad de las intervenciones farmacológicas y psicológicas para el tratamiento del trastorno de ansiedad social en adolescentes: Revisión sistemática de la literatura con metaanálisis en redEffectiveness and safety of pharmacological and psychological interventions for treating social anxiety disorder in adolescents: A systematic literature review and network meta-analysisTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMWalter HJ, Bukstein OG, Abright AR, Keable H, Ramtekkar U, Ripperger-Suhler J, et al. Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents With Anxiety Disorders. Vol. 59, Journal of the American Academy of Child and Adolescent Psychiatry. United States; 2020. p. 1107–24.World Health Organization. Adolescent health [Internet]. 2022 [cited 2023 May 27]. Available from: https://www.who.int/health-topics/adolescent-health#tab=tab_1Connolly SD, Bernstein GA. Practice parameter for the assessment and treatment of children and adolescents with anxiety disorders. J Am Acad Child Adolesc Psychiatry. 2007;46(2):267–83.Salzer S, Stefini A, Kronmüller KT, Leibing E, Leichsenring F, Henningsen P, et al. Cognitive-behavioral and psychodynamic therapy in adolescents with social anxiety disorder: A multicenter randomized controlled trial. Psychother Psychosom. 2018;87(4):223–33.Carlton CN, Sullivan-Toole H, Strege M V., Ollendick TH, Richey JA. Mindfulness-Based Interventions for Adolescent Social Anxiety: A Unique Convergence of Factors. Front Psychol. 2020;11(July).Andrews G, Bell C, Boyce P, Gale C, Lampe L, Marwat O, et al. Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the treatment of panic disorder, social anxiety disorder and generalised anxiety disorder. Australian and New Zealand Journal of Psychiatry. 2018;52(12):1109–72.Katzman MA, Bleau P, Blier P, Chokka P, Kjernisted K, Van Ameringen M, et al. Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders. BMC Psychiatry. 2014;14(SUPPL.1):1–83.Hunger C, Hilzinger R, Klewinghaus L, Deusser L, Sander A, Mander J, et al. Comparing Cognitive Behavioral Therapy and Systemic Therapy for Social Anxiety Disorder: Randomized Controlled Pilot Trial (SOPHO-CBT/ST). Fam Process. 2020;59(4):1389–406.Ameringen M Van, Turna J, Patterson B, Lau C. Pharmacotherapy for Adolescent Social Phobia. Social Anxiety and Phobia in Adolescents. 2015;301–22.Centers for Disease Control and Prevention. Anxiety and Depression in Children | CDC. Centers for Disease Control and Prevention. 2020.Agency for Healthcare Research and Quality. Anxiety in Children. Anxiety in Children: Comparative Effectiveness Review. 2020;(192):1–222.Wang Z, Whiteside SPH, Sim L, Farah W, Morrow AS, Alsawas M, et al. Comparative effectiveness and safety of cognitive behavioral therapy and pharmacotherapy for childhood anxiety disorders: A systematic review and meta-analysis. JAMA Pediatr. 2017;171(11):1049–56.Nordh M, Wahlund T, Jolstedt M, Sahlin H, Bjureberg J, Ahlen J, et al. Therapist-Guided Internet-Delivered Cognitive Behavioral Therapy vs Internet-Delivered Supportive Therapy for Children and Adolescents with Social Anxiety Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2021;78(7):705–13.Harrer M, Cuijpers P, Furukawa TA, Ebert DD. Doing meta-analysis with R: a hands-on guide. Chapman and Hall/CRC; 2021.Asociación Americana de Psiquiatría. Guía de consulta criterios diagnósticos de los del DSM-5. 2013.Center for Behavioral Health Statistics and Quality. DSM-5 Changes: Implications for Child Serious Emotional Disturbance (unpublished internal documentation). 2016;(June):66.Kalalo B, Marlietama CA, Cristabel G. Validity of the Liebowitz Social Anxiety Scale (LSAS) Measurement Tool. JPPP-Jurnal Penelitian dan Pengukuran Psikologi. 2021;10(1):18–26.Morrison J. Guía para el diagnóstico clínico. The Guilford Press. 2013. 5–664 p.Grupo de Gestión Integrada para la Salud Mental. Boletín de salud mental Salud mental en niños, niñas y adolescentes. Ministerio De Salud. 2017;1–24.Nordahl HM, Vogel PA, Morken G, Stiles TC, Sandvik P, Wells A. Paroxetine, cognitive therapy or their combination in the treatment of social anxiety disorder with and without avoidant personality disorder: A randomized clinical trial. Psychother Psychosom. 2016;85(6):346–56.National Collaborating Centre for Mental Health. Social anxiety disorder: recognition, assessment and treatment. In British Psychological Society; 2013.American Academy of Child & Adolescent Psychiatry. Psychotherapy for Children and Adolescents: Different Types. 2019.Strawn JR, Sakolsky DJ, Rynn MA. Psychopharmacologic Treatment of Children and Adolescents with Anxiety Disorders. Child Adolesc Psychiatr Clin N Am. 2012;21(3):527–39.Gordon D, Wong J, Heimberg RG. Cognitive-behavioral therapy for social anxiety disorder: The state of the science. 2014;Pharmacotherapy for anxiety disorders in children and adolescents.Patel DR, Feucht C, Brown K, Ramsay J. Pharmacological treatment of anxiety disorders in children and adolescents: A review for practitioners. Transl Pediatr. 2018;7(1):23–35.Pelligrino L, Pierce C, Walkup JT. Pharmacological management of childhood and adolescent anxiety disorders. Anxiety Disorders in Children and Adolescents, Second edition. 2011;367–91.Patel DR, Feucht C, Brown K, Ramsay J. Pharmacological treatment of anxiety disorders in children and adolescents: A review for practitioners. Transl Pediatr. 2018;7(1):23–35.Quah SKL, McIver L, Roberts AC, Santangelo AM. Trait anxiety mediated by amygdala serotonin transporter in the common marmoset. Journal of Neuroscience. 2020;40(24):4739–49.Pharmacotherapy for anxiety disorders in children and adolescents.Medina J, García de León M. Efectos secundarios de los antidepresivos. Vigilia sueño. 2004;48–57.Da Prada M, Kettler R, Keller HH, Burkard WP, Muggli-Maniglio D, Haefely WE. Neurochemical profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type A. Journal of Pharmacology and Experimental Therapeutics. 1989 Jan 1;248(1):400 LP – 414.Baker HJ, Lawrence PJ, Karalus J, Creswell C, Waite P. The Effectiveness of Psychological Therapies for Anxiety Disorders in Adolescents: A Meta-Analysis. Clin Child Fam Psychol Rev. 2021;24(4):765–82.Zhou X, Zhang Y, Furukawa TA, Cuijpers P, Pu J, Weisz JR, et al. Different Types and Acceptability of Psychotherapies for Acute Anxiety Disorders in Children and Adolescents: A Network Meta-analysis. JAMA Psychiatry. 2019;76(1):41–50.Cervin M, Lundgren T. Technology-delivered cognitive-behavioral therapy for pediatric anxiety disorders: a meta-analysis of remission, posttreatment anxiety, and functioning. J Child Psychol Psychiatry. 2022;63(1):7–18.Carpenter JK, Andrews LA, Witcraft SM, Powers MB, Smits JAJ, Hofmann SG. Cognitive behavioral therapy for anxiety and related disorders: A meta‐analysis of randomized placebo‐controlled trials. Depress Anxiety. 2018;35(6):502–14.Mayo-Wilson E, Dias S, Mavranezouli I, Kew K, Clark DM, Ades AE, et al. Psychological and pharmacological interventions for social anxiety disorder in adults: A systematic review and network meta-analysis. Lancet Psychiatry. 2014;1(5):368–76.Dobson E, Bloch M, Strawn JR. Efficacy and tolerability of pharmacotherapy for pediatric anxiety disorders. Journal of Clinical Psychiatry. 2019;Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page M, et al. Cochrane Handbook for Systematic Reviews of Interventions. The Cochrane Collaboration. 2019. 1–39 p.Administration FD. What is a Serious Adverse Event? Http://Www.Fda.Gov/Safety/Medwatch/Howtoreport/Ucm053087.Htm. 2011. p. 1–2.Grupo de Gestión Integrada para la Salud Mental. Boletín de salud mental Salud mental en niños, niñas y adolescentes. Ministerio De Salud. 2017;1–24.Song F. What is indirect comparison. Hayward Medical Communications. 2009;1–6.Catalá-López F, Tobías A, Roqué M. Conceptos básicos del metaanálisis en red. Aten Primaria. 2014;46(10):573–81.Schwarzer G, Carpenter JR, Rücker G. Meta-analysis with R. Springer, editor. 2015.Schwarzer G, Carpenter JR, Rücker G. Meta-analysis with R. Springer, editor. 2015.Salanti G. Indirect and mixed‐treatment comparison, network, or multiple‐treatments meta‐analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool. Res Synth Methods. 2012;3(2):80–97.Catalá-López F, Tobías A, Roqué M. Conceptos básicos del metaanálisis en red. Aten Primaria. 2014;46(10):573–81.Rücker G, Krahn U, König J, Efthimiou O, Schwarzer G. Netmeta: network meta-analysis using frequentist methods. R package version. 2019;1.Schwarzer G, Schwarzer MG. Package ‘meta’. The R foundation for statistical computing. 2012Dias S, Welton NJ, Sutton AJ, Ades AE. NICE DSU technical support document 2: a generalised linear modelling framework for pairwise and network meta-analysis of randomised controlled trials. 2011Cohen J. Statistical power analysis. Current Directions in Psychological Sciences, 1, 98-101. 1992.Nikolakopoulou A, Higgins JPT, Papakonstantinou T, Chaimani A, Giovane C Del, Egger M, et al. Cinema: An approach for assessing confidence in the results of a network meta-analysis. PLoS Med. 2020 Apr 3;17(4):e1003082.Öst LG, Cederlund R, Reuterskiöld L. Behavioral treatment of social phobia in youth: Does parent education training improve the outcome? Behaviour Research and Therapy. 2015 Apr 1;67:19–29.Leigh E, Clark DM. Internet-delivered therapist-assisted cognitive therapy for adolescent social anxiety disorder (OSCA): a randomised controlled trial addressing preliminary efficacy and mechanisms of action. J Child Psychol Psychiatry. 2022Beidel DC, Turner SM, Morris TL. Behavioral treatment of childhood social phobia. J Consult Clin Psychol. 2000;68(6):1072–80Masia Warner C, Colognori D, Brice C, Herzig K, Mufson L, Lynch C, et al. Can school counselors deliver cognitive-behavioral treatment for social anxiety effectively? A randomized controlled trial. J Child Psychol Psychiatry. 2016 Nov 1;57(11):1229–38.Warner CM, Fisher PH, Shrout PE, Rathor S, Klein RG. Treating adolescents with social anxiety disorder in school: An attention control trial. J Child Psychol Psychiatry. 2007 Jul;48(7):676–86.Herbert JD, Gaudiano BA, Rheingold AA, Moitra E, Myers VH, Dalrymple KL, et al. Cognitive behavior therapy for generalized social anxiety disorder in adolescents: A randomized controlled trial. J Anxiety Disord. 2009 Mar;23(2):167–77.Melfsen S, Kühnemund M, Schwieger J, Warnke A, Stadler C, Poustka F, et al. Cognitive behavioral therapy of socially phobic children focusing on cognition: A randomised wait-list control study. Child Adolesc Psychiatry Ment Health. 2011 Feb 28;5.Salzer S, Stefini A, Kronmüller KT, Leibing E, Leichsenring F, Henningsen P, et al. Cognitive-behavioral and psychodynamic therapy in adolescents with social anxiety disorder: A multicenter randomized controlled trial. Psychother Psychosom. 2018 Aug 1;87(4):223–33.Gil-Bernal F, Hernández-Guzmán L. Tratamiento cognitivo-conductual para niños mexicanos con fobia social Tratamiento cognitivo-conductual para niños mexicanos con fobia social *. Vol. 40. 2009.Olivares J, Olivares-Olivares PJ, Rosa-Alcázar AI, Montesinos L, Macià D. Contribución de la competencia del terapeuta en el tratamiento de adolescentes con fobia social generalizada. Psicothema. 2014;26(4):483–9.Olivares-Olivares P, Rosa-Alcázar AI, Olivares-Rodríguez J. Does individual attention improve the effect of group treatment of adolescents with social phobia? International Journal of Clinical and Health Psychology [Internet]. 2008;8(2):465–81. Available from: http://www.redalyc.org/articulo.oa?id=33712001008Sánchez-García R, Olivares J. Effectiveness of a program for early detection/intervention in children/adolescents with generalized social phobia [Internet]. Vol. 25. 2009. Available from: http://revistas.um.es/analespsRosa-Alcázar AI, Olivares-Rodríguez J, Olivares-Olivares P, Olivares J. El Papel de la Planifi cación de la Interacción en el Tratamiento de Adolescentes con Fobia Social Generalizada* The Role of Planned Interaction in the Treatment of Generalized Social Phobia of Personality, Assessment and Psychological Treatment. 2007;25:205–12.Asbrand J, Heinrichs N, Schmidtendorf S, Nitschke K, Tuschen-Caffier B. Experience Versus Report: Where Are Changes Seen After Exposure-Based Cognitive-Behavioral Therapy? A Randomized Controlled Group Treatment of Childhood Social Anxiety Disorder. Child Psychiatry Hum Dev. 2020 Jun 1;51(3):427–41.Spence SH, Donovan CL, March S, Kenardy JA, Hearn CS. Generic versus disorder specific cognitive behavior therapy for social anxiety disorder in youth: A randomized controlled trial using internet delivery. Behaviour Research and Therapy. 2017 Mar 1;90:41–57.Dineen Wagner K, Berard R, Stein MB, Wetherhold E, Carpenter DJ, Perera P, et al. A Multicenter, Randomized, Double-blind, Placebo-Controlled Trial of Paroxetine in Children and Adolescents With Social Anxiety Disorder. 2004.Olivares J, Rosa-Alcázar AI, Olivares-Olivares PJ. Transmisión de información cualificada frente a tratamiento psicológico estructurado de adolescentes con fobia social generalizada. Int J Clin Health Psychol. 2009;9(2):241–58.Ingul JM, Aune T, Nordahl HM. A randomized controlled trial of individual cognitive therapy, group cognitive behaviour therapy and attentional placebo for adolescent social phobia. Psychother Psychosom. 2013 Dec;83(1):54–61.March JS, Entusah AR, Rynn M, Albano AM, Tourian KA. A Randomized Controlled Trial of Venlafaxine ER Versus Placebo in Pediatric Social Anxiety Disorder. Biol Psychiatry. 2007 Nov 15;62(10):1149–54.Tillfors M, Andersson G, Ekselius L, Furmark T, Lewenhaupt S, Karlsson A, et al. A randomized trial of internet-delivered treatment for social anxiety disorder in high school students. Cogn Behav Ther. 2011;40(2):147–57.Olivares-Olivares PJ, Ortiz-González PF, Olivares J. Role of social skills training in adolescents with social anxiety disorder. International Journal of Clinical and Health Psychology. 2019 Jan 1;19(1):41–8.Amorós-Boix M, Rosa-Alcázar AI, Olivares-Olivares PJ. Papel de la focalización de la atención en el tratamiento de la fobia social generalizada en adolescentes [Internet]. Vol. 27, anales de psicología. 2011. Available from: http://revistas.um.es/analespsBeidel DC, Turner SM, Sallee FR, Ammerman RT, Crosby LA, Pathak S. SET-C versus fluoxetine in the treatment of childhood social phobia. J Am Acad Child Adolesc Psychiatry. 2007;46(12):1622–32.Nordh M, Wahlund T, Jolstedt M, Sahlin H, Bjureberg J, Ahlen J, et al. Therapist-Guided Internet-Delivered Cognitive Behavioral Therapy vs Internet-Delivered Supportive Therapy for Children and Adolescents with Social Anxiety Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2021 Jul 1;78(7):705–13.Spence SH, Donovan C, Brechman-Toussaint M. The Treatment of Childhood Social Phobia : The Effectiveness of a Social Skills Training-based, Cognitive-behavioural Intervention, with and without Parental Involvement. Vol. 41, J. Child Psychol. Psychiat. 2000Bandelow B, Michaelis S, Wedekind D. Treatment of anxiety disorders. Dialogues Clin Neurosci. 2022Agency for Healthcare Research, Quality. Anxiety in Children. Anxiety in Children: Comparative Effectiveness Review. 2020;(192):1–222.Wang Z, Whiteside SPH, Sim L, Farah W, Morrow AS, Alsawas M, et al. Comparative effectiveness and safety of cognitive behavioral therapy and pharmacotherapy for childhood anxiety disorders: A systematic review and meta-analysis. JAMA Pediatr. 2017;171(11):1049–56.Cervin M, Lundgren T. Technology-delivered cognitive-behavioral therapy for pediatric anxiety disorders: a meta-analysis of remission, posttreatment anxiety, and functioning. J Child Psychol Psychiatry. 2022;63(1):7–18.Christ C, Schouten MJE, Blankers M, van Schaik DJF, Beekman ATF, Wisman MA, et al. Internet and computer-based cognitive behavioral therapy for anxiety and depression in adolescents and young adults: Systematic review and meta-analysis. Vol. 22, Journal of Medical Internet Research. JMIR Publications Inc.; 2020.Zhou X, Zhang Y, Furukawa TA, Cuijpers P, Pu J, Weisz JR, et al. Different Types and Acceptability of Psychotherapies for Acute Anxiety Disorders in Children and Adolescents: A Network Meta-analysis. JAMA Psychiatry. 2019;76(1):41–50.Spadoni C. Pediatric Drug Development: Challenges and Opportunities. Curr Ther Res Clin Exp [Internet]. 2018 Dec 28;90:119–22. Available from: https://pubmed.ncbi.nlm.nih.gov/31388366Auby P. Pharmaceutical research in paediatric populations and the new EU Paediatric Legislation: an industry perspective. Child Adolesc Psychiatry Ment Health [Internet]. 2008 Dec 8;2(1):38. Available from: https://pubmed.ncbi.nlm.nih.gov/19063723Nordh M, Wahlund T, Jolstedt M, Sahlin H, Bjureberg J, Ahlen J, et al. Therapist-Guided Internet-Delivered Cognitive Behavioral Therapy vs Internet-Delivered Supportive Therapy for Children and Adolescents with Social Anxiety Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2021;78(7):705–13.EstudiantesInvestigadoresMaestrosPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/84388/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1.032.463.536.2023.pdf1.032.463.536.2023.pdfTesis de Maestría en Epidemiología Clínicaapplication/pdf19274461https://repositorio.unal.edu.co/bitstream/unal/84388/2/1.032.463.536.2023.pdff239e448989db682b59008649005c454MD52THUMBNAIL1.032.463.536.2023.pdf.jpg1.032.463.536.2023.pdf.jpgGenerated Thumbnailimage/jpeg6306https://repositorio.unal.edu.co/bitstream/unal/84388/3/1.032.463.536.2023.pdf.jpgff58cd749296373a17e07ead532de4bdMD53unal/84388oai:repositorio.unal.edu.co:unal/843882023-08-15 23:04:06.9Repositorio Institucional Universidad Nacional de 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