Sarcomas primarios de sistema nervioso central en pacientes pediátricos: características radiológicas y patológicas
ilustraciones, fotografías, gráficas, tablas
- Autores:
-
Ojeda Gómez, Juan Sebastián Alonso
- Tipo de recurso:
- Fecha de publicación:
- 2021
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/80908
- Palabra clave:
- 610 - Medicina y salud::616 - Enfermedades
Enfermedades del Sistema Nervioso Central
Radiología
Central Nervous System Diseases
Radiology
Sarcoma
Sarcoma
Sistema nervioso central
Sarcoma
Tumor cerebral
Imágenes diagnósticas
Central nervous system
Sarcoma
Brain tumor
Diagnostic imaging
- Rights
- openAccess
- License
- Atribución-SinDerivadas 4.0 Internacional
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Sarcomas primarios de sistema nervioso central en pacientes pediátricos: características radiológicas y patológicas |
| dc.title.translated.eng.fl_str_mv |
Primary central nervous system sarcomas in children: radiological and pathological features |
| title |
Sarcomas primarios de sistema nervioso central en pacientes pediátricos: características radiológicas y patológicas |
| spellingShingle |
Sarcomas primarios de sistema nervioso central en pacientes pediátricos: características radiológicas y patológicas 610 - Medicina y salud::616 - Enfermedades Enfermedades del Sistema Nervioso Central Radiología Central Nervous System Diseases Radiology Sarcoma Sarcoma Sistema nervioso central Sarcoma Tumor cerebral Imágenes diagnósticas Central nervous system Sarcoma Brain tumor Diagnostic imaging |
| title_short |
Sarcomas primarios de sistema nervioso central en pacientes pediátricos: características radiológicas y patológicas |
| title_full |
Sarcomas primarios de sistema nervioso central en pacientes pediátricos: características radiológicas y patológicas |
| title_fullStr |
Sarcomas primarios de sistema nervioso central en pacientes pediátricos: características radiológicas y patológicas |
| title_full_unstemmed |
Sarcomas primarios de sistema nervioso central en pacientes pediátricos: características radiológicas y patológicas |
| title_sort |
Sarcomas primarios de sistema nervioso central en pacientes pediátricos: características radiológicas y patológicas |
| dc.creator.fl_str_mv |
Ojeda Gómez, Juan Sebastián Alonso |
| dc.contributor.advisor.spa.fl_str_mv |
Moreno Gómez, Luz Angela |
| dc.contributor.author.spa.fl_str_mv |
Ojeda Gómez, Juan Sebastián Alonso |
| dc.subject.ddc.spa.fl_str_mv |
610 - Medicina y salud::616 - Enfermedades |
| topic |
610 - Medicina y salud::616 - Enfermedades Enfermedades del Sistema Nervioso Central Radiología Central Nervous System Diseases Radiology Sarcoma Sarcoma Sistema nervioso central Sarcoma Tumor cerebral Imágenes diagnósticas Central nervous system Sarcoma Brain tumor Diagnostic imaging |
| dc.subject.decs.spa.fl_str_mv |
Enfermedades del Sistema Nervioso Central Radiología |
| dc.subject.decs.eng.fl_str_mv |
Central Nervous System Diseases Radiology |
| dc.subject.lemb.spa.fl_str_mv |
Sarcoma |
| dc.subject.lemb.eng.fl_str_mv |
Sarcoma |
| dc.subject.proposal.spa.fl_str_mv |
Sistema nervioso central Sarcoma Tumor cerebral Imágenes diagnósticas |
| dc.subject.proposal.eng.fl_str_mv |
Central nervous system Sarcoma Brain tumor Diagnostic imaging |
| description |
ilustraciones, fotografías, gráficas, tablas |
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2021 |
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2021-12-09 |
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2022-02-08T16:08:47Z |
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2022-02-08T16:08:47Z |
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Trabajo de grado - Especialidad Médica |
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info:eu-repo/semantics/masterThesis |
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info:eu-repo/semantics/acceptedVersion |
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Text |
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http://purl.org/redcol/resource_type/TM |
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acceptedVersion |
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https://repositorio.unal.edu.co/handle/unal/80908 |
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Universidad Nacional de Colombia |
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Repositorio Institucional Universidad Nacional de Colombia |
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https://repositorio.unal.edu.co/ |
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https://repositorio.unal.edu.co/handle/unal/80908 https://repositorio.unal.edu.co/ |
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Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
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spa |
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spa |
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Bireme |
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Al-Gahtany M, Shroft M, Bouffet E, Dirks P, Drake J, Humphreys R, et al. Primary central nervous system sarcomas in children: Clinical, radiological, and pathological features. Vol. 19, Child’s Nervous System. 2003. p. 808–17. Thorp NJ, Taylor RE. Management of central nervous system tumours in children. Clinical Oncology. 2014;26(7):438–45. Tihan Tarik, Griffin Ann ÖS. Primary sarcomas of the central nervous system: UCSF experince(1985-2005). Turkish J Pathol. 2007;23(1):5–15. Oliveira AM, Scheithauer BW, Salomao DR, Parisi JE, Burger PC, Nascimento AG. Primary Sarcomas of the Brain and Spinal Cord: A Study of 18 Cases. Am J Surg Pathol [Internet]. 2002;26(8). Benesch M, von Bueren AO, Dantonello T, von Hoff K, Pietsch T, Leuschner I, et al. Primary intracranial soft tissue sarcoma in children and adolescents: A cooperative analysis of the European CWS and HIT study groups. Journal of Neuro-Oncology. 2013 Feb;111(3):337–45. Paulus W, Slowik F, Jellinger K, Paulus W, Slowik F, Jellinger K. Primary intracranial sarcomas: histopathological features of 19 cases. Vol. 18, Histopathology. 1991. Mumert ML, Walsh MT, Jensen EM, Jensen RL. Pleomorphic liposarcoma originating from intracranial dura mater. Journal of Neuro-Oncology. 2010 Mar;97(1):149–53. Rao KI, Malicki DM, Crawford JR. Primary intraventricular central nervous system rhabdomyosarcoma. Pediatric Neurology. 2015 Jan 1;52(1):130–1. Barkovich AJ, Raybaud C. Pediatric Neuroimaging [Internet]. Wolters Kluwer; 2018. Brandão LA, Young Poussaint T. Posterior Fossa Tumors. Vol. 27, Neuroimaging Clinics of North America. W.B. Saunders; 2017. p. 1–37. Bekiesinska-Figatowska M, Duczkowska A, Duczkowski M, Bragoszewska H, Romaniuk-Doroszewska A, Iwanowska B, et al. CNS Metastases from Bone and Soft Tissue Sarcomas in Children, Adolescents, and Young Adults: Are They Really So Rare? BioMed Research International. 2017;2017. Lindford A, McIntyre B, Marsh R, MacKinnon CA, Davis C, Tan ST. Outcomes of the Treatment of Head and Neck Sarcomas in a Tertiary Referral Center. Frontiers in Surgery. 2015 May 19;2. Crosley CJ, Mishkin M, Rorke LB. Congenital Sarcoma of the Brain: Diagnosis During the Neonatal Period. Am J Dis Child [Internet]. 1974 Oct 1;128(4):523–6. van Vliet MAT, Bravenboer B, Kock HCL v, Teepen JLJM. Meningeal sarcoma 249. Vol. 11, J. Perinat. Med. 1983. BAILEY P. INTRACRANIAL SARCOMATOUS TUMORS OF LEPTOMENINGEAL ORIGIN. Arch Surg [Internet]. 1929 Apr 1;18(4):1359–402. Xiao W, Mohseny AB, Hogendoorn PCW, Cleton-Jansen A-M. Mesenchymal stem cell transformation and sarcoma genesis. Clinical Sarcoma Research. 2013 Dec;3(1). Merimsky O, Lepechoux C, Terrier P, Vanel D, Delord JP, Lecesne A. Primary Sarcomas of the Central Nervous System [Internet]. Vol. 58, Clinical Study Oncology. 2000. Maher OM, Khatua S, Mukherjee D, Olar A, Lazar A, Luthra R, et al. Primary intracranial soft tissue sarcomas in children, adolescents, and young adults: single institution experience and review of the literature. Journal of Neuro-Oncology. 2016 Mar 1;127(1):155–63. Kirk IR, Dominguez R, Castillo M. Congenital primary cerebral angiosarcoma: CT, US, and MR findings. Vol. 22, Pediatr Radiol. 1992. Yenifeth E BC, Luz Ángela MG, Rubén Danilo MC, Alfonso Javier LC, Lina Jaramillo B, Edna M. QC. Sarcoma meníngeo en un niño: presentación de caso. Revista Colombia Radiológica. 2012;23. Chaigneau L, Patrikidou A, Ray‐Coquard I, Valentin T, Linassier C, Bay JO, et al. Brain Metastases from Adult Sarcoma: Prognostic Factors and Impact of Treatment. A Retrospective Analysis from the French Sarcoma Group (GSF/GETO). The Oncologist. 2018 Aug;23(8):948–55. Lewis AJ. Sarcoma metastatic to the brain. Cancer. 1988 Feb;61(3):593–601. Maslehaty H, Nabavi A, Mehdorn HM. Primary Intracranial Leiomyosarcoma – Case Report and Principles for Treatment [Internet]. 2016. Mcdonald P, Guha A, Provias J. Primary intracranial fibrosarcoma with intratumoral hemorrhage: Neuropathological diagnosis with review of the literature. Vol. 35, Z Journal of Neuro-Oncology. 1997. Lafay-Cousin L, Lindzon G, Taylor MD, Hader W, Hawkins C, Nordal R, et al. Successful treatment of primary intracranial sarcoma with the ICE chemotherapy regimen and focal radiation in children. Journal of Neurosurgery: Pediatrics. 2016 Mar 1;17(3):298–302. Mena H, Ribas J, Enzinger F, Parisim, Joseph. Primary angiosarcoma of the central nervous system. Journal of Neurosugery . 1991;15(1):73–6. Basirjafari S, Poureisa M, Shahhoseini B, Zarei M, Aghayari Sheikh Neshin S, Anvari Aria S, et al. Apparent diffusion coefficient values and non-homogeneity of diffusion in brain tumors in diffusion-weighted MRI. Acta radiol [Internet]. 2019 Jul 2;61(2):244–52. Murakami R, Hirai T, Sugahara T, Fukuoka H, Toya R, Nishimura S, et al. Grading Astrocytic Tumors by Using Apparent Diffusion Coefficient Parameters: Superiority of a One- versus Two-Parameter Pilot Method. Radiology [Internet]. 2009 Jun 1;251(3):838–45. Phuttharak W, Thammaroj J, Wara-Asawapati S, Panpeng K. Grading Gliomas Capability: Comparison between Visual Assessment and Apparent Diffusion Coefficient (ADC) Value Measurement on Diffusion-Weighted Imaging (DWI). Asian Pacific J Cancer Prev [Internet]. 2020;21(2):385–90. Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol [Internet]. 2021 Aug 1;23(8):1231–51. Machota Junior MM, Gentili AC, Marques FM, Maciel PR, Ogata SA, Bleggi-Torres LF. Sarcoma indiferenciado primário no sistema nervoso central. J Bras Patol e Med Lab [Internet]. 2012 Apr [cited 2021 Oct 25];48(2):135–8. Schaefer PW, Grant PE, Gonzalez RG. Diffusion-weighted MR Imaging of the Brain. Radiology [Internet]. 2000 Nov 1;217(2):331–45. Helenius J, Soinne L, Perkiö J, Salonen O, Kangasmäki A, Kaste M, et al. Diffusion-weighted MR imaging in normal human brains in various age groups. Am J Neuroradiol. 2002;23(2):194–9. Azeemuddin M, Nizamani WM, Tariq MU, Wasay M. Role of ADC values and ratios of MRI scan in differentiating typical from atypical/anaplastic meningiomas. J Pak Med Assoc. 2018;68(9):1403–6. Domínguez-Pinilla N, Martínez de Aragón A, Diéguez Tapias S, Toldos O, Hinojosa Bernal J, Rigal Andrés M, et al. Evaluating the apparent diffusion coefficient in MRI studies as a means of determining paediatric brain tumour stages. Neurol (English Ed. 2016;31(7):459–65. Bradley WG. MR appearance of hemorrhage in the brain. Radiology. 1993;189(1):15–26. Osborn AG, Hedlund GL, Salzman KL. Osborn’s Brain E-Book [Internet]. Elsevier Health Sciences; 2017. Nute JL, le Roux L, Chandler AG, Baladandayuthapani V, Schellingerhout D, Cody DD. Differentiation of Low-Attenuation Intracranial Hemorrhage and Calcification Using Dual-Energy Computed Tomography in a Phantom System [Internet]. 2014. Lambertz N, Hindy N el, Adler C, Rump K, Adamzik M, Keyvani K, et al. Expression of aquaporin 5 and the AQP5 polymorphism A(-1364)C in association with peritumoral brain edema in meningioma patients. Journal of Neuro-Oncology. 2013 Apr;112(2):297–305. |
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Bogotá - Medicina - Especialidad en Radiología e Imágenes Diagnósticas |
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Departamento de Imágenes diagnósticas |
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Atribución-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Moreno Gómez, Luz Angela4dc8236356cadbe91dad4e0cabaa36e5600Ojeda Gómez, Juan Sebastián Alonso505d42ca7cbca44c1cedb7b9bd903de26002022-02-08T16:08:47Z2022-02-08T16:08:47Z2021-12-09https://repositorio.unal.edu.co/handle/unal/80908Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, fotografías, gráficas, tablasLos sarcomas primarios de SNC son una patología rara y existe poca literatura que aborde en detalle sus características imagenológicas. El presente es un estudio retrospectivo descriptivo que pretende realizar una caracterización clínica, imagenológica y patológica de estas neoplasias. Se recolectaron 31 pacientes entre el 2008 y 2021 atendidos en Fundación HOMI. Se revisaron las historias clínicas, y se analizaron muestras de patología y las imágenes diagnósticas (TC, RM). Hubo 19 niños y 12 niñas, entre 1-17 años (promedio 9 años). La gran mayoría presentó cefalea y vómito como primera manifestación clínica. Los tumores fueron predominantemente supratentoriales (96%) y de localización frontal (62%) y parietal (21%). En el 33% de los casos el tumor cruzó la línea media. La mayor proporción de las masas fueron unifocales, con bordes bien definidos y de gran tamaño (4.2-7.7 cm). El índice de actividad se midió con KI67, evidenciando una proliferación elevada (>30%) en el 86% de los casos y zonas de marcado pleomorfismo. En la RM las neoplasias fueron hipointensas en T1 e hiperintensas en T2, presentaron realce con la administración de medio de contraste y restricción a la difusión. Además, se identificaron con frecuencia áreas de hemorragia y necrosis; y en menor medida, quistes y calcificaciones. Tras el seguimiento se observó una mortalidad del 58%, la mayor parte en pacientes que tuvieron recaídas. Se requiere de estudios multicéntricos para establecer resultados estadísticamente significativos con respecto a sobrevida y otros desenlaces. (Texto tomado de la fuente).Primary CNS sarcomas are extremely rare, yet very aggressive tumors that are associated with high morbimortality rates. There is scarce literature about their radiologic features. The aim of this retrospective study is to describe the clinical, pathological and imaging features of these neoplasms. For this purpose, 31 patients treated in Fundación HOMI were collected between 2008 and 2021. Their medical records were reviewed, and the pathology samples and images (CT, MRI) were analyzed. There were 19 boys and 12 girls, between 1-17 years (mean age 9 years). The vast majority presented with headaches and vomiting as the first clinical manifestation. The tumors were predominantly supratentorial (96%) and were located in frontal (62%) and parietal (21%) lobes. In 33% of the patients the tumor located crossing the midline. The highest proportion of the masses were unifocal, had well defined borders and large size (4.2-7.7 cm). The proliferation index was measured with KI67, showing a high proliferation rate (KI57>30%) in 86% of the cases. In the MRI, the neoplasms showed T1 hypointensity, T2 hiperintensity, heterogeneous post-contrast enhancement and diffusion restriction. Furthermore, areas of hemorrhage (96%), necrosis (79%) and calcifications (21%) were identified. A global mortality of 58% was observed. Most of the deaths presented in children who had relapses. Multicenter studies are required to establish statistically significant results regarding survival and other outcomes.Incluye anexosEspecialidades MédicasEspecialista en Radiología e Imágenes DiagnósticasSerie de casosNeuroimágenesxv, 46 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Especialidad en Radiología e Imágenes DiagnósticasDepartamento de Imágenes diagnósticasFacultad de MedicinaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::616 - EnfermedadesEnfermedades del Sistema Nervioso CentralRadiologíaCentral Nervous System DiseasesRadiologySarcomaSarcomaSistema nervioso centralSarcomaTumor cerebralImágenes diagnósticasCentral nervous systemSarcomaBrain tumorDiagnostic imagingSarcomas primarios de sistema nervioso central en pacientes pediátricos: características radiológicas y patológicasPrimary central nervous system sarcomas in children: radiological and pathological featuresTrabajo de grado - Especialidad Médicainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBiremeAl-Gahtany M, Shroft M, Bouffet E, Dirks P, Drake J, Humphreys R, et al. Primary central nervous system sarcomas in children: Clinical, radiological, and pathological features. Vol. 19, Child’s Nervous System. 2003. p. 808–17.Thorp NJ, Taylor RE. Management of central nervous system tumours in children. Clinical Oncology. 2014;26(7):438–45.Tihan Tarik, Griffin Ann ÖS. Primary sarcomas of the central nervous system: UCSF experince(1985-2005). Turkish J Pathol. 2007;23(1):5–15.Oliveira AM, Scheithauer BW, Salomao DR, Parisi JE, Burger PC, Nascimento AG. Primary Sarcomas of the Brain and Spinal Cord: A Study of 18 Cases. Am J Surg Pathol [Internet]. 2002;26(8).Benesch M, von Bueren AO, Dantonello T, von Hoff K, Pietsch T, Leuschner I, et al. Primary intracranial soft tissue sarcoma in children and adolescents: A cooperative analysis of the European CWS and HIT study groups. Journal of Neuro-Oncology. 2013 Feb;111(3):337–45.Paulus W, Slowik F, Jellinger K, Paulus W, Slowik F, Jellinger K. Primary intracranial sarcomas: histopathological features of 19 cases. Vol. 18, Histopathology. 1991.Mumert ML, Walsh MT, Jensen EM, Jensen RL. Pleomorphic liposarcoma originating from intracranial dura mater. Journal of Neuro-Oncology. 2010 Mar;97(1):149–53.Rao KI, Malicki DM, Crawford JR. Primary intraventricular central nervous system rhabdomyosarcoma. Pediatric Neurology. 2015 Jan 1;52(1):130–1.Barkovich AJ, Raybaud C. Pediatric Neuroimaging [Internet]. Wolters Kluwer; 2018.Brandão LA, Young Poussaint T. Posterior Fossa Tumors. Vol. 27, Neuroimaging Clinics of North America. W.B. Saunders; 2017. p. 1–37.Bekiesinska-Figatowska M, Duczkowska A, Duczkowski M, Bragoszewska H, Romaniuk-Doroszewska A, Iwanowska B, et al. CNS Metastases from Bone and Soft Tissue Sarcomas in Children, Adolescents, and Young Adults: Are They Really So Rare? BioMed Research International. 2017;2017.Lindford A, McIntyre B, Marsh R, MacKinnon CA, Davis C, Tan ST. Outcomes of the Treatment of Head and Neck Sarcomas in a Tertiary Referral Center. Frontiers in Surgery. 2015 May 19;2.Crosley CJ, Mishkin M, Rorke LB. Congenital Sarcoma of the Brain: Diagnosis During the Neonatal Period. Am J Dis Child [Internet]. 1974 Oct 1;128(4):523–6.van Vliet MAT, Bravenboer B, Kock HCL v, Teepen JLJM. Meningeal sarcoma 249. Vol. 11, J. Perinat. Med. 1983.BAILEY P. INTRACRANIAL SARCOMATOUS TUMORS OF LEPTOMENINGEAL ORIGIN. Arch Surg [Internet]. 1929 Apr 1;18(4):1359–402.Xiao W, Mohseny AB, Hogendoorn PCW, Cleton-Jansen A-M. Mesenchymal stem cell transformation and sarcoma genesis. Clinical Sarcoma Research. 2013 Dec;3(1).Merimsky O, Lepechoux C, Terrier P, Vanel D, Delord JP, Lecesne A. Primary Sarcomas of the Central Nervous System [Internet]. Vol. 58, Clinical Study Oncology. 2000.Maher OM, Khatua S, Mukherjee D, Olar A, Lazar A, Luthra R, et al. Primary intracranial soft tissue sarcomas in children, adolescents, and young adults: single institution experience and review of the literature. Journal of Neuro-Oncology. 2016 Mar 1;127(1):155–63.Kirk IR, Dominguez R, Castillo M. Congenital primary cerebral angiosarcoma: CT, US, and MR findings. Vol. 22, Pediatr Radiol. 1992.Yenifeth E BC, Luz Ángela MG, Rubén Danilo MC, Alfonso Javier LC, Lina Jaramillo B, Edna M. QC. Sarcoma meníngeo en un niño: presentación de caso. Revista Colombia Radiológica. 2012;23.Chaigneau L, Patrikidou A, Ray‐Coquard I, Valentin T, Linassier C, Bay JO, et al. Brain Metastases from Adult Sarcoma: Prognostic Factors and Impact of Treatment. A Retrospective Analysis from the French Sarcoma Group (GSF/GETO). The Oncologist. 2018 Aug;23(8):948–55.Lewis AJ. Sarcoma metastatic to the brain. Cancer. 1988 Feb;61(3):593–601.Maslehaty H, Nabavi A, Mehdorn HM. Primary Intracranial Leiomyosarcoma – Case Report and Principles for Treatment [Internet]. 2016.Mcdonald P, Guha A, Provias J. Primary intracranial fibrosarcoma with intratumoral hemorrhage: Neuropathological diagnosis with review of the literature. Vol. 35, Z Journal of Neuro-Oncology. 1997.Lafay-Cousin L, Lindzon G, Taylor MD, Hader W, Hawkins C, Nordal R, et al. Successful treatment of primary intracranial sarcoma with the ICE chemotherapy regimen and focal radiation in children. Journal of Neurosurgery: Pediatrics. 2016 Mar 1;17(3):298–302.Mena H, Ribas J, Enzinger F, Parisim, Joseph. Primary angiosarcoma of the central nervous system. Journal of Neurosugery . 1991;15(1):73–6.Basirjafari S, Poureisa M, Shahhoseini B, Zarei M, Aghayari Sheikh Neshin S, Anvari Aria S, et al. Apparent diffusion coefficient values and non-homogeneity of diffusion in brain tumors in diffusion-weighted MRI. Acta radiol [Internet]. 2019 Jul 2;61(2):244–52.Murakami R, Hirai T, Sugahara T, Fukuoka H, Toya R, Nishimura S, et al. Grading Astrocytic Tumors by Using Apparent Diffusion Coefficient Parameters: Superiority of a One- versus Two-Parameter Pilot Method. Radiology [Internet]. 2009 Jun 1;251(3):838–45.Phuttharak W, Thammaroj J, Wara-Asawapati S, Panpeng K. Grading Gliomas Capability: Comparison between Visual Assessment and Apparent Diffusion Coefficient (ADC) Value Measurement on Diffusion-Weighted Imaging (DWI). Asian Pacific J Cancer Prev [Internet]. 2020;21(2):385–90.Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol [Internet]. 2021 Aug 1;23(8):1231–51.Machota Junior MM, Gentili AC, Marques FM, Maciel PR, Ogata SA, Bleggi-Torres LF. Sarcoma indiferenciado primário no sistema nervoso central. J Bras Patol e Med Lab [Internet]. 2012 Apr [cited 2021 Oct 25];48(2):135–8.Schaefer PW, Grant PE, Gonzalez RG. Diffusion-weighted MR Imaging of the Brain. Radiology [Internet]. 2000 Nov 1;217(2):331–45.Helenius J, Soinne L, Perkiö J, Salonen O, Kangasmäki A, Kaste M, et al. 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Journal of Neuro-Oncology. 2013 Apr;112(2):297–305.InvestigadoresPúblico generalORIGINAL1015449345.2021.pdf1015449345.2021.pdfTesis de Especialidad en Radiología e Imágenes Diagnósticasapplication/pdf1885372https://repositorio.unal.edu.co/bitstream/unal/80908/1/1015449345.2021.pdf8608b84b3f29659f2d20a004f2a0f74aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-84074https://repositorio.unal.edu.co/bitstream/unal/80908/2/license.txt8153f7789df02f0a4c9e079953658ab2MD52THUMBNAIL1015449345.2021.pdf.jpg1015449345.2021.pdf.jpgGenerated Thumbnailimage/jpeg4962https://repositorio.unal.edu.co/bitstream/unal/80908/3/1015449345.2021.pdf.jpg6164402974a9755ebd8e51622b8ff11eMD53unal/80908oai:repositorio.unal.edu.co:unal/809082023-08-01 23:03:32.8Repositorio Institucional Universidad Nacional de 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