Estudio de la formación de azaciclofanos derivados de L-Tirosina y su interacción con zinc
ilustraciones, diagramas
- Autores:
-
Cháves Sánchez, Sebastián Camilo
- Tipo de recurso:
- Doctoral thesis
- Fecha de publicación:
- 2024
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/86083
- Palabra clave:
- 540 - Química y ciencias afines::547 - Química orgánica
Tirosina/química
Tyrosine/chemistry
Azaciclofanos
L - tirosina
Amina
Reacción tipo Mannich
Formaldehído
Enlace de hidrógeno
Azacyclophanes
L - tyrosine
Mannich type reaction
hydrogen bond
Amine
Formaldehyde
Investigación química
Chemical research
Macrociclo
macrocycle
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Estudio de la formación de azaciclofanos derivados de L-Tirosina y su interacción con zinc |
| dc.title.translated.eng.fl_str_mv |
Study of the formation of azacyclophanes derived from L-Tyrosine and its interaction with zinc |
| title |
Estudio de la formación de azaciclofanos derivados de L-Tirosina y su interacción con zinc |
| spellingShingle |
Estudio de la formación de azaciclofanos derivados de L-Tirosina y su interacción con zinc 540 - Química y ciencias afines::547 - Química orgánica Tirosina/química Tyrosine/chemistry Azaciclofanos L - tirosina Amina Reacción tipo Mannich Formaldehído Enlace de hidrógeno Azacyclophanes L - tyrosine Mannich type reaction hydrogen bond Amine Formaldehyde Investigación química Chemical research Macrociclo macrocycle |
| title_short |
Estudio de la formación de azaciclofanos derivados de L-Tirosina y su interacción con zinc |
| title_full |
Estudio de la formación de azaciclofanos derivados de L-Tirosina y su interacción con zinc |
| title_fullStr |
Estudio de la formación de azaciclofanos derivados de L-Tirosina y su interacción con zinc |
| title_full_unstemmed |
Estudio de la formación de azaciclofanos derivados de L-Tirosina y su interacción con zinc |
| title_sort |
Estudio de la formación de azaciclofanos derivados de L-Tirosina y su interacción con zinc |
| dc.creator.fl_str_mv |
Cháves Sánchez, Sebastián Camilo |
| dc.contributor.advisor.spa.fl_str_mv |
Quevedo Pastor, Ariel Rodolfo |
| dc.contributor.author.spa.fl_str_mv |
Cháves Sánchez, Sebastián Camilo |
| dc.contributor.researchgroup.spa.fl_str_mv |
Química Macrocíclica |
| dc.contributor.orcid.spa.fl_str_mv |
Chaves, Sebastián [0000-0001-7479-7858] |
| dc.contributor.cvlac.spa.fl_str_mv |
Chaves, Sebastian [0001703007] |
| dc.contributor.researchgate.spa.fl_str_mv |
Chaves, Sebastián [Sebastian-Chaves-Sanchez] |
| dc.contributor.googlescholar.spa.fl_str_mv |
Chaves, Sebastián [e2tLfbwAAAAJ] |
| dc.subject.ddc.spa.fl_str_mv |
540 - Química y ciencias afines::547 - Química orgánica |
| topic |
540 - Química y ciencias afines::547 - Química orgánica Tirosina/química Tyrosine/chemistry Azaciclofanos L - tirosina Amina Reacción tipo Mannich Formaldehído Enlace de hidrógeno Azacyclophanes L - tyrosine Mannich type reaction hydrogen bond Amine Formaldehyde Investigación química Chemical research Macrociclo macrocycle |
| dc.subject.decs.spa.fl_str_mv |
Tirosina/química |
| dc.subject.decs.eng.fl_str_mv |
Tyrosine/chemistry |
| dc.subject.proposal.spa.fl_str_mv |
Azaciclofanos L - tirosina Amina Reacción tipo Mannich Formaldehído Enlace de hidrógeno |
| dc.subject.proposal.eng.fl_str_mv |
Azacyclophanes L - tyrosine Mannich type reaction hydrogen bond Amine Formaldehyde |
| dc.subject.unesco.spa.fl_str_mv |
Investigación química |
| dc.subject.unesco.eng.fl_str_mv |
Chemical research |
| dc.subject.wikidata.spa.fl_str_mv |
Macrociclo |
| dc.subject.wikidata.eng.fl_str_mv |
macrocycle |
| description |
ilustraciones, diagramas |
| publishDate |
2024 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-14T20:16:07Z |
| dc.date.available.none.fl_str_mv |
2024-05-14T20:16:07Z |
| dc.date.issued.none.fl_str_mv |
2024-04-18 |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Doctorado |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_db06 |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/TD |
| format |
http://purl.org/coar/resource_type/c_db06 |
| status_str |
acceptedVersion |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.unal.edu.co/handle/unal/86083 |
| dc.identifier.instname.spa.fl_str_mv |
Universidad Nacional de Colombia |
| dc.identifier.reponame.spa.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
| dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.unal.edu.co/ |
| url |
https://repositorio.unal.edu.co/handle/unal/86083 https://repositorio.unal.edu.co/ |
| identifier_str_mv |
Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
| dc.language.iso.spa.fl_str_mv |
spa |
| language |
spa |
| dc.relation.references.spa.fl_str_mv |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Quevedo Pastor, Ariel Rodolfof1eca04d10b58980ca0c01fd730e0f20600Cháves Sánchez, Sebastián Camilo9700c615cd15dbf44e021934713127a1Química MacrocíclicaChaves, Sebastián [0000-0001-7479-7858]Chaves, Sebastian [0001703007]Chaves, Sebastián [Sebastian-Chaves-Sanchez]Chaves, Sebastián [e2tLfbwAAAAJ]2024-05-14T20:16:07Z2024-05-14T20:16:07Z2024-04-18https://repositorio.unal.edu.co/handle/unal/86083Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasEn este trabajo se estudió la síntesis de azaciclofanos derivados de L-tirosina empleando la estrategia de síntesis denominada “Síntesis asistida por enlace de hidrógeno”. Los resultados permiten establecer que la estrategia de síntesis permite obtener azaciclofanos pentacíclicos simétricos por reacciones de 2 componentes y asimétricos por reacciones de 3 componentes. Esta estrategia de síntesis permite obtener ciclofanos bencílicos simétricos con sustituyentes sobre el nitrógeno por reacciones de dos componentes y asimétricos por reacción de tres componentes. Cabe mencionar que efectos estéricos e interacciones ácido-base pueden influir en el curso de la reacción para la obtención del producto macrocíclico u oligómeros lineales. Se determino que los azaciclofanos derivados de L-tirosina interactúan con Zn 2+ por la periferia del macrociclo por la parte alifática y que su relación estequiométrica es 1:1 entre el azaciclofano y el metal, con la mayoría de ciclofanos estudiados. (Texto tomado de la fuente).In this work, the synthesis of azacyclophanes derived from L-tyrosine was studied using the synthesis strategy called “Hydrogen bond-assisted synthesis”. The results allow us to establish that the synthesis strategy allows obtaining symmetrical pentacyclic azacyclophanes by 2-component reactions and asymmetric by 3-component reactions. This synthesis strategy allows obtaining symmetrical benzylic cyclophanes with substituents on the nitrogen by two-component reactions and asymmetrical ones by three-component reaction. It is worth mentioning that steric effects and acid-base interactions can influence the course of the reaction to obtain the macrocyclic product or linear oligomers. It was determined that azacyclophanes derived from L-tyrosine interact with Zn2+ at the periphery of the macrocycle on the aliphatic part and that their stoichiometric relationship is 1:1 between azacyclophane and the metal, with the majority of cyclophanes studied.DoctoradoDoctor en Ciencias - QuímicaSíntesis orgánicaxxix, 157 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Doctorado en Ciencias - QuímicaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá540 - Química y ciencias afines::547 - Química orgánicaTirosina/químicaTyrosine/chemistryAzaciclofanosL - tirosinaAminaReacción tipo MannichFormaldehídoEnlace de hidrógenoAzacyclophanesL - tyrosineMannich type reactionhydrogen bondAmineFormaldehydeInvestigación químicaChemical researchMacrociclomacrocycleEstudio de la formación de azaciclofanos derivados de L-Tirosina y su interacción con zincStudy of the formation of azacyclophanes derived from L-Tyrosine and its interaction with zincTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_db06Texthttp://purl.org/redcol/resource_type/TDE. 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Chem, vol. 37, pp. 4052–4058, 1998.InvestigadoresMaestrosLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86083/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1014216534.2024.pdf1014216534.2024.pdfTesis de Doctorado en Ciencias - Químicaapplication/pdf5706071https://repositorio.unal.edu.co/bitstream/unal/86083/2/1014216534.2024.pdf73003aaa42a6d263f75d604a3f679f2aMD52THUMBNAIL1014216534.2024.pdf.jpg1014216534.2024.pdf.jpgGenerated Thumbnailimage/jpeg4902https://repositorio.unal.edu.co/bitstream/unal/86083/3/1014216534.2024.pdf.jpgb2b107c1c79f642d8d3cff3f86d1f42eMD53unal/86083oai:repositorio.unal.edu.co:unal/860832024-08-24 23:14:16.077Repositorio Institucional Universidad Nacional de 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