Búsqueda de agonistas LXR en plantas colombianas con potencial terapéutico para la enfermedad de Alzheimer

ilustraciones, graficas

Autores:: Bustos Rangel, Angie Milena

Tipo de recurso:

Fecha de publicación:: 2021

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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network_acronym_str	UNACIONAL2
network_name_str	Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv	Búsqueda de agonistas LXR en plantas colombianas con potencial terapéutico para la enfermedad de Alzheimer
dc.title.translated.eng.fl_str_mv	Search for LXR agonists in Colombian plants with therapeutic potential for Alzheimer's disease
title	Búsqueda de agonistas LXR en plantas colombianas con potencial terapéutico para la enfermedad de Alzheimer
spellingShingle	Búsqueda de agonistas LXR en plantas colombianas con potencial terapéutico para la enfermedad de Alzheimer 610 - Medicina y salud::616 - Enfermedades Nectandra reticulata Agonists Agonistas Extractos vegetales plant extracts Enfermedad de Alzheimer Alzheimer Disease Enfermedad de Alzheimer Paraquat Ceramida Glutamato Myristicaceae Lauraceae Rutaceae Alzheimer's disease Paraquat Ceramide Glutamate
title_short	Búsqueda de agonistas LXR en plantas colombianas con potencial terapéutico para la enfermedad de Alzheimer
title_full	Búsqueda de agonistas LXR en plantas colombianas con potencial terapéutico para la enfermedad de Alzheimer
title_fullStr	Búsqueda de agonistas LXR en plantas colombianas con potencial terapéutico para la enfermedad de Alzheimer
title_full_unstemmed	Búsqueda de agonistas LXR en plantas colombianas con potencial terapéutico para la enfermedad de Alzheimer
title_sort	Búsqueda de agonistas LXR en plantas colombianas con potencial terapéutico para la enfermedad de Alzheimer
dc.creator.fl_str_mv	Bustos Rangel, Angie Milena
dc.contributor.advisor.none.fl_str_mv	Sandoval-Hernandez, Adrián Gabriel Ávila Murillo, Mónica Constanza
dc.contributor.author.none.fl_str_mv	Bustos Rangel, Angie Milena
dc.contributor.researchgroup.spa.fl_str_mv	Muerte Celular Productos Naturales Vegetales Bioactivos y Quimica EcoIogica
dc.subject.ddc.spa.fl_str_mv	610 - Medicina y salud::616 - Enfermedades
topic	610 - Medicina y salud::616 - Enfermedades Nectandra reticulata Agonists Agonistas Extractos vegetales plant extracts Enfermedad de Alzheimer Alzheimer Disease Enfermedad de Alzheimer Paraquat Ceramida Glutamato Myristicaceae Lauraceae Rutaceae Alzheimer's disease Paraquat Ceramide Glutamate
dc.subject.other.none.fl_str_mv	Nectandra reticulata
dc.subject.other.eng.fl_str_mv	Agonists
dc.subject.other.spa.fl_str_mv	Agonistas
dc.subject.agrovoc.none.fl_str_mv	Extractos vegetales plant extracts
dc.subject.decs.spa.fl_str_mv	Enfermedad de Alzheimer
dc.subject.decs.eng.fl_str_mv	Alzheimer Disease
dc.subject.proposal.spa.fl_str_mv	Enfermedad de Alzheimer Paraquat Ceramida Glutamato
dc.subject.proposal.other.fl_str_mv	Myristicaceae Lauraceae Rutaceae
dc.subject.proposal.eng.fl_str_mv	Alzheimer's disease Paraquat Ceramide Glutamate
description	ilustraciones, graficas
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-09-23T17:45:28Z
dc.date.available.none.fl_str_mv	2021-09-23T17:45:28Z
dc.date.issued.none.fl_str_mv	2021-07-13
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/80277
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/80277 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
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dc.publisher.department.spa.fl_str_mv	Departamento de Química
dc.publisher.faculty.spa.fl_str_mv	Facultad de Ciencias
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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spelling	Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Sandoval-Hernandez, Adrián Gabriel2bd70ff6a3a7af73c5e7d7ef2dceb9f0600Ávila Murillo, Mónica Constanzad26839373d12f4b4932a0ceebaaf03b1600Bustos Rangel, Angie Milena71a88ac417806449e664313363018698Muerte CelularProductos Naturales Vegetales Bioactivos y Quimica EcoIogica2021-09-23T17:45:28Z2021-09-23T17:45:28Z2021-07-13https://repositorio.unal.edu.co/handle/unal/80277Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, graficasLa enfermedad de Alzheimer es la demencia más común en la población mundial, tiene una etiología desconocida y no cuenta con un tratamiento efectivo. Se caracteriza por la agregación del péptido amiloide β y Tau hiperfosforilado, aumento de radicales libres, desregulación lipídica y exitotoxicidad. Teniendo en cuenta esto, los receptores X hepáticos, se postulan como una diana terapéutica, ya que son factores de transcripción que regulan genes encargados de la homeostasis de colesterol y se asocian con mecanismos de eliminación del péptido amiloide β, una menor fosforilación de Tau y una menor respuesta inflamatoria, etc. En este trabajo, se contó con 82 extractos de Angiospermas basales colombianas, a los que se les evaluó su actividad agonista sobre los receptores nucleares LXR β, actividad inhibitoria de acetil colinesterasa y actividad antioxidante, seguida de la evaluación in vivo del efecto protector frente a ambientes tóxicos de paraquat, ceramida y glutamato. Se encontró que, los extractos de Z. martinicense, Zanthoxylum sp., Z. rohifolium, N. reticulata, N. membranácea, Nectandra sp., Myristicaceae sp. 1 y Myristicaceae sp. 2 tienen un efecto agonista sobre LXR β, acompañado de una actividad antioxidante. Adicionalmente, el extracto etanólico de Myriticaceae sp.2 y las fracciones de Z. rhoifolium, Z. martinicense y Zanthoxylum sp., mostraron una marcada actividad inhibitoria de AChE. Por último, Z. rohifolium, disminuye el efecto de concentraciones tóxicas de glutamato. Lo que deja en evidencia el potencial de estos extractos naturales para el tratamiento de la EA. (texto tomado de la fuente)Alzheimer's disease is the most common dementia in the world, has an unknown etiology and d oes not have effective treatment. It is characterized by the aggregation of amyloid peptide β and tau hyperphosphorylation, increased free radicals, lipid deregulation, and excitotoxicity. Considering this, liver X receptors are postulated as a therapeutic target, as they are transcription factors that regulate genes responsible for cholesterol homeostasis and are associated with mechanisms of removal of amyloid peptide β, lower phosphorylation of Tau and lower inflammatory response, etc. In this work, 82 extracts of basal Angiosperms obtained in Colombia were counted, which were evaluated for their agonist activity on LXR β nuclear receptors, continuing with in vitro evaluation of anti-acetylcholinesterase activity and antioxidant activity, followed by in vivo assessment of the protective effect against toxic environments of paraquat, ceramide, and glutamate. Finding that extracts from Z. martinicense, Zanthoxylum sp. Z. rohifolium, N. reticulata, N. membranácea, Nectandra sp., Myristicaceae sp. 1 and Myristicaceae sp. 2 have an agonist effect on LXR β, accompanied by antioxidant activity and particularly, the ethanolic extract of Miriticaceae sp.2 and the fractions of Z. rhoifolium, Z. martinicense and Zanthoxylum sp., showed a marked inhibitory activity of AChE and Z. rohifolium, decreases the effect of toxic concentrations of glutamate. Which highlights the potential of these natural extracts for the treatment of EA.A la Universidad Nacional de Colombia, al programa curricular de la Maestría en Ciencias – Bioquímica y los grupos de investigación de Muerte celular y el grupo de química de productos naturales bioactivos (QUIPRONAB), que permitieron mi formación profesional. Al Ministerio de Ciencia y Tecnología por la financiación de esta investigación mediante los proyectos, Bioprospección del potencial terapéutico de extractos vegetales de las familias Lauraceae y Rutaceae asociados a la actividad farmacológica de LXR en un modelo murino de enfermedad de Alzheimer y análisis computacional" -RC-737 DE 2018 y “Evaluación de los mecanismos moleculares asociados a la activación farmacológica de LXR en modelos de la enfermedad de Alzheimer y del potencial terapéutico de un extracto de Nectandra reticulata (Lauraceae)” RC-727 de 2018 . Al Ministerio de Medio Ambiente por el otorgamiento del Otros N° 21 al Contrato Marco de Acceso a Recursos Genéticos y sus Productos Derivados N° 121 del 22 de enero de 2016 suscrito entre el Ministerio de Ambiente y Desarrollo Sostenible y la Universidad Nacional de Colombia, por medio del cual se ampara el uso para investigación del material vegetal que hace parte de esta investigación. A mis directores de tesis Adrián Sandoval y Mónica Ávila y a los profesores que han acompañado mi proceso de formación profesional.MaestríaMagíster en Ciencias - BioquímicaEnfermedades neurodegenerativas150 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias - BioquímicaDepartamento de QuímicaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::616 - EnfermedadesNectandra reticulataAgonistsAgonistasExtractos vegetalesplant extractsEnfermedad de AlzheimerAlzheimer DiseaseEnfermedad de AlzheimerParaquatCeramidaGlutamatoMyristicaceaeLauraceaeRutaceaeAlzheimer's diseaseParaquatCeramideGlutamateBúsqueda de agonistas LXR en plantas colombianas con potencial terapéutico para la enfermedad de AlzheimerSearch for LXR agonists in Colombian plants with therapeutic potential for Alzheimer's diseaseTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMAbo, K. 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Archives of Pharmacal Research, 32(9), 1245–1251. https://doi.org/10.1007/s12272-009-1910-xBioprospección del potencial terapéutico de extractos vegetales de las familias Lauraceae y Rutaceae asociados a la actividad farmacológica de LXR en un modelo murino de enfermedad de Alzheimer y análisis computacional" -RC-737 DE 2018Evaluación de los mecanismos moleculares asociados a la activación farmacológica de LXR en modelos de la enfermedad de Alzheimer y del potencial terapéutico de un extracto de Nectandra reticulata (Lauraceae)” RC-727 de 2018Ministerio de Ciencia y TecnologíaInvestigadoresPúblico generalORIGINAL1022384698.2021.pdf1022384698.2021.pdfTesis de Maestría en Ciencias - Bioquímicaapplication/pdf4065719https://repositorio.unal.edu.co/bitstream/unal/80277/2/1022384698.2021.pdffc902f644fcfc0af97f202264e61f393MD52LICENSElicense.txtlicense.txttext/plain; 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GVyZWNob3MgZGUgYXV0b3IgcXVlIGNvbmxsZXZlIGxhIGRpc3RyaWJ1Y2nDs24gZGUgZXN0b3MgYXJjaGl2b3MgeSBtZXRhZGF0b3MuCkFsIGhhY2VyIGNsaWMgZW4gZWwgc2lndWllbnRlIGJvdMOzbiwgdXN0ZWQgaW5kaWNhIHF1ZSBlc3TDoSBkZSBhY3VlcmRvIGNvbiBlc3RvcyB0w6lybWlub3MuCgpVTklWRVJTSURBRCBOQUNJT05BTCBERSBDT0xPTUJJQSAtIMOabHRpbWEgbW9kaWZpY2FjacOzbiAyNy8yMC8yMDIwCg==

Búsqueda de agonistas LXR en plantas colombianas con potencial terapéutico para la enfermedad de Alzheimer

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