Diseño de la estructura interna de un andamio (scaffold) para tejido óseo

ilustraciones, diagramas, fotografías

Autores:
Toro Toro, Lina Fernanda
Tipo de recurso:
Fecha de publicación:
2024
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/86869
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/86869
https://repositorio.unal.edu.co/
Palabra clave:
610 - Medicina y salud::615 - Farmacología y terapéutica
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
Ingeniería de Tejidos/métodos
Estereolitografía
Tecnología
Tissue Engineering/methods
Stereolithography
Technology
Scaffolds
Diseño
Ingeniera de tejidos óseo
Manufactura aditiva (MA)
Celdas poliédricas
Voronoi
Scaffolds
Design
Bone tissue engineer
Additive manufacturing (AM)
Polyhedral cells
Voronoi
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
id UNACIONAL2_e6718206d1a0b57199a563fa3f1a52fe
oai_identifier_str oai:repositorio.unal.edu.co:unal/86869
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Diseño de la estructura interna de un andamio (scaffold) para tejido óseo
dc.title.translated.eng.fl_str_mv Design of the internal structure of a scaffold for bone tissue
title Diseño de la estructura interna de un andamio (scaffold) para tejido óseo
spellingShingle Diseño de la estructura interna de un andamio (scaffold) para tejido óseo
610 - Medicina y salud::615 - Farmacología y terapéutica
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
Ingeniería de Tejidos/métodos
Estereolitografía
Tecnología
Tissue Engineering/methods
Stereolithography
Technology
Scaffolds
Diseño
Ingeniera de tejidos óseo
Manufactura aditiva (MA)
Celdas poliédricas
Voronoi
Scaffolds
Design
Bone tissue engineer
Additive manufacturing (AM)
Polyhedral cells
Voronoi
title_short Diseño de la estructura interna de un andamio (scaffold) para tejido óseo
title_full Diseño de la estructura interna de un andamio (scaffold) para tejido óseo
title_fullStr Diseño de la estructura interna de un andamio (scaffold) para tejido óseo
title_full_unstemmed Diseño de la estructura interna de un andamio (scaffold) para tejido óseo
title_sort Diseño de la estructura interna de un andamio (scaffold) para tejido óseo
dc.creator.fl_str_mv Toro Toro, Lina Fernanda
dc.contributor.advisor.spa.fl_str_mv Garzón Alvarado, Diego Alexander
Velasco Peña, Marco Antonio
dc.contributor.author.spa.fl_str_mv Toro Toro, Lina Fernanda
dc.contributor.researchgroup.spa.fl_str_mv Gnum Grupo de Modelado y Métodos Numericos en Ingeniería
dc.contributor.orcid.spa.fl_str_mv Toro Toro, Lina Fernanda [0000-0002-0979-3241]
dc.contributor.cvlac.spa.fl_str_mv Toro Toro, Lina Fernanda [https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001720717]
dc.subject.ddc.spa.fl_str_mv 610 - Medicina y salud::615 - Farmacología y terapéutica
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
topic 610 - Medicina y salud::615 - Farmacología y terapéutica
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
Ingeniería de Tejidos/métodos
Estereolitografía
Tecnología
Tissue Engineering/methods
Stereolithography
Technology
Scaffolds
Diseño
Ingeniera de tejidos óseo
Manufactura aditiva (MA)
Celdas poliédricas
Voronoi
Scaffolds
Design
Bone tissue engineer
Additive manufacturing (AM)
Polyhedral cells
Voronoi
dc.subject.decs.spa.fl_str_mv Ingeniería de Tejidos/métodos
Estereolitografía
Tecnología
dc.subject.decs.eng.fl_str_mv Tissue Engineering/methods
Stereolithography
Technology
dc.subject.proposal.spa.fl_str_mv Scaffolds
Diseño
Ingeniera de tejidos óseo
Manufactura aditiva (MA)
Celdas poliédricas
Voronoi
dc.subject.proposal.eng.fl_str_mv Scaffolds
Design
Bone tissue engineer
Additive manufacturing (AM)
Polyhedral cells
Voronoi
description ilustraciones, diagramas, fotografías
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-09-26T19:58:53Z
dc.date.available.none.fl_str_mv 2024-09-26T19:58:53Z
dc.date.issued.none.fl_str_mv 2024-09-09
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/86869
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/86869
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.indexed.spa.fl_str_mv Bireme
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dc.rights.license.spa.fl_str_mv Atribución-NoComercial 4.0 Internacional
dc.rights.uri.spa.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
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dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv Bogotá - Ingeniería - Maestría en Ingeniería - Materiales y Procesos
dc.publisher.faculty.spa.fl_str_mv Facultad de Ingeniería
dc.publisher.place.spa.fl_str_mv Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá
institution Universidad Nacional de Colombia
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spelling Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Garzón Alvarado, Diego Alexander3bd3300e515de537404ed24aaad21afe600Velasco Peña, Marco Antoniobb4cd0c04e320d75286a75bbe3f48188600Toro Toro, Lina Fernanda1a70d19b4b60d97bd67552ca4bd69759600Gnum Grupo de Modelado y Métodos Numericos en IngenieríaToro Toro, Lina Fernanda [0000-0002-0979-3241]Toro Toro, Lina Fernanda [https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001720717]2024-09-26T19:58:53Z2024-09-26T19:58:53Z2024-09-09https://repositorio.unal.edu.co/handle/unal/86869Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramas, fotografíasLa ingeniería de tejidos óseos busca la regeneración de tejido óseo dañado o perdido. Los scaffolds son estructuras tridimensionales que proporcionan un andamiaje para el crecimiento de células y tejidos. Los avances en las tecnologías de manufactura aditiva (MA) han facilitado la fabricación de scaffolds complejos y personalizados. Este estudio evaluó el diseño y fabricación de scaffolds para ingeniería de tejido óseo basados en la arquitectura interna del hueso. Se utilizaron geometrías de poliedros y diagramas Voronoi con tamaños de celdas de 1.500 µm a 1.250 µm y trabéculas de 200 µm a 250 µm. Los scaffolds se fabricaron mediante estereolitografía (SLA). Se evaluó la precisión geométrica y dimensional de los scaffolds comparando el modelo CAD, STL y MA, así como su rugosidad superficial y propiedades mecánicas. Los resultados mostraron que las geometrías fabricadas presentaban poros cerrados en las esquinas entre celdas y en el centro de la celda unitaria. Esto se debe al proceso de manufactura, el tamaño de la celda y la complejidad geométrica. Los scaffolds se sometieron a ensayos a compresión para evaluar su viabilidad como sustituto óseo. Los resultados mostraron que la geometría del octaedro truncado con tamaño de celda de 1.250 µm y tamaño de trabécula de 250 µm presentó los valores más altos del módulo elástico, esfuerzo y deformación. por último, se evalúa los scaffolds por análisis de elementos finitos (FEA) para comparar con los resultados experimentales y encontrar la geometría adecuada para el hueso trabecular. (Texto tomado de la fuente).Bone tissue engineering seeks the regeneration of damaged or lost bone tissue. Scaffolds are three-dimensional structures that provide a scaffolding for the growth of cells and tissues. Advances in additive manufacturing (AM) technologies have facilitated the manufacturing of complex and customized scaffolds. This study evaluated the design and fabrication of scaffolds for bone tissue engineering based on the internal architecture of the bone. Polyhedra geometries and Voronoi diagrams were used with cell sizes from 1,500 µm to 1,250 µm and trabeculae from 200 µm to 250 µm. The scaffolds were manufactured using stereolithography (SLA). The geometric and dimensional precision of the scaffolds was evaluated by comparing the CAD, STL and MA model, as well as their surface roughness and mechanical properties. The results showed that the fabricated geometries presented closed pores at the corners between cells and in the center of the unit cell. This is due to the manufacturing process, cell size and geometric complexity. The scaffolds were subjected to compression tests to evaluate their viability as a bone substitute. The results showed that the geometry of the truncated octahedron with a cell size of 1,250 µm and a trabecula size of 250 µm presented the highest values of elastic modulus, stress and deformation. Finally, the scaffolds are evaluated by finite element analysis (FEA) to compare with the experimental results and find the appropriate geometry for the trabecular bone.MaestríaMagíster en Ingeniería - Materiales y ProcesosMecanobiología de órganos y tejidosxxi, 131 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ingeniería - Maestría en Ingeniería - Materiales y ProcesosFacultad de IngenieríaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::615 - Farmacología y terapéutica620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingenieríaIngeniería de Tejidos/métodosEstereolitografíaTecnologíaTissue Engineering/methodsStereolithographyTechnologyScaffoldsDiseñoIngeniera de tejidos óseoManufactura aditiva (MA)Celdas poliédricasVoronoiScaffoldsDesignBone tissue engineerAdditive manufacturing (AM)Polyhedral cellsVoronoiDiseño de la estructura interna de un andamio (scaffold) para tejido óseoDesign of the internal structure of a scaffold for bone tissueTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBiremeF. 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Herath et al., “Mechanical and geometrical study of 3D printed Voronoi scaffold design for large bone defects,” Mater Des, vol. 212, Dec. 2021, doi: 10.1016/j.matdes.2021.110224.EstudiantesInvestigadoresMaestrosPúblico generalORIGINAL1013601639.2024.pdf1013601639.2024.pdfTesis de Maestría en Ingeniería - Materiales y Procesosapplication/pdf6967366https://repositorio.unal.edu.co/bitstream/unal/86869/4/1013601639.2024.pdfa901c4e4205d570eb3799ba09dd7b847MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86869/5/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD55THUMBNAIL1013601639.2024.pdf.jpg1013601639.2024.pdf.jpgGenerated Thumbnailimage/jpeg4850https://repositorio.unal.edu.co/bitstream/unal/86869/6/1013601639.2024.pdf.jpgdeaed7101c139fcaf9bae6ad0574ee50MD56unal/86869oai:repositorio.unal.edu.co:unal/868692024-09-26 23:11:54.957Repositorio Institucional Universidad Nacional de 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