Encapsulamiento de aceite de cannabis para uso como ingrediente activo en productos de consumo cosmético
ilustraciones (principalmente a color), diagramas, mapas
- Autores:
-
Flórez Bautista, Bayron Germán
- Tipo de recurso:
- Fecha de publicación:
- 2024
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/86364
- Palabra clave:
- 540 - Química y ciencias afines::542 - Técnicas, procedimientos, aparatos, equipos, materiales
660 - Ingeniería química::668 - Tecnología de otros productos orgánicos
Cosmética
Cosmeticos
Beauty culture
Cosmetics
Microencapsulación
Aceite de cannabis
Coalescencia
Potencial Z
Emulsión
Cosméticos
Microencapsulation
Cannabis oil
Coalescence
Z Potential
Emulsion
Cosmetics
Aceite de cannabis
Cannabis oil
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional
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Universidad Nacional de Colombia |
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|
dc.title.spa.fl_str_mv |
Encapsulamiento de aceite de cannabis para uso como ingrediente activo en productos de consumo cosmético |
dc.title.translated.eng.fl_str_mv |
Encapsulation of cannabis oil for use as an active ingredient in cosmetic consumer products |
title |
Encapsulamiento de aceite de cannabis para uso como ingrediente activo en productos de consumo cosmético |
spellingShingle |
Encapsulamiento de aceite de cannabis para uso como ingrediente activo en productos de consumo cosmético 540 - Química y ciencias afines::542 - Técnicas, procedimientos, aparatos, equipos, materiales 660 - Ingeniería química::668 - Tecnología de otros productos orgánicos Cosmética Cosmeticos Beauty culture Cosmetics Microencapsulación Aceite de cannabis Coalescencia Potencial Z Emulsión Cosméticos Microencapsulation Cannabis oil Coalescence Z Potential Emulsion Cosmetics Aceite de cannabis Cannabis oil |
title_short |
Encapsulamiento de aceite de cannabis para uso como ingrediente activo en productos de consumo cosmético |
title_full |
Encapsulamiento de aceite de cannabis para uso como ingrediente activo en productos de consumo cosmético |
title_fullStr |
Encapsulamiento de aceite de cannabis para uso como ingrediente activo en productos de consumo cosmético |
title_full_unstemmed |
Encapsulamiento de aceite de cannabis para uso como ingrediente activo en productos de consumo cosmético |
title_sort |
Encapsulamiento de aceite de cannabis para uso como ingrediente activo en productos de consumo cosmético |
dc.creator.fl_str_mv |
Flórez Bautista, Bayron Germán |
dc.contributor.advisor.none.fl_str_mv |
Rodríguez Niño, Gerardo |
dc.contributor.author.none.fl_str_mv |
Flórez Bautista, Bayron Germán |
dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Investigación en Procesos Químicos y Bioquímicos |
dc.subject.ddc.spa.fl_str_mv |
540 - Química y ciencias afines::542 - Técnicas, procedimientos, aparatos, equipos, materiales 660 - Ingeniería química::668 - Tecnología de otros productos orgánicos |
topic |
540 - Química y ciencias afines::542 - Técnicas, procedimientos, aparatos, equipos, materiales 660 - Ingeniería química::668 - Tecnología de otros productos orgánicos Cosmética Cosmeticos Beauty culture Cosmetics Microencapsulación Aceite de cannabis Coalescencia Potencial Z Emulsión Cosméticos Microencapsulation Cannabis oil Coalescence Z Potential Emulsion Cosmetics Aceite de cannabis Cannabis oil |
dc.subject.lemb.spa.fl_str_mv |
Cosmética Cosmeticos |
dc.subject.lemb.eng.fl_str_mv |
Beauty culture Cosmetics |
dc.subject.proposal.spa.fl_str_mv |
Microencapsulación Aceite de cannabis Coalescencia Potencial Z Emulsión Cosméticos |
dc.subject.proposal.eng.fl_str_mv |
Microencapsulation Cannabis oil Coalescence Z Potential Emulsion Cosmetics |
dc.subject.umls.spa.fl_str_mv |
Aceite de cannabis |
dc.subject.umls.eng.fl_str_mv |
Cannabis oil |
description |
ilustraciones (principalmente a color), diagramas, mapas |
publishDate |
2024 |
dc.date.accessioned.none.fl_str_mv |
2024-07-03T00:03:36Z |
dc.date.available.none.fl_str_mv |
2024-07-03T00:03:36Z |
dc.date.issued.none.fl_str_mv |
2024 |
dc.type.spa.fl_str_mv |
Trabajo de grado - Maestría |
dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/masterThesis |
dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.coarversion.spa.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.content.spa.fl_str_mv |
Text |
dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/TM |
status_str |
publishedVersion |
dc.identifier.uri.none.fl_str_mv |
https://repositorio.unal.edu.co/handle/unal/86364 |
dc.identifier.instname.spa.fl_str_mv |
Universidad Nacional de Colombia |
dc.identifier.reponame.spa.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.unal.edu.co/ |
url |
https://repositorio.unal.edu.co/handle/unal/86364 https://repositorio.unal.edu.co/ |
identifier_str_mv |
Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
dc.language.iso.spa.fl_str_mv |
spa |
language |
spa |
dc.relation.references.spa.fl_str_mv |
Abe, A., Aggarwal, S. L., Aglietto, M., Aida, T., Ajroldi, G., Albertsson, A.-C., Allcock, H. R., Allen, G., Allen, N. S., Al-Malaika, S., Amass, A. J., Arlaud, P., Armstrong, R. C., Arthur, J. C., & Atkins, E. D. T. (1996). Comprehensive Polymer Science and Supplements (1st ed.). Elsevier Science. https://www.sciencedirect.com/referencework/9780080967011/comprehensive-polymer-science-and-supplements Ali, A., & Akhtar, N. (2015). The safety and efficacy of 3% Cannabis seeds extract cream for reduction of human cheek skin sebum and erythema content. Pakistan Journal of Pharmaceutical Sciences, 28(4), 1389–1395. https://pubmed.ncbi.nlm.nih.gov/26142529/ Anandharamakrishnan, C., & Padma Ishwarya, S. (2015). Spray Drying Techniques for Food Ingredient Encapsulation. Spray Drying Techniques for Food Ingredient Encapsulation, 1–296. https://doi.org/10.1002/9781118863985 Appendino, G., Gibbons, S., Giana, A., Pagani, A., Grassi, G., Stavri, M., Smith, E., & Rahman, M. M. (2008). Antibacterial cannabinoids from Cannabis sativa: A structure-activity study. Journal of Natural Products, 71(8), 1427–1430. https://doi.org/10.1021/np8002673 Babiker, E. E., Uslu, N., Al Juhaimi, F., Mohamed Ahmed, I. A., Ghafoor, K., Özcan, M. M., & Almusallam, I. A. (2021). Effect of roasting on antioxidative properties, polyphenol profile and fatty acids composition of hemp (Cannabis sativa L.) seeds. LWT, 139, 110537. https://doi.org/10.1016/J.LWT.2020.110537 Barrie, N., Kuruppu, V., Manolios, E., Ali, M., Moghaddam, M., & Manolios, N. (2017). Endocannabinoids in arthritis: current views and perspective. International Journal of Rheumatic Diseases, 20(7), 789–797. https://doi.org/10.1111/1756-185X.13146 Binks, B. P. (1998). Modern Aspects of Emulsion Science. In Modern Aspects of Emulsion Science. The Royal Society of Chemistry. https://doi.org/10.1039/9781847551474 Blake, A., Wan, B. A., Malek, L., DeAngelis, C., Diaz, P., Lao, N., Chow, E., & O’Hearn, S. (2017). A selective review of medical cannabis in cancer pain management. In Annals of Palliative Medicine (Vol. 6, Issue Suppl 2, pp. S215–S222). AME Publishing Company. https://doi.org/10.21037/apm.2017.08.05 Burger, W., & Burge, M. J. (2009). Principles of Digital Image Processing. In Ian Mackie (Ed.), Interactive Image Processing for Machine Vision. Springer Berlin Heidelberg. https://doi.org/10.1007/978-1-84800-195-4 Burgess, D. J. (1990). Practical analysis of complex coacervate systems. Journal of Colloid and Interface Science, 140(1), 227–238. https://doi.org/10.1016/0021-9797(90)90338-O Burgess, D. J., & Carless, J. E. (1984). Microelectrophoretic studies of gelatin and acacia for the prediction of complex coacervation. Journal of Colloid and Interface Science, 98(1), 1–8. https://doi.org/10.1016/0021-9797(84)90472-7 Burgess, Diane J. (1994). Complex Coacervation: Microcapsule Formation. Macromolecular Complexes in Chemistry and Biology, 285–300. https://doi.org/10.1007/978-3-642-78469-9_17 Butler, J. A. V. (1948). Theory of the Stability of Lyophobic Colloids. Nature 1948 162:4113, 162(4113), 315–316. https://doi.org/10.1038/162315b0 Casanova, F., & Santos, L. (2016). Encapsulation of cosmetic active ingredients for topical application-a review. Journal of Microencapsulation, 33(1), 1–17. https://doi.org/10.3109/02652048.2015.1115900 Casanova, M. L., Blázquez, C., Martínez-Palacio, J., Villanueva, C., Fernández-Aceñero, M. J., Huffman, J. W., Jorcano, J. L., & Guzmán, M. (2003). Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. The Journal of Clinical Investigation, 111(1), 43–50. https://doi.org/10.1172/JCI16116 Chang, S. K. C., & Zhang, Y. (2017). Protein Analysis BT - Food Analysis (S. Suzanne Nielsen (ed.); Fifth). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-319-45776-5_18 Changoer, L., & Anastassov, G. (2019). Method to treat psoriasis (Patent No. US20190060250A1). https://patentcenter.uspto.gov/applications/16106420 Chattopadhyay, P., Huff, R., & Shekunov, B. Y. (2006). Drug encapsulation using supercritical fluid extraction of emulsions. Journal of Pharmaceutical Sciences, 95(3), 667–679. https://doi.org/10.1002/JPS.20555 Chattopadhyay, P., Shekunov, B. Y., Yim, D., Cipolla, D., Boyd, B., & Farr, S. (2007). Production of solid lipid nanoparticle suspensions using supercritical fluid extraction of emulsions (SFEE) for pulmonary delivery using the AERx system. Advanced Drug Delivery Reviews, 59(6), 444–453. https://doi.org/10.1016/J.ADDR.2007.04.010 Chattopadhyay, Pratibhash, Shekunov, B. Y., Seitzinger, J. S., & Huff, R. W. (2003). Particles from supercritical fluid extraction of emulsion (Patent No. US 6988051B2). Chelliah, M. P., Zinn, Z., Khuu, P., & Teng, J. M. C. (2018). Self-initiated use of topical cannabidiol oil for epidermolysis bullosa. Pediatric Dermatology, 35(4), e224–e227. https://doi.org/10.1111/pde.13545 Choudhury, N., Meghwal, M., & Das, K. (2021). Microencapsulation: An overview on concepts, methods, properties and applications in foods. Food Frontiers, 2(4), 426–442. https://doi.org/10.1002/FFT2.94 Cocero, M. J., Martín, Á., Mattea, F., & Varona, S. (2009). Encapsulation and co-precipitation processes with supercritical fluids: Fundamentals and applications. The Journal of Supercritical Fluids, 47(3), 546–555. https://doi.org/10.1016/J.SUPFLU.2008.08.015 Curt Thies, Donald N. Schulz, Richie Davis, J. Bock, & Paul Dubin. (1994). Macromolecular Complexes in Chemistry and Biology. In Macromolecular Complexes in Chemistry and Biology (1st ed.). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-78469-9 Da Porto, C., Decorti, D., & Tubaro, F. (2012). Fatty acid composition and oxidation stability of hemp (Cannabis sativa L.) seed oil extracted by supercritical carbon dioxide. Industrial Crops and Products, 36(1), 401–404. https://doi.org/10.1016/J.INDCROP.2011.09.015 Daniels, R., & Mittermaier, E. M. (1995). Influence of pH adjustment on microcapsules obtained from complex coacervation of gelatin and acacia. Journal of Microencapsulation, 12(6), 591–599. https://doi.org/10.3109/02652049509006789 De Kruif, C. G., Weinbreck, F., & De Vries, R. (2004). Complex coacervation of proteins and anionic polysaccharides. Current Opinion in Colloid & Interface Science, 9(5), 340–349. https://doi.org/10.1016/J.COCIS.2004.09.006 De Paul J. Flory. (1953). Principles of Polymer Chemistry - Paul J. Flory (1st ed.). Cornell University Press.https://books.google.com.co/books?id=CQ0EbEkT5R0C&printsec=frontcover&redir_esc=y#v=onepage&q&f=false Devi, N., Sarmah, M., Khatun, B., & Maji, T. K. (2017). Encapsulation of active ingredients in polysaccharide–protein complex coacervates. In Advances in Colloid and Interface Science (Vol. 239, pp. 136–145). Elsevier. https://doi.org/10.1016/j.cis.2016.05.009 Douglas A. Skoog, F. James Holler, T. A. N. (2000). Principios de análisis instrumental. McGraw-Hill. Euromonitor International. (2015). Statistics Redesign | Passport. Portal-Euromonitor-Com.Esc-Web.Lib.Cbs.Dk. https://www.portal.euromonitor.com/StatisticsEvolution/index Euromonitor International. (2022). Skin care in colombia. Euromonitor Internacional, May. https://www.euromonitor.com/skin-care-in-colombia/report Fernandes Ramos, M., Boston, D., Kinney, C. A., Coblinski, J. A., & de Oliveira Camargo, F. A. (2021). Sourcing Cannabis sativa L. by thermogravimetric analysis. Science & Justice, 61(4), 401–409. https://doi.org/10.1016/J.SCIJUS.2021.03.002 Gegotek, ., Biernacki, M., mbrozewicz, E., Surazyński, ., Wroński, ., & Skrzydlewska, E. (2016). The cross-talk between electrophiles, antioxidant defence and the endocannabinoid system in fibroblasts and keratinocytes after UVA and UVB irradiation. Journal of Dermatological Science, 81(2), 107–117. https://doi.org/10.1016/J.JDERMSCI.2015.11.005 Ghaderi, R. (2000). A Supercritical Fluids Extraction Process for the Production of Drug Loaded Biodegradable Microparticles [Uppsala University]. https://www.diva-portal.org/smash/get/diva2:160613/FULLTEXT01.pdf Gumfekar, S. P. (2020). Physicochemical characterization techniques in the encapsulation of active molecules. Encapsulation of Active Molecules and Their Delivery System, 9–22. https://doi.org/10.1016/B978-0-12-819363-1.00002-8 Hanna, M., & York, P. (1994). Method and apparatus for the formation of particles (Patent No. 9313642). Henriquez, E. (2023, January). CBD Global Market: Opportunities Across Fmcg | Market Research Report | Euromonitor. https://www.euromonitor.com/cbd-global-market-opportunities-across-fmcg/report Henriquez, E. (Euromonitor). (2023). CBD Global Market: Opportunities Across Fmcg. In Euromonitor International. Huggins, M. L. (1942). Some properties of solutions of long-chain compounds. Journal of Physical Chemistry, 46(1), 151–158. https://doi.org/10.1021/J150415A018/ASSET/J150415A018.FP.PNG_V03 Hunter, R. J. (1988). Zeta Potential in Colloidal Science (R. H. Ottewill & R. L. Rowell (eds.); 1st ed.). Academic Press. Ishwarya, S. P., & Anandharamakrishnan, C. (2017). Spray Drying. In C. A. S. Padma Ishwarya (Ed.), Handbook of Drying for Dairy Products (pp. 57–94). John Wiley & Sons, Ltd. https://doi.org/10.1002/9781118930526.CH5 Jafari, S. M., Assadpoor, E., He, Y., & Bhandari, B. (2008). Encapsulation Efficiency of Food Flavours and Oils during Spray Drying. Http://Dx.Doi.Org/10.1080/07373930802135972, 26(7), 816–835. https://doi.org/10.1080/07373930802135972 Jizomoto, H., Kanaoka, E., Sugita, K., & Hirano, K. (1993). Gelatin-acacia microcapsules for trapping micro oil droplets containing lipophilic drugs and ready disintegration in the gastrointestinal tract. Pharmaceutical Research, 10(8), 1115–1122. https://doi.org/10.1023/A:1018951814939 Jun-xia, X., Hai-yan, Y., & Jian, Y. (2011). Microencapsulation of sweet orange oil by complex coacervation with soybean protein isolate/gum Arabic. Food Chemistry, 125(4), 1267–1272. https://doi.org/10.1016/J.FOODCHEM.2010.10.063 Karsa, D. R., & Stephenson, R. A. (1993). Encapsulation and Controlled Release. In Encapsulation and Controlled Release. https://doi.org/10.1533/9781845698218 Kato, A., Sato, T., & Kobayashi, K. (1989). Emulsifying Properties of Protein–Polysaccharide Complexes and Hybrids. Agricultural and Biological Chemistry, 53(8), 2147–2152. https://doi.org/10.1080/00021369.1989.10869639 Kikic, I., & Vecchione, F. (2003). Supercritical impregnation of polymers. Current Opinion in Solid State and Materials Science, 7(4–5), 399–405. https://doi.org/10.1016/J.COSSMS.2003.09.001 Kwak, H. S. (2014). Nano- and Microencapsulation for Foods. In Nano- and Microencapsulation for Foods (Vol. 9781118292). https://doi.org/10.1002/9781118292327 Luzzi, L. A., & Gerraughty, R. J. (1967). Effects of Selected Variables on the Microencapsulation of Solids. Journal of Pharmaceutical Sciences, 56(5), 634–638.https://doi.org/10.1002/JPS.2600560519 Lv, Y., Zhang, X., Zhang, H., Abbas, S., & Karangwa, E. (2013). The study of pH-dependent complexation between gelatin and gum arabic by morphology evolution and conformational transition. Food Hydrocolloids, 30(1), 323–332. https://doi.org/10.1016/J.FOODHYD.2012.06.007 Maor, Y., Yu, J., Kuzontkoski, P. M., Dezube, B. J., Zhang, X., & Groopman, J. E. (2012). Cannabidiol Inhibits Growth and Induces Programmed Cell Death in Kaposi Sarcoma-Associated Herpesvirus-Infected Endothelium. Genes and Cancer, 3(7–8), 512–520. https://doi.org/10.1177/1947601912466556/ASSET/IMAGES/LARGE/10.1177_1947601912466556-FIG7.JPEG Martins, I. M., Barreiro, M. F., Coelho, M., & Rodrigues, A. E. (2014). Microencapsulation of essential oils with biodegradable polymeric carriers for cosmetic applications. Chemical Engineering Journal, 245, 191–200. https://doi.org/10.1016/J.CEJ.2014.02.024 Mattea, F., Martín, Á., Matías-Gago, A., & Cocero, M. J. (2009). Supercritical antisolvent precipitation from an emulsion: β-Carotene nanoparticle formation. The Journal of Supercritical Fluids, 51(2), 238–247. https://doi.org/10.1016/J.SUPFLU.2009.08.013 Mhando, H. B., Sahini, M. G., & Makangara, J. J. (2023). Chemical profiling of Cannabis sativa from eleven Tanzanian regions. Heliyon, 9(5), e15892. https://doi.org/10.1016/J.HELIYON.2023.E15892 Mintel. (2023). Tabulate Search Results. https://www.gnpd.com/sinatra/analysis/tabulate/4JvzWY7ZcC/ Mishima, K., Matsuyama, K., Tanabe, D., Yamauchi, S., Young, T. J., & Johnston, K. P. (2000). Microencapsulation of proteins by rapid expansion of supercritical solution with a nonsolvent. AIChE Journal, 46(4), 857–865. https://doi.org/10.1002/AIC.690460418 Mishra, M. (2015). Handbook of Encapsulation and Controlled Release. In Handbook of Encapsulation and Controlled Release (1st ed.). CRC Press. https://doi.org/10.1201/b19038 Muthukumar, M., & Edwards, S. F. (1989). Chain Statistics and Scaling Concepts. In Comprehensive Polymer Science and Supplements (pp. 1–47). Pergamon. https://doi.org/10.1016/B978-0-08-096701-1.00038-0 Nakagawa, K., & Nagao, H. (2012). Microencapsulation of oil droplets using freezing-induced gelatin–acacia complex coacervation. Colloids and Surfaces A:Physicochemical and Engineering Aspects, 411, 129–139. https://doi.org/10.1016/J.COLSURFA.2012.07.010 Oláh, A., Markovics, A., Szabó-Papp, J., Szabó, P. T., Stott, C., Zouboulis, C. C., & Bíró, T. (2016). Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment. Experimental Dermatology, 25(9), 701–707. https://doi.org/10.1111/exd.13042 Oláh, A., Tóth, B. I., Borbíró, I., Sugawara, K., Szöllõsi, A. G., Czifra, G., Pál, B., Ambrus, L., Kloepper, J., Camera, E., Ludovici, M., Picardo, M., Voets, T., Zouboulis, C. C., Paus, R., & Bíró, T. (2014). Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes. Journal of Clinical Investigation, 124(9), 3713–3724. https://doi.org/10.1172/JCI64628 Palmieri, G. F., Martell, S., Lauri, D., & Wehrle, P. (2008). Gelatin-Acacia Complex Coacervation as a Method for Ketoprofen Microencapsulation. Https://Doi.Org/10.3109/03639049609065925, 22(9–10), 951–957. https://doi.org/10.3109/03639049609065925 Porta, G. Della, & Reverchon, E. (2008). Nanostructured microspheres produced by supercritical fluid extraction of emulsions. Biotechnology and Bioengineering, 100(5), 1020–1033. https://doi.org/10.1002/BIT.21845 Prakash, S., & Bhathena, J. (2006). Microencapsulation. Wiley Encyclopedia of Biomedical Engineering. https://doi.org/10.1002/9780471740360.EBS1524 Prata, A. S., & Grosso, C. R. F. (2015). Influence of the Oil Phase on the Microencapsulation by Complex Coacervation. Journal of the American Oil Chemists’ Society, 92(7), 1063–1072. https://doi.org/10.1007/S11746-015-2670-Z Preedy, V. R. (2017). Handbook of Cannabis and Related Pathologies. In Handbook of Cannabis and Related Pathologies. Elsevier. https://doi.org/10.1016/c2013-0-18721-1 Rähse, W. (2019a). Proposals for the Formulation of Creams. In Cosmetic Creams (pp. 275–308). https://doi.org/10.1002/9783527812219.ch8 Rähse, W. (2019b). Cosmetic creams: Development, manufacture and marketing of effective skin care products. In Cosmetic Creams: Development, Manufacture and Marketing of Effective Skin Care Products. wiley.https://doi.org/10.1002/9783527812219 Rähse, W. (2019c). Active Ingredients for Special Products. In Cosmetic Creams (pp. 231–273). John Wiley & Sons, Ltd. https://doi.org/10.1002/9783527812219.ch7 Rähse, W. (2019d). Composition of Creams for Skin Care. Cosmetic Creams, 131–173. https://doi.org/10.1002/9783527812219.CH5 Rähse, W. (2019e). Proven Active Ingredients for Various Categories of Skin Creams. In Cosmetic Creams (pp. 175–230). John Wiley & Sons, Ltd. https://doi.org/10.1002/9783527812219.ch6 Rodriguez, F., Cohen, C., Ober, C. K., & Archer, L. (2014). Principles of Polymer Systems. In Principles of Polymer Systems (6th ed.). CRC Press. https://doi.org/10.1201/b17873 Rousi, Z., Malhiac, C., Fatouros, D. G., & Paraskevopoulou, A. (2019). Complex coacervates formation between gelatin and gum Arabic with different arabinogalactan protein fraction content and their characterization. Food Hydrocolloids, 96, 577–588. https://doi.org/10.1016/J.FOODHYD.2019.06.009 Santos, M. B., de Carvalho, C. W. P., & Garcia-Rojas, E. E. (2021). Microencapsulation of vitamin D3 by complex coacervation using carboxymethyl tara gum (Caesalpinia spinosa) and gelatin A. Food Chemistry, 343, 128529. https://doi.org/10.1016/J.FOODCHEM.2020.128529 Sarika, P. R., Pavithran, A., & James, N. R. (2015). Cationized gelatin/gum arabic polyelectrolyte complex: Study of electrostatic interactions. Food Hydrocolloids, 49, 176–182. https://doi.org/10.1016/J.FOODHYD.2015.02.039 Schmitt, C., Sanchez, C., Desobry-Banon, S., & Hardy, J. (1998). Structure and technofunctional properties of protein-polysaccharide complexes: a review. Critical Reviews in Food Science and Nutrition, 38(8), 689–753. https://doi.org/10.1080/10408699891274354 Schmitt, C., Sanchez, C., Desobry-Banon, S., & Hardy, J. (2010). Structure and Technofunctional Properties of Protein-Polysaccharide Complexes: A Review. Http://Dx.Doi.Org/10.1080/10408699891274354, 38(8), 689–753. https://doi.org/10.1080/10408699891274354 Shao, K., Stewart, C., & Grant-Kels, J. M. (2021). Cannabis and the skin. Clinics in Dermatology, 39(5), 784–795. https://doi.org/10.1016/j.clindermatol.2021.05.006 Sliwka, W. (1975). Microencapsulation. In S. Benita (Ed.), Angewandte Chemie International Edition in English (2nd ed., Vol. 14, Issue 8). CRC Press. https://doi.org/10.1002/anie.197505391 Soliman, E., & Van Dross, R. (2016). Anandamide-induced endoplasmic reticulum stress and apoptosis are mediated by oxidative stress in non-melanoma skin cancer: Receptor-independent endocannabinoid signaling. Molecular Carcinogenesis, 55(11), 1807–1821. https://doi.org/10.1002/MC.22429 Sonawane;, S. H. ;Nationa. I. of ., Bhanvase, B. . ;R . N. U., & Sivakumar, M. of N. (2020). Encapsulation of Active Molecules and Their Delivery System. In Encapsulation of Active Molecules and Their Delivery System. Elsevier. https://doi.org/10.1016/c2018-0-05369-4 Strongin, R. M., Meehan-Atrash, J., & Vialpando, M. (2021). Recent Advances in the Science of Cannabis. Recent Advances in the Science of Cannabis. https://doi.org/10.1201/9780429274893/RECENT-ADVANCES-SCIENCE-CANNABIS-ROBERT-STRONGIN-JIRIES-MEEHAN-ATRASH-MONICA-VIALPANDO Sudhakar, Y. N., Selvakumar, M., & Bhat, D. K. (2018). An introduction of Biopolymer Electrolytes. In Biopolymer Electrolytes (pp. 1–34). Elsevier. https://doi.org/10.1016/B978-0-12-813447-4.00001-7 Tadros, T. F. (2009). Emulsion Science and Technology: A General Introduction. In Emulsion Science and Technology (pp. 1–56). John Wiley & Sons, Ltd. https://doi.org/10.1002/9783527626564.ch1 Tadros, T. F. (2017). 13. Applications of suspensions in cosmetics and personal care. In Suspension Concentrates (pp. 311–324). De Gruyter. https://doi.org/10.1515/9783110486872-014 Takenaka, H., Kawashima, Y., & Lin, S. Y. (1980). Micromeritic properties of sulfamethoxazole microcapsules prepared by gelatin-acacia coacervation. Journal of Pharmaceutical Sciences, 69(5), 513–516. https://doi.org/10.1002/JPS.2600690509 Tavares, L., & Noreña, C. P. Z. (2020). Encapsulation of Ginger Essential Oil Using Complex Coacervation Method: Coacervate Formation, Rheological Property, and Physicochemical Characterization. Food and Bioprocess Technology, 13(8), 1405–1420. https://doi.org/10.1007/S11947-020-02480-3/METRICS Thomas, B. F. (2016). The Analytical Chemistry of Cannabis Emerging Issues in Analytical Chemistry Series Editor. http://www.sciencedirect.com:5070/book/9780128046463/the-analytical-chemistry-of-cannabis Timilsena, Y. P., Wang, B., Adhikari, R., & Adhikari, B. (2016). Preparation and characterization of chia seed protein isolate–chia seed gum complex coacervates. Food Hydrocolloids, 52, 554–563. https://doi.org/10.1016/J.FOODHYD.2015.07.033 Timilsena, Y. P., Wang, B., Adhikari, R., & Adhikari, B. (2017). Advances in microencapsulation of polyunsaturated fatty acids (PUFAs)-rich plant oils using complex coacervation: A review. Food Hydrocolloids, 69, 369–381. https://doi.org/10.1016/J.FOODHYD.2017.03.007 Tolstoguzov, V. (2003). Some thermodynamic considerations in food formulation. Food Hydrocolloids, 17(1), 1–23. https://doi.org/10.1016/S0268-005X(01)00111-4 Tomasko, D. L., Li, H., Liu, D., Han, X., Wingert, M. J., Lee, L. J., & Koelling, K. W. (2003). A Review of CO2 Applications in the Processing of Polymers. Industrial and Engineering Chemistry Research, 42(25), 6431–6456. https://doi.org/10.1021/ie030199z Turgeon, S. L., Beaulieu, M., Schmitt, C., & Sanchez, C. (2003). Protein–polysaccharide interactions: phase-ordering kinetics, thermodynamic and structural aspects. Current Opinion in Colloid & Interface Science, 8(4–5), 401–414. https://doi.org/10.1016/S1359-0294(03)00093-1 Varona, S., Rodríguez-Rojo, S., Martín, Á., Cocero, M. J., & Duarte, C. M. M. (2011). Supercritical impregnation of lavandin (Lavandula hybrida) essential oil in modified starch. Journal of Supercritical Fluids, 58(2), 313–319. https://doi.org/10.1016/j.supflu.2011.06.003 Wang, C. S., Natale, G., Virgilio, N., & Heuzey, M. C. (2016). Synergistic gelation of gelatin B with xanthan gum. Food Hydrocolloids, 60, 374–383. https://doi.org/10.1016/J.FOODHYD.2016.03.043 Wang, Y., Dave, R. N., & Pfeffer, R. (2004). Polymer coating/encapsulation of nanoparticles using a supercritical anti-solvent process. The Journal of Supercritical Fluids, 28(1), 85–99. https://doi.org/10.1016/S0896-8446(03)00011-1 Weidner, E., Petermann, M., & Knez, Z. (2003). Multifunctional composites by high-pressure spray processes. Current Opinion in Solid State and Materials Science, 7(4–5), 385–390. https://doi.org/10.1016/J.COSSMS.2003.09.002 Westbrook, G., Angus, A., Abbas, A., Scott Livingston, A., Mackinson, D., Borjas, D., Yum, H., Grigorijevaite, K., Balciauskaite, K., Valenti, N., Inan, P., Puri, S., Dutton, S., & Milenkovic, Z. (2023, January 17). Top 10 Global Consumer Trends 2023 | Euromonitor. Euromonitor International. https://go.euromonitor.com/white-paper-EC-2023-Top-10-Global-Consumer-Trends-EN.html Wilsey, B., Marcotte, T., Deutsch, R., Gouaux, B., Sakai, S., & Donaghe, H. (2013). Low-dose vaporized cannabis significantly improves neuropathic pain. Journal of Pain, 14(2), 136–148. https://doi.org/10.1016/j.jpain.2012.10.009 Yeo, S. Do, & Kiran, E. (2005). Formation of polymer particles with supercritical fluids: A review. The Journal of Supercritical Fluids, 34(3), 287–308. https://doi.org/10.1016/J.SUPFLU.2004.10.006 Zuidam, N. J., & Nedović, V. . (2010). Encapsulation technologies for active food ingredients and food processing. In N.J. Zuidam & Viktor Nedovic (Eds.), Encapsulation Technologies for Active Food Ingredients and Food Processing (1st ed.). Springer New York. https://doi.org/10.1007/978-1-4419-1008-0/COVER |
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Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Rodríguez Niño, Gerardocc3b4036a9c5c30dd1f98cb2b8b858c3600Flórez Bautista, Bayron Germán520843b1b1275af25c85a37e75543f8aGrupo de Investigación en Procesos Químicos y Bioquímicos2024-07-03T00:03:36Z2024-07-03T00:03:36Z2024https://repositorio.unal.edu.co/handle/unal/86364Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones (principalmente a color), diagramas, mapasEl aceite de cannabis debido a la presencia de cannabinoides, terpenoides y flavonoides presenta funciones activas y de valor nutricional o en tratamientos para la epilepsia, manejo del dolor, inflamación y desordenes neurodegenerativos. Debido a la variedad de las propiedades físicas de sus compuestos, esta puede presentar diferentes retos a la hora de su integración como ingrediente activo en productos. Entre estos se relacionan impactos de en el perfil olfativo, impacto en la estabilizas del producto y modificaciones o pérdida de metabolitos deseados. A modo de presentar un abordaje para enfrentar estos retos, se propone la encapsulación del aceite como una metodología que permite cubrir estos frentes. Para este abordaje, se hace un primer acercamiento alrededor de la contextualización de la planta de cannabis, sus compuestos, mercado actual de su extracto y su uso en diferentes productos en el mercado reciente. Posteriormente se aborda los mecanismos de encapsulación, sus principios y el desarrollo de tres diferentes rutas para su obtención. Realizado este contexto, se selecciona la coalescencia como mecanismo de encapsulamiento debido principalmente a su acceso tecnológico y de insumos. Así mismo, debido a la falta de bibliografía de la encapsulación del aceite bajo esta metodología y materiales encapsulantes, se diseña el proceso por medio de la revisión bibliográfica de este en otras aplicaciones. A partir de esto, se obtienen partículas de un tamaño medio de 9,43μm que posteriormente son caracterizadas por medio de la medición de su potencial Z en diferentes medios de pH, análisis termogravimétrico y la presentación de su morfología por medio de microscopia electrónica de barrido. A través de estos análisis se pudo identificar la encapsulación del aceite, así como la estabilidad de estas en un medio dado para la aplicación cosmética planteada. En torno a su aplicación cosmética, se evalúo el impacto a tres diferentes concentraciones (0.15%, 0.20% y 0,25%) dentro de la formulación emulsionada cosmética. Esta estabilidad se desarrolla sometiendo al producto en un ambiente de 45°C en horno y corroborando por medio cualitativo tras su centrifugación la no separación de fases a lo largo del mes de evaluación. Finalmente, se encontró la metodología capaz de formar partículas que proveen la protección y asilamiento del aceite, igualmente, que cargas superficiales pueden favorecer la estabilidad de los sistemas emulsionados (Texto tomado de la fuente).Cannabis oil, due to the presence of cannabinoids, terpenoids and flavonoids, has active functions and nutritional value or in treatments for epilepsy, pain management, inflammation, and neurodegenerative disorders. Due to the variety of physical properties of its compounds, it can present different challenges related with its integration as an active ingredient in products. These include impacts on the olfactory profile, impact on the stability of the product and modifications or loss of desired metabolites. To present an approach to face these challenges, oil encapsulation is proposed as a methodology that allows these fronts to be covered. For this approach, at first, it has made the contextualization of the cannabis plant, its compounds, current market for its extract and its use in different products in the recent market. Subsequently, the encapsulation mechanisms, their principles, and the development of three different routes to obtain them. Once this context is realized, coalescence is selected as an encapsulation mechanism mainly due to its technological and input access. Likewise, due to the lack of bibliography on oil encapsulation under this methodology and encapsulating materials, the process is designed through a bibliographic review of it in other applications. From this, particles with an average size of 9.43 μm are obtained, which are subsequently characterized by measuring their Z potential in different pH media, thermogravimetric analysis, and the presentation of their morphology by scanning electron microscopy. Through these analyzes it was possible to identify the encapsulation of the oil, as well as its stability in a specific medium for the proposed cosmetic application. Regarding its cosmetic application, the impact was evaluated at three different concentrations (0.15%, 0.20% and 0.25%) within the cosmetic emulsified formulation. This stability is developed by subjecting the product to an environment of 45°C in an oven and corroborating by qualitative means after centrifugation the non-separation of phases throughout the month of evaluation. Finally, the methodology was found capable of forming particles that provide protection and isolation of the oil, likewise, that surface charges can favor the stability of the emulsified systems (Texto tomado de la fuente).MaestríaMagíster en Ingeniería - Ingeniería QuímicaDiseño de ProductoIngeniería Química y Ambiental.Sede Bogotáxx, 105 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ingeniería - Maestría en Ingeniería - Ingeniería QuímicaFacultad de IngenieríaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá540 - Química y ciencias afines::542 - Técnicas, procedimientos, aparatos, equipos, materiales660 - Ingeniería química::668 - Tecnología de otros productos orgánicosCosméticaCosmeticosBeauty cultureCosmeticsMicroencapsulaciónAceite de cannabisCoalescenciaPotencial ZEmulsiónCosméticosMicroencapsulationCannabis oilCoalescenceZ PotentialEmulsionCosmeticsAceite de cannabisCannabis oilEncapsulamiento de aceite de cannabis para uso como ingrediente activo en productos de consumo cosméticoEncapsulation of cannabis oil for use as an active ingredient in cosmetic consumer productsTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/TMAbe, A., Aggarwal, S. L., Aglietto, M., Aida, T., Ajroldi, G., Albertsson, A.-C., Allcock, H. R., Allen, G., Allen, N. S., Al-Malaika, S., Amass, A. J., Arlaud, P., Armstrong, R. C., Arthur, J. C., & Atkins, E. D. T. (1996). Comprehensive Polymer Science and Supplements (1st ed.). Elsevier Science. https://www.sciencedirect.com/referencework/9780080967011/comprehensive-polymer-science-and-supplementsAli, A., & Akhtar, N. (2015). The safety and efficacy of 3% Cannabis seeds extract cream for reduction of human cheek skin sebum and erythema content. Pakistan Journal of Pharmaceutical Sciences, 28(4), 1389–1395. https://pubmed.ncbi.nlm.nih.gov/26142529/Anandharamakrishnan, C., & Padma Ishwarya, S. (2015). Spray Drying Techniques for Food Ingredient Encapsulation. Spray Drying Techniques for Food Ingredient Encapsulation, 1–296. https://doi.org/10.1002/9781118863985Appendino, G., Gibbons, S., Giana, A., Pagani, A., Grassi, G., Stavri, M., Smith, E., & Rahman, M. M. (2008). Antibacterial cannabinoids from Cannabis sativa: A structure-activity study. Journal of Natural Products, 71(8), 1427–1430. https://doi.org/10.1021/np8002673Babiker, E. E., Uslu, N., Al Juhaimi, F., Mohamed Ahmed, I. A., Ghafoor, K., Özcan, M. M., & Almusallam, I. A. (2021). Effect of roasting on antioxidative properties, polyphenol profile and fatty acids composition of hemp (Cannabis sativa L.) seeds. LWT, 139, 110537. https://doi.org/10.1016/J.LWT.2020.110537Barrie, N., Kuruppu, V., Manolios, E., Ali, M., Moghaddam, M., & Manolios, N. (2017). Endocannabinoids in arthritis: current views and perspective. International Journal of Rheumatic Diseases, 20(7), 789–797. https://doi.org/10.1111/1756-185X.13146Binks, B. P. (1998). Modern Aspects of Emulsion Science. In Modern Aspects of Emulsion Science. The Royal Society of Chemistry. https://doi.org/10.1039/9781847551474Blake, A., Wan, B. A., Malek, L., DeAngelis, C., Diaz, P., Lao, N., Chow, E., & O’Hearn, S. (2017). A selective review of medical cannabis in cancer pain management. In Annals of Palliative Medicine (Vol. 6, Issue Suppl 2, pp. S215–S222). AME Publishing Company. https://doi.org/10.21037/apm.2017.08.05Burger, W., & Burge, M. J. (2009). Principles of Digital Image Processing. In Ian Mackie (Ed.), Interactive Image Processing for Machine Vision. Springer Berlin Heidelberg. https://doi.org/10.1007/978-1-84800-195-4Burgess, D. J. (1990). Practical analysis of complex coacervate systems. Journal of Colloid and Interface Science, 140(1), 227–238. https://doi.org/10.1016/0021-9797(90)90338-OBurgess, D. J., & Carless, J. E. (1984). Microelectrophoretic studies of gelatin and acacia for the prediction of complex coacervation. Journal of Colloid and Interface Science, 98(1), 1–8. https://doi.org/10.1016/0021-9797(84)90472-7Burgess, Diane J. (1994). Complex Coacervation: Microcapsule Formation. Macromolecular Complexes in Chemistry and Biology, 285–300. https://doi.org/10.1007/978-3-642-78469-9_17Butler, J. A. V. (1948). Theory of the Stability of Lyophobic Colloids. Nature 1948 162:4113, 162(4113), 315–316. https://doi.org/10.1038/162315b0Casanova, F., & Santos, L. (2016). Encapsulation of cosmetic active ingredients for topical application-a review. Journal of Microencapsulation, 33(1), 1–17. https://doi.org/10.3109/02652048.2015.1115900Casanova, M. L., Blázquez, C., Martínez-Palacio, J., Villanueva, C., Fernández-Aceñero, M. J., Huffman, J. W., Jorcano, J. L., & Guzmán, M. (2003). Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. The Journal of Clinical Investigation, 111(1), 43–50. https://doi.org/10.1172/JCI16116Chang, S. K. C., & Zhang, Y. (2017). Protein Analysis BT - Food Analysis (S. Suzanne Nielsen (ed.); Fifth). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-319-45776-5_18Changoer, L., & Anastassov, G. (2019). Method to treat psoriasis (Patent No. US20190060250A1). https://patentcenter.uspto.gov/applications/16106420Chattopadhyay, P., Huff, R., & Shekunov, B. Y. (2006). Drug encapsulation using supercritical fluid extraction of emulsions. Journal of Pharmaceutical Sciences, 95(3), 667–679. https://doi.org/10.1002/JPS.20555Chattopadhyay, P., Shekunov, B. Y., Yim, D., Cipolla, D., Boyd, B., & Farr, S. (2007). Production of solid lipid nanoparticle suspensions using supercritical fluid extraction of emulsions (SFEE) for pulmonary delivery using the AERx system. Advanced Drug Delivery Reviews, 59(6), 444–453. https://doi.org/10.1016/J.ADDR.2007.04.010Chattopadhyay, Pratibhash, Shekunov, B. Y., Seitzinger, J. S., & Huff, R. W. (2003). Particles from supercritical fluid extraction of emulsion (Patent No. US 6988051B2).Chelliah, M. P., Zinn, Z., Khuu, P., & Teng, J. M. C. (2018). Self-initiated use of topical cannabidiol oil for epidermolysis bullosa. Pediatric Dermatology, 35(4), e224–e227. https://doi.org/10.1111/pde.13545Choudhury, N., Meghwal, M., & Das, K. (2021). Microencapsulation: An overview on concepts, methods, properties and applications in foods. Food Frontiers, 2(4), 426–442. https://doi.org/10.1002/FFT2.94Cocero, M. J., Martín, Á., Mattea, F., & Varona, S. (2009). Encapsulation and co-precipitation processes with supercritical fluids: Fundamentals and applications. The Journal of Supercritical Fluids, 47(3), 546–555. https://doi.org/10.1016/J.SUPFLU.2008.08.015Curt Thies, Donald N. Schulz, Richie Davis, J. Bock, & Paul Dubin. (1994). Macromolecular Complexes in Chemistry and Biology. In Macromolecular Complexes in Chemistry and Biology (1st ed.). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-78469-9Da Porto, C., Decorti, D., & Tubaro, F. (2012). Fatty acid composition and oxidation stability of hemp (Cannabis sativa L.) seed oil extracted by supercritical carbon dioxide. Industrial Crops and Products, 36(1), 401–404. https://doi.org/10.1016/J.INDCROP.2011.09.015Daniels, R., & Mittermaier, E. M. (1995). Influence of pH adjustment on microcapsules obtained from complex coacervation of gelatin and acacia. Journal of Microencapsulation, 12(6), 591–599. https://doi.org/10.3109/02652049509006789De Kruif, C. G., Weinbreck, F., & De Vries, R. (2004). Complex coacervation of proteins and anionic polysaccharides. Current Opinion in Colloid & Interface Science, 9(5), 340–349. https://doi.org/10.1016/J.COCIS.2004.09.006De Paul J. Flory. (1953). Principles of Polymer Chemistry - Paul J. Flory (1st ed.). Cornell University Press.https://books.google.com.co/books?id=CQ0EbEkT5R0C&printsec=frontcover&redir_esc=y#v=onepage&q&f=falseDevi, N., Sarmah, M., Khatun, B., & Maji, T. K. (2017). Encapsulation of active ingredients in polysaccharide–protein complex coacervates. In Advances in Colloid and Interface Science (Vol. 239, pp. 136–145). Elsevier. https://doi.org/10.1016/j.cis.2016.05.009Douglas A. Skoog, F. James Holler, T. A. N. (2000). Principios de análisis instrumental. McGraw-Hill.Euromonitor International. (2015). Statistics Redesign | Passport. Portal-Euromonitor-Com.Esc-Web.Lib.Cbs.Dk. https://www.portal.euromonitor.com/StatisticsEvolution/indexEuromonitor International. (2022). Skin care in colombia. Euromonitor Internacional, May. https://www.euromonitor.com/skin-care-in-colombia/reportFernandes Ramos, M., Boston, D., Kinney, C. A., Coblinski, J. A., & de Oliveira Camargo, F. A. (2021). Sourcing Cannabis sativa L. by thermogravimetric analysis. Science & Justice, 61(4), 401–409. https://doi.org/10.1016/J.SCIJUS.2021.03.002Gegotek, ., Biernacki, M., mbrozewicz, E., Surazyński, ., Wroński, ., & Skrzydlewska, E. (2016). The cross-talk between electrophiles, antioxidant defence and the endocannabinoid system in fibroblasts and keratinocytes after UVA and UVB irradiation. Journal of Dermatological Science, 81(2), 107–117. https://doi.org/10.1016/J.JDERMSCI.2015.11.005Ghaderi, R. (2000). A Supercritical Fluids Extraction Process for the Production of Drug Loaded Biodegradable Microparticles [Uppsala University]. https://www.diva-portal.org/smash/get/diva2:160613/FULLTEXT01.pdfGumfekar, S. P. (2020). Physicochemical characterization techniques in the encapsulation of active molecules. Encapsulation of Active Molecules and Their Delivery System, 9–22. https://doi.org/10.1016/B978-0-12-819363-1.00002-8Hanna, M., & York, P. (1994). Method and apparatus for the formation of particles (Patent No. 9313642).Henriquez, E. (2023, January). CBD Global Market: Opportunities Across Fmcg | Market Research Report | Euromonitor. https://www.euromonitor.com/cbd-global-market-opportunities-across-fmcg/reportHenriquez, E. (Euromonitor). (2023). CBD Global Market: Opportunities Across Fmcg. In Euromonitor International.Huggins, M. L. (1942). Some properties of solutions of long-chain compounds. Journal of Physical Chemistry, 46(1), 151–158. https://doi.org/10.1021/J150415A018/ASSET/J150415A018.FP.PNG_V03Hunter, R. J. (1988). Zeta Potential in Colloidal Science (R. H. Ottewill & R. L. Rowell (eds.); 1st ed.). Academic Press.Ishwarya, S. P., & Anandharamakrishnan, C. (2017). Spray Drying. In C. A. S. Padma Ishwarya (Ed.), Handbook of Drying for Dairy Products (pp. 57–94). John Wiley & Sons, Ltd. https://doi.org/10.1002/9781118930526.CH5Jafari, S. M., Assadpoor, E., He, Y., & Bhandari, B. (2008). Encapsulation Efficiency of Food Flavours and Oils during Spray Drying. Http://Dx.Doi.Org/10.1080/07373930802135972, 26(7), 816–835. https://doi.org/10.1080/07373930802135972Jizomoto, H., Kanaoka, E., Sugita, K., & Hirano, K. (1993). Gelatin-acacia microcapsules for trapping micro oil droplets containing lipophilic drugs and ready disintegration in the gastrointestinal tract. Pharmaceutical Research, 10(8), 1115–1122. https://doi.org/10.1023/A:1018951814939Jun-xia, X., Hai-yan, Y., & Jian, Y. (2011). Microencapsulation of sweet orange oil by complex coacervation with soybean protein isolate/gum Arabic. Food Chemistry, 125(4), 1267–1272. https://doi.org/10.1016/J.FOODCHEM.2010.10.063Karsa, D. R., & Stephenson, R. A. (1993). Encapsulation and Controlled Release. In Encapsulation and Controlled Release. https://doi.org/10.1533/9781845698218Kato, A., Sato, T., & Kobayashi, K. (1989). Emulsifying Properties of Protein–Polysaccharide Complexes and Hybrids. Agricultural and Biological Chemistry, 53(8), 2147–2152. https://doi.org/10.1080/00021369.1989.10869639Kikic, I., & Vecchione, F. (2003). Supercritical impregnation of polymers. Current Opinion in Solid State and Materials Science, 7(4–5), 399–405. https://doi.org/10.1016/J.COSSMS.2003.09.001Kwak, H. S. (2014). Nano- and Microencapsulation for Foods. In Nano- and Microencapsulation for Foods (Vol. 9781118292). https://doi.org/10.1002/9781118292327Luzzi, L. A., & Gerraughty, R. J. (1967). Effects of Selected Variables on the Microencapsulation of Solids. Journal of Pharmaceutical Sciences, 56(5), 634–638.https://doi.org/10.1002/JPS.2600560519Lv, Y., Zhang, X., Zhang, H., Abbas, S., & Karangwa, E. (2013). The study of pH-dependent complexation between gelatin and gum arabic by morphology evolution and conformational transition. Food Hydrocolloids, 30(1), 323–332. https://doi.org/10.1016/J.FOODHYD.2012.06.007Maor, Y., Yu, J., Kuzontkoski, P. M., Dezube, B. J., Zhang, X., & Groopman, J. E. (2012). Cannabidiol Inhibits Growth and Induces Programmed Cell Death in Kaposi Sarcoma-Associated Herpesvirus-Infected Endothelium. Genes and Cancer, 3(7–8), 512–520. https://doi.org/10.1177/1947601912466556/ASSET/IMAGES/LARGE/10.1177_1947601912466556-FIG7.JPEGMartins, I. M., Barreiro, M. F., Coelho, M., & Rodrigues, A. E. (2014). Microencapsulation of essential oils with biodegradable polymeric carriers for cosmetic applications. Chemical Engineering Journal, 245, 191–200. https://doi.org/10.1016/J.CEJ.2014.02.024Mattea, F., Martín, Á., Matías-Gago, A., & Cocero, M. J. (2009). Supercritical antisolvent precipitation from an emulsion: β-Carotene nanoparticle formation. The Journal of Supercritical Fluids, 51(2), 238–247. https://doi.org/10.1016/J.SUPFLU.2009.08.013Mhando, H. B., Sahini, M. G., & Makangara, J. J. (2023). Chemical profiling of Cannabis sativa from eleven Tanzanian regions. Heliyon, 9(5), e15892. https://doi.org/10.1016/J.HELIYON.2023.E15892Mintel. (2023). Tabulate Search Results. https://www.gnpd.com/sinatra/analysis/tabulate/4JvzWY7ZcC/Mishima, K., Matsuyama, K., Tanabe, D., Yamauchi, S., Young, T. J., & Johnston, K. P. (2000). Microencapsulation of proteins by rapid expansion of supercritical solution with a nonsolvent. AIChE Journal, 46(4), 857–865. https://doi.org/10.1002/AIC.690460418Mishra, M. (2015). Handbook of Encapsulation and Controlled Release. In Handbook of Encapsulation and Controlled Release (1st ed.). CRC Press. https://doi.org/10.1201/b19038Muthukumar, M., & Edwards, S. F. (1989). Chain Statistics and Scaling Concepts. In Comprehensive Polymer Science and Supplements (pp. 1–47). Pergamon. https://doi.org/10.1016/B978-0-08-096701-1.00038-0Nakagawa, K., & Nagao, H. (2012). Microencapsulation of oil droplets using freezing-induced gelatin–acacia complex coacervation. Colloids and Surfaces A:Physicochemical and Engineering Aspects, 411, 129–139. https://doi.org/10.1016/J.COLSURFA.2012.07.010Oláh, A., Markovics, A., Szabó-Papp, J., Szabó, P. T., Stott, C., Zouboulis, C. C., & Bíró, T. (2016). Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment. Experimental Dermatology, 25(9), 701–707. https://doi.org/10.1111/exd.13042Oláh, A., Tóth, B. I., Borbíró, I., Sugawara, K., Szöllõsi, A. G., Czifra, G., Pál, B., Ambrus, L., Kloepper, J., Camera, E., Ludovici, M., Picardo, M., Voets, T., Zouboulis, C. C., Paus, R., & Bíró, T. (2014). Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes. Journal of Clinical Investigation, 124(9), 3713–3724. https://doi.org/10.1172/JCI64628Palmieri, G. F., Martell, S., Lauri, D., & Wehrle, P. (2008). Gelatin-Acacia Complex Coacervation as a Method for Ketoprofen Microencapsulation. Https://Doi.Org/10.3109/03639049609065925, 22(9–10), 951–957. https://doi.org/10.3109/03639049609065925Porta, G. Della, & Reverchon, E. (2008). Nanostructured microspheres produced by supercritical fluid extraction of emulsions. Biotechnology and Bioengineering, 100(5), 1020–1033. https://doi.org/10.1002/BIT.21845Prakash, S., & Bhathena, J. (2006). Microencapsulation. Wiley Encyclopedia of Biomedical Engineering. https://doi.org/10.1002/9780471740360.EBS1524Prata, A. S., & Grosso, C. R. F. (2015). Influence of the Oil Phase on the Microencapsulation by Complex Coacervation. Journal of the American Oil Chemists’ Society, 92(7), 1063–1072. https://doi.org/10.1007/S11746-015-2670-ZPreedy, V. R. (2017). Handbook of Cannabis and Related Pathologies. In Handbook of Cannabis and Related Pathologies. Elsevier. https://doi.org/10.1016/c2013-0-18721-1Rähse, W. (2019a). Proposals for the Formulation of Creams. In Cosmetic Creams (pp. 275–308). https://doi.org/10.1002/9783527812219.ch8Rähse, W. (2019b). Cosmetic creams: Development, manufacture and marketing of effective skin care products. In Cosmetic Creams: Development, Manufacture and Marketing of Effective Skin Care Products. wiley.https://doi.org/10.1002/9783527812219Rähse, W. (2019c). Active Ingredients for Special Products. In Cosmetic Creams (pp. 231–273). John Wiley & Sons, Ltd. https://doi.org/10.1002/9783527812219.ch7Rähse, W. (2019d). Composition of Creams for Skin Care. Cosmetic Creams, 131–173. https://doi.org/10.1002/9783527812219.CH5Rähse, W. (2019e). Proven Active Ingredients for Various Categories of Skin Creams. In Cosmetic Creams (pp. 175–230). John Wiley & Sons, Ltd. https://doi.org/10.1002/9783527812219.ch6Rodriguez, F., Cohen, C., Ober, C. K., & Archer, L. (2014). Principles of Polymer Systems. In Principles of Polymer Systems (6th ed.). CRC Press. https://doi.org/10.1201/b17873Rousi, Z., Malhiac, C., Fatouros, D. G., & Paraskevopoulou, A. (2019). Complex coacervates formation between gelatin and gum Arabic with different arabinogalactan protein fraction content and their characterization. Food Hydrocolloids, 96, 577–588. https://doi.org/10.1016/J.FOODHYD.2019.06.009Santos, M. B., de Carvalho, C. W. P., & Garcia-Rojas, E. E. (2021). Microencapsulation of vitamin D3 by complex coacervation using carboxymethyl tara gum (Caesalpinia spinosa) and gelatin A. Food Chemistry, 343, 128529. https://doi.org/10.1016/J.FOODCHEM.2020.128529Sarika, P. R., Pavithran, A., & James, N. R. (2015). Cationized gelatin/gum arabic polyelectrolyte complex: Study of electrostatic interactions. Food Hydrocolloids, 49, 176–182. https://doi.org/10.1016/J.FOODHYD.2015.02.039Schmitt, C., Sanchez, C., Desobry-Banon, S., & Hardy, J. (1998). Structure and technofunctional properties of protein-polysaccharide complexes: a review. Critical Reviews in Food Science and Nutrition, 38(8), 689–753. https://doi.org/10.1080/10408699891274354Schmitt, C., Sanchez, C., Desobry-Banon, S., & Hardy, J. (2010). Structure and Technofunctional Properties of Protein-Polysaccharide Complexes: A Review. Http://Dx.Doi.Org/10.1080/10408699891274354, 38(8), 689–753. https://doi.org/10.1080/10408699891274354Shao, K., Stewart, C., & Grant-Kels, J. M. (2021). Cannabis and the skin. Clinics in Dermatology, 39(5), 784–795. https://doi.org/10.1016/j.clindermatol.2021.05.006Sliwka, W. (1975). Microencapsulation. In S. Benita (Ed.), Angewandte Chemie International Edition in English (2nd ed., Vol. 14, Issue 8). CRC Press. https://doi.org/10.1002/anie.197505391Soliman, E., & Van Dross, R. (2016). Anandamide-induced endoplasmic reticulum stress and apoptosis are mediated by oxidative stress in non-melanoma skin cancer: Receptor-independent endocannabinoid signaling. Molecular Carcinogenesis, 55(11), 1807–1821. https://doi.org/10.1002/MC.22429Sonawane;, S. H. ;Nationa. I. of ., Bhanvase, B. . ;R . N. U., & Sivakumar, M. of N. (2020). Encapsulation of Active Molecules and Their Delivery System. In Encapsulation of Active Molecules and Their Delivery System. Elsevier. https://doi.org/10.1016/c2018-0-05369-4Strongin, R. M., Meehan-Atrash, J., & Vialpando, M. (2021). Recent Advances in the Science of Cannabis. Recent Advances in the Science of Cannabis. https://doi.org/10.1201/9780429274893/RECENT-ADVANCES-SCIENCE-CANNABIS-ROBERT-STRONGIN-JIRIES-MEEHAN-ATRASH-MONICA-VIALPANDOSudhakar, Y. N., Selvakumar, M., & Bhat, D. K. (2018). An introduction of Biopolymer Electrolytes. In Biopolymer Electrolytes (pp. 1–34). Elsevier. https://doi.org/10.1016/B978-0-12-813447-4.00001-7Tadros, T. F. (2009). Emulsion Science and Technology: A General Introduction. In Emulsion Science and Technology (pp. 1–56). John Wiley & Sons, Ltd. https://doi.org/10.1002/9783527626564.ch1Tadros, T. F. (2017). 13. Applications of suspensions in cosmetics and personal care. In Suspension Concentrates (pp. 311–324). De Gruyter. https://doi.org/10.1515/9783110486872-014Takenaka, H., Kawashima, Y., & Lin, S. Y. (1980). Micromeritic properties of sulfamethoxazole microcapsules prepared by gelatin-acacia coacervation. Journal of Pharmaceutical Sciences, 69(5), 513–516. https://doi.org/10.1002/JPS.2600690509Tavares, L., & Noreña, C. P. Z. (2020). Encapsulation of Ginger Essential Oil Using Complex Coacervation Method: Coacervate Formation, Rheological Property, and Physicochemical Characterization. Food and Bioprocess Technology, 13(8), 1405–1420. https://doi.org/10.1007/S11947-020-02480-3/METRICSThomas, B. F. (2016). The Analytical Chemistry of Cannabis Emerging Issues in Analytical Chemistry Series Editor. http://www.sciencedirect.com:5070/book/9780128046463/the-analytical-chemistry-of-cannabisTimilsena, Y. P., Wang, B., Adhikari, R., & Adhikari, B. (2016). Preparation and characterization of chia seed protein isolate–chia seed gum complex coacervates. Food Hydrocolloids, 52, 554–563. https://doi.org/10.1016/J.FOODHYD.2015.07.033Timilsena, Y. P., Wang, B., Adhikari, R., & Adhikari, B. (2017). Advances in microencapsulation of polyunsaturated fatty acids (PUFAs)-rich plant oils using complex coacervation: A review. Food Hydrocolloids, 69, 369–381. https://doi.org/10.1016/J.FOODHYD.2017.03.007Tolstoguzov, V. (2003). Some thermodynamic considerations in food formulation. Food Hydrocolloids, 17(1), 1–23. https://doi.org/10.1016/S0268-005X(01)00111-4Tomasko, D. L., Li, H., Liu, D., Han, X., Wingert, M. J., Lee, L. J., & Koelling, K. W. (2003). A Review of CO2 Applications in the Processing of Polymers. Industrial and Engineering Chemistry Research, 42(25), 6431–6456. https://doi.org/10.1021/ie030199zTurgeon, S. L., Beaulieu, M., Schmitt, C., & Sanchez, C. (2003). Protein–polysaccharide interactions: phase-ordering kinetics, thermodynamic and structural aspects. Current Opinion in Colloid & Interface Science, 8(4–5), 401–414. https://doi.org/10.1016/S1359-0294(03)00093-1Varona, S., Rodríguez-Rojo, S., Martín, Á., Cocero, M. J., & Duarte, C. M. M. (2011). Supercritical impregnation of lavandin (Lavandula hybrida) essential oil in modified starch. Journal of Supercritical Fluids, 58(2), 313–319. https://doi.org/10.1016/j.supflu.2011.06.003Wang, C. S., Natale, G., Virgilio, N., & Heuzey, M. C. (2016). Synergistic gelation of gelatin B with xanthan gum. Food Hydrocolloids, 60, 374–383. https://doi.org/10.1016/J.FOODHYD.2016.03.043Wang, Y., Dave, R. N., & Pfeffer, R. (2004). Polymer coating/encapsulation of nanoparticles using a supercritical anti-solvent process. The Journal of Supercritical Fluids, 28(1), 85–99. https://doi.org/10.1016/S0896-8446(03)00011-1Weidner, E., Petermann, M., & Knez, Z. (2003). Multifunctional composites by high-pressure spray processes. Current Opinion in Solid State and Materials Science, 7(4–5), 385–390. https://doi.org/10.1016/J.COSSMS.2003.09.002Westbrook, G., Angus, A., Abbas, A., Scott Livingston, A., Mackinson, D., Borjas, D., Yum, H., Grigorijevaite, K., Balciauskaite, K., Valenti, N., Inan, P., Puri, S., Dutton, S., & Milenkovic, Z. (2023, January 17). Top 10 Global Consumer Trends 2023 | Euromonitor. Euromonitor International. https://go.euromonitor.com/white-paper-EC-2023-Top-10-Global-Consumer-Trends-EN.htmlWilsey, B., Marcotte, T., Deutsch, R., Gouaux, B., Sakai, S., & Donaghe, H. (2013). Low-dose vaporized cannabis significantly improves neuropathic pain. Journal of Pain, 14(2), 136–148. https://doi.org/10.1016/j.jpain.2012.10.009Yeo, S. Do, & Kiran, E. (2005). Formation of polymer particles with supercritical fluids: A review. The Journal of Supercritical Fluids, 34(3), 287–308. https://doi.org/10.1016/J.SUPFLU.2004.10.006Zuidam, N. J., & Nedović, V. . (2010). Encapsulation technologies for active food ingredients and food processing. In N.J. Zuidam & Viktor Nedovic (Eds.), Encapsulation Technologies for Active Food Ingredients and Food Processing (1st ed.). Springer New York. https://doi.org/10.1007/978-1-4419-1008-0/COVERBibliotecariosEstudiantesInvestigadoresMaestrosPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86364/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1016073601.2024.pdf1016073601.2024.pdfTesis de Maestría en Ingeniería Química - Encapsulamiento de Aceite de Cannabisapplication/pdf5524367https://repositorio.unal.edu.co/bitstream/unal/86364/2/1016073601.2024.pdf6938098b7b36c46fc16fafe458c3b141MD52THUMBNAIL1016073601.2024.pdf.jpg1016073601.2024.pdf.jpgGenerated Thumbnailimage/jpeg5712https://repositorio.unal.edu.co/bitstream/unal/86364/3/1016073601.2024.pdf.jpge2e853ced6268abd2ae3711716deb66bMD53unal/86364oai:repositorio.unal.edu.co:unal/863642024-07-02 23:05:02.81Repositorio Institucional Universidad Nacional de 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