Nav1.5 cardiac sodium channels, regulation and clinical implications
Voltage-gated sodium channels constitute a group of membrane proteins widely distributed thought the body. In the heart, there are at least six different isoforms, being the Nav1.5 the most abundant. The channel is composed of an α subunit that is formed by four domains of six segments each, and fou...
- Autores:
-
León-Ariza, Henry Humberto
Valenzuela-Faccini, Natalia
Rojas-Ortega, Ariana Carolina
Botero-Rosas, Daniel Alfonso
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2014
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/65371
- Acceso en línea:
- https://repositorio.unal.edu.co/handle/unal/65371
http://bdigital.unal.edu.co/66394/
- Palabra clave:
- 61 Ciencias médicas; Medicina / Medicine and health
Canales de Sodio
Síndrome QT largo
Síndrome Brugada
NAV1.5 Voltage-Gated Sodium Channel
Long QT syndrome
Brugada syndrome
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2León-Ariza, Henry Humberto012ed26e-ac01-4a27-9528-c84b4fa69875300Valenzuela-Faccini, Nataliaad886eec-ea00-4b1b-a9af-0a6f7b11618a300Rojas-Ortega, Ariana Carolinaba184200-9df9-491b-97d0-15b7af50e131300Botero-Rosas, Daniel Alfonso1c8ae8e6-c485-40a7-9dcb-e52c5f949d903002019-07-03T00:14:53Z2019-07-03T00:14:53Z2014-10-01ISSN: 2357-3848https://repositorio.unal.edu.co/handle/unal/65371http://bdigital.unal.edu.co/66394/Voltage-gated sodium channels constitute a group of membrane proteins widely distributed thought the body. In the heart, there are at least six different isoforms, being the Nav1.5 the most abundant. The channel is composed of an α subunit that is formed by four domains of six segments each, and four much smaller β subunits that provide stability and integrate other channels into the α subunit. The function of the Nav1.5 channel is modulated by intracellular cytoskeleton proteins, extracellular proteins, calcium concentration, free radicals, and medications, among other things. The study of the channel and its alterations has grown thanks to its association with pathogenic conditions such as Long QT syndrome, Brugada syndrome, atrial fibrillation, arrhythmogenic ventricular dysplasia and complications during ischemic processes.Los canales de Sodio dependientes de voltaje constituyen un grupo de proteínas de membrana ampliamente distribuidas en el cuerpo humano. En el corazón se dispone de al menos seis diferentes isoformas de estos canales: los Nav1.5 son los más abundantes. El canal está constituido por una subunidad α, formada por cuatro dominios, cada uno de estos con seis segmentos y cuatro subunidades β mucho más pequeñas que estabilizan la estructura e integran la subunidad α de otros canales. La función del canal Nav1.5 se ve modulada por proteínas del citoesqueleto, proteínas extracelulares, concentraciones de calcio, radicales libres, medicamentos, entre otros. El estudio del canal y sus alteraciones se ha incrementado gracias a la asociación de este con condiciones patológicas como el síndrome de QT largo, el síndrome de Brugada, la fibrilación auricular, la displasia ventricular arritmogénica y por las complicaciones de en procesos isquémicos.application/pdfspaUniversidad Nacional de Colombia - Sede Bogotá - Facultad de Medicinahttps://revistas.unal.edu.co/index.php/revfacmed/article/view/44015Universidad Nacional de Colombia Revistas electrónicas UN Revista de la Facultad de MedicinaRevista de la Facultad de MedicinaLeón-Ariza, Henry Humberto and Valenzuela-Faccini, Natalia and Rojas-Ortega, Ariana Carolina and Botero-Rosas, Daniel Alfonso (2014) Nav1.5 cardiac sodium channels, regulation and clinical implications. Revista de la Facultad de Medicina, 62 (4). pp. 587-592. ISSN 2357-384861 Ciencias médicas; Medicina / Medicine and healthCanales de SodioSíndrome QT largoSíndrome BrugadaNAV1.5 Voltage-Gated Sodium ChannelLong QT syndromeBrugada syndromeNav1.5 cardiac sodium channels, regulation and clinical implicationsArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL44015-246771-1-PB.pdfapplication/pdf473690https://repositorio.unal.edu.co/bitstream/unal/65371/1/44015-246771-1-PB.pdfe0d05085e97470a1e2d7a4811b9efe90MD51THUMBNAIL44015-246771-1-PB.pdf.jpg44015-246771-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg7811https://repositorio.unal.edu.co/bitstream/unal/65371/2/44015-246771-1-PB.pdf.jpg0321668e740416a859fc13c62a58d5f2MD52unal/65371oai:repositorio.unal.edu.co:unal/653712023-05-19 23:46:44.415Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co |
| dc.title.spa.fl_str_mv |
Nav1.5 cardiac sodium channels, regulation and clinical implications |
| title |
Nav1.5 cardiac sodium channels, regulation and clinical implications |
| spellingShingle |
Nav1.5 cardiac sodium channels, regulation and clinical implications 61 Ciencias médicas; Medicina / Medicine and health Canales de Sodio Síndrome QT largo Síndrome Brugada NAV1.5 Voltage-Gated Sodium Channel Long QT syndrome Brugada syndrome |
| title_short |
Nav1.5 cardiac sodium channels, regulation and clinical implications |
| title_full |
Nav1.5 cardiac sodium channels, regulation and clinical implications |
| title_fullStr |
Nav1.5 cardiac sodium channels, regulation and clinical implications |
| title_full_unstemmed |
Nav1.5 cardiac sodium channels, regulation and clinical implications |
| title_sort |
Nav1.5 cardiac sodium channels, regulation and clinical implications |
| dc.creator.fl_str_mv |
León-Ariza, Henry Humberto Valenzuela-Faccini, Natalia Rojas-Ortega, Ariana Carolina Botero-Rosas, Daniel Alfonso |
| dc.contributor.author.spa.fl_str_mv |
León-Ariza, Henry Humberto Valenzuela-Faccini, Natalia Rojas-Ortega, Ariana Carolina Botero-Rosas, Daniel Alfonso |
| dc.subject.ddc.spa.fl_str_mv |
61 Ciencias médicas; Medicina / Medicine and health |
| topic |
61 Ciencias médicas; Medicina / Medicine and health Canales de Sodio Síndrome QT largo Síndrome Brugada NAV1.5 Voltage-Gated Sodium Channel Long QT syndrome Brugada syndrome |
| dc.subject.proposal.spa.fl_str_mv |
Canales de Sodio Síndrome QT largo Síndrome Brugada NAV1.5 Voltage-Gated Sodium Channel Long QT syndrome Brugada syndrome |
| description |
Voltage-gated sodium channels constitute a group of membrane proteins widely distributed thought the body. In the heart, there are at least six different isoforms, being the Nav1.5 the most abundant. The channel is composed of an α subunit that is formed by four domains of six segments each, and four much smaller β subunits that provide stability and integrate other channels into the α subunit. The function of the Nav1.5 channel is modulated by intracellular cytoskeleton proteins, extracellular proteins, calcium concentration, free radicals, and medications, among other things. The study of the channel and its alterations has grown thanks to its association with pathogenic conditions such as Long QT syndrome, Brugada syndrome, atrial fibrillation, arrhythmogenic ventricular dysplasia and complications during ischemic processes. |
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2014 |
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2014-10-01 |
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2019-07-03T00:14:53Z |
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2019-07-03T00:14:53Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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info:eu-repo/semantics/article |
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http://purl.org/coar/resource_type/c_6501 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Text |
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ISSN: 2357-3848 |
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https://repositorio.unal.edu.co/handle/unal/65371 |
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http://bdigital.unal.edu.co/66394/ |
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ISSN: 2357-3848 |
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spa |
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spa |
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https://revistas.unal.edu.co/index.php/revfacmed/article/view/44015 |
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Universidad Nacional de Colombia Revistas electrónicas UN Revista de la Facultad de Medicina Revista de la Facultad de Medicina |
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León-Ariza, Henry Humberto and Valenzuela-Faccini, Natalia and Rojas-Ortega, Ariana Carolina and Botero-Rosas, Daniel Alfonso (2014) Nav1.5 cardiac sodium channels, regulation and clinical implications. Revista de la Facultad de Medicina, 62 (4). pp. 587-592. ISSN 2357-3848 |
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Derechos reservados - Universidad Nacional de Colombia |
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Atribución-NoComercial 4.0 Internacional |
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