Biomechanical and mechanobiological model of the midpalatal suture formation process, by computational simulation

Maxillary expansion is an orthodontic procedure that is used to treat the transverse maxillary deficiency. This procedure increases the transversal measurement of the maxilla taking advantage of the presence of the fibrous tissue that joins the two horizontal portions of the palate, known as midpala...

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Autores:
Guerrero Vargas, José Alejandro
Tipo de recurso:
Doctoral thesis
Fecha de publicación:
2019
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/77286
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/77286
http://bdigital.unal.edu.co/74918/
Palabra clave:
Finite element analysis
Análisis de elementos finitos
Midpalatal Suture
Sutura Medial Palatina
Maxillary expansion
Expansión del Maxilar
Biomechanics
Biomecánica
Mechanobiology
Mecanobiología
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
id UNACIONAL2_df6719de89ceed568c0a6d112ee784e9
oai_identifier_str oai:repositorio.unal.edu.co:unal/77286
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Biomechanical and mechanobiological model of the midpalatal suture formation process, by computational simulation
title Biomechanical and mechanobiological model of the midpalatal suture formation process, by computational simulation
spellingShingle Biomechanical and mechanobiological model of the midpalatal suture formation process, by computational simulation
Finite element analysis
Análisis de elementos finitos
Midpalatal Suture
Sutura Medial Palatina
Maxillary expansion
Expansión del Maxilar
Biomechanics
Biomecánica
Mechanobiology
Mecanobiología
title_short Biomechanical and mechanobiological model of the midpalatal suture formation process, by computational simulation
title_full Biomechanical and mechanobiological model of the midpalatal suture formation process, by computational simulation
title_fullStr Biomechanical and mechanobiological model of the midpalatal suture formation process, by computational simulation
title_full_unstemmed Biomechanical and mechanobiological model of the midpalatal suture formation process, by computational simulation
title_sort Biomechanical and mechanobiological model of the midpalatal suture formation process, by computational simulation
dc.creator.fl_str_mv Guerrero Vargas, José Alejandro
dc.contributor.author.spa.fl_str_mv Guerrero Vargas, José Alejandro
dc.contributor.spa.fl_str_mv Garzón Alvarado, Diego Alexander
Barbosa de Las Casas, Estevam
dc.subject.proposal.spa.fl_str_mv Finite element analysis
Análisis de elementos finitos
Midpalatal Suture
Sutura Medial Palatina
Maxillary expansion
Expansión del Maxilar
Biomechanics
Biomecánica
Mechanobiology
Mecanobiología
topic Finite element analysis
Análisis de elementos finitos
Midpalatal Suture
Sutura Medial Palatina
Maxillary expansion
Expansión del Maxilar
Biomechanics
Biomecánica
Mechanobiology
Mecanobiología
description Maxillary expansion is an orthodontic procedure that is used to treat the transverse maxillary deficiency. This procedure increases the transversal measurement of the maxilla taking advantage of the presence of the fibrous tissue that joins the two horizontal portions of the palate, known as midpalatal suture. To overcome some adverse effects that are generated with this treatment, or to make changes in the technique, it is necessary to understand the behavior of the suture and the surrounding tissues. Consequently, this work seeks to evaluate the midpalatal suture formation processes, and its response to the presence of external loads such as those generated during the expansion, from both an experimental and computational perspective. Therefore, the project was developed by means of an experimental model, a computational mechanobiological model, a biomechanical computational model in 2D and a biomechanical computational model in 3D. For the development of the experimental model, an in vivo procedure was standardized to observe the effect of tensile loads on cellular activity inside the suture and on the expressions of some molecular factors located at the bone–suture–bone interface. The procedure can be used as a reference for future research on this suture. With respect to the mechanobiological model, the mathematical model proposed achieves to reproduce the cellular migration phenomena that are carried out as a consequence of the expansion loads application and simulates the remodeling processes that occur at the bone margins, replicating the initial states of the midpalatal suture morphology in humans and generating more complex interdigitation patterns in expanded sutures. In relation to the biomechanical models, it was possible to evaluate the influence of certain parameters, such as the interdigitation degree and the anchorage type used, in the structural behavior of the oral cavity when it is subjected to an maxillary expansion treatment. The experimentally findings and the biomechanical models derived from this research can be used by dentists and clinicians to understand some events that happen into the oral cavity during the period of treatment. On the other hand, the mechanobiological model could be the first approach looking for reproduce the molecular and cellular interaction into the midpalatal suture, when a maxillary expansion is applied, by a combination of a basic chemotaxis model and a reaction–diffusion model.
publishDate 2019
dc.date.issued.spa.fl_str_mv 2019-12-10
dc.date.accessioned.spa.fl_str_mv 2020-03-30T06:45:18Z
dc.date.available.spa.fl_str_mv 2020-03-30T06:45:18Z
dc.type.spa.fl_str_mv Trabajo de grado - Doctorado
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/doctoralThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
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dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/77286
dc.identifier.eprints.spa.fl_str_mv http://bdigital.unal.edu.co/74918/
url https://repositorio.unal.edu.co/handle/unal/77286
http://bdigital.unal.edu.co/74918/
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.ispartof.spa.fl_str_mv Universidad Nacional de Colombia Sede Bogotá Facultad de Ingeniería
Facultad de Ingeniería
Universidad Nacional de Colombia Sede Bogotá Facultad de Ingeniería Departamento de Ingeniería Mecánica y Mecatrónica Ingeniería Mecatrónica
Ingeniería Mecatrónica
Universidad Nacional de Colombia Sede Bogotá Facultad de Ingeniería Departamento de Ingeniería Mecánica y Mecatrónica Ingeniería Mecánica Universidad Nacional de Colombia Sede Medellín Facultad de Minas Escuela de Mecatrónica Ingeniería Mecánica
Ingeniería Mecánica
dc.relation.haspart.spa.fl_str_mv 62 Ingeniería y operaciones afines / Engineering
dc.relation.references.spa.fl_str_mv Guerrero Vargas, José Alejandro (2019) Biomechanical and mechanobiological model of the midpalatal suture formation process, by computational simulation. Doctorado thesis, Universidad Nacional de Colombia - Sede Bogotá - Universidad Federal de Minas Gerais.
dc.rights.spa.fl_str_mv Derechos reservados - Universidad Nacional de Colombia
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.license.spa.fl_str_mv Atribución-NoComercial 4.0 Internacional
dc.rights.uri.spa.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial 4.0 Internacional
Derechos reservados - Universidad Nacional de Colombia
http://creativecommons.org/licenses/by-nc/4.0/
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eu_rights_str_mv openAccess
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institution Universidad Nacional de Colombia
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spelling Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Garzón Alvarado, Diego AlexanderBarbosa de Las Casas, EstevamGuerrero Vargas, José Alejandro2fd93b12-c439-413c-81bb-a26089908e013002020-03-30T06:45:18Z2020-03-30T06:45:18Z2019-12-10https://repositorio.unal.edu.co/handle/unal/77286http://bdigital.unal.edu.co/74918/Maxillary expansion is an orthodontic procedure that is used to treat the transverse maxillary deficiency. This procedure increases the transversal measurement of the maxilla taking advantage of the presence of the fibrous tissue that joins the two horizontal portions of the palate, known as midpalatal suture. To overcome some adverse effects that are generated with this treatment, or to make changes in the technique, it is necessary to understand the behavior of the suture and the surrounding tissues. Consequently, this work seeks to evaluate the midpalatal suture formation processes, and its response to the presence of external loads such as those generated during the expansion, from both an experimental and computational perspective. Therefore, the project was developed by means of an experimental model, a computational mechanobiological model, a biomechanical computational model in 2D and a biomechanical computational model in 3D. For the development of the experimental model, an in vivo procedure was standardized to observe the effect of tensile loads on cellular activity inside the suture and on the expressions of some molecular factors located at the bone–suture–bone interface. The procedure can be used as a reference for future research on this suture. With respect to the mechanobiological model, the mathematical model proposed achieves to reproduce the cellular migration phenomena that are carried out as a consequence of the expansion loads application and simulates the remodeling processes that occur at the bone margins, replicating the initial states of the midpalatal suture morphology in humans and generating more complex interdigitation patterns in expanded sutures. In relation to the biomechanical models, it was possible to evaluate the influence of certain parameters, such as the interdigitation degree and the anchorage type used, in the structural behavior of the oral cavity when it is subjected to an maxillary expansion treatment. The experimentally findings and the biomechanical models derived from this research can be used by dentists and clinicians to understand some events that happen into the oral cavity during the period of treatment. On the other hand, the mechanobiological model could be the first approach looking for reproduce the molecular and cellular interaction into the midpalatal suture, when a maxillary expansion is applied, by a combination of a basic chemotaxis model and a reaction–diffusion model.Resumen: La expansión del maxilar es un procedimiento ortodóntico que se utiliza para tratar la deficiencia transversal del maxilar. Este procedimiento incrementa la medida transversal del maxilar aprovechando la presencia del tejido fibroso que une las dos porciones horizontales del paladar, conocido como sutura medial palatina. Para superar algunos efectos adversos que se generan con este tratamiento, o realizar cambios en la técnica, es necesario entender el comportamiento de la sutura y de los tejidos que la rodean. En consecuencia, este trabajo busca evaluar los procesos de formación de la sutura medial palatina, y su respuesta a la presencia de cargas externas como aquellas generadas durante la expansión, desde una perspectiva tanto experimental como computacional. Por lo tanto, el proyecto fue desarrollado por medio de un modelo experimental, un modelo computacional mecanobiológico, un modelo computacional biomecánico en 2D y un modelo computacional biomecánico en 3D. Para el desarrollo del modelo experimental se estandarizó un procedimiento in vivo que permitió observar el efecto de las cargas de tensión sobre la actividad celular al interior de la sutura y sobre las expresiones de algunos factores moleculares localizados en la interfaz hueso–sutura–hueso. El procedimiento podrá ser utilizado como referencia para la realización de futuras investigaciones en esta sutura. Con respecto al modelo mecanobiológico, el modelo matemático planteado logra reproducir los fenómenos de migración celular que se producen como consecuencia de la aplicación de cargas de expansión y simula los procesos de remodelado que acontecen en los márgenes óseos, replicando los estados iniciales de la morfología de la sutura medial palatina en humanos y generando patrones de interdigitación de mayor complejidad en suturas expandidas. En relación a los modelos biomecánicos, fue posible evaluar la influencia de ciertos parámetros, como el grado de interdigitación y el tipo de anclaje empleado, en el comportamiento estructural de la cavidad oral cuando es sometida a un tratamiento de expansión del maxilar. Los hallazgos experimentales y los modelos biomecánicos derivados de esta investigación pueden ser utilizados por odontólogos y clínicos para comprender algunos eventos que ocurren en la cavidad oral durante el período del tratamiento. Por otro lado, el modelo mecanobiológico podría ser el primer enfoque que busca reproducir la interacción molecular y celular en la sutura medial palatina, cuando se aplica una expansión del maxilar, mediante una combinación de un modelo de quimiotaxis básico y un modelo de reacción–difusión.Doctoradoapplication/pdfspaUniversidad Nacional de Colombia Sede Bogotá Facultad de IngenieríaFacultad de IngenieríaUniversidad Nacional de Colombia Sede Bogotá Facultad de Ingeniería Departamento de Ingeniería Mecánica y Mecatrónica Ingeniería MecatrónicaIngeniería MecatrónicaUniversidad Nacional de Colombia Sede Bogotá Facultad de Ingeniería Departamento de Ingeniería Mecánica y Mecatrónica Ingeniería Mecánica Universidad Nacional de Colombia Sede Medellín Facultad de Minas Escuela de Mecatrónica Ingeniería MecánicaIngeniería Mecánica62 Ingeniería y operaciones afines / EngineeringGuerrero Vargas, José Alejandro (2019) Biomechanical and mechanobiological model of the midpalatal suture formation process, by computational simulation. Doctorado thesis, Universidad Nacional de Colombia - Sede Bogotá - Universidad Federal de Minas Gerais.Biomechanical and mechanobiological model of the midpalatal suture formation process, by computational simulationTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_db06Texthttp://purl.org/redcol/resource_type/TDFinite element analysisAnálisis de elementos finitosMidpalatal SutureSutura Medial PalatinaMaxillary expansionExpansión del MaxilarBiomechanicsBiomecánicaMechanobiologyMecanobiologíaORIGINAL1032390988Parte2.2019.pdfapplication/pdf15436210https://repositorio.unal.edu.co/bitstream/unal/77286/1/1032390988Parte2.2019.pdf9cc4f4560fc6a6e62e927bdb3f85b0cdMD511032390988Parte1.2019.pdfapplication/pdf16952425https://repositorio.unal.edu.co/bitstream/unal/77286/2/1032390988Parte1.2019.pdfff18e04a0e7fe8fe3fb8ed13c5770316MD52THUMBNAIL1032390988Parte2.2019.pdf.jpg1032390988Parte2.2019.pdf.jpgGenerated Thumbnailimage/jpeg7107https://repositorio.unal.edu.co/bitstream/unal/77286/3/1032390988Parte2.2019.pdf.jpgb5635a13925e763548389ebcd3f9da0fMD531032390988Parte1.2019.pdf.jpg1032390988Parte1.2019.pdf.jpgGenerated Thumbnailimage/jpeg5297https://repositorio.unal.edu.co/bitstream/unal/77286/4/1032390988Parte1.2019.pdf.jpg8734edc382c3f6dcd823e962a753fb7aMD54unal/77286oai:repositorio.unal.edu.co:unal/772862024-07-17 23:13:13.362Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co