Efecto de los parámetros geométricos de la celda unitaria TPMS y los parámetros de impresión por fotopolimerización en la rugosidad superficial de scaffolds para cultivo de tejido óseo in vitro

ilustraciones, diagramas, fotografías, tablas

Autores:
Ramírez Rodríguez, Carlos Andrés
Tipo de recurso:
Fecha de publicación:
2024
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/86970
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/86970
https://repositorio.unal.edu.co/
Palabra clave:
610 - Medicina y salud::611 - Anatomía humana, citología, histología
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
670 - Manufactura::679 -Otros productos de materiales específicos
Propiedades de Superficie
Ingeniería de Tejidos
Surface Properties
Tissue Engineering
TEJIDO OSEO
Bone
TPMS
Offset
Unit cell size
Exposure time
Surface roughness
Tamaño de celda unitaria
Tiempo de exposición
Rugosidad superficia
Rights
openAccess
License
Atribución-NoComercial-SinDerivadas 4.0 Internacional
id UNACIONAL2_deba28851a748183e6f1a06913ed919a
oai_identifier_str oai:repositorio.unal.edu.co:unal/86970
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Efecto de los parámetros geométricos de la celda unitaria TPMS y los parámetros de impresión por fotopolimerización en la rugosidad superficial de scaffolds para cultivo de tejido óseo in vitro
dc.title.translated.eng.fl_str_mv Effect of the geometric parameters of the TPMS unit cell and the photopolymerization printing parameters on the surface roughness of scaffolds for in vitro bone tissue culture
title Efecto de los parámetros geométricos de la celda unitaria TPMS y los parámetros de impresión por fotopolimerización en la rugosidad superficial de scaffolds para cultivo de tejido óseo in vitro
spellingShingle Efecto de los parámetros geométricos de la celda unitaria TPMS y los parámetros de impresión por fotopolimerización en la rugosidad superficial de scaffolds para cultivo de tejido óseo in vitro
610 - Medicina y salud::611 - Anatomía humana, citología, histología
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
670 - Manufactura::679 -Otros productos de materiales específicos
Propiedades de Superficie
Ingeniería de Tejidos
Surface Properties
Tissue Engineering
TEJIDO OSEO
Bone
TPMS
Offset
Unit cell size
Exposure time
Surface roughness
Tamaño de celda unitaria
Tiempo de exposición
Rugosidad superficia
title_short Efecto de los parámetros geométricos de la celda unitaria TPMS y los parámetros de impresión por fotopolimerización en la rugosidad superficial de scaffolds para cultivo de tejido óseo in vitro
title_full Efecto de los parámetros geométricos de la celda unitaria TPMS y los parámetros de impresión por fotopolimerización en la rugosidad superficial de scaffolds para cultivo de tejido óseo in vitro
title_fullStr Efecto de los parámetros geométricos de la celda unitaria TPMS y los parámetros de impresión por fotopolimerización en la rugosidad superficial de scaffolds para cultivo de tejido óseo in vitro
title_full_unstemmed Efecto de los parámetros geométricos de la celda unitaria TPMS y los parámetros de impresión por fotopolimerización en la rugosidad superficial de scaffolds para cultivo de tejido óseo in vitro
title_sort Efecto de los parámetros geométricos de la celda unitaria TPMS y los parámetros de impresión por fotopolimerización en la rugosidad superficial de scaffolds para cultivo de tejido óseo in vitro
dc.creator.fl_str_mv Ramírez Rodríguez, Carlos Andrés
dc.contributor.advisor.spa.fl_str_mv Narváez Tovar, Carlos Alberto
Garzón Alvarado, Diego Alexander
dc.contributor.author.spa.fl_str_mv Ramírez Rodríguez, Carlos Andrés
dc.contributor.researchgroup.spa.fl_str_mv Innovación en Procesos de Manufactura E Ingeniería de Materiales (Ipmim)
laboratorio de Biomiméticos: Grupo de Mecanobiología de Órganos y Tejidos
dc.contributor.orcid.spa.fl_str_mv Ramirez Rodriguez, Carlos Andres [0000-0001-6592-9804]
dc.subject.ddc.spa.fl_str_mv 610 - Medicina y salud::611 - Anatomía humana, citología, histología
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
670 - Manufactura::679 -Otros productos de materiales específicos
topic 610 - Medicina y salud::611 - Anatomía humana, citología, histología
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
670 - Manufactura::679 -Otros productos de materiales específicos
Propiedades de Superficie
Ingeniería de Tejidos
Surface Properties
Tissue Engineering
TEJIDO OSEO
Bone
TPMS
Offset
Unit cell size
Exposure time
Surface roughness
Tamaño de celda unitaria
Tiempo de exposición
Rugosidad superficia
dc.subject.decs.spa.fl_str_mv Propiedades de Superficie
Ingeniería de Tejidos
dc.subject.decs.eng.fl_str_mv Surface Properties
Tissue Engineering
dc.subject.lemb.spa.fl_str_mv TEJIDO OSEO
dc.subject.lemb.eng.fl_str_mv Bone
dc.subject.proposal.eng.fl_str_mv TPMS
Offset
Unit cell size
Exposure time
Surface roughness
dc.subject.proposal.spa.fl_str_mv Tamaño de celda unitaria
Tiempo de exposición
Rugosidad superficia
description ilustraciones, diagramas, fotografías, tablas
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-10-16T13:03:35Z
dc.date.available.none.fl_str_mv 2024-10-16T13:03:35Z
dc.date.issued.none.fl_str_mv 2024
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/86970
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/86970
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
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dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá
institution Universidad Nacional de Colombia
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spelling Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Narváez Tovar, Carlos Alberto0682c1cb706afbfff1c2b72f1e3d48c5Garzón Alvarado, Diego Alexandera780fc0a2dd14ac611c37bca9998c94bRamírez Rodríguez, Carlos Andrés3cb7c43140bd2a709166e1b796b326c8Innovación en Procesos de Manufactura E Ingeniería de Materiales (Ipmim)laboratorio de Biomiméticos: Grupo de Mecanobiología de Órganos y TejidosRamirez Rodriguez, Carlos Andres [0000-0001-6592-9804]2024-10-16T13:03:35Z2024-10-16T13:03:35Z2024https://repositorio.unal.edu.co/handle/unal/86970Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramas, fotografías, tablasEl objetivo principal de esta investigación es determinar el efecto de los parámetros geométricos de la celda unitaria TPMS y los parámetros de impresión por procesos de fotopolimerización en la rugosidad superficial de scaffolds que puedan ser utilizados en cultivo de tejido óseo in vitro. La metodología seguida abarcó la definición de los requerimientos fundamentales para los scaffolds empleados en cultivo de tejido óseo in vitro, la determinación de los parámetros geométricos y dimensionales de las celdas unitarias estudiadas; esto por medio de mapas de manufacturabildiad calculados, considerando las dos formas de construir las celdas TPMS (Walled y Offset), el tamaño de poro adecuado, la porosidad y las condiciones de manufacturabilidad dadas por la permeabilidad y la construcción de espesores delgados mediante el proceso de fotopolimerización MSLA. Posteriormente se realizó la fabricación y medición de la rugosidad superficial de acuerdo con el diseño experimental de Taguchi definido con un arreglo L9; y por último, se desarrolló el análisis estadístico para identificar el efecto que tienen los factores estudiados sobre la rugosidad superficial medida en Sa y Ra. Los resultados indicaron que el Giroide, especialmente el Giroide Walled, tiene el mayor espacio de diseño. Sin embargo, se destacó que el Giroide Offset demostró ser más eficiente en la construcción de espesores delgados y presentó una mayor permeabilidad en comparación con las demás TPMS estudiadas. Luego de un estudio exploratorio y su posterior análisis, se definieron los factores específicos para la investigación que corresponden a: el tamaño de celda unitaria, con niveles de 1,5 mm, 1,75 mm y 2,0 mm, el Offset con niveles de -0,2 mm, -0,1 mm y 0,0 mm, por último, el espesor de capa con niveles de 0,03 mm, 0,05 mm y 0,1 mm. Los valores de la rugosidad superficial Sa obtenidos oscilan, en promedio, entre 10,2 y 29,5 µm. Los valores de Ra en dirección longitudinal (RaL) oscilan, en promedio, entre 7,45 y 24,35 µm, mientras que los de Ra en dirección transversal (RaT) la hacen, entre 2,71 y 5,95 µm. Del análisis de estos resultados se evidenció que existe un cambio en el valor de la rugosidad superficial entre tratamientos; es decir, existe influencia de alguno de los factores. Además, los tratamientos se pueden agrupar según el espesor de capa, es decir, aquellos que comparten el mismo espesor de capa muestran resultados muy cercanos. De forma general, se observó que la variabilidad de los datos aumenta con el espesor de capa. Las pruebas estadísticas aplicadas mostraron que el espesor de capa es el único factor que afecta significativamente las variables Sa y RaL. Sin embargo, para RaT, tanto el tamaño de celda unitaria como el espesor de capa son significativos. En conclusión, se establece que el espesor de capa es el factor más influyente en la rugosidad superficial, independientemente de la dirección de medición (Texto tomado de la fuente).The main objective of this research is to determine the effect of the geometric parameters of the TPMS unit cell and the printing parameters by photopolymerization processes on the surface roughness of scaffolds that can be used in in vitro bone tissue cultivation. The methodology followed encompassed the definition of the fundamental requirements for scaffolds used in in vitro bone tissue cultivation, the determination of the geometric and dimensional parameters of the studied unit cells; this was done through calculated manufacturability maps, considering the two ways of constructing TPMS cells (Walled and Offset), the appropriate pore size, porosity, and manufacturability conditions given by permeability and the construction of thin thicknesses. Subsequently, the manufacturing and measurement of surface roughness were carried out according to the Taguchi experimental design defined with an L9 array, and finally, statistical analysis was developed to identify the effect of the studied factors on surface roughness measured in Sa and Ra. The results indicated that the Gyroid, especially the Walled Gyroid, has the largest design space. However, it was highlighted that the Offset Gyroid proved to be more efficient in constructing thin thicknesses and showed higher permeability compared to the other TPMS studied. After an exploratory study and subsequent analysis, specific factors for the research were defined, corresponding to the unit cell size with levels of 1.5 mm, 1.75 mm, and 2.0 mm, the Offset with levels of -0.2 mm, -0.1 mm, and 0.0 mm, and finally, the layer thickness with levels of 0,03 mm, 0,05 mm, and 0,1 mm. The values of the Sa surface roughness obtained range, on average, between 10.2 and 29.5 µm. The values of Ra in the longitudinal direction (RaL) range, on average, between 7.45 and 24.35 µm, while those of Ra in the transverse direction (RaT) range between 2.71 and 5.95 µm. From the analysis of these results, it was evident that there is a change in the value of surface roughness between treatments; that is, there is an influence of some factors. Additionally, the treatments can be grouped according to the layer thickness; in other words, those sharing the same layer thickness show very close results. In general, it was observed that the variability of the data increases with the layer thickness. The applied statistical tests showed that layer thickness is the only factor that significantly affects the variables Sa and RaL. However, for RaT, both the unit cell size and layer thickness are significant. In conclusion, it is established that layer thickness is the most influential factor in surface roughness, regardless of the measurement direction.MaestríaMagister en Ingeniería - Materiales y ProcesosProcesos de manufactura y metalurgiaxvi, 144 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ingeniería - Maestría en Ingeniería - Materiales y ProcesosFacultad de IngenieríaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::611 - Anatomía humana, citología, histología620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería670 - Manufactura::679 -Otros productos de materiales específicosPropiedades de SuperficieIngeniería de TejidosSurface PropertiesTissue EngineeringTEJIDO OSEOBoneTPMSOffsetUnit cell sizeExposure timeSurface roughnessTamaño de celda unitariaTiempo de exposiciónRugosidad superficiaEfecto de los parámetros geométricos de la celda unitaria TPMS y los parámetros de impresión por fotopolimerización en la rugosidad superficial de scaffolds para cultivo de tejido óseo in vitroEffect of the geometric parameters of the TPMS unit cell and the photopolymerization printing parameters on the surface roughness of scaffolds for in vitro bone tissue cultureTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMA. 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Thumbnailimage/jpeg5425https://repositorio.unal.edu.co/bitstream/unal/86970/3/Tesis%20de%20Maestria%20Carlos%20Andres%20Ramirez.pdf.jpgd91bb77e027bfa2d4fbef3553e9a1b48MD53unal/86970oai:repositorio.unal.edu.co:unal/869702024-10-16 23:51:23.289Repositorio Institucional Universidad Nacional de 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