Variación de las concentraciones séricas de alfa-fetoproteína en yeguas criollas colombianas durante el último tercio de la gestación

ilustraciones, graficas

Autores:: Reina Rueda, Karen Johanna

Tipo de recurso:

Fecha de publicación:: 2022

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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oai_identifier_str	oai:repositorio.unal.edu.co:unal/83231
network_acronym_str	UNACIONAL2
network_name_str	Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv	Variación de las concentraciones séricas de alfa-fetoproteína en yeguas criollas colombianas durante el último tercio de la gestación
dc.title.translated.eng.fl_str_mv	Variation in serum concentrations of alpha-fetoprotein in criollo mares Colombians during the last third of the gestation
title	Variación de las concentraciones séricas de alfa-fetoproteína en yeguas criollas colombianas durante el último tercio de la gestación
spellingShingle	Variación de las concentraciones séricas de alfa-fetoproteína en yeguas criollas colombianas durante el último tercio de la gestación 590 - Animales::599 - Mamíferos 630 - Agricultura y tecnologías relacionadas Desarrollo embrionario Periodo de Gestación Embriología Etapas del desarrollo animal Animal developmental stages Alfafetoproteína Placenta Equinos Gestación Feto Alphafetoprotein Placenta Equine Gestation Fetus Enfermedad animal Animal diseases
title_short	Variación de las concentraciones séricas de alfa-fetoproteína en yeguas criollas colombianas durante el último tercio de la gestación
title_full	Variación de las concentraciones séricas de alfa-fetoproteína en yeguas criollas colombianas durante el último tercio de la gestación
title_fullStr	Variación de las concentraciones séricas de alfa-fetoproteína en yeguas criollas colombianas durante el último tercio de la gestación
title_full_unstemmed	Variación de las concentraciones séricas de alfa-fetoproteína en yeguas criollas colombianas durante el último tercio de la gestación
title_sort	Variación de las concentraciones séricas de alfa-fetoproteína en yeguas criollas colombianas durante el último tercio de la gestación
dc.creator.fl_str_mv	Reina Rueda, Karen Johanna
dc.contributor.advisor.none.fl_str_mv	Lozano Marquez, Harvey
dc.contributor.author.none.fl_str_mv	Reina Rueda, Karen Johanna
dc.contributor.researchgroup.spa.fl_str_mv	Reproducción Animal y Salud de Hato
dc.subject.ddc.spa.fl_str_mv	590 - Animales::599 - Mamíferos 630 - Agricultura y tecnologías relacionadas
topic	590 - Animales::599 - Mamíferos 630 - Agricultura y tecnologías relacionadas Desarrollo embrionario Periodo de Gestación Embriología Etapas del desarrollo animal Animal developmental stages Alfafetoproteína Placenta Equinos Gestación Feto Alphafetoprotein Placenta Equine Gestation Fetus Enfermedad animal Animal diseases
dc.subject.agrovoc.spa.fl_str_mv	Desarrollo embrionario Periodo de Gestación Embriología
dc.subject.lemb.spa.fl_str_mv	Etapas del desarrollo animal
dc.subject.lemb.eng.fl_str_mv	Animal developmental stages
dc.subject.proposal.spa.fl_str_mv	Alfafetoproteína Placenta Equinos Gestación Feto
dc.subject.proposal.eng.fl_str_mv	Alphafetoprotein Placenta Equine Gestation Fetus
dc.subject.unesco.spa.fl_str_mv	Enfermedad animal
dc.subject.unesco.eng.fl_str_mv	Animal diseases
description	ilustraciones, graficas
publishDate	2022
dc.date.issued.none.fl_str_mv	2022
dc.date.accessioned.none.fl_str_mv	2023-02-01T21:49:21Z
dc.date.available.none.fl_str_mv	2023-02-01T21:49:21Z
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/83231
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/83231 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
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spelling	Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Lozano Marquez, Harveyfcce978e956977e359245b237a58c945Reina Rueda, Karen Johannabfdf7755bb8b967f5e15e2ab7c8ec7dbReproducción Animal y Salud de Hato2023-02-01T21:49:21Z2023-02-01T21:49:21Z2022https://repositorio.unal.edu.co/handle/unal/83231Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, graficasLa evaluación de la gestación por medio de biomarcadores y ultrasonografía para detectar patologías fetales y placentarias son herramientas importantes para el diagnóstico oportuno de patologías del feto y la placenta. La Alfafetoproteína (AFP) es una glicoproteína producida por el hígado fetal y a través de la placenta llega a sangre periférica de la madre durante la gestación. Este biomarcador ha sido utilizado en medicina humana para detectar patologías fetales y placentarias. Los objetivos del estudio fueron determinar la variación de la concentración de Alfafetoproteína en yeguas de grupo racial criollo colombiano en la Sabana de Bogotá durante el último tercio de la gestación y asociar la variación sérica de Alfafetoproteína con los cambios ultrasonográficos de la placenta y feto, el tipo de parto y la sobrevivencia neonatal. Dentro de los materiales y métodos se utilizó una población de 21 yeguas gestantes a las cuales se les tomaron muestras de sangre de la vena yugular y un examen ultrasonográfico rectal y transabdominal, para evaluar la unión útero placentaria, la frecuencia cardiaca del feto, órbita fetal y el diámetro de la arteria aorta fetal a partir del séptimo mes de gestación hasta el parto. La concentración de Alfafetoproteína fue medida por un ensayo de ELISA para AFP especie: Equus caballus de USBiologycal®. Se analizaron los datos por medio de medidas repetidas en el tiempo, para evaluar los cambios mes a mes. La concentración de Alfafetoproteína presentó un aumento a medida que avanzó la gestación. No se encontraron diferencias estadísticamente significativas en su concentración en los meses de gestación evaluados, como tampoco una relación con los parámetros ultrasonográficos de feto y placenta. Los parámetros de viabilidad, el grosor útero placentario transabdominal y transrectal, el diámetro de la aorta y la órbita fetal aumentan a medida que avanza la gestación, a excepción de la frecuencia cardiaca la cual disminuye con el avance de la gestación. Se encontró un diámetro aórtico menor al reportado en razas de mayor tamaño, no se observó un efecto de la edad, el peso de la yegua, el sexo de la cría y el método de reproducción sobre los parámetros de viabilidad. Esto con el fin de brindar una nueva herramienta para la evaluación de viabilidad fetal y patologías de la placenta en el último tercio de la gestación. Estos parámetros de viabilidad fetal tomados de yeguas con gestaciones normales sirven de guía para evaluar clínicamente el desarrollo de la gestación en yeguas criollas colombianas. (Texto tomado de la fuente)The evaluation of pregnancy through biomarkers and ultrasonography to detect fetal and placental pathologies are important tools for the early diagnosis of fetal and placental pathologies in horses. Alphafetoprotein (AFP) is a glycoprotein produced by the fetal liver and reaches the mother's peripheral blood through the placenta during pregnancy. This biomarker has been used in human medicine to detect fetal and placental pathologies. The objectives of the study are to determine the variation of the concentration of AFP in mares of the Colombian Creole racial group in the Bogota savanna during the last third of gestation and associate the serum variation of AFP with the ultrasound changes of the placenta and fetus, type of delivery and neonatal survival. A population of n=21 pregnant mares was used, from which blood samples were taken from the jugular vein, and a rectal and transabdominal ultrasonographic examination, this was used to evaluate the uteroplacental union, fetal heart rate, fetal orbit, and the diameter of the fetal aortic artery from the seventh month of gestation until delivery; AFP concentration was measured by an ELISA assay for AFP species: Equus caballus from USBiologycal®; the data was analyzed using repeated measures over time to assess month to month changes. Although AFP concentration showed an increase as gestation progressed, no statistically significant differences were found in its concentration in the gestational months evaluated, and there was no relationship with the ultrasonographic parameters of the fetus and placenta. Furthermore, it was found that viability parameters increase as gestation progresses, except for heart rate, which decreases with advancing gestation. An aortic diameter smaller than reported in larger breeds was found. No effect of age, the weight of the mare, the sex of the foal and the method of reproduction was observed. This study seeks to provide a new tool for the evaluation of fetal viability and pathologies of the placenta in the last third of gestation and serve as a guide to clinically evaluate the development of pregnancy in Colombian Creole maresMaestríaMagíster en Salud Animal o Magíster en Producción Animalestudio prospectivo de investigaciónReproducción animalxv, 68 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina Veterinaria y de Zootecnia - Maestría en Salud y Producción AnimalFacultad de Medicina Veterinaria y de ZootecniaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá590 - Animales::599 - Mamíferos630 - Agricultura y tecnologías relacionadasDesarrollo embrionarioPeriodo de GestaciónEmbriologíaEtapas del desarrollo animalAnimal developmental stagesAlfafetoproteínaPlacentaEquinosGestaciónFetoAlphafetoproteinPlacentaEquineGestationFetusEnfermedad animalAnimal diseasesVariación de las concentraciones séricas de alfa-fetoproteína en yeguas criollas colombianas durante el último tercio de la gestaciónVariation in serum concentrations of alpha-fetoprotein in criollo mares Colombians during the last third of the gestationTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMAbd-Elnaeim, M., Leiser, R., Wilsher, S., & Allen, W. 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International Anesthesiology Clinics, 45(2), 27–37. https://doi.org/10.1097/AIA.0b013e318034194Descripción de parámetros biométricos fetales y concentración de alfafetoproteína en yeguas de grupo racial criollo colombiano en el último tercio de la gestaciónEstudiantesInvestigadoresMaestrosLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/83231/3/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD53ORIGINAL531775772022.2022.pdf531775772022.2022.pdfTesis de Maestría en Salud Animalapplication/pdf877049https://repositorio.unal.edu.co/bitstream/unal/83231/5/531775772022.2022.pdf79d802193566128a5d48f83bba43607cMD55THUMBNAIL531775772022.2022.pdf.jpg531775772022.2022.pdf.jpgGenerated Thumbnailimage/jpeg4725https://repositorio.unal.edu.co/bitstream/unal/83231/6/531775772022.2022.pdf.jpgb08f9f7ba68b3d579df8c3a2bd30fbe4MD56unal/83231oai:repositorio.unal.edu.co:unal/832312024-08-15 23:15:16.031Repositorio Institucional Universidad Nacional de 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Variación de las concentraciones séricas de alfa-fetoproteína en yeguas criollas colombianas durante el último tercio de la gestación

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