Entendiendo el rol del lncRNA durante la gastrulación en las especies de acropora: A. tenuis y A. digitifera

ilustraciones, diagramas

Autores:: Rodríguez Riascos, Yamile Andrea

Tipo de recurso:

Fecha de publicación:: 2023

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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network_acronym_str	UNACIONAL2
network_name_str	Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv	Entendiendo el rol del lncRNA durante la gastrulación en las especies de acropora: A. tenuis y A. digitifera
dc.title.translated.eng.fl_str_mv	The role of lncRNA during gastrulation in Acropora species: A. tenuis and A. digitifera
title	Entendiendo el rol del lncRNA durante la gastrulación en las especies de acropora: A. tenuis y A. digitifera
spellingShingle	Entendiendo el rol del lncRNA durante la gastrulación en las especies de acropora: A. tenuis y A. digitifera 570 - Biología Antozoos Anthozoa Corales LncRNA Transcriptoma Genómica comparativa Ortología Estructura secundaria conservada
title_short	Entendiendo el rol del lncRNA durante la gastrulación en las especies de acropora: A. tenuis y A. digitifera
title_full	Entendiendo el rol del lncRNA durante la gastrulación en las especies de acropora: A. tenuis y A. digitifera
title_fullStr	Entendiendo el rol del lncRNA durante la gastrulación en las especies de acropora: A. tenuis y A. digitifera
title_full_unstemmed	Entendiendo el rol del lncRNA durante la gastrulación en las especies de acropora: A. tenuis y A. digitifera
title_sort	Entendiendo el rol del lncRNA durante la gastrulación en las especies de acropora: A. tenuis y A. digitifera
dc.creator.fl_str_mv	Rodríguez Riascos, Yamile Andrea
dc.contributor.advisor.none.fl_str_mv	Clara Isabel, Bermúdez Santana
dc.contributor.author.none.fl_str_mv	Rodríguez Riascos, Yamile Andrea
dc.contributor.editor.none.fl_str_mv	Reyes Bermúdez, Alejandro
dc.contributor.researchgroup.spa.fl_str_mv	Grupo de Investigación: RN´omica teórica y computacional
dc.subject.ddc.spa.fl_str_mv	570 - Biología
topic	570 - Biología Antozoos Anthozoa Corales LncRNA Transcriptoma Genómica comparativa Ortología Estructura secundaria conservada
dc.subject.decs.spa.fl_str_mv	Antozoos
dc.subject.decs.eng.fl_str_mv	Anthozoa
dc.subject.lemb.spa.fl_str_mv	Corales
dc.subject.proposal.spa.fl_str_mv	LncRNA Transcriptoma Genómica comparativa Ortología Estructura secundaria conservada
description	ilustraciones, diagramas
publishDate	2023
dc.date.accessioned.none.fl_str_mv	2023-08-31T16:44:23Z
dc.date.available.none.fl_str_mv	2023-08-31T16:44:23Z
dc.date.issued.none.fl_str_mv	2023
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	DataPaper
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/84620
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/84620 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
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spelling	Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Clara Isabel, Bermúdez Santanaac7e6426971ef745c06f9be60a974224Rodríguez Riascos, Yamile Andreaeb837cf5d34c8e4323d0d24b0f8336d4Reyes Bermúdez, AlejandroGrupo de Investigación: RN´omica teórica y computacional2023-08-31T16:44:23Z2023-08-31T16:44:23Z2023https://repositorio.unal.edu.co/handle/unal/84620Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasLos ARN largos no codificantes (lncRNA) desempeñan funciones reguladoras en una amplia gama de procesos biológicos bien definidos como la regulación génica, la epigenética y el anda- miaje molecular. Sin embargo, para muchas especies de corales, la ausencia de un ensamblaje del genomas y transcriptomas completos, impide la identificación integral de los lncRNA. Gracias a los avances recientes en la tecnologı́a de secuenciación Existe nueva información en datos que respectan a genomas borrares y transcriptomas con niveles de ensamblajes que van hasta cromosomas, sentando las bases para la identificación y caracterización de lncRNA de su expresión en diversos tejidos. El objetivo de este estudio fue entender el papel de los lncRNA en la gastrulación de tres especies del género Acropora incluyendo datos de expre- sión de las fases del desarrollo de Acropora digitifera, Acropora tenuis y anotar los lncRNA resultantes en función de su potencial para la ortologı́a con lncRNA conocidos entre estas especies, además de validar por estructura conservada estas moléculas. Para dar respuesta a esta necesidad y usando el ensamblaje del transcriptoma de novo, se logro identificar 4.326 lncRNA potenciales con expresión diferencial para A. digitifera y 3.375 lncRNA en A. tenuis de los cuales detectaron lncRNAs sobreregulados y especie-especı́ficos para gástrula con un total de 56 en A. digitifera y 21 en A. tenuis, de de lncRNA de alta confianza, 25 se encuentran en homologı́a de secuencia en las dos especies mencinadas anteriormente y 74 tienen ortólogos entre las tres especies de Acropora. Además a estos lncRNA en términos de las relaciones de estabilidad termodinámica y conservación estructural, se detectaron 2258 estructuras, se las cuales se identificaron 56 estructuras en A. digitifera y 21 en A. tenuis que poseen expresión diferencial en la etapa de gástrula, pero que no están en ortologı́a y que son considerados especie-especı́ficos en esta etapa del desarrollo. En conjunto, este trabajo proporciona un recurso valioso para el estudio comparativo, funcional y estructural de los lncRNA lo que facilitarı́a la comprensión del papel de estas moléculas en procesos del desarrollo de corales. (Texto tomado de la fuente)Long non-coding RNAs (lncRNAs) play regulatory roles in a wide range of well-defined bio- logical processes such as gene regulation, epigenetics, and molecular scaffolding. However, for many coral species, the absence of a complete genome and transcriptome assembly prevents the comprehensive identification of lncRNAs. Recent advances in sequencing technology re- veal new information data regarding deletion genomes and transcriptomes with assembly levels ranging up to chromosomes, laying the foundation for lncRNA identification and cha- racterization of their expression in various tissues. This study aimed to understand the role of lncRNAs in the gastrulation of three species of the Acropora genus including expression data from the developmental stages of Acropora digitifera, and Acropora tenuis and to anno- tate the resulting lncRNAs according to their potential for orthology with known lncRNAs among these species, in addition to validating by conserved structure these molecules. In response to this need and using de novo transcriptome assembly, we identified 4,326 diffe- rentially expressed potential lncRNAs for A. digitifera and 3,375 lncRNAs in A. tenuis of which we detected over-regulated and species-specific lncRNAs for gastrula with a total of 56 in A. digitifera and 21 in A. tenuis, of the high-confidence lncRNAs, 25 are in sequen- ce homology in the two species mentioned above and 74 have orthologs among the three Acropora species. In addition to these lncRNAs in terms of thermodynamic stability and structural conservation relationships, 2258 structures were detected, of which 56 structures were identified in A. digitifera and 21 inA. tenuis that possesses differential expression at the gastrula stage, but is not in ortholog and is considered species-specific at this stage of development. Taken together, this work provides a valuable resource for the comparative, functional, and structural study of lncRNAs that will facilitate understanding these mole- cules’ role in coral developmental processes.MaestríaMagíster en Ciencias - BiologíaGenómica Comparativaxv, 80 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias - BiologíaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá570 - BiologíaAntozoosAnthozoaCoralesLncRNATranscriptomaGenómica comparativaOrtologíaEstructura secundaria conservadaEntendiendo el rol del lncRNA durante la gastrulación en las especies de acropora: A. tenuis y A. digitiferaThe role of lncRNA during gastrulation in Acropora species: A. tenuis and A. digitiferaTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionDataPaperhttp://purl.org/redcol/resource_type/TMJ. A. Schwarz, P. B. Brokstein, C. Voolstra, A. Y. Terry, D. J. 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Bevilacqua, “Bridging the gap between in vitro and in vivo rna folding,” Quarterly reviews of biophysics, vol. 49, p. e10, 2016.LICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/84620/3/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD53ORIGINAL3957420077.2023.pdf3957420077.2023.pdfTesis de Maestría en Ciencias - Biologíaapplication/pdf2594749https://repositorio.unal.edu.co/bitstream/unal/84620/4/3957420077.2023.pdf331c0c9bdaef2a69013c1647465313faMD54THUMBNAIL3957420077.2023.pdf.jpg3957420077.2023.pdf.jpgGenerated Thumbnailimage/jpeg3917https://repositorio.unal.edu.co/bitstream/unal/84620/5/3957420077.2023.pdf.jpg5c6dcefb3630bdf0578e67f5e2822bceMD55unal/84620oai:repositorio.unal.edu.co:unal/846202024-08-05 23:10:24.272Repositorio Institucional Universidad Nacional de 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