Efectos modulatorios del litio sobre la cascada de señalización mediada por fosfoinositoles en cultivo neuronal primario

ilustraciones, graficas

Autores:: Guevara Espitia, Camilo Andrés

Tipo de recurso:

Fecha de publicación:: 2021

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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network_acronym_str	UNACIONAL2
network_name_str	Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv	Efectos modulatorios del litio sobre la cascada de señalización mediada por fosfoinositoles en cultivo neuronal primario
dc.title.translated.eng.fl_str_mv	Modulatory effects of lithium on the phosphoinositide signaling cascade in primary neuronal culture
title	Efectos modulatorios del litio sobre la cascada de señalización mediada por fosfoinositoles en cultivo neuronal primario
spellingShingle	Efectos modulatorios del litio sobre la cascada de señalización mediada por fosfoinositoles en cultivo neuronal primario 610 - Medicina y salud::616 - Enfermedades Cerebro brain Litio Cascada de los fosfoinositoles Embrion de pollo Neuronas de Purkinje Lithium PLC-pathway Chick embryo Purkinje Neurons Embriones animales
title_short	Efectos modulatorios del litio sobre la cascada de señalización mediada por fosfoinositoles en cultivo neuronal primario
title_full	Efectos modulatorios del litio sobre la cascada de señalización mediada por fosfoinositoles en cultivo neuronal primario
title_fullStr	Efectos modulatorios del litio sobre la cascada de señalización mediada por fosfoinositoles en cultivo neuronal primario
title_full_unstemmed	Efectos modulatorios del litio sobre la cascada de señalización mediada por fosfoinositoles en cultivo neuronal primario
title_sort	Efectos modulatorios del litio sobre la cascada de señalización mediada por fosfoinositoles en cultivo neuronal primario
dc.creator.fl_str_mv	Guevara Espitia, Camilo Andrés
dc.contributor.advisor.none.fl_str_mv	Nasi Lignarolo, Enrico
dc.contributor.author.none.fl_str_mv	Guevara Espitia, Camilo Andrés
dc.contributor.researchgroup.spa.fl_str_mv	Biofísica de la Señalización Celular
dc.subject.ddc.spa.fl_str_mv	610 - Medicina y salud::616 - Enfermedades
topic	610 - Medicina y salud::616 - Enfermedades Cerebro brain Litio Cascada de los fosfoinositoles Embrion de pollo Neuronas de Purkinje Lithium PLC-pathway Chick embryo Purkinje Neurons Embriones animales
dc.subject.agrovocuri.spa.fl_str_mv	Cerebro
dc.subject.agrovocuri.eng.fl_str_mv	brain
dc.subject.proposal.spa.fl_str_mv	Litio Cascada de los fosfoinositoles Embrion de pollo Neuronas de Purkinje
dc.subject.proposal.eng.fl_str_mv	Lithium PLC-pathway Chick embryo Purkinje Neurons
dc.subject.unesco.spa.fl_str_mv	Embriones animales
description	ilustraciones, graficas
publishDate	2021
dc.date.issued.none.fl_str_mv	2021
dc.date.accessioned.none.fl_str_mv	2022-03-15T19:47:42Z
dc.date.available.none.fl_str_mv	2022-03-15T19:47:42Z
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/81226
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/81226 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
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dc.rights.license.spa.fl_str_mv	Atribución-NoComercial 4.0 Internacional
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dc.format.extent.spa.fl_str_mv	87 páginas
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv	Bogotá - Ciencias - Maestría en Ciencias - Biología
dc.publisher.department.spa.fl_str_mv	Departamento de Biología
dc.publisher.faculty.spa.fl_str_mv	Facultad de Ciencias
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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spelling	Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Nasi Lignarolo, Enricob880efc08f05d0579d6f076cca5dd9cdGuevara Espitia, Camilo Andrésd1bc825565e82f9c29d403a417c22709Biofísica de la Señalización Celular2022-03-15T19:47:42Z2022-03-15T19:47:42Z2021https://repositorio.unal.edu.co/handle/unal/81226Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, graficasEl litio es el fármaco estándar para el tratamiento del trastorno bipolar. Sin embargo, su mecanismo de acción a nivel celular no está dilucidado. En líneas celulares en nuestro laboratorio se observaron efectos modulatorios del litio sobre respuestas fisiológicas dependientes de la vîa de los fosfoinositoles. Considerando la expresión de distintas isoformas de las proteínas Gq y PLCβ en el sistema nervioso, este trabajo se propuso extender estas observaciones a un primer modelo neuronal. Para ello se utilizaron cultivos primarios de neuronas enzimáticamente disociadas de cerebelo de embrión de pollo. Algunas neuronas fueron identificadas como células de Purkinje y su estimulación con el agonista glutamatérgico quisquilato evocó corrientes de entrada registradas con la técnica de patch clamp e incrementos de calcio intracelular medidos con indicadores fluorescentes de calcio. El rol de la vía de la PLC sobre estas respuestas fue comprobado mostrando su sensibilidad al inhibidor de la PLC U-73122 y la contribución mayoritaria de depósitos intracelulares sobre la movilización de calcio. Finalmente se examinó el efecto del litio sobre las respuestas al quisquilato. En algunas células, exposición aguda a 10mM de litio produjo potenciación de la respuesta mientras que en otras hubo una depresión. Este efecto dual puede ser producto de dos subpoblaciones de neuronas con expresión de diferentes isoformas de la PLCβ. Este trabajo constituye el primer reporte del efecto del litio sobre respuestas asociadas a la vía de la PLC en neuronas primarias de pollo, y abre las puertas para su exploración en otras regiones cerebrales. (Texto tomado de la fuente)Lithium is the treatment of choice for bipolar disorder. However, its cellular mechanism of action has not been elucidated. Previous work from our laboratory found modulatory effects of lithium on physiological responses dependent on the phosphoinositide signaling pathway in mammalian cell lines. Considering the expression of different isoforms of Gq protein and PLCβ in the nervous system, this work aims to extend these observations into a first neuronal model. To achieve this, primary cultures of enzymatically dissociated neurons from chick embryo cerebellum were developed. Some neurons were identified as Purkinje cells and their stimulation with the glutamatergic agonist quisqualate evoked inward currents recorded with the patch clamp technique and increases in intracellular calcium measured with fluorescent calcium indicators. The role of the PLC pathway on these responses was verified by showing its sensitivity to the PLC inhibitor U-73122 and the main contribution of intracellular compartments on calcium mobilization. Finally, the effect of lithium on the responses evoked by quisqualate was examined. In some cells, acute exposure to 10mM lithium potentiated the response, while in others it was depressed. We suggest that the observed effect is the consequence of two subpopulations of neurons with different expression of PLCβ isoforms. This work constitutes the first report in chick primary neurons of the effect of lithium on the PLC pathway and is a first step for the exploration of this phenomenon in other brain regions.MaestríaMagíster en Ciencias - BiologíaFisiología Celular87 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias - BiologíaDepartamento de BiologíaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::616 - EnfermedadesCerebrobrainLitioCascada de los fosfoinositolesEmbrion de polloNeuronas de PurkinjeLithiumPLC-pathwayChick embryoPurkinje NeuronsEmbriones animalesEfectos modulatorios del litio sobre la cascada de señalización mediada por fosfoinositoles en cultivo neuronal primarioModulatory effects of lithium on the phosphoinositide signaling cascade in primary neuronal cultureTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMAbdul-Ghani, M. 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Neuroscience Letters, 603, 84–88. https://doi.org/10.1016/j.neulet.2015.07.027EstudiantesInvestigadoresPúblico generalORIGINAL1014256546.2021.pdf1014256546.2021.pdfTesis de Maestría en Biologíaapplication/pdf1626616https://repositorio.unal.edu.co/bitstream/unal/81226/1/1014256546.2021.pdf584bd8a816e82875f24536ed28854bd4MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-84074https://repositorio.unal.edu.co/bitstream/unal/81226/2/license.txt8153f7789df02f0a4c9e079953658ab2MD52THUMBNAIL1014256546.2021.pdf.jpg1014256546.2021.pdf.jpgGenerated Thumbnailimage/jpeg5299https://repositorio.unal.edu.co/bitstream/unal/81226/3/1014256546.2021.pdf.jpg4f530172cab2795d2a615e6257e72abbMD53unal/81226oai:repositorio.unal.edu.co:unal/812262023-08-02 23:04:10.676Repositorio Institucional Universidad Nacional de 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Efectos modulatorios del litio sobre la cascada de señalización mediada por fosfoinositoles en cultivo neuronal primario

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