Evaluation of conductive nanofillers addition in scaffolds for myocardial tissue engineering application

ilustraciones, diagramas, fotografías

Autores:: Muñoz González, Ana María

Tipo de recurso:: Doctoral thesis

Fecha de publicación:: 2024

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: eng

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network_acronym_str	UNACIONAL2
network_name_str	Universidad Nacional de Colombia
repository_id_str
dc.title.eng.fl_str_mv	Evaluation of conductive nanofillers addition in scaffolds for myocardial tissue engineering application
dc.title.translated.spa.fl_str_mv	Evaluación de la adición de nanorrellenos conductores en andamios para aplicaciones de ingeniería de tejidos miocárdicos
title	Evaluation of conductive nanofillers addition in scaffolds for myocardial tissue engineering application
spellingShingle	Evaluation of conductive nanofillers addition in scaffolds for myocardial tissue engineering application Materiales Biocompatibles/análisis Ingeniería de Tejidos/métodos Miocardio/patología Biocompatible Materials/analysis Tissue Engineering/methods Myocardium/pathology Electrospinning Nanofiller Electroconductive Polycaprolactone Polypyrrole Graphene Scaffold Tissue engineering Electrohilado Relleno conductor Nanorelleno Policaprolactona Polipirrol Grafeno Andamio Ingeniería de tejidos
title_short	Evaluation of conductive nanofillers addition in scaffolds for myocardial tissue engineering application
title_full	Evaluation of conductive nanofillers addition in scaffolds for myocardial tissue engineering application
title_fullStr	Evaluation of conductive nanofillers addition in scaffolds for myocardial tissue engineering application
title_full_unstemmed	Evaluation of conductive nanofillers addition in scaffolds for myocardial tissue engineering application
title_sort	Evaluation of conductive nanofillers addition in scaffolds for myocardial tissue engineering application
dc.creator.fl_str_mv	Muñoz González, Ana María
dc.contributor.advisor.spa.fl_str_mv	Clavijo Grimaldo, Aleida Dianney
dc.contributor.author.spa.fl_str_mv	Muñoz González, Ana María
dc.contributor.researchgroup.spa.fl_str_mv	Biomecánica
dc.contributor.orcid.spa.fl_str_mv	https://orcid.org/0000-0002-3191-9891
dc.contributor.cvlac.spa.fl_str_mv	https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001661109
dc.subject.decs.spa.fl_str_mv	Materiales Biocompatibles/análisis Ingeniería de Tejidos/métodos Miocardio/patología
topic	Materiales Biocompatibles/análisis Ingeniería de Tejidos/métodos Miocardio/patología Biocompatible Materials/analysis Tissue Engineering/methods Myocardium/pathology Electrospinning Nanofiller Electroconductive Polycaprolactone Polypyrrole Graphene Scaffold Tissue engineering Electrohilado Relleno conductor Nanorelleno Policaprolactona Polipirrol Grafeno Andamio Ingeniería de tejidos
dc.subject.decs.eng.fl_str_mv	Biocompatible Materials/analysis Tissue Engineering/methods Myocardium/pathology
dc.subject.proposal.eng.fl_str_mv	Electrospinning Nanofiller Electroconductive Polycaprolactone Polypyrrole Graphene Scaffold Tissue engineering
dc.subject.proposal.spa.fl_str_mv	Electrohilado Relleno conductor Nanorelleno Policaprolactona Polipirrol Grafeno Andamio Ingeniería de tejidos
description	ilustraciones, diagramas, fotografías
publishDate	2024
dc.date.accessioned.none.fl_str_mv	2024-07-04T19:58:01Z
dc.date.available.none.fl_str_mv	2024-07-04T19:58:01Z
dc.date.issued.none.fl_str_mv	2024-06-30
dc.type.spa.fl_str_mv	Trabajo de grado - Doctorado
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/doctoralThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.coar.spa.fl_str_mv	http://purl.org/coar/resource_type/c_db06
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TD
format	http://purl.org/coar/resource_type/c_db06
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/86396
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/86396 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	eng
language	eng
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv	Bogotá - Ingeniería - Doctorado en Ingeniería - Ciencia y Tecnología de Materiales
dc.publisher.faculty.spa.fl_str_mv	Facultad de Ingeniería
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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repository.name.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
repository.mail.fl_str_mv	repositorio_nal@unal.edu.co
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spelling	Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Clavijo Grimaldo, Aleida Dianney0f5f59dcd59278828f92bde97781e0fd600Muñoz González, Ana Maríae7eb51455bc4068cf0e104465ef4f59fBiomecánicahttps://orcid.org/0000-0002-3191-9891https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=00016611092024-07-04T19:58:01Z2024-07-04T19:58:01Z2024-06-30https://repositorio.unal.edu.co/handle/unal/86396Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramas, fotografíasThis thesis explores the design, fabrication, and of polymeric nanofiber scaffolds with electroconductive nanofillers for cardiac tissue engineering, focusing on myocardial tissue repair through differentiated incorporation of graphene and polypyrrole (PPy) into polycaprolactone (PCL) matrices via electrospinning. The work aims to establish fabrication parameters and assess the morphological, mechanical, chemical, electrical and biocompatibility properties of the scaffolds, with the goal of selecting those that offer optimal theorical electromechanical coupling with myocardial tissue. Two strategies are distinguished: one focused on scaffolds doped with graphene, which show improvements in structural uniformity and mechanical properties, and another on scaffolds enriched with PPy, noted for their significant electrical conductivity. Both strategies present specific advantages, such as enhanced hydrophilicity and the promotion of cell adhesion and proliferation, crucial for tissue regeneration. Despite challenges like the uniform dispersion of nanoparticles and matching the mechanical properties to those of native myocardium, the research highlights the potential of in situ polymerization of PPy as a balanced method for achieving scaffolds with optimized electrical properties and biocompatibility.Esta tesis explora el diseño, fabricación y análisis de andamios de nanofibras poliméricas con nanorrellenos electroconductivos para la ingeniería de tejidos cardíacos, centrándose en la reparación del tejido miocárdico mediante la incorporación diferenciada de grafeno y polipirrol (PPy) en matrices de policaprolactona (PCL) a través del electrohilado. El trabajo tiene como objetivo establecer parámetros de fabricación y evaluar las propiedades morfológicas, mecánicas, químicas, eléctricas y de biocompatibilidad de los andamios, con el fin de seleccionar aquellos que ofrezcan un acoplamiento electromecánico teórico óptimo con el tejido miocárdico. Se distinguen dos estrategias: una centrada en andamios dopados con grafeno, que muestran mejoras en la uniformidad estructural y propiedades mecánicas, y otra en andamios enriquecidos con PPy, conocidos por su significativa conductividad eléctrica. Ambas estrategias presentan ventajas específicas, como la mejora de la hidrofilicidad y la promoción de la adhesión y proliferación celular, cruciales para la regeneración del tejido. A pesar de desafíos como la dispersión uniforme de nanopartículas y la correspondencia de las propiedades mecánicas con las del miocardio nativo, la investigación resalta el potencial de la polimerización in situ de PPy como un método equilibrado para lograr andamios con propiedades eléctricas y biocompatibilidad optimizadas. (Texto tomado de la fuente).DoctoradoDoctor en IngenieríaNanomateriales e ingeniería tisularxv, 201 páginasapplication/pdfengUniversidad Nacional de ColombiaBogotá - Ingeniería - Doctorado en Ingeniería - Ciencia y Tecnología de MaterialesFacultad de IngenieríaBogotá, ColombiaUniversidad Nacional de Colombia - Sede BogotáEvaluation of conductive nanofillers addition in scaffolds for myocardial tissue engineering applicationEvaluación de la adición de nanorrellenos conductores en andamios para aplicaciones de ingeniería de tejidos miocárdicosTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_db06Texthttp://purl.org/redcol/resource_type/TDAbbasi, A. M. R., Marsalkova, M., & Militky, J. (2013). Conductometry and Size Characterization of Polypyrrole Nanoparticles Produced by Ball Milling. Journal of Nanoparticles, 2013, 1–4. https://doi.org/10.1155/2013/690407Abdul Rahman, N., & Bahruji, H. (2022). 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Nature Biomedical Engineering, 6(4), 327–338. https://doi.org/10.1038/s41551-022-00885-3Materiales Biocompatibles/análisisIngeniería de Tejidos/métodosMiocardio/patologíaBiocompatible Materials/analysisTissue Engineering/methodsMyocardium/pathologyElectrospinningNanofillerElectroconductivePolycaprolactonePolypyrroleGrapheneScaffoldTissue engineeringElectrohiladoRelleno conductorNanorellenoPolicaprolactonaPolipirrolGrafenoAndamioIngeniería de tejidosInvestigadoresLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86396/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1018457635.2024.pdf1018457635.2024.pdfTesis de Doctorado en Ingeniería - Ciencia y Tecnología de Materialesapplication/pdf8351722https://repositorio.unal.edu.co/bitstream/unal/86396/2/1018457635.2024.pdf2b2c977576b138d0ee47089d03cb9283MD52THUMBNAIL1018457635.2024.pdf.jpg1018457635.2024.pdf.jpgGenerated 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Evaluation of conductive nanofillers addition in scaffolds for myocardial tissue engineering application

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