Estudio in silico de la interacción entre la insulina glargina y el receptor híbrido IR/IGF1R

ilustraciones a color, diagramas

Autores:: Arévalo Corredor, Luis Fernando

Tipo de recurso:

Fecha de publicación:: 2023

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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network_acronym_str	UNACIONAL2
network_name_str	Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv	Estudio in silico de la interacción entre la insulina glargina y el receptor híbrido IR/IGF1R
dc.title.translated.eng.fl_str_mv	In silico study of the interaction between insulin glargine and the hybrid IR/IGF1R receptor.
title	Estudio in silico de la interacción entre la insulina glargina y el receptor híbrido IR/IGF1R
spellingShingle	Estudio in silico de la interacción entre la insulina glargina y el receptor híbrido IR/IGF1R 610 - Medicina y salud::615 - Farmacología y terapéutica Insulina glargina Receptor IGF Tipo 1 Receptor de insulina Insulin glargine Receptor, IGF Type 1 Receptor, insulin Glargina Receptor Insulina Receptor IGF1R Docking molecular Receptores Insulin glargine Insulin receptor IGF1R receptor Molecular docking Receptors Docking (molecular) Acoplamiento molecular
title_short	Estudio in silico de la interacción entre la insulina glargina y el receptor híbrido IR/IGF1R
title_full	Estudio in silico de la interacción entre la insulina glargina y el receptor híbrido IR/IGF1R
title_fullStr	Estudio in silico de la interacción entre la insulina glargina y el receptor híbrido IR/IGF1R
title_full_unstemmed	Estudio in silico de la interacción entre la insulina glargina y el receptor híbrido IR/IGF1R
title_sort	Estudio in silico de la interacción entre la insulina glargina y el receptor híbrido IR/IGF1R
dc.creator.fl_str_mv	Arévalo Corredor, Luis Fernando
dc.contributor.advisor.spa.fl_str_mv	Gómez Alegría, Claudio Jaime González Beltrán, Martha Margarita
dc.contributor.author.spa.fl_str_mv	Arévalo Corredor, Luis Fernando
dc.contributor.researchgroup.spa.fl_str_mv	Unimol
dc.contributor.cvlac.spa.fl_str_mv	AREVALO CORREDOR, LUIS FERNANDO
dc.subject.ddc.spa.fl_str_mv	610 - Medicina y salud::615 - Farmacología y terapéutica
topic	610 - Medicina y salud::615 - Farmacología y terapéutica Insulina glargina Receptor IGF Tipo 1 Receptor de insulina Insulin glargine Receptor, IGF Type 1 Receptor, insulin Glargina Receptor Insulina Receptor IGF1R Docking molecular Receptores Insulin glargine Insulin receptor IGF1R receptor Molecular docking Receptors Docking (molecular) Acoplamiento molecular
dc.subject.decs.spa.fl_str_mv	Insulina glargina Receptor IGF Tipo 1 Receptor de insulina
dc.subject.decs.eng.fl_str_mv	Insulin glargine Receptor, IGF Type 1 Receptor, insulin
dc.subject.proposal.spa.fl_str_mv	Glargina Receptor Insulina Receptor IGF1R Docking molecular Receptores
dc.subject.proposal.eng.fl_str_mv	Insulin glargine Insulin receptor IGF1R receptor Molecular docking Receptors
dc.subject.wikidata.eng.fl_str_mv	Docking (molecular)
dc.subject.wikidata.spa.fl_str_mv	Acoplamiento molecular
description	ilustraciones a color, diagramas
publishDate	2023
dc.date.issued.none.fl_str_mv	2023-12
dc.date.accessioned.none.fl_str_mv	2024-02-05T20:43:16Z
dc.date.available.none.fl_str_mv	2024-02-05T20:43:16Z
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/85626
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/85626 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
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dc.publisher.faculty.spa.fl_str_mv	Facultad de Ciencias
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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spelling	Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Gómez Alegría, Claudio Jaime14d6222499960e7da2ec46b1cf91a329600González Beltrán, Martha Margaritaab8cd0438ed94a8fa4239d2c0244d792600Arévalo Corredor, Luis Fernandocc61acb570c2bfe17a2d55e10307501dUnimolAREVALO CORREDOR, LUIS FERNANDO2024-02-05T20:43:16Z2024-02-05T20:43:16Z2023-12https://repositorio.unal.edu.co/handle/unal/85626Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones a color, diagramasIntroducción: La insulina glargina se une a receptores de la familia IR-IGF1R, incluyendo al receptor de insulina (IR) y de IGF1 (IGF1R) que regulan metabolismo, división y diferenciación celular. Las células también expresan receptores híbridos IR/IGF1R que se han asociado con efectos mitogénicos in vitro. Aunque existe bastante información de la estructura y mecanismo de activación de los receptores IR e IGF1R, se conoce muy poco del reconocimiento y activación de los receptores híbridos. Objetivo: Mediante acercamiento In silico, proponer un hipotético modelo estructural del receptor híbrido IR/IGF1R y estudiar la interacción glargina-receptor en dicho modelo. Metodología: Se utilizaron herramientas bioinformáticas (Swiss-model, ClusPro, LZerD y HADDOCK) para construir modelos computacionales del receptor híbrido. Resultados: Se obtuvo un total de 182 modelos computacionales del receptor híbrido IR/IGF1R, seleccionado finalmente un modelo del receptor libre (sin glargina o Apo-receptor) y otro del receptor con glargina unida (Holo-receptor), y se analizaron las interacciones ligando-receptor involucradas. Las afinidades teóricas calculadas (Kd) para el complejo glargina-receptor presentaron valores de 1.4 y 7.0 nM para los protómeros IR e IGF1R, respectivamente, lo que concuerda relativamente bien con datos experimentales reportados por otros autores. Conclusiones: Se proponen dos modelos computacionales de la estructura 3D del receptor híbrido IR/IGF1R, uno en su estado apo-y otro en su estado holo-receptor, describiendo las interacciones ligando-receptor encontradas. (Texto tomado de la fuente)Introduction: Insulin glargine binds to the IR-IGF1R family of receptors, which include the insulin receptor (IR) and the IGF1 receptor (IGF1R) governing cell metabolism, cell division, and differentiation. Cells also express hybrid IR/IGF1R receptors that have been associated with mitogenic effects in vitro. Although there is considerable information on the structure and activation mechanism of IR and IGF1R receptors, very little is known about the recognition and activation of the hybrid receptors. Aims: Using an in silico approach, to propose a hypothetical structural model of the hybrid IR/IGF1R receptor and to study the glargine-receptor interaction in this model. Methods: Bioinformatics tools (Swiss-model, ClusPro, LZerD and HADDOCK) were used to build computational models of the hybrid receptor. Results: A total of 182 computational models of the hybrid IR/IGF1R receptor were obtained, finally selecting a model of the free receptor without glargine (Apo-receptor) and another of the receptor with glargine bound (Holo-receptor), and the ligand-receptor interactions involved were analyzed. The calculated theoretical affinities (Kd) for the glargine-receptor complex presented values of 1.4 and 7.0 nM for the IR and IGF1R protomers, respectively, which agrees relatively well with experimental data reported by other authors. Conclusions: Two computational models for the 3D structure of the hybrid IR/IGF1R receptor are proposed, one for its apo-and the other for its holo-receptor state, and we describe the ligand-receptor interactions found.no aplicaMaestríaMagíster en Ciencias FarmacéuticasSe utilizaron herramientas bioinformáticas (Swiss-model, ClusPro, LZerD y HADDOCK) para construir modelos computacionales del receptor híbrido.Farmacología Molecular125 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias FarmacéuticasFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::615 - Farmacología y terapéuticaInsulina glarginaReceptor IGF Tipo 1Receptor de insulinaInsulin glargineReceptor, IGF Type 1Receptor, insulinGlarginaReceptor InsulinaReceptor IGF1RDocking molecularReceptoresInsulin glargineInsulin receptorIGF1R receptorMolecular dockingReceptorsDocking (molecular)Acoplamiento molecularEstudio in silico de la interacción entre la insulina glargina y el receptor híbrido IR/IGF1RIn silico study of the interaction between insulin glargine and the hybrid IR/IGF1R receptor.Trabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMAbbott, A. 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