Estudio termodinámico de la solubilidad de sulfadiazina en mezclas acuosas de Carbitol y N-Metil-Pirrolidona

Ilustraciones y tablas

Autores:: Osorio Amado, Irmis Patricia

Tipo de recurso:

Fecha de publicación:: 2021

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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dc.title.spa.fl_str_mv	Estudio termodinámico de la solubilidad de sulfadiazina en mezclas acuosas de Carbitol y N-Metil-Pirrolidona
dc.title.translated.eng.fl_str_mv	Thermodynamic study of the solubility of sulfadiazine in aqueous mixtures of Carbitol and N-Methyl-Pyrrolidone
title	Estudio termodinámico de la solubilidad de sulfadiazina en mezclas acuosas de Carbitol y N-Metil-Pirrolidona
spellingShingle	Estudio termodinámico de la solubilidad de sulfadiazina en mezclas acuosas de Carbitol y N-Metil-Pirrolidona 540 - Química y ciencias afines Solutions Soluciones Physical and theoretical chemistry Fisicoquímica Antibióticos Antibiotics N-metil-pirrolidona Carbitol Solubilidad Sulfadiazina Solvatación preferencial Sulfadiazine Carbitol Water solubility Cosolvency Preferential solvation Solubility
title_short	Estudio termodinámico de la solubilidad de sulfadiazina en mezclas acuosas de Carbitol y N-Metil-Pirrolidona
title_full	Estudio termodinámico de la solubilidad de sulfadiazina en mezclas acuosas de Carbitol y N-Metil-Pirrolidona
title_fullStr	Estudio termodinámico de la solubilidad de sulfadiazina en mezclas acuosas de Carbitol y N-Metil-Pirrolidona
title_full_unstemmed	Estudio termodinámico de la solubilidad de sulfadiazina en mezclas acuosas de Carbitol y N-Metil-Pirrolidona
title_sort	Estudio termodinámico de la solubilidad de sulfadiazina en mezclas acuosas de Carbitol y N-Metil-Pirrolidona
dc.creator.fl_str_mv	Osorio Amado, Irmis Patricia
dc.contributor.advisor.none.fl_str_mv	Martínez Rodríguez, Fleming
dc.contributor.author.none.fl_str_mv	Osorio Amado, Irmis Patricia
dc.contributor.researchgroup.spa.fl_str_mv	Grupo de Investigaciones Farmacéutico-Fisicoquímicas
dc.subject.ddc.spa.fl_str_mv	540 - Química y ciencias afines
topic	540 - Química y ciencias afines Solutions Soluciones Physical and theoretical chemistry Fisicoquímica Antibióticos Antibiotics N-metil-pirrolidona Carbitol Solubilidad Sulfadiazina Solvatación preferencial Sulfadiazine Carbitol Water solubility Cosolvency Preferential solvation Solubility
dc.subject.decs.eng.fl_str_mv	Solutions
dc.subject.decs.spa.fl_str_mv	Soluciones
dc.subject.lem.eng.fl_str_mv	Physical and theoretical chemistry
dc.subject.lemb.spa.fl_str_mv	Fisicoquímica Antibióticos
dc.subject.lemb.eng.fl_str_mv	Antibiotics
dc.subject.proposal.spa.fl_str_mv	N-metil-pirrolidona Carbitol Solubilidad Sulfadiazina Solvatación preferencial
dc.subject.proposal.eng.fl_str_mv	Sulfadiazine Carbitol Water solubility Cosolvency Preferential solvation Solubility
description	Ilustraciones y tablas
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-09-16T15:41:16Z
dc.date.available.none.fl_str_mv	2021-09-16T15:41:16Z
dc.date.issued.none.fl_str_mv	2021-02
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/80215
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/80215 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.indexed.spa.fl_str_mv	Bireme
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
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institution	Universidad Nacional de Colombia
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spelling	Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Martínez Rodríguez, Fleming59595ca65dfb3c1612425d7ede691a3cOsorio Amado, Irmis Patricia03012c67ad381bae9d0d875e4201ea13600Grupo de Investigaciones Farmacéutico-Fisicoquímicas2021-09-16T15:41:16Z2021-09-16T15:41:16Z2021-02https://repositorio.unal.edu.co/handle/unal/80215Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/Ilustraciones y tablasIn the present study, the solubility of sulfadiazine in aqueous mixtures of Carbitol and N-methyl-2-pyrrolidone (NMP) at 278.15 K - 313.15 K was analyzed. It was found that the solubility of sulfadiazine in aqueous Carbitol mixtures did not vary with temperature. For aqueous mixtures of NMP, it was found that the trend of the increase in solubility was different for rich mixtures in NMP. This could be by a possible phase change of the crystalline structure of sulfadiazine. The thermodynamic properties of solution, mixture and transfer were calculated. The preferential solvation parameters of sulfadiazine were determined using the experimental solubility values and the thermodynamic functions of solution by means of the inverse Kirkwood-Buff integrals (IKBI) method. For both cosolvent systems, it was found that sulfadiazine is preferentially solvated by water in water-rich mixtures, probably due to the hydrophobic hydration phenomenon, but preferentially solvated by Carbitol or NMP in cosolvent-rich mixtures, probably due to the behavior of sulfadiazine as Lewis acid in front of the cosolvent molecules. The enthalpy-entropy relationship of the (NMP + water) system was analyzed, finding a non-linear relationship by plotting the enthalpy of solution as a function of the Gibbs energy of solution. Finally, when evaluating the sulfadiazine solubility values calculated using the semi-empirical Jouyban-Acree and the extended Hildebrand models, notable deviations were obtained with respect to the experimental values. The smallest mean percentage deviations % MPD were achieved with the extended Hildebrand model using an order 5 polynomial, obtaining a value of 0.88% for the (Carbitol + water) system and 1.47% for the (NMP + water) system, both at 313.15 K.En el presente estudio se determinó la solubilidad de la sulfadiazina en mezclas acuosas de Carbitol y N-metil-pirrolidona (NMP) en el rango de temperaturas de 278,15 K a 313,15 K. Se encontró que la solubilidad de la sulfadiazina en mezclas acuosas de Carbitol no varió con la temperatura. Para la solubilidad de sulfadiazina en mezclas acuosas de NMP se encontró que la tendencia del aumento de solubilidad era diferente para mezclas ricas en NMP, lo que podría ser explicado por un posible cambio de fase de la estructura cristalina de la sulfadiazina. Se calcularon además las funciones termodinámicas aparentes de solución, mezcla y transferencia de dichos sistemas. Los parámetros de solvatación preferencial de la sulfadiazina se hallaron utilizando los valores de solubilidad experimentales y las funciones termodinámicas de solución por medio del método de las integrales inversas de Kirkwood-Buff (IKBI, Inverse Kirkwood-Buff Integrals). Para ambos sistemas de cosolventes, se encontró que la sulfadiazina es solvatada preferencialmente por agua en mezclas ricas en agua, debido probablemente al fenómeno de hidratación hidrofóbica, pero solvatada preferencialmente por Carbitol o NMP en mezclas ricas en cosolvente, debido probablemente al comportamiento de la sulfadiazina como ácido de Lewis frente a las moléculas de los cosolventes. Se analizó la relación entálpica-entrópica del sistema (NMP + agua) encontrando una relación no lineal al graficar la entalpía de solución en función de la energía de Gibbs de solución. Finalmente, al evaluar los valores de solubilidad de sulfadiazina calculados mediante los modelos semiempíricos de Jouyban-Acree y el modelo extendido de Hildebrand se obtuvieron desviaciones notables con respecto a los valores experimentales. Las menores desviaciones promedio porcentuales se lograron con el modelo extendido de Hildebrand utilizando un polinomio de orden 5 para calcular el factor W, obteniendo un porcentaje de 0,88% para el sistema (Carbitol + agua) y de 1,47% para el sistema (NMP + agua), ambos a 313,15 K. (Texto tomado de la fuente).Incluye anexosMaestríaMagíster en Ciencias Farmacéuticasxvi, 131 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias FarmacéuticasDepartamento de FarmaciaFacultad de CienciasUniversidad Nacional de Colombia - Sede Bogotá540 - Química y ciencias afinesSolutionsSolucionesPhysical and theoretical chemistryFisicoquímicaAntibióticosAntibioticsN-metil-pirrolidonaCarbitolSolubilidadSulfadiazinaSolvatación preferencialSulfadiazineCarbitolWater solubilityCosolvencyPreferential solvationSolubilityEstudio termodinámico de la solubilidad de sulfadiazina en mezclas acuosas de Carbitol y N-Metil-PirrolidonaThermodynamic study of the solubility of sulfadiazine in aqueous mixtures of Carbitol and N-Methyl-PyrrolidoneTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBiremeAcree, W. E. (1992). 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Journal of Chemical Thermodynamics, 149, 106190. https://doi.org/10.1016/j.jct.2020.106190Público generalORIGINAL1098715256.2021.pdf1098715256.2021.pdfTesis de Maestria en Ciencias Farmacéuticasapplication/pdf2531622https://repositorio.unal.edu.co/bitstream/unal/80215/2/1098715256.2021.pdff8df3be5e9f655b53d84bb0eff395333MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-83964https://repositorio.unal.edu.co/bitstream/unal/80215/3/license.txtcccfe52f796b7c63423298c2d3365fc6MD53THUMBNAIL1098715256.2021.pdf.jpg1098715256.2021.pdf.jpgGenerated Thumbnailimage/jpeg5223https://repositorio.unal.edu.co/bitstream/unal/80215/4/1098715256.2021.pdf.jpgbe3bee1ba338adc9e538595265fe46e6MD54unal/80215oai:repositorio.unal.edu.co:unal/802152024-07-29 23:12:32.513Repositorio Institucional Universidad Nacional de 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GVyZWNob3MgZGUgYXV0b3IgcXVlIGNvbmxsZXZlIGxhIGRpc3RyaWJ1Y2nDs24gZGUgZXN0b3MgYXJjaGl2b3MgeSBtZXRhZGF0b3MuCkFsIGhhY2VyIGNsaWMgZW4gZWwgc2lndWllbnRlIGJvdMOzbiwgdXN0ZWQgaW5kaWNhIHF1ZSBlc3TDoSBkZSBhY3VlcmRvIGNvbiBlc3RvcyB0w6lybWlub3MuCgpVTklWRVJTSURBRCBOQUNJT05BTCBERSBDT0xPTUJJQSAtIMOabHRpbWEgbW9kaWZpY2FjacOzbiAyNy8yMC8yMDIwCg==

Estudio termodinámico de la solubilidad de sulfadiazina en mezclas acuosas de Carbitol y N-Metil-Pirrolidona

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