Mechanism of action of isothiocyanates. a review

Isothiocyanates (ITC), originating from the enzymatic degra- dation of glucosinolates (GSL), which are secondary metabolites of Brassicaceae plants, exhibit anticarcinogenic properties due to their ability to induce cytoprotective genes. The mechanisms of cytotoxic and cytostatic effects of ITC incl...

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Autores:
Molina Vargas, Luis Federico
Tipo de recurso:
Article of journal
Fecha de publicación:
2013
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/40118
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/40118
http://bdigital.unal.edu.co/30215/
Palabra clave:
apoptosis
glucosinolatos
estrés oxidativo
fitoalexinas
metabolitos secundarios.
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
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spelling Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Molina Vargas, Luis Federico6386f241-e932-4025-82db-24cb70a333db3002019-06-28T09:28:53Z2019-06-28T09:28:53Z2013https://repositorio.unal.edu.co/handle/unal/40118http://bdigital.unal.edu.co/30215/Isothiocyanates (ITC), originating from the enzymatic degra- dation of glucosinolates (GSL), which are secondary metabolites of Brassicaceae plants, exhibit anticarcinogenic properties due to their ability to induce cytoprotective genes. The mechanisms of cytotoxic and cytostatic effects of ITC include induction of apoptosis, inhibition of cell cycle progression and inhibition of angiogenesis. Regulation of apoptosis by ITC is accomplished primarily through the mitochondrial release of cytochrome c, Bcl-2 family regulation, MAPK signaling and subsequent activation of caspases. A significant portion of the chemopreventive effects of ITC may be associated with the inhibition of the metabolic activation of carcinogens by cytochrome P450 (phase I), along with increased induction of phase II detoxifying enzymes.application/pdfspaUniversidad Nacional de Colombia, Facultad de Agronomía, Centro Editorialhttp://revistas.unal.edu.co/index.php/agrocol/article/view/28987Universidad Nacional de Colombia Revistas electrónicas UN Agronomía ColombianaAgronomía ColombianaAgronomía Colombiana; Vol. 31, núm. 1 (2013); 68-75 Agronomía Colombiana; Vol. 31, núm. 1 (2013); 68-75 2357-3732 0120-9965Molina Vargas, Luis Federico (2013) Mechanism of action of isothiocyanates. a review. Agronomía Colombiana; Vol. 31, núm. 1 (2013); 68-75 Agronomía Colombiana; Vol. 31, núm. 1 (2013); 68-75 2357-3732 0120-9965 .Mechanism of action of isothiocyanates. a reviewArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTapoptosisglucosinolatosestrés oxidativofitoalexinasmetabolitos secundarios.ORIGINAL28987-169815-2-PB.pdfapplication/pdf147105https://repositorio.unal.edu.co/bitstream/unal/40118/1/28987-169815-2-PB.pdfac16e3c7cef489ddd269cfed1ceecdabMD51THUMBNAIL28987-169815-2-PB.pdf.jpg28987-169815-2-PB.pdf.jpgGenerated Thumbnailimage/jpeg8554https://repositorio.unal.edu.co/bitstream/unal/40118/2/28987-169815-2-PB.pdf.jpgcadb9d780a1b7fca297073f6100b71d8MD52unal/40118oai:repositorio.unal.edu.co:unal/401182024-01-23 23:07:33.092Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co
dc.title.spa.fl_str_mv Mechanism of action of isothiocyanates. a review
title Mechanism of action of isothiocyanates. a review
spellingShingle Mechanism of action of isothiocyanates. a review
apoptosis
glucosinolatos
estrés oxidativo
fitoalexinas
metabolitos secundarios.
title_short Mechanism of action of isothiocyanates. a review
title_full Mechanism of action of isothiocyanates. a review
title_fullStr Mechanism of action of isothiocyanates. a review
title_full_unstemmed Mechanism of action of isothiocyanates. a review
title_sort Mechanism of action of isothiocyanates. a review
dc.creator.fl_str_mv Molina Vargas, Luis Federico
dc.contributor.author.spa.fl_str_mv Molina Vargas, Luis Federico
dc.subject.proposal.spa.fl_str_mv apoptosis
glucosinolatos
estrés oxidativo
fitoalexinas
metabolitos secundarios.
topic apoptosis
glucosinolatos
estrés oxidativo
fitoalexinas
metabolitos secundarios.
description Isothiocyanates (ITC), originating from the enzymatic degra- dation of glucosinolates (GSL), which are secondary metabolites of Brassicaceae plants, exhibit anticarcinogenic properties due to their ability to induce cytoprotective genes. The mechanisms of cytotoxic and cytostatic effects of ITC include induction of apoptosis, inhibition of cell cycle progression and inhibition of angiogenesis. Regulation of apoptosis by ITC is accomplished primarily through the mitochondrial release of cytochrome c, Bcl-2 family regulation, MAPK signaling and subsequent activation of caspases. A significant portion of the chemopreventive effects of ITC may be associated with the inhibition of the metabolic activation of carcinogens by cytochrome P450 (phase I), along with increased induction of phase II detoxifying enzymes.
publishDate 2013
dc.date.issued.spa.fl_str_mv 2013
dc.date.accessioned.spa.fl_str_mv 2019-06-28T09:28:53Z
dc.date.available.spa.fl_str_mv 2019-06-28T09:28:53Z
dc.type.spa.fl_str_mv Artículo de revista
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url https://repositorio.unal.edu.co/handle/unal/40118
http://bdigital.unal.edu.co/30215/
dc.language.iso.spa.fl_str_mv spa
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dc.relation.spa.fl_str_mv http://revistas.unal.edu.co/index.php/agrocol/article/view/28987
dc.relation.ispartof.spa.fl_str_mv Universidad Nacional de Colombia Revistas electrónicas UN Agronomía Colombiana
Agronomía Colombiana
dc.relation.ispartofseries.none.fl_str_mv Agronomía Colombiana; Vol. 31, núm. 1 (2013); 68-75 Agronomía Colombiana; Vol. 31, núm. 1 (2013); 68-75 2357-3732 0120-9965
dc.relation.references.spa.fl_str_mv Molina Vargas, Luis Federico (2013) Mechanism of action of isothiocyanates. a review. Agronomía Colombiana; Vol. 31, núm. 1 (2013); 68-75 Agronomía Colombiana; Vol. 31, núm. 1 (2013); 68-75 2357-3732 0120-9965 .
dc.rights.spa.fl_str_mv Derechos reservados - Universidad Nacional de Colombia
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.license.spa.fl_str_mv Atribución-NoComercial 4.0 Internacional
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dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial 4.0 Internacional
Derechos reservados - Universidad Nacional de Colombia
http://creativecommons.org/licenses/by-nc/4.0/
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia, Facultad de Agronomía, Centro Editorial
institution Universidad Nacional de Colombia
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