Caracterización de los trastornos de la función sexual femenina en pacientes con esclerosis múltiple en el HUN en el año 2020
ilustraciones, gráficas, tablas
- Autores:
-
Arenas Díaz, Rubén Darío
- Tipo de recurso:
- Fecha de publicación:
- 2021
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/80654
- Palabra clave:
- 610 - Medicina y salud::618 - Ginecología, obstetricia, pediatría, geriatría
Pacientes
Sexualidad
Salud de la Mujer
Patients
Sexuality
Women's Health
Esclerosis múltiple
Mujeres
Disfunción sexual
Multiple sclerosis
Women
Sexual dysfunction
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional
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Caracterización de los trastornos de la función sexual femenina en pacientes con esclerosis múltiple en el HUN en el año 2020 |
| dc.title.translated.eng.fl_str_mv |
Characterization of female sexual function disorders in patients with multiple sclerosis in the national university hospital of Colombia in 2020 |
| title |
Caracterización de los trastornos de la función sexual femenina en pacientes con esclerosis múltiple en el HUN en el año 2020 |
| spellingShingle |
Caracterización de los trastornos de la función sexual femenina en pacientes con esclerosis múltiple en el HUN en el año 2020 610 - Medicina y salud::618 - Ginecología, obstetricia, pediatría, geriatría Pacientes Sexualidad Salud de la Mujer Patients Sexuality Women's Health Esclerosis múltiple Mujeres Disfunción sexual Multiple sclerosis Women Sexual dysfunction |
| title_short |
Caracterización de los trastornos de la función sexual femenina en pacientes con esclerosis múltiple en el HUN en el año 2020 |
| title_full |
Caracterización de los trastornos de la función sexual femenina en pacientes con esclerosis múltiple en el HUN en el año 2020 |
| title_fullStr |
Caracterización de los trastornos de la función sexual femenina en pacientes con esclerosis múltiple en el HUN en el año 2020 |
| title_full_unstemmed |
Caracterización de los trastornos de la función sexual femenina en pacientes con esclerosis múltiple en el HUN en el año 2020 |
| title_sort |
Caracterización de los trastornos de la función sexual femenina en pacientes con esclerosis múltiple en el HUN en el año 2020 |
| dc.creator.fl_str_mv |
Arenas Díaz, Rubén Darío |
| dc.contributor.advisor.spa.fl_str_mv |
Saavedra Estupiñán, Miriam |
| dc.contributor.author.spa.fl_str_mv |
Arenas Díaz, Rubén Darío |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Investigación en Neurología de la Universidad Nacional de Colombia - Neuronal |
| dc.contributor.subjectmatterexpert.spa.fl_str_mv |
Cardenas Robledo, Simón |
| dc.subject.ddc.spa.fl_str_mv |
610 - Medicina y salud::618 - Ginecología, obstetricia, pediatría, geriatría |
| topic |
610 - Medicina y salud::618 - Ginecología, obstetricia, pediatría, geriatría Pacientes Sexualidad Salud de la Mujer Patients Sexuality Women's Health Esclerosis múltiple Mujeres Disfunción sexual Multiple sclerosis Women Sexual dysfunction |
| dc.subject.decs.spa.fl_str_mv |
Pacientes Sexualidad Salud de la Mujer |
| dc.subject.decs.eng.fl_str_mv |
Patients Sexuality Women's Health |
| dc.subject.proposal.spa.fl_str_mv |
Esclerosis múltiple Mujeres Disfunción sexual |
| dc.subject.proposal.eng.fl_str_mv |
Multiple sclerosis Women Sexual dysfunction |
| description |
ilustraciones, gráficas, tablas |
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2021 |
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2021-11-05T21:32:17Z |
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2021-11-05T21:32:17Z |
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2021 |
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Trabajo de grado - Especialidad Médica |
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info:eu-repo/semantics/masterThesis |
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Universidad Nacional de Colombia |
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Repositorio Institucional Universidad Nacional de Colombia |
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https://repositorio.unal.edu.co/ |
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https://repositorio.unal.edu.co/handle/unal/80654 https://repositorio.unal.edu.co/ |
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Friese MA, Schattling B, Fugger L. Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis. Nat Rev Neurol [Internet]. 2014;10(4):225–38. Available from: http://dx.doi.org/10.1038/nrneurol.2014.37 Reich DS, Lucchinetti CF, Calabresi PA. Multiple Sclerosis. Longo DL, editor. N Engl J Med [Internet]. 2018 Jan 11;378(2):169–80. Available from: http://www.nejm.org/doi/10.1056/NEJMra1401483 Nafee T, Watanabe R, Fregni F. Multiple sclerosis. Lancet Neurol [Internet]. 2018;138(10130):263–95. Available from: http://dx.doi.org/10.1016/S0140-6736(18)30481-1 Jiménez-Pérez CE. Estado actual de la esclerosis múltiple en Colombia Current state of multiple sclerosis in Colombia Trabajo original. Acta Neurol Colomb. 2015;31(4):385–90. Toro J, Cárdenas S, Fernando Martínez C, Urrutia J, Díaz C. Multiple sclerosis in Colombia and other Latin American Countries. Mult Scler Relat Disord [Internet]. 2013 Apr;2(2):80–9. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2211034812001010 Nourbakhsh B, Mowry EM. Multiple sclerosis risk factors and pathogenesis. Contin Lifelong Learn Neurol. 2019;25(3):596–610. Dobson R, Giovannoni G. Multiple sclerosis - a review. Eur J Neurol [Internet]. 2019 Jan;26(1):27–40. Available from: http://doi.wiley.com/10.1111/ene.13819 Lublin FD, Reingold SC, Cohen JA. Defining the clinical course of multiple sclerosis: The 2013 revisions. Neurology [Internet]. 2014 Jul 15;83(3):278–86. Available from: http://www.neurology.org/cgi/doi/10.1212/WNL.0000000000000560 Okuda DT, Mowry EM, Beheshtian A, Waubant E, Baranzini SE, Goodin DS, et al. Incidental MRI anomalies suggestive of multiple sclerosis: The radiologically isolated syndrome. Neurology. 2009;72(9):800–5. Okuda D, Mowry E, Cree B, Crabtree E, Goodin D, Waubant E PD. Asymptomatic spinal cord lesions predict disease progression in radiologically isolated syndrome. Neurology [Internet]. 2011;76(8):686–92. Available from: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed13&NEWS=N&AN=361331776 Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol [Internet]. 2018 Feb;17(2):162–73. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1474442217304702 Fisniku LK, Brex PA, Altmann DR, Miszkiel KA, Benton CE, Lanyon R, et al. Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis. Brain [Internet]. 2008 Feb 7;131(3):808–17. Available from: https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awm329 Gelfand JM. Multiple sclerosis. In: Handbook of Clinical Neurology [Internet]. 1st ed. Elsevier B.V.; 2014. p. 269–90. Available from: http://dx.doi.org/10.1016/B978-0-444-52001-2.00011-X Confavreux C, Vukusic S, Moreau T, Adeleine P. Relapses and Progression of Disability in Multiple Sclerosis. N Engl J Med [Internet]. 2000 Nov 16;343(20):1430–8. Available from: http://www.nejm.org/doi/abs/10.1056/NEJM200011163432001 Richards RG, Sampson FC, Beard SM, Tappenden P. A review of the natural history and epidemiology of multiple sclerosis: implications for resource allocation and health economic models. Health Technol Assess (Rockv) [Internet]. 2002;6(10). Available from: https://www.journalslibrary.nihr.ac.uk/hta/hta6100/ Guy JR, Qi X. Optic neuritis. In: Ocular Disease [Internet]. Elsevier; 2010. p. 278–88. Available from: https://linkinghub.elsevier.com/retrieve/pii/B9780702029837000371 Jacob A, Weinshenker BG. An approach to the diagnosis of acute transverse myelitis. Vol. 28, Seminars in Neurology. 2008. p. 105–20. Mariano R, Flanagan EP, Weinshenker BG, Palace J. A practical approach to the diagnosis of spinal cord lesions. Pract Neurol [Internet]. 2018 Jun;18(3):187–200. Available from: http://pn.bmj.com/lookup/doi/10.1136/practneurol-2017-001845 Ciccarelli O, Cohen JA, Reingold SC, Weinshenker et all. Spinal cord involvement in multiple sclerosis and neuromyelitis optica spectrum disorders. Lancet Neurol. 2019;18(2):185–97. Gresty M, Ell L, Findley L. Acquired pendular nystagmus: its characteristics, localising value and pathophysiology. J Neurol Neurosurg Psychiatry [Internet]. 1982 May 1;45(5):431–9. Available from: http://jnnp.bmj.com/cgi/doi/10.1136/jnnp.45.5.431 Nafee T, Watanabe R, Fregni F. Multiple Sclerosis. In: Neuromethods [Internet]. Elsevier Ltd; 2018. p. 263–95. Available from: http://dx.doi.org/10.1016/S0140-6736(18)30481-1 Karabudak R, Dahdaleh M, Aljumah M, Alroughani R, Alsharoqi IA, AlTahan AM, et al. Functional clinical outcomes in multiple sclerosis: Current status and future prospects. Mult Scler Relat Disord [Internet]. 2015 May;4(3):192–201. Available from: http://dx.doi.org/10.1016/j.msard.2015.03.004 Minden SL, Frankel D, Hadden L, Perloff J, Srinath KP, Hoaglin DC. The Sonya Slifka Longitudinal Multiple Sclerosis Study : Mult Scler. 2006;(January 2005):24–38. Kanchandani R, Howe JG. Lhermitte’s sign in multiple sclerosis: A clinical survey and review of the literature. J Neurol Neurosurg Psychiatry. 1982;45(4):308–12. Maloni H. Cognitive Impairment in Multiple Sclerosis. J Nurse Pract [Internet]. 2018 Mar;14(3):172–7. Available from: http://dx.doi.org/10.1016/S1474-4422(08)70259-X de Sèze M, Ruffion A, Denys P, Joseph PA, Perrouin-Verbe B. The neurogenic bladder in multiple sclerosis: Review of the literature and proposal of management guidelines. Mult Scler. 2007;13(7):915–28. Nakipoglu GF, Kaya AZ, Orhan G, Tezen O, Tunc H, Ozgirgin N, et al. Urinary dysfunction in multiple sclerosis. J Clin Neurosci. 2009;16(10):1321–4. Kantarci OH, Weinshenker BG. Prognostic factors in multiple sclerosis. Handb Mult Sclerosis, Third Ed. 2001;79(07):449–63. Filippi M, Bar-Or A, Piehl F, Preziosa P, Solari A, Vukusic S, et al. Multiple sclerosis. Nat Rev Dis Prim [Internet]. 2018 Dec 8 [cited 2019 Sep 3];4(1):43. Available from: http://www.nature.com/articles/s41572-018-0041-4 Frohman EM, Racke MK, Raine CS. Multiple Sclerosis — The Plaque and Its Pathogenesis. N Engl J Med [Internet]. 2006 Mar 2;354(9):942–55. Available from: http://www.nejm.org/doi/abs/10.1056/NEJMra052130 Baecher-Allan C, Kaskow BJ, Weiner HL. Multiple Sclerosis: Mechanisms and Immunotherapy. Neuron [Internet]. 2018 Feb;97(4):742–68. Available from: https://doi.org/10.1016/j.neuron.2018.01.021 Dendrou CA, Fugger L, Friese MA. Immunopathology of multiple sclerosis. Nat Rev Immunol [Internet]. 2015 Sep 7;15(9):545–58. Available from: http://dx.doi.org/10.1038/nri3871 Przybek J, Gniatkowska I, Mirowska-Guzel D, Członkowska A. Evolution of diagnostic criteria for multiple sclerosis. Neurol Neurochir Pol [Internet]. 2015 Sep;49(5):313–21. Available from: https://linkinghub.elsevier.com/retrieve/pii/S002838431500122X Chataway J. Evolving diagnostic criteria for multiple sclerosis. Lancet Neurol [Internet]. 2018;17(2):118. Available from: http://dx.doi.org/10.1016/S1474-4422(17)30463-5 Rovira Á, Wattjes MP, Tintoré M, Tur C, Yousry TA, Sormani MP, et al. Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis - Clinical implementation in the diagnostic process. Nat Rev Neurol [Internet]. 2015;11(8):471–82. Available from: http://dx.doi.org/10.1038/nrneurol.2015.106 Brownlee WJ, Hardy TA, Fazekas F, Miller DH. Diagnosis of multiple sclerosis: progress and challenges. Lancet [Internet]. 2017 Apr;389(10076):1336–46. Available from: http://dx.doi.org/10.1016/S0140-6736(16)30959-X Pryce G, Baker D. Oligoclonal bands in multiple sclerosis; Functional significance and therapeutic implications. Does the specificity matter? Mult Scler Relat Disord [Internet]. 2018 Oct;25:131–7. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2211034818302414 Michel L, Larochelle C, Prat A. Update on treatments in multiple sclerosis. Press Medicale [Internet]. 2015;44(4):e137–51. Available from: http://dx.doi.org/10.1016/j.lpm.2015.02.008 Montalban X, Gold R, Thompson AJ, Otero-Romero S, Amato MP, Chandraratna D, et al. ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis. Mult Scler J [Internet]. 2018 Feb 20;24(2):96–120. Available from: http://journals.sagepub.com/doi/10.1177/1352458517751049 Rae-Grant A, Day GS, Marrie RA, Rabinstein A, Cree BAC, Gronseth GS, et al. Practice guideline recommendations summary: Disease-modifying therapies for adults with multiple sclerosis. Neurology. 2018;90(17):777–88. Burt RK, Balabanov R, Burman J, Sharrack B, Snowden JA, Oliveira MC, et al. Effect of Nonmyeloablative Hematopoietic Stem Cell Transplantation vs Continued Disease-Modifying Therapy on Disease Progression in Patients with Relapsing-Remitting Multiple Sclerosis: A Randomized Clinical Trial. JAMA - J Am Med Assoc. 2019;321(2):165–74. Winkelmann A, Loebermann M, Reisinger EC, Hartung HP, Zettl UK. Disease-modifying therapies and infectious risks in multiple sclerosis. Nat Rev Neurol [Internet]. 2016;12(4):217–33. Available from: http://dx.doi.org/10.1038/nrneurol.2016.21 Soelberg Sorensen P. Safety concerns and risk management of multiple sclerosis therapies. Acta Neurol Scand. 2017;136(3):168–86. Montalban X, Hauser SL, Kappos L, Arnold DL, Bar-Or A, Comi G, et al. Ocrelizumab versus placebo in primary progressive multiple sclerosis. N Engl J Med. 2017;376(3):209–20. Giovannoni G. Disease-modifying treatments for early and advanced multiple sclerosis. Curr Opin Neurol [Internet]. 2018 Jun;31(3):233–43. Available from: http://insights.ovid.com/crossref?an=00019052-201806000-00002 Tur C, Moccia M, Barkhof F, Chataway J, Sastre-Garriga J, Thompson AJ, et al. Assessing treatment outcomes in multiple sclerosis trials and in the clinical setting. Nat Rev Neurol. 2018;14(2):75–93. Varhaug KN, Torkildsen Ø, Myhr KM, Vedeler CA. Neurofilament light chain as a biomarker in multiple sclerosis. Front Neurol. 2019;10(APR):1–6. Freedman MS, Selchen D, Arnold DL, Prat A, Banwell B, Yeung M, et al. Treatment optimization in MS: Canadian MS Working Group updated recommendations. Can J Neurol Sci. 2013;40(3):307–23. Clayton AH, Valladares Juarez EM. Female Sexual Dysfunction. Med Clin North Am [Internet]. 2019;103(4):681–98. Available from: https://doi.org/10.1016/j.mcna.2019.02.008 Perelman MA. The Sexual Tipping Point®: A Mind/Body Model for Sexual Medicine. J Sex Med [Internet]. 2009 Mar;6(3):629–32. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1743609515324334 Meston CM, Buss DM. Why humans have sex. Arch Sex Behav. 2007;36(4):477–507. Bronner G, Elran E, Golomb J, Korczyn AD. Female sexuality in multiple sclerosis: The multidimensional nature of the problem and the intervention. Acta Neurol Scand. 2010;121(5):289–301. Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: Prevalence and predictors. J Am Med Assoc. 1999;281(6):537–44. Lammerink EAG, de Bock GH, Pascal A, van Beek AP, van den Bergh ACM, Sattler MGA, et al. A Survey of Female Sexual Functioning in the General Dutch Population. J Sex Med [Internet]. 2017;14(7):937–49. Available from: http://dx.doi.org/10.1016/j.jsxm.2017.04.676 Nappi RE, Nijland EA. Women’s perception of sexuality around the menopause: Outcomes of a European telephone survey. Eur J Obstet Gynecol Reprod Biol. 2008;137(1):10–6. Valadares ALR, Lui-Filho JF, Costa-Paiva L, Pinto-Neto AM. Middle-aged female sexual dysfunction and multimorbidity: A population-based study. Menopause. 2016;23(3):304–10. Chedraui P, Pérez-López FR, Sánchez H, Aguirre W, Martínez N, Miranda O, et al. Assessment of sexual function of mid-aged Ecuadorian women with the 6-item Female Sexual Function Index. Maturitas [Internet]. 2012;71(4):407–12. Available from: http://dx.doi.org/10.1016/j.maturitas.2012.01.013 Espitia-De La Hoz FJ. Prevalence and characterisation of sexual dysfunctions in women, in 12 Colombian cities, 2009-2016. Rev Colomb Obstet Ginecol. 2018;69(1):9–21. Basson R, Berman J, Burnett A, Derogatis L, Ferguson D, Fourcroy J, et al. Report of the international consensus development conference on female sexual dysfunction: Definitions and classifications. J Urol. 2000;163(3):888–93. Nce N. Neuroscience. 5th Edition. 5th Editio. Sinauer; 2013. Munarriz R, Kim NN, Goldstein I, Traish AM. Biology of female sexual function. Urol Clin North Am. 2002;29(3):685–93. Panicker JN, Fowler CJ. Lower urinary tract dysfunction in patients with multiple sclerosis [Internet]. 1st ed. Vol. 130, Neurology of Sexual and Bladder Disorders. Elsevier B.V.; 2015. 371–381 p. Available from: http://dx.doi.org/10.1016/B978-0-444-63247-0.00021-3 Yeung J, Pauls RN. Anatomy of the Vulva and the Female Sexual Response. Obstet Gynecol Clin North Am [Internet]. 2016;43(1):27–44. Available from: http://dx.doi.org/10.1016/j.ogc.2015.10.011 Jeong GW, Park K, Youn G, Kang HK, Kim HJ, Seo JJ, et al. Assessment of cerebrocortical regions associated with sexual arousal in premenopausal and menopausal women by using BOLD-based functional MRI. J Sex Med. 2005;2(5):645–51. Meston CM, Hull E, Levin RJ, Sipski M. Disorders of Orgasm in Women. J Sex Med [Internet]. 2004 Jul;1(1):66–8. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1743609515300473 Nusbaum MRH, Hamilton C, Lenahan P. Chronic Illness and Sexual Functioning. Am Fam Physician [Internet]. 2003;15(67(2)):347–54. Available from: https://www.aafp.org/afp/2003/0115/p347.html Bartnik P, Wielgoś A, Kacperczyk J, Pisarz K, Szymusik I, Podlecka-Piętowska A, et al. Sexual dysfunction in female patients with relapsing-remitting multiple sclerosis. Brain Behav. 2017;7(6):1–7. Orasanu B, Frasure H, Wyman A, Mahajan ST. Sexual dysfunction in patients with multiple sclerosis. Mult Scler Relat Disord [Internet]. 2013;2(2):117–23. Available from: http://dx.doi.org/10.1016/j.msard.2012.10.005 Ashtari F, Rezvani R, Afshar H. Sexual dysfunction in women with multiple sclerosis: Dimensions and contributory factors. J Res Med Sci [Internet]. 2014 Mar;19(3):228–33. Available from: https//www.ncbi.nlm.nih.gov/pmc/articles/PMC4061644/ F F, B G. Introduction to intimacy and sexuality in MS. MS Focus. 2005;4(6):1–28. Fraser C, Mahoney J, McGurl J. Correlates of sexual dysfunction in men and women with multiple sclerosis. J Neurosci Nurs. 2008;40(5):312–7. De Santi L, Sessa E, Calabró RS. Sexual dysfunction in multiple sclerosis. Male Sex Dysfunctions Neurol Dis From Pathophysiol to Rehabil. 2011;93–104. Çelik DB, Poyraz EÇ, Bingöl A, İdiman E, Özakbaş S, Kaya D. Sexual dysfunction ın multiple sclerosis: Gender differences. J Neurol Sci [Internet]. 2013 Jan;324(1–2):17–20. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0022510X12004686 Thompson AJ, Toosy AT, Ciccarelli O. Pharmacological management of symptoms in multiple sclerosis: Current approaches and future directions. Lancet Neurol [Internet]. 2010;9(12):1182–99. Available from: http://dx.doi.org/10.1016/S1474-4422(10)70249-0 Foley FW, LaRocca NG, Sanders AS, Zemon V. Rehabilitation of intimacy and sexual dysfunction in couples with multiple sclerosis. Mult Scler. 2001;7(6):417–21. Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, et al. The female sexual function index (Fsfi): A multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther. 2000;26(2):191–205. Vallejo-Medina P, Pérez-Durán C, Saavedra-Roa A. Translation, Adaptation, and Preliminary Validation of the Female Sexual Function Index into Spanish (Colombia). Arch Sex Behav. 2018;47(3):797–810. Blümel M JE, Binfa E L, Cataldo A P, Carrasco V A, Izaguirre L H, Sarrá C S. Índice De Función Sexual Femenina: Un Test Para Evaluar La Sexualidad De La Mujer. Rev Chil Obstet Ginecol. 2004;69(2):118–25. Lew-Starowicz M, Rola R. Prevalence of sexual dysfunctions among women with multiple sclerosis. Sex Disabil. 2013;31(2):141–53. Ashtari F, Rezvani R, Afshar H. Sexual dysfunction in women with multiple sclerosis: Dimensions and contributory factors. J Res Med Sci. 2014;19(3):228–33 |
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Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Saavedra Estupiñán, Miriam721acb8604a7f09700bbc8025995c357Arenas Díaz, Rubén Darío338cce95033d76a406f9aa4d8e12b8e8Grupo de Investigación en Neurología de la Universidad Nacional de Colombia - NeuronalCardenas Robledo, Simón20202021-11-05T21:32:17Z2021-11-05T21:32:17Z2021https://repositorio.unal.edu.co/handle/unal/80654Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, gráficas, tablasLa disfunción sexual puede afectar hasta el 70% de las pacientes con esclerosis múltiple (EM) según estudios previos y es un determinante importante de calidad de vida. En Colombia desconocemos los datos sobre los trastornos sexuales en mujeres con EM y es necesario para incluir este aspecto en su atención. Objetivo: Identificar y caracterizar los trastornos de la función sexual femenina en mujeres en edad fértil con diagnóstico de EM el Hospital Universitario Nacional de la ciudad de Bogotá durante el año 2020 utilizando el índice de función sexual femenina (IFSF). Metodología: Estudio observacional analítico de corte transversal. Se incluyeron mujeres en edad reproductiva con diagnóstico de EM según los criterios de McDonald del 2017. Se excluyeron las pacientes que no tuvieron relaciones sexuales en las 4 semanas previas, discapacidad cognitiva, mujeres con historia de histerectomía, embarazadas o aquellas en los primeros 6 meses de posparto o con recaída de la enfermedad en los 3 meses previos. Se utilizó un cuestionario autoadministrado con las variables sociodemográficas y el IFSF, que puntúa diferentes dominios de la función sexual de acuerdo con la frecuencia informada de síntomas sexuales específicos durante el último mes. Se determinó la frecuencia general y específica de cada dominio de disfunción sexual. Resultados: De 145 mujeres elegibles, 73 respondieron al cuestionario y 47 cumplieron con los criterios del estudio. La edad media (DE) fue de 35,6 (6,4) años. La frecuencia global de disfunción sexual fue del 38,3%. La puntuación IFSF en mujeres afectadas y no afectadas fue 21,1 (4,4) y 30,3 (2,1), p<0.001. La frecuencia de disfunción por dominio específico fue 34% para el deseo sexual, 29,8% para el orgasmo, 17% para excitación y satisfacción, 14,9% para el dolor y 8,5% para la lubricación. En el análisis exploratorio no se encontraron asociaciones estadísticamente significativas entre la disfunción sexual y las variables sociodemográficas y clínicas estudiadas. Conclusiones: En las mujeres en edad reproductiva con diagnostico de EM del Hospital Universitario Nacional existe una frecuencia de disfunción sexual cercana a un tercio de la población de estudio, similar a la prevalencia en la población general colombiana. No se encontraron asociaciones con las características sociodemográficas y clínicas estudiadas. Se requieren intervenciones para establecer un plan diagnostico y terapéutico para los trastornos de la función sexual femenina. (Texto tomado de la fuente).Sexual dysfunction can affect up to 70% of women with Multiple Sclerosis (MS) and is an important determinant of quality of life. Since sexual dysfunction involves physiologic and cultural determinants, its frequency varies in different regions. In Colombia, the prevalence of sexual dysfunction in the general population of women is approximately 32,97%, but data on sexual disorders in women with MS are non-existent. Objectives: To identify and characterize sexual dysfunction in women with childbearing potential diagnosed with MS using the female sexual function index (FSFI). Methods: This is an analytical observational cross-sectional study. Women with MS according to 2017 McDonald criteria and with childbearing potential were included; patients with cognitive disability, with previous hysterectomy, pregnant or in the 6 months postpartum or with relapse in the previous 3 months were excluded. A self-reported questionnaire with sociodemographic variables and the FSFI was used. This scores different domains of sexual function according to the reported frequency of specific sexual symptoms during the last month. We determined the overall and domain-specific frequency of sexual dysfunction and assessed their relationship with demographic and MS variables using student’s t and X2 tests. Conclusions: Sexual dysfunction is highly frequent in women with MS in a proportion comparable to that of the general population in Colombia. No associations were found with the sociodemographic and clinical characteristics studied. Further research is warranted to determine the associated factors, and its impact in quality of life.Incluye anexosEspecialidades MédicasEspecialista en Neurología Clínicaxv, 94 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Especialidad en Neurología ClínicaDepartamento de Medicina InternaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::618 - Ginecología, obstetricia, pediatría, geriatríaPacientesSexualidadSalud de la MujerPatientsSexualityWomen's HealthEsclerosis múltipleMujeresDisfunción sexualMultiple sclerosisWomenSexual dysfunctionCaracterización de los trastornos de la función sexual femenina en pacientes con esclerosis múltiple en el HUN en el año 2020Characterization of female sexual function disorders in patients with multiple sclerosis in the national university hospital of Colombia in 2020Trabajo de grado - Especialidad Médicainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBiremeFriese MA, Schattling B, Fugger L. Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis. Nat Rev Neurol [Internet]. 2014;10(4):225–38. Available from: http://dx.doi.org/10.1038/nrneurol.2014.37Reich DS, Lucchinetti CF, Calabresi PA. Multiple Sclerosis. Longo DL, editor. N Engl J Med [Internet]. 2018 Jan 11;378(2):169–80. Available from: http://www.nejm.org/doi/10.1056/NEJMra1401483Nafee T, Watanabe R, Fregni F. Multiple sclerosis. Lancet Neurol [Internet]. 2018;138(10130):263–95. Available from: http://dx.doi.org/10.1016/S0140-6736(18)30481-1Jiménez-Pérez CE. Estado actual de la esclerosis múltiple en Colombia Current state of multiple sclerosis in Colombia Trabajo original. Acta Neurol Colomb. 2015;31(4):385–90.Toro J, Cárdenas S, Fernando Martínez C, Urrutia J, Díaz C. Multiple sclerosis in Colombia and other Latin American Countries. Mult Scler Relat Disord [Internet]. 2013 Apr;2(2):80–9. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2211034812001010Nourbakhsh B, Mowry EM. Multiple sclerosis risk factors and pathogenesis. Contin Lifelong Learn Neurol. 2019;25(3):596–610.Dobson R, Giovannoni G. Multiple sclerosis - a review. Eur J Neurol [Internet]. 2019 Jan;26(1):27–40. Available from: http://doi.wiley.com/10.1111/ene.13819Lublin FD, Reingold SC, Cohen JA. Defining the clinical course of multiple sclerosis: The 2013 revisions. Neurology [Internet]. 2014 Jul 15;83(3):278–86. Available from: http://www.neurology.org/cgi/doi/10.1212/WNL.0000000000000560Okuda DT, Mowry EM, Beheshtian A, Waubant E, Baranzini SE, Goodin DS, et al. Incidental MRI anomalies suggestive of multiple sclerosis: The radiologically isolated syndrome. Neurology. 2009;72(9):800–5.Okuda D, Mowry E, Cree B, Crabtree E, Goodin D, Waubant E PD. Asymptomatic spinal cord lesions predict disease progression in radiologically isolated syndrome. Neurology [Internet]. 2011;76(8):686–92. Available from: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed13&NEWS=N&AN=361331776Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol [Internet]. 2018 Feb;17(2):162–73. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1474442217304702Fisniku LK, Brex PA, Altmann DR, Miszkiel KA, Benton CE, Lanyon R, et al. Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis. Brain [Internet]. 2008 Feb 7;131(3):808–17. Available from: https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awm329Gelfand JM. Multiple sclerosis. In: Handbook of Clinical Neurology [Internet]. 1st ed. Elsevier B.V.; 2014. p. 269–90. Available from: http://dx.doi.org/10.1016/B978-0-444-52001-2.00011-XConfavreux C, Vukusic S, Moreau T, Adeleine P. Relapses and Progression of Disability in Multiple Sclerosis. N Engl J Med [Internet]. 2000 Nov 16;343(20):1430–8. Available from: http://www.nejm.org/doi/abs/10.1056/NEJM200011163432001Richards RG, Sampson FC, Beard SM, Tappenden P. A review of the natural history and epidemiology of multiple sclerosis: implications for resource allocation and health economic models. Health Technol Assess (Rockv) [Internet]. 2002;6(10). Available from: https://www.journalslibrary.nihr.ac.uk/hta/hta6100/Guy JR, Qi X. Optic neuritis. In: Ocular Disease [Internet]. Elsevier; 2010. p. 278–88. Available from: https://linkinghub.elsevier.com/retrieve/pii/B9780702029837000371Jacob A, Weinshenker BG. An approach to the diagnosis of acute transverse myelitis. Vol. 28, Seminars in Neurology. 2008. p. 105–20.Mariano R, Flanagan EP, Weinshenker BG, Palace J. A practical approach to the diagnosis of spinal cord lesions. Pract Neurol [Internet]. 2018 Jun;18(3):187–200. Available from: http://pn.bmj.com/lookup/doi/10.1136/practneurol-2017-001845Ciccarelli O, Cohen JA, Reingold SC, Weinshenker et all. Spinal cord involvement in multiple sclerosis and neuromyelitis optica spectrum disorders. Lancet Neurol. 2019;18(2):185–97.Gresty M, Ell L, Findley L. Acquired pendular nystagmus: its characteristics, localising value and pathophysiology. J Neurol Neurosurg Psychiatry [Internet]. 1982 May 1;45(5):431–9. Available from: http://jnnp.bmj.com/cgi/doi/10.1136/jnnp.45.5.431Nafee T, Watanabe R, Fregni F. Multiple Sclerosis. In: Neuromethods [Internet]. Elsevier Ltd; 2018. p. 263–95. Available from: http://dx.doi.org/10.1016/S0140-6736(18)30481-1Karabudak R, Dahdaleh M, Aljumah M, Alroughani R, Alsharoqi IA, AlTahan AM, et al. Functional clinical outcomes in multiple sclerosis: Current status and future prospects. Mult Scler Relat Disord [Internet]. 2015 May;4(3):192–201. Available from: http://dx.doi.org/10.1016/j.msard.2015.03.004Minden SL, Frankel D, Hadden L, Perloff J, Srinath KP, Hoaglin DC. The Sonya Slifka Longitudinal Multiple Sclerosis Study : Mult Scler. 2006;(January 2005):24–38.Kanchandani R, Howe JG. Lhermitte’s sign in multiple sclerosis: A clinical survey and review of the literature. J Neurol Neurosurg Psychiatry. 1982;45(4):308–12.Maloni H. Cognitive Impairment in Multiple Sclerosis. J Nurse Pract [Internet]. 2018 Mar;14(3):172–7. Available from: http://dx.doi.org/10.1016/S1474-4422(08)70259-Xde Sèze M, Ruffion A, Denys P, Joseph PA, Perrouin-Verbe B. The neurogenic bladder in multiple sclerosis: Review of the literature and proposal of management guidelines. Mult Scler. 2007;13(7):915–28.Nakipoglu GF, Kaya AZ, Orhan G, Tezen O, Tunc H, Ozgirgin N, et al. Urinary dysfunction in multiple sclerosis. J Clin Neurosci. 2009;16(10):1321–4.Kantarci OH, Weinshenker BG. Prognostic factors in multiple sclerosis. Handb Mult Sclerosis, Third Ed. 2001;79(07):449–63.Filippi M, Bar-Or A, Piehl F, Preziosa P, Solari A, Vukusic S, et al. Multiple sclerosis. Nat Rev Dis Prim [Internet]. 2018 Dec 8 [cited 2019 Sep 3];4(1):43. Available from: http://www.nature.com/articles/s41572-018-0041-4Frohman EM, Racke MK, Raine CS. Multiple Sclerosis — The Plaque and Its Pathogenesis. N Engl J Med [Internet]. 2006 Mar 2;354(9):942–55. Available from: http://www.nejm.org/doi/abs/10.1056/NEJMra052130Baecher-Allan C, Kaskow BJ, Weiner HL. Multiple Sclerosis: Mechanisms and Immunotherapy. Neuron [Internet]. 2018 Feb;97(4):742–68. Available from: https://doi.org/10.1016/j.neuron.2018.01.021Dendrou CA, Fugger L, Friese MA. Immunopathology of multiple sclerosis. Nat Rev Immunol [Internet]. 2015 Sep 7;15(9):545–58. Available from: http://dx.doi.org/10.1038/nri3871Przybek J, Gniatkowska I, Mirowska-Guzel D, Członkowska A. Evolution of diagnostic criteria for multiple sclerosis. Neurol Neurochir Pol [Internet]. 2015 Sep;49(5):313–21. Available from: https://linkinghub.elsevier.com/retrieve/pii/S002838431500122XChataway J. Evolving diagnostic criteria for multiple sclerosis. Lancet Neurol [Internet]. 2018;17(2):118. Available from: http://dx.doi.org/10.1016/S1474-4422(17)30463-5Rovira Á, Wattjes MP, Tintoré M, Tur C, Yousry TA, Sormani MP, et al. Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis - Clinical implementation in the diagnostic process. Nat Rev Neurol [Internet]. 2015;11(8):471–82. Available from: http://dx.doi.org/10.1038/nrneurol.2015.106Brownlee WJ, Hardy TA, Fazekas F, Miller DH. Diagnosis of multiple sclerosis: progress and challenges. Lancet [Internet]. 2017 Apr;389(10076):1336–46. Available from: http://dx.doi.org/10.1016/S0140-6736(16)30959-XPryce G, Baker D. Oligoclonal bands in multiple sclerosis; Functional significance and therapeutic implications. Does the specificity matter? Mult Scler Relat Disord [Internet]. 2018 Oct;25:131–7. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2211034818302414Michel L, Larochelle C, Prat A. Update on treatments in multiple sclerosis. Press Medicale [Internet]. 2015;44(4):e137–51. Available from: http://dx.doi.org/10.1016/j.lpm.2015.02.008Montalban X, Gold R, Thompson AJ, Otero-Romero S, Amato MP, Chandraratna D, et al. ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis. Mult Scler J [Internet]. 2018 Feb 20;24(2):96–120. Available from: http://journals.sagepub.com/doi/10.1177/1352458517751049Rae-Grant A, Day GS, Marrie RA, Rabinstein A, Cree BAC, Gronseth GS, et al. Practice guideline recommendations summary: Disease-modifying therapies for adults with multiple sclerosis. Neurology. 2018;90(17):777–88.Burt RK, Balabanov R, Burman J, Sharrack B, Snowden JA, Oliveira MC, et al. Effect of Nonmyeloablative Hematopoietic Stem Cell Transplantation vs Continued Disease-Modifying Therapy on Disease Progression in Patients with Relapsing-Remitting Multiple Sclerosis: A Randomized Clinical Trial. JAMA - J Am Med Assoc. 2019;321(2):165–74.Winkelmann A, Loebermann M, Reisinger EC, Hartung HP, Zettl UK. Disease-modifying therapies and infectious risks in multiple sclerosis. Nat Rev Neurol [Internet]. 2016;12(4):217–33. Available from: http://dx.doi.org/10.1038/nrneurol.2016.21Soelberg Sorensen P. Safety concerns and risk management of multiple sclerosis therapies. Acta Neurol Scand. 2017;136(3):168–86.Montalban X, Hauser SL, Kappos L, Arnold DL, Bar-Or A, Comi G, et al. Ocrelizumab versus placebo in primary progressive multiple sclerosis. N Engl J Med. 2017;376(3):209–20.Giovannoni G. Disease-modifying treatments for early and advanced multiple sclerosis. Curr Opin Neurol [Internet]. 2018 Jun;31(3):233–43. Available from: http://insights.ovid.com/crossref?an=00019052-201806000-00002Tur C, Moccia M, Barkhof F, Chataway J, Sastre-Garriga J, Thompson AJ, et al. Assessing treatment outcomes in multiple sclerosis trials and in the clinical setting. Nat Rev Neurol. 2018;14(2):75–93.Varhaug KN, Torkildsen Ø, Myhr KM, Vedeler CA. Neurofilament light chain as a biomarker in multiple sclerosis. Front Neurol. 2019;10(APR):1–6.Freedman MS, Selchen D, Arnold DL, Prat A, Banwell B, Yeung M, et al. Treatment optimization in MS: Canadian MS Working Group updated recommendations. Can J Neurol Sci. 2013;40(3):307–23.Clayton AH, Valladares Juarez EM. Female Sexual Dysfunction. Med Clin North Am [Internet]. 2019;103(4):681–98. Available from: https://doi.org/10.1016/j.mcna.2019.02.008Perelman MA. The Sexual Tipping Point®: A Mind/Body Model for Sexual Medicine. J Sex Med [Internet]. 2009 Mar;6(3):629–32. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1743609515324334Meston CM, Buss DM. Why humans have sex. Arch Sex Behav. 2007;36(4):477–507.Bronner G, Elran E, Golomb J, Korczyn AD. Female sexuality in multiple sclerosis: The multidimensional nature of the problem and the intervention. Acta Neurol Scand. 2010;121(5):289–301.Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: Prevalence and predictors. J Am Med Assoc. 1999;281(6):537–44.Lammerink EAG, de Bock GH, Pascal A, van Beek AP, van den Bergh ACM, Sattler MGA, et al. A Survey of Female Sexual Functioning in the General Dutch Population. J Sex Med [Internet]. 2017;14(7):937–49. Available from: http://dx.doi.org/10.1016/j.jsxm.2017.04.676Nappi RE, Nijland EA. Women’s perception of sexuality around the menopause: Outcomes of a European telephone survey. Eur J Obstet Gynecol Reprod Biol. 2008;137(1):10–6.Valadares ALR, Lui-Filho JF, Costa-Paiva L, Pinto-Neto AM. Middle-aged female sexual dysfunction and multimorbidity: A population-based study. Menopause. 2016;23(3):304–10.Chedraui P, Pérez-López FR, Sánchez H, Aguirre W, Martínez N, Miranda O, et al. Assessment of sexual function of mid-aged Ecuadorian women with the 6-item Female Sexual Function Index. Maturitas [Internet]. 2012;71(4):407–12. Available from: http://dx.doi.org/10.1016/j.maturitas.2012.01.013Espitia-De La Hoz FJ. Prevalence and characterisation of sexual dysfunctions in women, in 12 Colombian cities, 2009-2016. Rev Colomb Obstet Ginecol. 2018;69(1):9–21.Basson R, Berman J, Burnett A, Derogatis L, Ferguson D, Fourcroy J, et al. Report of the international consensus development conference on female sexual dysfunction: Definitions and classifications. J Urol. 2000;163(3):888–93.Nce N. Neuroscience. 5th Edition. 5th Editio. Sinauer; 2013.Munarriz R, Kim NN, Goldstein I, Traish AM. Biology of female sexual function. Urol Clin North Am. 2002;29(3):685–93.Panicker JN, Fowler CJ. Lower urinary tract dysfunction in patients with multiple sclerosis [Internet]. 1st ed. Vol. 130, Neurology of Sexual and Bladder Disorders. Elsevier B.V.; 2015. 371–381 p. Available from: http://dx.doi.org/10.1016/B978-0-444-63247-0.00021-3Yeung J, Pauls RN. Anatomy of the Vulva and the Female Sexual Response. Obstet Gynecol Clin North Am [Internet]. 2016;43(1):27–44. Available from: http://dx.doi.org/10.1016/j.ogc.2015.10.011Jeong GW, Park K, Youn G, Kang HK, Kim HJ, Seo JJ, et al. Assessment of cerebrocortical regions associated with sexual arousal in premenopausal and menopausal women by using BOLD-based functional MRI. J Sex Med. 2005;2(5):645–51.Meston CM, Hull E, Levin RJ, Sipski M. Disorders of Orgasm in Women. J Sex Med [Internet]. 2004 Jul;1(1):66–8. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1743609515300473Nusbaum MRH, Hamilton C, Lenahan P. Chronic Illness and Sexual Functioning. Am Fam Physician [Internet]. 2003;15(67(2)):347–54. Available from: https://www.aafp.org/afp/2003/0115/p347.htmlBartnik P, Wielgoś A, Kacperczyk J, Pisarz K, Szymusik I, Podlecka-Piętowska A, et al. Sexual dysfunction in female patients with relapsing-remitting multiple sclerosis. Brain Behav. 2017;7(6):1–7.Orasanu B, Frasure H, Wyman A, Mahajan ST. Sexual dysfunction in patients with multiple sclerosis. Mult Scler Relat Disord [Internet]. 2013;2(2):117–23. Available from: http://dx.doi.org/10.1016/j.msard.2012.10.005Ashtari F, Rezvani R, Afshar H. Sexual dysfunction in women with multiple sclerosis: Dimensions and contributory factors. J Res Med Sci [Internet]. 2014 Mar;19(3):228–33. Available from: https//www.ncbi.nlm.nih.gov/pmc/articles/PMC4061644/F F, B G. Introduction to intimacy and sexuality in MS. MS Focus. 2005;4(6):1–28.Fraser C, Mahoney J, McGurl J. Correlates of sexual dysfunction in men and women with multiple sclerosis. J Neurosci Nurs. 2008;40(5):312–7.De Santi L, Sessa E, Calabró RS. Sexual dysfunction in multiple sclerosis. Male Sex Dysfunctions Neurol Dis From Pathophysiol to Rehabil. 2011;93–104.Çelik DB, Poyraz EÇ, Bingöl A, İdiman E, Özakbaş S, Kaya D. Sexual dysfunction ın multiple sclerosis: Gender differences. J Neurol Sci [Internet]. 2013 Jan;324(1–2):17–20. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0022510X12004686Thompson AJ, Toosy AT, Ciccarelli O. Pharmacological management of symptoms in multiple sclerosis: Current approaches and future directions. Lancet Neurol [Internet]. 2010;9(12):1182–99. Available from: http://dx.doi.org/10.1016/S1474-4422(10)70249-0Foley FW, LaRocca NG, Sanders AS, Zemon V. Rehabilitation of intimacy and sexual dysfunction in couples with multiple sclerosis. Mult Scler. 2001;7(6):417–21.Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, et al. The female sexual function index (Fsfi): A multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther. 2000;26(2):191–205.Vallejo-Medina P, Pérez-Durán C, Saavedra-Roa A. Translation, Adaptation, and Preliminary Validation of the Female Sexual Function Index into Spanish (Colombia). Arch Sex Behav. 2018;47(3):797–810.Blümel M JE, Binfa E L, Cataldo A P, Carrasco V A, Izaguirre L H, Sarrá C S. Índice De Función Sexual Femenina: Un Test Para Evaluar La Sexualidad De La Mujer. Rev Chil Obstet Ginecol. 2004;69(2):118–25.Lew-Starowicz M, Rola R. Prevalence of sexual dysfunctions among women with multiple sclerosis. Sex Disabil. 2013;31(2):141–53.Ashtari F, Rezvani R, Afshar H. Sexual dysfunction in women with multiple sclerosis: Dimensions and contributory factors. J Res Med Sci. 2014;19(3):228–33InvestigadoresPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-84074https://repositorio.unal.edu.co/bitstream/unal/80654/1/license.txt8153f7789df02f0a4c9e079953658ab2MD51ORIGINAL1052397943.2021.pdf1052397943.2021.pdfTesis de Especialidad en Neurología Clínicaapplication/pdf5502186https://repositorio.unal.edu.co/bitstream/unal/80654/2/1052397943.2021.pdfb5b7db2cc60b8f49a46715af1f52afa0MD52THUMBNAIL1052397943.2021.pdf.jpg1052397943.2021.pdf.jpgGenerated Thumbnailimage/jpeg5116https://repositorio.unal.edu.co/bitstream/unal/80654/3/1052397943.2021.pdf.jpge56c3dcb73a12ca00acc8c31bf81d573MD53unal/80654oai:repositorio.unal.edu.co:unal/806542023-07-30 23:04:24.363Repositorio Institucional Universidad Nacional de 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