Dinámica de algunos virus respiratorios en dos granjas porcinas tecnificadas en el trópico alto colombiano
ilustraciones, diagramas
- Autores:
-
Tarazona Manrique, Luis Edgar
- Tipo de recurso:
- Fecha de publicación:
- 2024
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/85879
- Palabra clave:
- 590 - Animales::599 - Mamíferos
630 - Agricultura y tecnologías relacionadas::636 - Producción animal
Virus de los animales
Enfermedades respiratorias
Producción animal
Animal viruses
respiratory diseases
animal production
Análisis molecular
Complejo respiratorio porcino
Diagnóstico
Patógenos respiratorios
Virología
Molecular analysis
Porcine respiratory complex
Diagnosis
Respiratory Pathogens
Virology
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Dinámica de algunos virus respiratorios en dos granjas porcinas tecnificadas en el trópico alto colombiano |
| dc.title.translated.eng.fl_str_mv |
Dynamics of some respiratory viruses in two techinified pig farms in the Colombian high tropics |
| title |
Dinámica de algunos virus respiratorios en dos granjas porcinas tecnificadas en el trópico alto colombiano |
| spellingShingle |
Dinámica de algunos virus respiratorios en dos granjas porcinas tecnificadas en el trópico alto colombiano 590 - Animales::599 - Mamíferos 630 - Agricultura y tecnologías relacionadas::636 - Producción animal Virus de los animales Enfermedades respiratorias Producción animal Animal viruses respiratory diseases animal production Análisis molecular Complejo respiratorio porcino Diagnóstico Patógenos respiratorios Virología Molecular analysis Porcine respiratory complex Diagnosis Respiratory Pathogens Virology |
| title_short |
Dinámica de algunos virus respiratorios en dos granjas porcinas tecnificadas en el trópico alto colombiano |
| title_full |
Dinámica de algunos virus respiratorios en dos granjas porcinas tecnificadas en el trópico alto colombiano |
| title_fullStr |
Dinámica de algunos virus respiratorios en dos granjas porcinas tecnificadas en el trópico alto colombiano |
| title_full_unstemmed |
Dinámica de algunos virus respiratorios en dos granjas porcinas tecnificadas en el trópico alto colombiano |
| title_sort |
Dinámica de algunos virus respiratorios en dos granjas porcinas tecnificadas en el trópico alto colombiano |
| dc.creator.fl_str_mv |
Tarazona Manrique, Luis Edgar |
| dc.contributor.advisor.spa.fl_str_mv |
Jaime Correa, Jairo Aureliano |
| dc.contributor.author.spa.fl_str_mv |
Tarazona Manrique, Luis Edgar |
| dc.contributor.researchgroup.spa.fl_str_mv |
Centro de investigación en infectología e inmunología veterinaria - CI3V |
| dc.contributor.orcid.spa.fl_str_mv |
https://orcid.org/0000-0003-2819-0582 |
| dc.contributor.cvlac.spa.fl_str_mv |
https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000169270 |
| dc.contributor.scopus.spa.fl_str_mv |
http://www.scopus.com/inward/authorDetails.url?authorID=57219535130&partnerID=MN8TOARS |
| dc.contributor.researchgate.spa.fl_str_mv |
https://www.researchgate.net/profile/Luis-Tarazona-Manrique |
| dc.contributor.googlescholar.spa.fl_str_mv |
https://scholar.google.es/citations?user=ZLYqyhoAAAAJ&hl=es |
| dc.subject.ddc.spa.fl_str_mv |
590 - Animales::599 - Mamíferos 630 - Agricultura y tecnologías relacionadas::636 - Producción animal |
| topic |
590 - Animales::599 - Mamíferos 630 - Agricultura y tecnologías relacionadas::636 - Producción animal Virus de los animales Enfermedades respiratorias Producción animal Animal viruses respiratory diseases animal production Análisis molecular Complejo respiratorio porcino Diagnóstico Patógenos respiratorios Virología Molecular analysis Porcine respiratory complex Diagnosis Respiratory Pathogens Virology |
| dc.subject.agrovoc.spa.fl_str_mv |
Virus de los animales Enfermedades respiratorias Producción animal |
| dc.subject.agrovoc.eng.fl_str_mv |
Animal viruses respiratory diseases animal production |
| dc.subject.proposal.spa.fl_str_mv |
Análisis molecular Complejo respiratorio porcino Diagnóstico Patógenos respiratorios Virología |
| dc.subject.proposal.eng.fl_str_mv |
Molecular analysis Porcine respiratory complex Diagnosis Respiratory Pathogens Virology |
| description |
ilustraciones, diagramas |
| publishDate |
2024 |
| dc.date.accessioned.none.fl_str_mv |
2024-04-08T19:03:14Z |
| dc.date.available.none.fl_str_mv |
2024-04-08T19:03:14Z |
| dc.date.issued.none.fl_str_mv |
2024-03-13 |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Maestría |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/masterThesis |
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info:eu-repo/semantics/acceptedVersion |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/TM |
| status_str |
acceptedVersion |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.unal.edu.co/handle/unal/85879 |
| dc.identifier.instname.spa.fl_str_mv |
Universidad Nacional de Colombia |
| dc.identifier.reponame.spa.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
| dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.unal.edu.co/ |
| url |
https://repositorio.unal.edu.co/handle/unal/85879 https://repositorio.unal.edu.co/ |
| identifier_str_mv |
Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
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spa |
| language |
spa |
| dc.relation.indexed.spa.fl_str_mv |
Agrosavia Agrovoc |
| dc.relation.references.spa.fl_str_mv |
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Transboundary and Emerging Diseases, 68(6), 2949–2956. https://doi.org/10.1111/tbed.14238 Baudon, E., Peyre, M., Peiris, M., & Cowling, B. J. (2017). Epidemiological features of influenza circulation in swine populations: A systematic review and meta-analysis. In PLoS ONE (Vol. 12, Issue 6). Public Library of Science. https://doi.org/10.1371/journal.pone.0179044 Bjustrom-Kraft, J., Christopher-Hennings, J., Daly, R., Main, R., Torrison, J., Thurn, M., & Zimmerman DVM, J. (2018). The use of oral fluid diagnostics in swine medicine. Journal of Swine Health and Production, 26(5), 262–269. http://www.aasv.org/shap.html. Brockmeier, S. L., Halbur, P. G., & Thacker, E. L. (2002). PORCINE RESPIRATORY DISEASE COMPLEX. In Polymicrobial diseases Canelli, E., Borghetti, P., Ferrari, L., De Angelis, E., Ferrarini, G., Catella, A., Ogno, G., & Martelli, P. (2016). Immune response to PCV2 vaccination in PRRSV viraemic piglets. 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(2006). PREVALENCIA SEROLÓGICA DEL SÍNDROME REPRODUCTIVO Y RESPIRATORIO PORCINO (PRRS) EN CERDOS DE EXPLOTACIONES EXTENSIVAS DE COLOMBIA. Revista de La Facultad de Medicina Veterinaria y de Zootecnia, 53(1), 33–41. https://revistas.unal.edu.co/index.php/remevez/article/view/17799 Cságola, A., Zádori, Z., Mészáros, I., & Tuboly, T. (2016). Detection of Porcine Parvovirus 2 (Ungulate Tetraparvovirus 3) Specific Antibodies and Examination of the Serological Profile of an Infected Swine Herd. PLoS ONE, 11(3). https://doi.org/10.1371/journal.pone.0151036 Diaz, A., Marthaler, D., Culhane, M., Sreevatsan, S., Alkhamis, M., Torremorell, M., Schultz-Cherry, S., & Jude, S. (2017). Complete Genome Sequencing of Influenza A Viruses within Swine Farrow-to-Wean Farms Reveals the Emergence, Persistence, and Subsidence of Diverse Viral Genotypes. 91, 745–762. https://doi.org/10.1128/JVI Duinhof, T. F., van Schaik, G., van Esch, E. J. B., & Wellenberg, G. J. (2011). Detection of PRRSV circulation in herds without clinical signs of PRRS: Comparison of five age groups to assess the preferred age group and sample size. Veterinary Microbiology, 150(1–2), 180–184. https://doi.org/10.1016/J.VETMIC.2011.01.001 Espinoza, A. C., & Velásquez, M. R. (2021). Porcine reproductive and respiratory syndrome: A review of the etiological agent and its influence on the current behaviour of the disease. Revista de Investigaciones Veterinarias Del Peru, 32(1). https://doi.org/10.15381/RIVEP.V32I1.19645 Figueras-Gourgues, S., Fraile, L., Segalés, J., Hernández-Caravaca, I., López-Úbeda, R., García-Vázquez, F. A., Gomez-Duran, O., & Grosse-Liesner, B. (2019). Effect of Porcine circovirus 2 (PCV-2) maternally derived antibodies on performance and PCV-2 viremia in vaccinated piglets under field conditions. Porcine Health Management, 5(1). https://doi.org/10.1186/s40813-019-0128-7 Flórez R, J., Vera A, V., Lora M, Á., & Ramírez-Nieto, G. (2018). Evaluación molecular de la presencia del virus de influenza A en cerdos en plantas de beneficio en Colombia. Revista MVZ Córdoba, 23(S), 7013–7024. https://doi.org/10.21897/rmvz.1424 Franzo, G., & Segalés, J. (2020). Porcine circovirus 2 genotypes, immunity and vaccines: Multiple genotypes but one single serotype. In Pathogens (Vol. 9, Issue 12, pp. 1–12). MDPI AG. https://doi.org/10.3390/pathogens9121049 Gainor, K., Fortuna, Y. C., Alakkaparambil, A. S., González, W., Malik, Y. S., & Ghosh, S. (2023). Detection and Complete Genomic Analysis of Porcine circovirus 3 (PCV3) in Diarrheic Pigs from the Dominican Republic: First Report on PCV3 from the Caribbean Region. Pathogens, 12(2). https://doi.org/10.3390/pathogens12020250 Gale, C., Velazquez, E., & Pattison, E. (2020). The impact of swine influenza and how to control it on farm. Livestock, 25(2), 105–110. https://doi.org/10.12968/live.2020.25.2.105 Garrido-Mantilla, J., Culhane, M. R., & Torremorell, M. (2020). Transmission of influenza A virus and porcine reproductive and respiratory syndrome virus using a novel nurse sow model: A proof of concept. Veterinary Research, 51(1). https://doi.org/10.1186/s13567-020-00765-1 Grau-Roma, L., Hjulsager, C. K., Sibila, M., Kristensen, C. S., López-Soria, S., Enøe, C., Casal, J., Bøtner, A., Nofrarías, M., Bille-Hansen, V., Fraile, L., Baekbo, P., Segalés, J., & Larsen, L. E. (2009). Infection, excretion and seroconversion dynamics of porcine circovirus type 2 (PCV2) in pigs from post-weaning multisystemic wasting syndrome (PMWS) affected farms in Spain and Denmark. Veterinary Microbiology, 135(3–4), 272–282. https://doi.org/10.1016/j.vetmic.2008.10.007 Gray, G., McCarthy, T., Capuano, A., Setterquist, S., Olsen, C., Alavanja, M., & Lynch, C. (2007). Swine workers and swine influenza virus infections. Emerging Infectious Diseases, 13(12), 1871–1878. Guo, K., Xu, L., Wu, M., Hou, Y., Jiang, Y., Lv, J., Xu, P., Fan, Z., Zhang, R., Xing, F., & Zhang, Y. (2019). A host factor GPNMB restricts porcine circovirus type 2 (PCV2) replication and interacts with PCV2 ORF5 protein. Frontiers in Microbiology, 10(JAN). https://doi.org/10.3389/fmicb.2018.03295 Guo, Z., Ruan, H., Qiao, S., Deng, R., & Zhang, G. (2020). Co-infection status of porcine circoviruses (PCV2 and PCV3) and porcine epidemic diarrhea virus (PEDV) in pigs with watery diarrhea in Henan province, central China: Co-infection of PCV2, PCV3 and PEDV. Microbial Pathogenesis, 142. https://doi.org/10.1016/j.micpath.2020.104047 Karlsson, E. A., Ciuoderis, K., Freiden, P. J., Seufzer, B., Jones, J. C., Johnson, J., Parra, R., Gongora, A., Cardenas, D., Barajas, D., Osorio, J. E., & Schultz-Cherry, S. (2013). Prevalence and characterization of influenza viruses in diverse species in Los Llanos, Colombia. 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Porcine Circovirus Type 2 ORF5 Protein Induces Autophagy to Promote Viral Replication via the PERK-eIF2α-ATF4 and mTOR-ERK1/2-AMPK Signaling Pathways in PK-15 Cells. Frontiers in Microbiology, 11. https://doi.org/10.3389/fmicb.2020.00320 Ma, Z., Liu, M., Liu, Z., Meng, F., Wang, H., Cao, L., Li, Y., Jiao, Q., Han, Z., & Liu, S. (2021). Epidemiological investigation of porcine circovirus type 2 and its coinfection rate in Shandong province in China from 2015 to 2018. BMC Veterinary Research, 17(1). https://doi.org/10.1186/s12917-020-02718-4 Maisonnasse, P., Bouguyon, E., Piton, G., Ezquerra, A., Urien, C., Deloizy, C., Bourge, M., Leplat, J. J., Simon, G., Chevalier, C., Vincent-Naulleau, S., Crisci, E., Montoya, M., Schwartz-Cornil, I., & Bertho, N. (2016). The respiratory DC/macrophage network at steady-state and upon influenza infection in the swine biomedical model. Mucosal Immunology, 9(4), 835–849. https://doi.org/10.1038/mi.2015.105 Mancipe, L. F., Ramírez-Nieto, G., Vera, V., & Jaime, J. (2014). Association of swine influenza H1N1 pandemic virus (SIV-H1N1p) with porcine respiratory disease complex in sows from commercial pig farms in Colombia. Virologica Sinica, 29(4), 242–249. https://doi.org/10.1007/s12250-014-3471-5 Mendoza Niño, E. (2015). Detección y caracterización del virus del Síndrome Reproductivo y Respiratorio Porcino en tres granjas de producción intensiva para el establecimiento del control local de la enfermedad. Miłek, D., Woźniak, A., Guzowska, M., & Stadejek, T. (2019). Detection patterns of porcine parvovirus (PPV) and novel porcine parvoviruses 2 through 6 (PPV2–PPV6) in Polish swine farms. Viruses, 11(5). https://doi.org/10.3390/v11050474 Nelsen, A., Lin, C. M., & Hause, B. M. (2021). Porcine Parvovirus 2 Is Predominantly Associated With Macrophages in Porcine Respiratory Disease Complex. Frontiers in Veterinary Science, 8. https://doi.org/10.3389/fvets.2021.726884 Nišavić, J., Milić, N., Radalj, A., Krnjaić, D., Milićević, D., Knežević, A., Radojičić, M., Obrenović, S., Ćosić, M., Tešović, B., Benković, D., & Živulj, A. (2021). Genetic Analysis and Distribution of Porcine Parvoviruses Detected in the Organs of Wild Boars in Serbia. Acta Veterinaria, 71(1), 32–46. https://doi.org/10.2478/acve-2021-0003 Novosel, D., Cadar, D., Tuboly, T., Jungic, A., Stadejek, T., Ait-Ali, T., & Cságola, A. (2018). Investigating porcine parvoviruses genogroup 2 infection using in situ polymerase chain reaction. BMC Veterinary Research, 14(1). https://doi.org/10.1186/s12917-018-1487-z Nurhayati, Wibawa, H., Mahawan, T., Zenal, F. C., Schoonman, L., Pfeiffer, C. N., Stevenson, M., & Punyapornwithaya, V. (2020). Herd-Level Risk Factors for Swine Influenza (H1N1) Seropositivity in West Java and Banten Provinces of Indonesia (2016–2017). Frontiers in Veterinary Science, 7. https://doi.org/10.3389/fvets.2020.544279 Opriessnig, T., & Halbur, P. G. (2012). Concurrent infections are important for expression of porcine circovirus associated disease. In Virus Research (Vol. 164, Issues 1–2, pp. 20–32). https://doi.org/10.1016/j.virusres.2011.09.014 Opriessnig, T., Karuppannan, A. K., Halbur, P. G., Calvert, J. G., Nitzel, G. P., Matzinger, S. R., & Meng, X. J. (2020). Porcine circovirus type 2a or 2b based experimental vaccines provide protection against PCV2d/porcine parvovirus 2 co-challenge. Vaccine, 38(8), 1975–1981. https://doi.org/10.1016/j.vaccine.2020.01.013 Osorio-Zambrano, W., Ospina-Jimenez, A., Alvarez-Muñoz, S., Gomez, A., & Ramirez-Nieto, G. C. (2022). Zooming in on the molecular characteristics of swine influenza virus circulating in Colombia before and after the H1N1pdm09 virus. Frontiers in Veterinary Science, 9, 01–12. https://doi.org/doi: 10.3389/fvets.2022.983304 Ouyang, T., Zhang, X., Liu, X., & Ren, L. 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Transboundary and Emerging Diseases, 68(6), 2936–2948. https://doi.org/10.1111/tbed.14204 Sarli, G., D’annunzio, G., Gobbo, F., Benazzi, C., & Ostanello, F. (2021). The role of pathology in the diagnosis of swine respiratory disease. Veterinary Sciences, 8(11). https://doi.org/10.3390/vetsci8110256 Schuele, L., Lizarazo-Forero, E., Cassidy, H., Strutzberg-Minder, K., Boehmer, J., Schuetze, S., et al. (2021). First detection of porcine respirovirus 1 in Germany and the Netherlands. Transbound. Emerg. Dis. 68. doi:10.1111/tbed.14100. Segalés, J., Allan, G., & Domingo, M. (2019). Chapter 30 Circoviruses. In J. Zimmerman, L. Karriker, A. Ramírez, K. Schwartz, G. Stevenson, & J. Zhang (Eds.), Diseases of Swine (Eleventh Edition, pp. 473–487). John Wiley & Sons, Inc. https://doi.org/https://doi.org/10.1002/9781119350927.ch30 Segalés, J., Valero, O., Espinal, A., López-Soria, S., Nofrarías, M., Calsamiglia, M., & Sibila, M. (2012). Exploratory study on the influence of climatological parameters on Mycoplasma hyopneumoniae infection dynamics. International Journal of Biometeorology, 56(6), 1167–1171. https://doi.org/10.1007/s00484-011-0487-5 Sha, H., Zhang, H., Chen, Y., Huang, L., Zhao, M., & Wang, N. (2022). Research Progress on the NSP9 Protein of Porcine Reproductive and Respiratory Syndrome Virus. Frontiers in Veterinary Science, 9. https://doi.org/10.3389/fvets.2022.872205 Shang, S. bin, Jin, Y. L., Jiang, X. tao, Zhou, J. Y., Zhang, X., Xing, G., He, J. L., & Yan, Y. (2009). Fine mapping of antigenic epitopes on capsid proteins of porcine circovirus, and antigenic phenotype of porcine circovirus Type 2. Molecular Immunology, 46(3), 327–334. https://doi.org/10.1016/j.molimm.2008.10.028 Shen, H., Liu, X., Zhang, P., Wang, S., Liu, Y., Zhang, L., & Song, C. (2020). Porcine circovirus 3 Cap inhibits type I interferon signaling through interaction with STAT2. Virus Research, 275, 197804. https://doi.org/10.1016/J.VIRUSRES.2019.197804 Shen, W., Wang, Z., Ning, K., Cheng, F., Engelhardt, J. F., Yan, Z., & Qiu, J. (2021). Hairpin Transfer-Independent Parvovirus DNA Replication Produces Infectious Virus. Journal of Virology, 95(20). https://doi.org/10.1128/jvi.01108-21 Shi, C., Liu, Y., Ding, Y., Zhang, Y., & Zhang, J. (2015). PRRSV receptors and their roles in virus infection. In Archives of Microbiology (Vol. 197, Issue 4, pp. 503–512). Springer Verlag. https://doi.org/10.1007/s00203-015-1088-1 Shi, R., Hou, L., Wei, L., Quan, R., Zhou, B., Jiang, H., Wang, J., Zhu, S., Song, J., Wang, D., & Liu, J. (2021). Porcine Circovirus Type 3 Enters Into PK15 Cells Through Clathrin- and Dynamin-2-Mediated Endocytosis in a Rab5/Rab7 and pH-Dependent Fashion. Frontiers in Microbiology, 12. https://doi.org/10.3389/fmicb.2021.636307 Shin, G.-E., Park, J.-Y., Lee, K.-K., Ko, M.-K., Ku, B.-K., Park, C.-K., & Jeoung, H.-Y. (2022). 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Archives of Virology, 154(5), 887–890. https://doi.org/10.1007/s00705-009-0381-1 Taubenberger, J. K., & Morens, D. M. (2008). The pathology of influenza virus infections. Annual Review of Pathology: Mechanisms of Disease, 3, 499–522. https://doi.org/10.1146/annurev.pathmechdis.3.121806.154316 Turlewicz-Podbielska, H., Włodarek, J., & Pomorska-Mól, M. (2020). Noninvasive strategies for surveillance of swine viral diseases: a review. Journal of Veterinary Diagnostic Investigation, 32(4), 503–512. https://doi.org/10.1177/1040638720936616 Vasin, A. v., Temkina, O. A., Egorov, V. v., Klotchenko, S. A., Plotnikova, M. A., & Kiselev, O. I. (2014). Molecular mechanisms enhancing the proteome of influenza A viruses: An overview of recently discovered proteins. In Virus Research (Vol. 185, pp. 53–63). Elsevier. https://doi.org/10.1016/j.virusres.2014.03.015 Vilalta, C., Sanhueza, J., Garrido, J., Murray, D., Morrison, R., Corzo, C. A., & Torremorell, M. (2019). Indirect assessment of porcine reproductive and respiratory syndrome virus status in pigs prior to weaning by sampling sows and the environment. Veterinary Microbiology, 237. https://doi.org/10.1016/j.vetmic.2019.108406 Vincent, A. L., Ma, W., Lager, K. M., Janke, B. H., & Richt, J. A. (2008). Chapter 3 Swine Influenza Viruses. A North American Perspective. Advances in Virus Research, 72, 127154. https://doi.org/10.1016/S0065-3527(08)00403-X Wang, Q., Sun, Z., Li, J., Qin, T., Ma, H., Chen, S., Peng, D., & Liu, X. (2021). Identification of a universal antigen epitope of influenza A virus using peptide microarray. BMC Veterinary Research, 17(1). https://doi.org/10.1186/s12917-020-02725-5 Wang, R., & Zhang, Y. J. (2014). Antagonizing interferon-mediated immune response by porcine reproductive and respiratory syndrome virus. BioMed Research International, 2014. https://doi.org/10.1155/2014/315470 Wang, Y., Noll, L., Porter, E., Stoy, C., Dong, J., Anderson, J., Fu, J., Pogranichniy, R., Woodworth, J., Peddireddi, L., & Bai, J. (2020). Development of a differential multiplex realtime PCR assay for porcine circovirus type 2 (PCV2) genotypes PCV2a, PCV2b and PCV2d. Journal of https://doi.org/10.1016/j.jviromet.2020.113971 Welch, M., Park, J., Gauger, P., Harmon, K., Lin, K., Piñeyro, P., Zhang, J. (2017). Porcine Parainfluenza Virus Type 1 (PPIV-1) in U.S. swine: summary of veterinary diagnostic laboratory data. Iowa State University https://www.iastatedigitalpress.com/air/article/id/5961/ Welch, M., Park, J., Harmon, K., Zhang, J., Piñeyro, P., Giménez-Lirola, L., et al. (2021). Pathogenesis of a novel porcine parainfluenza virus type 1 isolate in conventional and colostrum deprived/caesarean derived pigs. Virol. 563. doi:10.1016/j.virol.2021.08.015. Wozniak, A., Cybulski, P., Denes, L., Balka, G., Stadejek, T. (2022). Detection of porcine respirovirus 1 (PRV1) in Poland: incidence of co-infections with influenza a virus (IAV) and Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) in herds with a respiratory disease. Viruses.14:148. doi:10.3390/v14010148. Xiao, C. T., Gerber, P. F., Giménez-Lirola, L. G., Halbur, P. G., & Opriessnig, T. (2013). Characterization of porcine parvovirus type 2 (PPV2) which is highly prevalent in the USA. Veterinary Microbiology, 161(3–4), 325–330. https://doi.org/10.1016/j.vetmic.2012.07.038 Xu, H., Li, C., Li, W., Zhao, J., Gong, B., Sun, Q., Tang, Y. D., Xiang, L., Leng, C., Peng, J., Wang, Q., Meng, F., Yu, Y., An, T., Cai, X., Tian, Z. J., & Zhang, H. (2022). Novel characteristics of Chinese NADC34-like PRRSV during 2020–2021. Transboundary and Emerging Diseases. https://doi.org/10.1111/tbed.14485 Xu, P. L., Zhang, Y., Zhao, Y., Zheng, H. H., Han, H. Y., Zhang, H. X., Chen, H. Y., Yang, M. F., & Zheng, L. L. (2018). Detection and phylogenetic analysis of porcine circovirus type 3 central China. Transboundary and Emerging Diseases, 65(5), 1163–1169. https://doi.org/10.1111/tbed.12920 Xu, Y., Ye, M., Sun, S., Cao, Q., Luo, J., Wang, Y., Zheng, W., Meurens, F., Chen, N., & Zhu, J. (2022). CD163-Expressing Porcine Macrophages Support NADC30-like and NADC34-like PRRSV Infections. Viruses, 14(9), 2056. https://doi.org/10.3390/v14092056 Yao, J., Qin, Y., Zeng, Y., Ouyang, K., Chen, Y., Huang, W., & Wei, Z. (2019). Genetic analysis of porcine circovirus type 2 (PCV2) strains between 2002 and 2016 reveals PCV2 mutant predominating in porcine population in Guangxi, China. BMC Veterinary Research, 15(1). https://doi.org/10.1186/s12917-019-1859-z Yaeger, M., & van Alstine, W. (2019). Respiratory System. In J. Zimmerman, L. Karriker, A. Ramírez, K. Schuwartz, G. Stevenson, & J. Zhang (Eds.), Diseases of Swine (11th ed., Vol. 1, pp. 393–407). John Wiley & Son. Yang, L., & Zhang, Y. J. (2017). Antagonizing cytokine-mediated JAK-STAT signaling by porcine reproductive and respiratory syndrome virus. Veterinary Microbiology, 209, 57–65. https://doi.org/10.1016/j.vetmic.2016.12.036 Yang, S., Zhang, D., Ji, Z., Zhang, Y., Wang, Y., Chen, X., He, Y., Lu, X., Li, R., Guo, Y., Shen, Q., Ji, L., Wang, X., Li, Y., & Zhang, W. (2022). Viral Metagenomics Reveals Diverse Viruses in Tissue Samples of Diseased Pigs. Viruses, 14(9), 2048. https://doi.org/10.3390/v14092048 Ye, X., Berg, M., Fossum, C., Wallgren, P., & Blomström, A. L. (2018). Detection and genetic characterisation of porcine circovirus 3 from pigs in Sweden. Virus Genes, 54(3), 466–469. https://doi.org/10.1007/s11262-018-1553-4 Zepeda-Cervantes, J., Cruz-Reséndiz, A., Sampieri, A., Carreón-Nápoles, R., SánchezBetancourt, J. I., & Vaca, L. (2019). 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Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Jaime Correa, Jairo Aureliano8cc0127ec9c208df6d04bfba649e1f39Tarazona Manrique, Luis Edgar6e51fcad78a7bcbdb824e72cf22f1796600Centro de investigación en infectología e inmunología veterinaria - CI3Vhttps://orcid.org/0000-0003-2819-0582https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000169270http://www.scopus.com/inward/authorDetails.url?authorID=57219535130&partnerID=MN8TOARShttps://www.researchgate.net/profile/Luis-Tarazona-Manriquehttps://scholar.google.es/citations?user=ZLYqyhoAAAAJ&hl=es2024-04-08T19:03:14Z2024-04-08T19:03:14Z2024-03-13https://repositorio.unal.edu.co/handle/unal/85879Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasEl complejo respiratorio porcino (PCR) es una entidad multifactorial que afecta negativamente a los cerdos en todas las etapas productivas, su variado comportamiento requiere un estudio particular en cada país y región geográfica. Este trabajo tuvo como objetivo determinar la dinámica de algunos virus respiratorios relacionados con la PCR en dos fincas del trópico alto colombiano, una positiva para PRRSV y la otra negativa. Se realizó un estudio longitudinal entre marzo y septiembre de 2022. Se hicieron tres muestreos bimensuales por granja donde se colectaron muestras de fluidos orales, piso de maternidad, glándulas mamarias, comederos, objetos de enriquecimiento ambiental y suero de cerdos ubicados en las etapas de predestete, preceba, finalización. Se hizo detección de virus asociados con el CRP (PPRSV, SIV-A, PCV2, PCV3, PPV2 y PPIV-1) por técnicas de PCR y RT-PCT junto con qPCR. Se encontró que los virus circulan en las dos granjas en todas las etapas productivas de forma de mono y copresencias, siendo las de tipo doble y triple las más frecuentes y se asociaron con la presencia de PRRSV. Se evaluaron y asociaron variables climáticas con la dinámica viral encontrándose que estas se correlacionaron con la presencia de virus como PCV3 y PPV2, este último incrementó la mortalidad y retrasó el crecimiento de los cerdos. Los análisis de secuenciación de PPV2 muestran que pertenece al clado 1. Este es un estudio pionero para el país que contribuye a entender cómo se comportan los virus asociados al CRP en condiciones propias de Colombia como lo es en el trópico alto (entre 1500 y 2000 msnm), ese comportamiento se complementa estableciendo las copresencias y coinfecciones virales más importantes abriendo toda una línea de investigación sobre la temática del efecto de simultaneidad infecciosa en las granjas de producción de cerdo en Colombia. (Texto tomado de la fuente).The porcine respiratory complex (PRC) is a multifactorial entity that negatively affects pigs in all productive stages; its varied behavior requires a particular study in each country and geographical region. This work aimed to determine the dynamics of some respiratory viruses related to PRC in two farms in the Colombian high tropics, one positive for PRRSV and the other negative. A longitudinal study was carried out between March and September 2022. Three bimonthly samplings were carried out per farm, collecting samples of oral fluids, farrowing floor, mammary glands, feeders, environmental enrichment objects, and serum from pigs in the pre-weaning, pre-fattening, and fattening stages. PCR and RT-PCT techniques and qPCR detected viruses associated with PRC (PPRSV, SIV-A, PCV2, PCV3, PPV2, and PPIV-1). It was found that the viruses circulating in the two farms in all the productive stages in a mono and co-presence form, being the double and triple types the most frequent and were associated with the presence of PRRSV. Climatic variables were evaluated and associated with viral dynamics, finding that these correlated with viruses such as PCV3 and PPV2. The latter increased mortality and retarded the growth of pigs. Sequencing analyses of PPV2 show that it belongs to clade 1. This pioneering study for the country contributes to understanding how CRP-associated viruses behave in Colombian conditions, such as in the high tropics (between 1,500 and 2,000 masl). This behavior is complemented by establishing viral co-presences and coinfections. Most important, opening a whole line of research on the effect of infectious simultaneity in pig production farms in Colombia.La universidad financió el proyecto a través de convocatorias internas de apoyo a tesis de maestríaMaestríaMagíster en Salud Animal o Magíster en Producción AnimalSe realizó un estudio de tipo longitudinal, estratificado y comparativo en dos granjas tecnificadas ubicadas en el trópico alto colombiano durante el período comprendido entre marzo y septiembre del 2022. El estudio se realizó en el departamento de Cundinamarca, las dos granjas están ubicadas en municipios distintos, pero a altitudes similares, así: i) granja 1 (G1): ubicada a una altitud de 1350 msnm; y, ii) granja 2 (G2): ubicada a 1600 msnm, es decir, las dos están en la altura conocida como trópico alto colombiano (entre 1000 y 2000 msnm). La distancia entre las granjas y el laboratorio de virología y biología molecular de la Facultad de Medicina Veterinaria y de Zootecnia de la Universidad Nacional de Colombia no superaba los 60 kilómetros; y entre ellas, la distancia era de 91.5 kilómetros. Las granjas fueron seleccionadas por conveniencia (teniendo en cuenta el deseo manifiesto por los propietarios y veterinarios de participar en el estudio). Las dos granjas manejaban un sistema productivo de ciclo completo con sistema de flujo continuo (G1) y en bandas (G2) y contaban con un inventario total de 150 madres cada una; el fin productivo de las dos granjas es la cría, levante y finalización de cerdos destinados al faenado para consumo humano. El factor diferencial entre granjas fue que G1 tiene un registro histórico de la ausencia de PRRSV por diagnostico serológico (ELISA) mientras que la G2 tiene un registro histórico de presencia de PRRSV también por pruebas serológicas. Es importante señalar que en Colombia no se vacuna contra PRRSV Tomando en cuenta el sistema productivo de ciclo completo la población a evaluar fue dividida en cuatro diferentes etapas, así: (i) cerdos en pre-destete (PD: menos de 21 días de vida), (ii) pre-ceba (PC: 7 - 10 semanas de edad), (iii) ceba (CC: 12 - 15 semanas de edad) y (iv) finalización (CF: 18 - 22 semanas de edad); lo anterior basados en estudios previos del grupo de investigación (Mendoza, 2015) y lo recomendado por (Vilalta et al., 2018; 2019). Se realizó un muestreo longitudinal estratificado con una periodicidad bimensual por seis meses, es decir tres muestreos por granja. En G1, el primer muestreo fue el 14/03/2022, el segundo muestreo ocurrió el 08/06/2022 y se finalizó el 23/08/2022. Por su parte, el muestreo en G2 fue: inició el 22/04/2022, segundo muestreo el 29/06/2022 y el tercer muestreo en 07/09/2022. Dentro de los periodos climáticos de Colombia, los dos primeros muestreos para cada granja ocurrieron durante el primer período de lluvias que tiene el país (marzo-junio); mientras que el tercer muestreo se hizo durante el denominado período seco (ausencia de lluvias, agosto - septiembre). Se determinó un mínimo de tiempo entre cada muestreo entre granjas de 15 días con el fin de prevenir la contaminación de patógenos de una a la otra, así mismo, los materiales fueron preparados para cada muestreo y ningún sobrante de material utilizado en una granja fue llevado a la otra. Es necesario aclarar que no se evaluaron los mismos cerdos en cada muestreo en cada granja, sino que se tomaron muestras de animales que se encontraban en la etapa de desarrollo planteada para el muestro Los virus que se evaluaron en cada granja fueron: virus del síndrome respiratorio y reproductivo porcino (PRRSV), circovirus porcino tipo 2 (PCV2), circovirus porcino tipo 3 (PCV3), el virus de la influenza porcina (SIV) tipo A, Parvovirus porcino 2 (PPV2) y Parainfluenza porcina tipo 1 (PPIV-1). PCR A PUNTO FINAL: esta técnica se empleó para la detección molecular de SIV-A y PPV2 utilizando la enzima Taq Polimerasa Recombinante de Invitrogen® utilizando el siguiente protocolo: denaturación inicial a 94 °C durante 1 min, seguido por 38 ciclos cada uno con una denaturación a 94 °C durante 5 min, alineación a 57 °C durante 30 segundos (seg) y, extensión a 72 °C durante 1 min. La obtención de los fragmentos genómicos para secuenciación de los virus de las muestras positivas se realizó utilizando el siguiente protocolo: denaturación inicial a 98°C durante 1 min, seguido por 35 ciclos, cada uno con una denaturación a 98°C durante 15 seg, alineación a 57°C durante 30 seg y, extensión a 72°C durante 40 seg, utilizando la enzima Q5 High-Fidelity DNA polymerase. Esto se realizó en el equipo Bio-Rad C-1000 Touch. Luego de la PCR, los amplicones fueron visualizados en un gel de agarosa al 1.5%. qPCR: esta técnica se empleó para la detección molecular y la cuantificación de cargas de PRRSV, PCV2, PCV3, SIV-A y PPIV-1. Cada uno de estos agentes fue detectado utilizando primers y sondas específicas utilizadas y validadas en el laboratorio. El protocolo utilizado fue el siguiente: denaturación inicial a 95 °C durante 10 min, seguida de 42 ciclos con una denaturación a 95 °C por 15 seg, alineación a 60°C por 45 seg, extensión (detección de fluorescencia) a 72°C por 2 segundos a 530- 560 nm, y un ciclo final de 40°C por 30 seg. Empleando primers para secuenciación, se intentó la secuenciación parcial de genomas virales: PRRSV (ORF-5); PCV2 (Cap), PCV3 (Cap), SIV-A (H1-H3-H5-N1-N2), PPV2 (VP2). Con esto se realizó genotipificación de los virus encontrados. Esta secuenciación se realizó empleando el método de Sanger en el Servicio de Secuenciación y Análisis Molecular – SsiGMoL de la Universidad Nacional de Colombia. Las secuencias obtenidas fueron curadas empleando el programa Bioedit® y se realizó filogenia empleando MEGA7® comparando las secuencias obtenidas con las reportadas en las bases de datos (GenBank) utilizando el método estadístico “Maximun Likelihood”, con el método de filogenia de “Bootstrap” con 1000 réplicas, el método de inferencia Tamura-3 y el análisis “Gamma Distributed With Invariant Sites (G+I)”. La modificación final del árbol se realizó utilizando el programa FigTree versión 1.4.4. Con los resultados obtenidos se determinó el porcentaje de positividad de cada virus en cada granja, como también el porcentaje de positividad de cada una de las diferentes copresencias virales posibles. Aquí es importante aclarar que el termino rutinario empleado para la presencia simultánea de patógenos en un individuo es “coinfección”. En el presente estudio, la mayoría de las muestras fueron de tipo ambiental (fluidos orales, pisos de parideras, glándula mamaria, enriquecimiento ambiental y comederos), excepto los sueros. Consideramos que el termino coinfección no es el apropiado ya que al encontrar los virus en el ambiente no es indicativo de que los cerdos estén infectados. Así, decidimos emplear el término “copresencia” a lo largo del texto excepto cuando se hable particularmente de sueros donde se empleará el termino coinfección. Se establecieron diferencias entre los grupos evaluados tanto dentro de granja como entre granjas mediante estadística descriptiva. Igualmente, se analizó con estadística descriptiva el comportamiento de cada virus y copresencias a través del tiempo (evolución en el tiempo). Los análisis de asociación entre las variables climáticas y presencia de virus como también con las variables productivas se analizaron mediante correlación múltiple utilizando el método de Pearson con un nivel de significancia del 95%. Los análisis de resultados fueron asistidos por el analista estadígrafo del grupo de investigación y las gráficas fueron realizadas utilizando el programa Excel® para Windows 2010 y RStudio. El proyecto contó con el aval del Comité de Bioética de la Facultad de Medicina Veterinaria y de Zootecnia de la Universidad Nacional de Colombia, Sede Bogotá (Acta No. CB-FMVZ-UN-009-2022). La ejecución de este proyecto está sustentada según lo expuesto en la resolución 8430 de 1993 “Por la cual se establecen las normas científicas, técnicas y administrativas para la investigación en salud”. La ley 84 de 1989 “Por la cual se adopta el estatuto nacional de protección de los animales y se crean unas contravenciones y se regula lo referente a su procedimiento y competencia”, ley 576 del 2000 “Por la cual se expide el Código de Ética para el ejercicio profesional de la medicina veterinaria, la medicina veterinaria y zootecnia y la zootecnia”, y la ley 1774 de 2016 “por medio de la cual se modifican el código civil, la ley 84 de 1989”. Por último, el Código Penal, artículo 1 “Los animales como seres sintientes no son cosas, recibirán especial protección contra el sufrimiento y el dolor, en especial, el causado directa o indirectamente por los humanos, por lo cual en la presente ley se tipifican como punibles algunas conductas relacionadas con el maltrato a los animales, y se establece un procedimiento sancionatorio de carácter policivo y judicial”.Virología veterinariaxiv, 160 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina Veterinaria y de Zootecnia - Maestría en Salud y Producción AnimalFacultad de Medicina Veterinaria y de ZootecniaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá590 - Animales::599 - Mamíferos630 - Agricultura y tecnologías relacionadas::636 - Producción animalVirus de los animalesEnfermedades respiratoriasProducción animalAnimal virusesrespiratory diseasesanimal productionAnálisis molecularComplejo respiratorio porcinoDiagnósticoPatógenos respiratoriosVirologíaMolecular analysisPorcine respiratory complexDiagnosisRespiratory PathogensVirologyDinámica de algunos virus respiratorios en dos granjas porcinas tecnificadas en el trópico alto colombianoDynamics of some respiratory viruses in two techinified pig farms in the Colombian high tropicsTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMColombiahttp://vocab.getty.edu/page/tgn/1000050AgrosaviaAgrovocAlmario-Leiva, G., Suarez-Mesa, R., Uribe-García, F., & Rondón-Barragán, I. 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Porcine parvovirus infection activates mitochondria-mediated apoptotic signaling pathway by inducing ROS accumulation. https://doi.org/10.1186/s12985-016-0480-z Virology Journal, 13(1).Universidad Nacional de ColombiaInvestigadoresORIGINAL1116553822.2024.pdf1116553822.2024.pdfTesis de Maestría en Salud y Producción Animalapplication/pdf1952027https://repositorio.unal.edu.co/bitstream/unal/85879/6/1116553822.2024.pdf907781ca7b705c1f86357b9861f5a922MD56LICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/85879/7/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD57THUMBNAIL1116553822.2024.pdf.jpg1116553822.2024.pdf.jpgGenerated Thumbnailimage/jpeg5737https://repositorio.unal.edu.co/bitstream/unal/85879/8/1116553822.2024.pdf.jpgf48c174d638a74512eee68ead48f222dMD58unal/85879oai:repositorio.unal.edu.co:unal/858792024-04-08 23:07:14.321Repositorio Institucional Universidad Nacional de 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