Efectos del aislamiento social sobre la inducción de procesos de plasticidad y en el aprendizaje de estímulos contextuales asociados a la nicotina

ilustraciones, fotografías, diagramas

Autores:: Ballesteros-Acosta, Hans

Tipo de recurso:

Fecha de publicación:: 2023

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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network_acronym_str	UNACIONAL2
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repository_id_str
dc.title.spa.fl_str_mv	Efectos del aislamiento social sobre la inducción de procesos de plasticidad y en el aprendizaje de estímulos contextuales asociados a la nicotina
dc.title.translated.eng.fl_str_mv	Effects of social isolation on the induction of plasticity processes and the learning of nicotine-associated contextual stimuli
title	Efectos del aislamiento social sobre la inducción de procesos de plasticidad y en el aprendizaje de estímulos contextuales asociados a la nicotina
spellingShingle	Efectos del aislamiento social sobre la inducción de procesos de plasticidad y en el aprendizaje de estímulos contextuales asociados a la nicotina 150 - Psicología::156 - Psicología comparada Psicología del Adolescente Conducta del Adolescente Psychology, Adolescent Adolescent Behavior Adolescencia Aislamiento social Nicotina ΔFosB Sensibilización locomotora Preferencia condicionada de lugar Adolescence Social isolation Nicotine ΔFosB Locomotor sensitization Conditioned place preference
title_short	Efectos del aislamiento social sobre la inducción de procesos de plasticidad y en el aprendizaje de estímulos contextuales asociados a la nicotina
title_full	Efectos del aislamiento social sobre la inducción de procesos de plasticidad y en el aprendizaje de estímulos contextuales asociados a la nicotina
title_fullStr	Efectos del aislamiento social sobre la inducción de procesos de plasticidad y en el aprendizaje de estímulos contextuales asociados a la nicotina
title_full_unstemmed	Efectos del aislamiento social sobre la inducción de procesos de plasticidad y en el aprendizaje de estímulos contextuales asociados a la nicotina
title_sort	Efectos del aislamiento social sobre la inducción de procesos de plasticidad y en el aprendizaje de estímulos contextuales asociados a la nicotina
dc.creator.fl_str_mv	Ballesteros-Acosta, Hans
dc.contributor.advisor.none.fl_str_mv	Lamprea Rodríguez, Marisol Cortés-Patiño, Diana
dc.contributor.author.none.fl_str_mv	Ballesteros-Acosta, Hans
dc.contributor.researchgroup.spa.fl_str_mv	Neurociencia Básica y Cognoscitiva
dc.contributor.orcid.spa.fl_str_mv	Ballesteros-Acosta, Hans [0000000303879084]
dc.contributor.cvlac.spa.fl_str_mv	Ballesteros-Acosta, Hans [0001711713#]
dc.contributor.researchgate.spa.fl_str_mv	Ballesteros-Acosta, Hans [Hans-Ballesteros-Acosta]
dc.subject.ddc.spa.fl_str_mv	150 - Psicología::156 - Psicología comparada
topic	150 - Psicología::156 - Psicología comparada Psicología del Adolescente Conducta del Adolescente Psychology, Adolescent Adolescent Behavior Adolescencia Aislamiento social Nicotina ΔFosB Sensibilización locomotora Preferencia condicionada de lugar Adolescence Social isolation Nicotine ΔFosB Locomotor sensitization Conditioned place preference
dc.subject.decs.spa.fl_str_mv	Psicología del Adolescente Conducta del Adolescente
dc.subject.decs.eng.fl_str_mv	Psychology, Adolescent Adolescent Behavior
dc.subject.proposal.spa.fl_str_mv	Adolescencia Aislamiento social Nicotina ΔFosB Sensibilización locomotora Preferencia condicionada de lugar
dc.subject.proposal.eng.fl_str_mv	Adolescence Social isolation Nicotine ΔFosB Locomotor sensitization Conditioned place preference
description	ilustraciones, fotografías, diagramas
publishDate	2023
dc.date.accessioned.none.fl_str_mv	2023-07-25T17:39:09Z
dc.date.available.none.fl_str_mv	2023-07-25T17:39:09Z
dc.date.issued.none.fl_str_mv	2023
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/84265
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/84265 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
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dc.publisher.faculty.spa.fl_str_mv	Facultad de Ciencias Humanas
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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spelling	Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Lamprea Rodríguez, Marisola14f7906338f9d662885067f2e6abfe0600Cortés-Patiño, Diana2ba7758fb394fe8bb5791be0ccf901ed600Ballesteros-Acosta, Hans5b0f4033c5c72fb1bcea6a25218d1d56600Neurociencia Básica y CognoscitivaBallesteros-Acosta, Hans [0000000303879084]Ballesteros-Acosta, Hans [0001711713#]Ballesteros-Acosta, Hans [Hans-Ballesteros-Acosta]2023-07-25T17:39:09Z2023-07-25T17:39:09Z2023https://repositorio.unal.edu.co/handle/unal/84265Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, fotografías, diagramasLa interacción social resulta fundamental para el apropiado desarrollo del sistema nervioso y la adquisición de habilidades de supervivencia. Se ha demostrado que impedir las interacciones sociales durante la adolescencia aumenta los efectos de las drogas psicoactivas; sin embargo, existen pocos reportes sobre el impacto del aislamiento social sobre los efectos de la nicotina. El presente estudio evaluó los efectos del aislamiento social durante la adolescencia sobre (1) la acumulación del factor de transcripción ΔFosB en la corteza prelímbica, el núcleo accumbens y el núcleo paraventricular del tálamo, (2) la sensibilización a los efectos locomotores de la nicotina tras su administración repetida y (3) la preferencia condicionada de lugar inducida por diferentes dosis de nicotina (0,1 o 0,3 mg/kg). Los resultados indican que los animales aislados acumulan menos ΔFosB en las estructuras del circuito de recompensa evaluadas. El aislamiento no afectó los procesos de sensibilización locomotora inducida por dosis bajas de nicotina, pero sí se observó un efecto sobre la inducción de una mayor preferencia por lugares asociados con la nicotina. Dicho cambio se mantuvo por más de cuatro sesiones de extinción, únicamente para la dosis más baja. No se observaron incrementos significativos durante el restablecimiento de la asociación para ninguna de las dosis. Los resultados sugieren que el aislamiento social durante la adolescencia no afecta los procesos subyacentes a la expresión de la sensibilización locomotora, pero aumenta la sensibilidad de los animales a los efectos asociativos de la nicotina, incrementando el valor de incentivo de los contextos asociados con la misma. Este efecto podría estar mediado por reducciones en la acumulación de ΔFosB en las estructuras del circuito de recompensa. (Texto tomado de la fuente)Social interaction is essential for the proper development of the nervous system and the acquisition of survival skills. Preventing social interactions during adolescence has been shown to increase the effects of psychoactive drugs; however, there are few reports on the impact of social isolation on the effects of nicotine. The present study evaluated the effects of social isolation during adolescence on (1) the accumulation of the transcription factor ΔFosB in the prelimbic cortex, nucleus accumbens, and paraventricular nucleus of the thalamus, (2) sensitization to the locomotor effects of nicotine after repeated administration, and (3) conditioned place preference induced by different doses of nicotine (0.1 or 0.3 mg/kg). The results indicate that isolated animals accumulated less ΔFosB in the reward circuit structures evaluated. Isolation did not affect locomotor sensitization processes induced by low doses of nicotine but an effect on the induction of increased preference for nicotine-associated locations was observed. Such a change was maintained for more than four extinction sessions, only for the lowest dose. No significant increases were observed during reinstatement of the association for any of the doses. The results suggest that social isolation during adolescence does not affect the processes underlying the expression of locomotor sensitization but increases the sensitivity of animals to the associative effects of nicotine, increasing the incentive value of nicotine-associated contexts. This effect could be mediated by reductions in the accumulation of ΔFosB in reward circuit structures.MaestríaMaestría en Psicología104 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias Humanas - Maestría en PsicologíaFacultad de Ciencias HumanasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá150 - Psicología::156 - Psicología comparadaPsicología del AdolescenteConducta del AdolescentePsychology, AdolescentAdolescent BehaviorAdolescenciaAislamiento socialNicotinaΔFosBSensibilización locomotoraPreferencia condicionada de lugarAdolescenceSocial isolationNicotineΔFosBLocomotor sensitizationConditioned place preferenceEfectos del aislamiento social sobre la inducción de procesos de plasticidad y en el aprendizaje de estímulos contextuales asociados a la nicotinaEffects of social isolation on the induction of plasticity processes and the learning of nicotine-associated contextual stimuliTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMAhsan, H. 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Neuropsychopharmacology, 36(5), 1021–1032. https://doi.org/10.1038/npp.2010.240Convocatoria pacto para la generación de nuevo conocimiento a través de proyectos de investigación científica en ciencias médicas y de la salud 2019 Proyecto Código 67701MincienciasEstudiantesInvestigadoresMaestrosPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/84265/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1015448642_2023.pdf1015448642_2023.pdfTesis de Maestría en Psicologíaapplication/pdf2251025https://repositorio.unal.edu.co/bitstream/unal/84265/2/1015448642_2023.pdf16699fa4dad3612af78b0f23a3f8c61fMD52THUMBNAIL1015448642_2023.pdf.jpg1015448642_2023.pdf.jpgGenerated Thumbnailimage/jpeg4251https://repositorio.unal.edu.co/bitstream/unal/84265/3/1015448642_2023.pdf.jpg9e4b351fd20b693aec6733029f079847MD53unal/84265oai:repositorio.unal.edu.co:unal/842652024-08-12 23:11:27.408Repositorio Institucional Universidad Nacional de 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