Development and validation of an analitycal methodology(hplc rp) theophylline determination
Now adays theophylline can be found in more than 30 pharmaceutical products; among them 10 are programmed liberation forms wich are used for respiratory diseases. For the characterization of these products one of the nine USP 23 dissolution assays is required.This research paper presents an alternat...
- Autores:
-
Ponce D´León, Luisa Fernanda
Rojas, Jaime
Oviedo, Alfredo
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 1999
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/23772
- Acceso en línea:
- https://repositorio.unal.edu.co/handle/unal/23772
http://bdigital.unal.edu.co/14809/
- Palabra clave:
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Ponce D´León, Luisa Fernanda27e34d8a-3cf3-4988-be13-b38792071a61300Rojas, Jaime2a00be03-4ada-44de-bca7-32d4720a142e300Oviedo, Alfredo38f856a6-3b23-452d-a195-21e207792ca03002019-06-25T21:18:30Z2019-06-25T21:18:30Z1999https://repositorio.unal.edu.co/handle/unal/23772http://bdigital.unal.edu.co/14809/Now adays theophylline can be found in more than 30 pharmaceutical products; among them 10 are programmed liberation forms wich are used for respiratory diseases. For the characterization of these products one of the nine USP 23 dissolution assays is required.This research paper presents an alternative method for the quantification of theophylline which can be used for the end product as well as in the dissolution test.The methodology includes the chromatographic separation by an octadecylsilane C-18 column, methanol/water as the movil phase and the spectrofotometric detection at 270 nm.En la actualidad la teofilina se comercializa en Colombia en más de 30 medicamentos, de los cuales alrededor de unos 10 son productos de liberación programada para el manejo de diferentes problemas respiratorios. Para la caracterización de estos productos es indispensable el desarrollo de una de las nueve pruebas de disolución que ofrece la USP 23. En el presente artículo se propone un método de cuantificación para la teofilina alternativo al indicado por la farmacopea y aplicable tanto a la valoración del producto terminado, como a la cuantificación de la cantidad disuelta durante la correspondiente prueba de disolución. El método comprende un proceso de separación cromatográfica en fase reversa mediante una columna de octadecilsilano C18, una fase móvil constituida exclusivamente por metanol/agua y detección espectrofotométrica a 270 nm.application/pdfspaRevista Colombiana de Ciencias Químico Farmacéuticashttp://revistas.unal.edu.co/index.php/rccquifa/article/view/9165Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico Farmacéuticas; Vol. 28, núm. 1 (1999) 0034-7418 1909-6356Ponce D´León, Luisa Fernanda and Rojas, Jaime and Oviedo, Alfredo (1999) Development and validation of an analitycal methodology(hplc rp) theophylline determination. Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 28, núm. 1 (1999) 0034-7418 1909-6356 .Development and validation of an analitycal methodology(hplc rp) theophylline determinationArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL9165-15360-1-PB.pdfapplication/pdf285483https://repositorio.unal.edu.co/bitstream/unal/23772/1/9165-15360-1-PB.pdf2bb67b3a85d3360ca6d7c0984198d7b7MD51THUMBNAIL9165-15360-1-PB.pdf.jpg9165-15360-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg2314https://repositorio.unal.edu.co/bitstream/unal/23772/2/9165-15360-1-PB.pdf.jpg459f7a232109f087205ce08c8ff4bbb2MD52unal/23772oai:repositorio.unal.edu.co:unal/237722023-10-13 23:06:15.306Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co |
| dc.title.spa.fl_str_mv |
Development and validation of an analitycal methodology(hplc rp) theophylline determination |
| title |
Development and validation of an analitycal methodology(hplc rp) theophylline determination |
| spellingShingle |
Development and validation of an analitycal methodology(hplc rp) theophylline determination |
| title_short |
Development and validation of an analitycal methodology(hplc rp) theophylline determination |
| title_full |
Development and validation of an analitycal methodology(hplc rp) theophylline determination |
| title_fullStr |
Development and validation of an analitycal methodology(hplc rp) theophylline determination |
| title_full_unstemmed |
Development and validation of an analitycal methodology(hplc rp) theophylline determination |
| title_sort |
Development and validation of an analitycal methodology(hplc rp) theophylline determination |
| dc.creator.fl_str_mv |
Ponce D´León, Luisa Fernanda Rojas, Jaime Oviedo, Alfredo |
| dc.contributor.author.spa.fl_str_mv |
Ponce D´León, Luisa Fernanda Rojas, Jaime Oviedo, Alfredo |
| description |
Now adays theophylline can be found in more than 30 pharmaceutical products; among them 10 are programmed liberation forms wich are used for respiratory diseases. For the characterization of these products one of the nine USP 23 dissolution assays is required.This research paper presents an alternative method for the quantification of theophylline which can be used for the end product as well as in the dissolution test.The methodology includes the chromatographic separation by an octadecylsilane C-18 column, methanol/water as the movil phase and the spectrofotometric detection at 270 nm. |
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1999 |
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1999 |
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2019-06-25T21:18:30Z |
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2019-06-25T21:18:30Z |
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spa |
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http://revistas.unal.edu.co/index.php/rccquifa/article/view/9165 |
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Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico Farmacéuticas Revista Colombiana de Ciencias Químico Farmacéuticas |
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Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 28, núm. 1 (1999) 0034-7418 1909-6356 |
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Ponce D´León, Luisa Fernanda and Rojas, Jaime and Oviedo, Alfredo (1999) Development and validation of an analitycal methodology(hplc rp) theophylline determination. Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 28, núm. 1 (1999) 0034-7418 1909-6356 . |
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