Development and validation of an analitycal methodology(hplc rp) theophylline determination
Now adays theophylline can be found in more than 30 pharmaceutical products; among them 10 are programmed liberation forms wich are used for respiratory diseases. For the characterization of these products one of the nine USP 23 dissolution assays is required.This research paper presents an alternat...
- Autores:
-
Ponce D´León, Luisa Fernanda
Rojas, Jaime
Oviedo, Alfredo
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 1999
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/23772
- Acceso en línea:
- https://repositorio.unal.edu.co/handle/unal/23772
http://bdigital.unal.edu.co/14809/
- Palabra clave:
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
| Summary: | Now adays theophylline can be found in more than 30 pharmaceutical products; among them 10 are programmed liberation forms wich are used for respiratory diseases. For the characterization of these products one of the nine USP 23 dissolution assays is required.This research paper presents an alternative method for the quantification of theophylline which can be used for the end product as well as in the dissolution test.The methodology includes the chromatographic separation by an octadecylsilane C-18 column, methanol/water as the movil phase and the spectrofotometric detection at 270 nm. |
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