Evaluation of the Topical Anti-inflammatory Activity and Antibacterial Activity of Methanol Extract in the Sideroxylon obtusifolium Leaves
Sideroxylon obtusifolium, known as "quixaba", is used for various medicinal purposes, including in cases of inflammation and bacterial infections, therefore, the study aimed to investigate the topical antibacterial and anti-inflammatory activity of the methanol extract obtained from the le...
- Autores:
-
Aquino, Pedro
Figueredo, Fernando Gomes
Pereira, Nara
Nascimento, Eloiza
Martin, Ana
Veras, Helenicy
Oliveira, Cícera
Ferreira, Sarah
Leandro, Livia
Silva, Monalisa
Menezes, Irwin
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2016
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/61225
- Acceso en línea:
- https://repositorio.unal.edu.co/handle/unal/61225
http://bdigital.unal.edu.co/60033/
- Palabra clave:
- 57 Ciencias de la vida; Biología / Life sciences; biology
antiinflamatorio
antibacterial
prospección fitoquímica
anti-inflammatory
antibacterial
chemical elucidation
anti-inflamatória
antibacteriana
prospecção fitoquímica
Antiinflamatorio
antibacterial
prospección fitoquímica
Sideroxylon obtusifolium
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Evaluation of the Topical Anti-inflammatory Activity and Antibacterial Activity of Methanol Extract in the Sideroxylon obtusifolium Leaves |
| title |
Evaluation of the Topical Anti-inflammatory Activity and Antibacterial Activity of Methanol Extract in the Sideroxylon obtusifolium Leaves |
| spellingShingle |
Evaluation of the Topical Anti-inflammatory Activity and Antibacterial Activity of Methanol Extract in the Sideroxylon obtusifolium Leaves 57 Ciencias de la vida; Biología / Life sciences; biology antiinflamatorio antibacterial prospección fitoquímica anti-inflammatory antibacterial chemical elucidation anti-inflamatória antibacteriana prospecção fitoquímica Antiinflamatorio antibacterial prospección fitoquímica Sideroxylon obtusifolium |
| title_short |
Evaluation of the Topical Anti-inflammatory Activity and Antibacterial Activity of Methanol Extract in the Sideroxylon obtusifolium Leaves |
| title_full |
Evaluation of the Topical Anti-inflammatory Activity and Antibacterial Activity of Methanol Extract in the Sideroxylon obtusifolium Leaves |
| title_fullStr |
Evaluation of the Topical Anti-inflammatory Activity and Antibacterial Activity of Methanol Extract in the Sideroxylon obtusifolium Leaves |
| title_full_unstemmed |
Evaluation of the Topical Anti-inflammatory Activity and Antibacterial Activity of Methanol Extract in the Sideroxylon obtusifolium Leaves |
| title_sort |
Evaluation of the Topical Anti-inflammatory Activity and Antibacterial Activity of Methanol Extract in the Sideroxylon obtusifolium Leaves |
| dc.creator.fl_str_mv |
Aquino, Pedro Figueredo, Fernando Gomes Pereira, Nara Nascimento, Eloiza Martin, Ana Veras, Helenicy Oliveira, Cícera Ferreira, Sarah Leandro, Livia Silva, Monalisa Menezes, Irwin |
| dc.contributor.author.spa.fl_str_mv |
Aquino, Pedro Figueredo, Fernando Gomes Pereira, Nara Nascimento, Eloiza Martin, Ana Veras, Helenicy Oliveira, Cícera Ferreira, Sarah Leandro, Livia Silva, Monalisa Menezes, Irwin |
| dc.subject.ddc.spa.fl_str_mv |
57 Ciencias de la vida; Biología / Life sciences; biology |
| topic |
57 Ciencias de la vida; Biología / Life sciences; biology antiinflamatorio antibacterial prospección fitoquímica anti-inflammatory antibacterial chemical elucidation anti-inflamatória antibacteriana prospecção fitoquímica Antiinflamatorio antibacterial prospección fitoquímica Sideroxylon obtusifolium |
| dc.subject.proposal.spa.fl_str_mv |
antiinflamatorio antibacterial prospección fitoquímica anti-inflammatory antibacterial chemical elucidation anti-inflamatória antibacteriana prospecção fitoquímica Antiinflamatorio antibacterial prospección fitoquímica Sideroxylon obtusifolium |
| description |
Sideroxylon obtusifolium, known as "quixaba", is used for various medicinal purposes, including in cases of inflammation and bacterial infections, therefore, the study aimed to investigate the topical antibacterial and anti-inflammatory activity of the methanol extract obtained from the leaves of S. obtusifolium. The phytochemical screening of the extract revealed the presence of several classes, including Phenols; Tannins, Flavonoids, catechins and alkaloids. Polyphenols and flavonoids present in this extract were quantified in 150.3 mg of gallic acid equivalents / g extract and 98.5 mg of quercetin equivalents / g extract, respectively. The results obtained by the microdilution tests have shown potential and modulation antibacterial activity when associated gentamicin, and amikacin for multidrug-resistant strains of Staphylococcus aureus. For Escherichia coli, there was synergism for amikacin, gentamicin having antagonism, the same effect was observed forPseudomonas aeruginosa on both antibiotics. In tests for acute models of inflammation by ear edema induced by croton oil, and phenol, the extract had a potent antiedematogenic significant effect (p 0.05). Therefore, the results can be observed biological activities of S. obtusifolium, which is consistent with its use in popular therapy. |
| publishDate |
2016 |
| dc.date.issued.spa.fl_str_mv |
2016-01-01 |
| dc.date.accessioned.spa.fl_str_mv |
2019-07-02T20:41:15Z |
| dc.date.available.spa.fl_str_mv |
2019-07-02T20:41:15Z |
| dc.type.spa.fl_str_mv |
Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_6501 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Text |
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http://purl.org/redcol/resource_type/ART |
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http://purl.org/coar/resource_type/c_6501 |
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publishedVersion |
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ISSN: 1900-1649 |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.unal.edu.co/handle/unal/61225 |
| dc.identifier.eprints.spa.fl_str_mv |
http://bdigital.unal.edu.co/60033/ |
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ISSN: 1900-1649 |
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https://repositorio.unal.edu.co/handle/unal/61225 http://bdigital.unal.edu.co/60033/ |
| dc.language.iso.spa.fl_str_mv |
spa |
| language |
spa |
| dc.relation.spa.fl_str_mv |
https://revistas.unal.edu.co/index.php/actabiol/article/view/48170 |
| dc.relation.ispartof.spa.fl_str_mv |
Universidad Nacional de Colombia Revistas electrónicas UN Acta Biológica Colombiana Acta Biológica Colombiana |
| dc.relation.references.spa.fl_str_mv |
Aquino, Pedro and Figueredo, Fernando Gomes and Pereira, Nara and Nascimento, Eloiza and Martin, Ana and Veras, Helenicy and Oliveira, Cícera and Ferreira, Sarah and Leandro, Livia and Silva, Monalisa and Menezes, Irwin (2016) Evaluation of the Topical Anti-inflammatory Activity and Antibacterial Activity of Methanol Extract in the Sideroxylon obtusifolium Leaves. Acta Biológica Colombiana, 21 (1). pp. 131-140. ISSN 1900-1649 |
| dc.rights.spa.fl_str_mv |
Derechos reservados - Universidad Nacional de Colombia |
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http://purl.org/coar/access_right/c_abf2 |
| dc.rights.license.spa.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial 4.0 Internacional Derechos reservados - Universidad Nacional de Colombia http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Universidad Nacional de Colombia - Sede Bogotá - Faculdad de Ciencias - Departamento de Biología |
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Universidad Nacional de Colombia |
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Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Aquino, Pedro8dac96dd-f05f-466a-9388-3cda39574469300Figueredo, Fernando Gomes5ba2e58c-62b2-4768-b61b-46c248bc5631300Pereira, Narac483aaed-baf2-4352-980b-a42fcf03931d300Nascimento, Eloizae43b6f56-7f51-49ec-bc07-aa8657ebdd9f300Martin, Ana34ba1aec-67e8-48e4-a892-dcd191d000d9300Veras, Helenicyc1b041f8-1f73-44e0-9041-1dcb1724c7f7300Oliveira, Cícerada985a8e-ec1e-4a63-8d78-fef602537df8300Ferreira, Sarah8a1dc17c-a7db-4028-9277-6ec2fbe5f08e300Leandro, Liviaa6804ed7-1ed8-40e0-9f7d-d0a94c89cd37300Silva, Monalisafbd7b0fc-17a9-4155-8569-d34b1d68c1ca300Menezes, Irwin826fd109-6b18-4f47-973d-ec69c83d9c793002019-07-02T20:41:15Z2019-07-02T20:41:15Z2016-01-01ISSN: 1900-1649https://repositorio.unal.edu.co/handle/unal/61225http://bdigital.unal.edu.co/60033/Sideroxylon obtusifolium, known as "quixaba", is used for various medicinal purposes, including in cases of inflammation and bacterial infections, therefore, the study aimed to investigate the topical antibacterial and anti-inflammatory activity of the methanol extract obtained from the leaves of S. obtusifolium. The phytochemical screening of the extract revealed the presence of several classes, including Phenols; Tannins, Flavonoids, catechins and alkaloids. Polyphenols and flavonoids present in this extract were quantified in 150.3 mg of gallic acid equivalents / g extract and 98.5 mg of quercetin equivalents / g extract, respectively. The results obtained by the microdilution tests have shown potential and modulation antibacterial activity when associated gentamicin, and amikacin for multidrug-resistant strains of Staphylococcus aureus. For Escherichia coli, there was synergism for amikacin, gentamicin having antagonism, the same effect was observed forPseudomonas aeruginosa on both antibiotics. In tests for acute models of inflammation by ear edema induced by croton oil, and phenol, the extract had a potent antiedematogenic significant effect (p 0.05). Therefore, the results can be observed biological activities of S. obtusifolium, which is consistent with its use in popular therapy.Sideroxylon obtusifolium conocida como quixaba, se utiliza para diversos fines medicinales, incluso en los casos de infecciones bacterianas y la inflamación, por lo tanto, este estudio tuvo como objetivo investigar la actividad antiinflamatoria tópica y antibacteriana del extracto de metanol obtenido de las hojas de S. obtusifolium. El tamizaje fitoquímico del extracto reveló la presencia de varias clases, incluyendo: fenoles; taninos pirogálicos, flavonoides, catequinas y alcaloides. Los polifenoles y flavonoides presentes en este extracto se cuantificaron en 150,3 mg de equivalentes de ácido/g de extracto gálico y 98,5 mg de extracto de quercetina equivalentes/g, respectivamente. Los resultados obtenidos por los ensayos de microdilución han mostrado actividad potencial y la modulación antibacteriana cuando se asocia gentamicina, amikacina y para las cepas resistentes a múltiples fármacos de Staphylococcus aureus. Para Escherichia coli, solo se obtuvo sinergismo con amikacina, y se observo antagonismo para gentamicina, este mismo efecto fue observado para Pseudomonas aeruginosa en ambos antibióticos. En las pruebas de modelos agudos de inflamación por edema de la oreja inducido por aceite de crotón, y el fenol, el extracto tuvo un efecto significativo antiedematogenic potente (p 0,05). Por lo tanto, los resultados muestran actividad biológica de S. obtusifolium, que es coherente con su uso en terapia popular.Sideroxylon obtusifolium, conhecida como quixaba, é utilizada para diversos fins medicinais, dentre eles em casos de inflamações e infecções bacterianas, com isso, o estudo teve por objetivo investigar a atividade antiedematogênica tópica e antibacteriana do extrato metanólico obtido das folhas de S. obtusifolium. Os resultados obtidos através dos testes de microdiluição e modulação mostraram potencial atividade antibacteriana quando associados a gentamicina e amicacina para cepas multirresistentes de Staphylococcus aureus. Para cepas de Escherichia coli, só houve modulação da atividade de aminoglicosídeos frente ao antibiótico amicacina havendo antagonismo para gentamicina, o mesmo efeito foi observado para Pseudomonas aeruginosas em ambos antibióticos. Nos testes para inflamação aguda através dos modelos de edema de orelha induzido por óleo de cróton e fenol, o extrato apresentou um potente efeito antiedematogêncio p 0,05. A prospecção fitoquímica do extrato foi feita e nela foram verificados diversos metabólitos com inúmeras atividades biológicas. Os polifenóis e flavonóides presentes neste extrato foram quantificados em 150,3 mg equivalentes de ácido gálico/ g de extrato e 98,5 mg equivalentes de quercetina/ g de extrato, respectivamente, o que explica o forte poder antioxidante presente nesta parte da planta. Diante dos resultados, podem-se observar atividades biológicas de S. obtusifolium, o que condiz com seu uso na terapia popular, no entanto como se trata de um extrato, substancias devem ser isoladas e testadas. Sendo assim este trabalho poderá servir como base para futuras pesquisas relacionadas a essa parte da planta.application/pdfspaUniversidad Nacional de Colombia - Sede Bogotá - Faculdad de Ciencias - Departamento de Biologíahttps://revistas.unal.edu.co/index.php/actabiol/article/view/48170Universidad Nacional de Colombia Revistas electrónicas UN Acta Biológica ColombianaActa Biológica ColombianaAquino, Pedro and Figueredo, Fernando Gomes and Pereira, Nara and Nascimento, Eloiza and Martin, Ana and Veras, Helenicy and Oliveira, Cícera and Ferreira, Sarah and Leandro, Livia and Silva, Monalisa and Menezes, Irwin (2016) Evaluation of the Topical Anti-inflammatory Activity and Antibacterial Activity of Methanol Extract in the Sideroxylon obtusifolium Leaves. Acta Biológica Colombiana, 21 (1). pp. 131-140. ISSN 1900-164957 Ciencias de la vida; Biología / Life sciences; biologyantiinflamatorioantibacterialprospección fitoquímicaanti-inflammatoryantibacterialchemical elucidationanti-inflamatóriaantibacterianaprospecção fitoquímicaAntiinflamatorioantibacterialprospección fitoquímicaSideroxylon obtusifoliumEvaluation of the Topical Anti-inflammatory Activity and Antibacterial Activity of Methanol Extract in the Sideroxylon obtusifolium LeavesArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL48170-266803-1-PB.pdfapplication/pdf526083https://repositorio.unal.edu.co/bitstream/unal/61225/1/48170-266803-1-PB.pdf4baa48f6780a7aeadb62e61b5954c04fMD51THUMBNAIL48170-266803-1-PB.pdf.jpg48170-266803-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg10331https://repositorio.unal.edu.co/bitstream/unal/61225/2/48170-266803-1-PB.pdf.jpg490a27e261fcaa55f9cf5ab68ea19b66MD52unal/61225oai:repositorio.unal.edu.co:unal/612252023-04-11 23:04:48.666Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co |