Identificación de bacterias resistentes a betalactámicos en aguas para riego agrícola en la Ramada, Cundinamarca.

fotografías a color, gráficas, ilustraciones, tablas

Autores:
Oviedo Cancino, Alejandra
Tipo de recurso:
Fecha de publicación:
2021
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/80288
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/80288
https://repositorio.unal.edu.co/
Palabra clave:
Aguas agrícolas
Resistencia antibióticos
Enterobacterias
Perfil de susceptibilidad
Detección de antibióticos
Agricultural waters
Resistance
Antibiotics
Sensitivity profile
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
id UNACIONAL2_c382d8960b390930d3bbfb6cca7443bd
oai_identifier_str oai:repositorio.unal.edu.co:unal/80288
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Identificación de bacterias resistentes a betalactámicos en aguas para riego agrícola en la Ramada, Cundinamarca.
dc.title.translated.eng.fl_str_mv Identification of bacteria resistant to beta-lactams in water for agricultural irrigation in La Ramada, Cundinamarca.
title Identificación de bacterias resistentes a betalactámicos en aguas para riego agrícola en la Ramada, Cundinamarca.
spellingShingle Identificación de bacterias resistentes a betalactámicos en aguas para riego agrícola en la Ramada, Cundinamarca.
Aguas agrícolas
Resistencia antibióticos
Enterobacterias
Perfil de susceptibilidad
Detección de antibióticos
Agricultural waters
Resistance
Antibiotics
Sensitivity profile
title_short Identificación de bacterias resistentes a betalactámicos en aguas para riego agrícola en la Ramada, Cundinamarca.
title_full Identificación de bacterias resistentes a betalactámicos en aguas para riego agrícola en la Ramada, Cundinamarca.
title_fullStr Identificación de bacterias resistentes a betalactámicos en aguas para riego agrícola en la Ramada, Cundinamarca.
title_full_unstemmed Identificación de bacterias resistentes a betalactámicos en aguas para riego agrícola en la Ramada, Cundinamarca.
title_sort Identificación de bacterias resistentes a betalactámicos en aguas para riego agrícola en la Ramada, Cundinamarca.
dc.creator.fl_str_mv Oviedo Cancino, Alejandra
dc.contributor.advisor.none.fl_str_mv Lopez, Martha Cristina
dc.contributor.author.none.fl_str_mv Oviedo Cancino, Alejandra
dc.contributor.educationalvalidator.none.fl_str_mv Leal Aura Lucia
Delgado Morales Rocio del Pilar
dc.contributor.researcher.none.fl_str_mv Reguero Maria Teresa
dc.contributor.researchgroup.spa.fl_str_mv Resiliencia y Saneamiento, RESA
dc.subject.proposal.spa.fl_str_mv Aguas agrícolas
Resistencia antibióticos
Enterobacterias
Perfil de susceptibilidad
Detección de antibióticos
topic Aguas agrícolas
Resistencia antibióticos
Enterobacterias
Perfil de susceptibilidad
Detección de antibióticos
Agricultural waters
Resistance
Antibiotics
Sensitivity profile
dc.subject.proposal.eng.fl_str_mv Agricultural waters
Resistance
Antibiotics
Sensitivity profile
description fotografías a color, gráficas, ilustraciones, tablas
publishDate 2021
dc.date.accessioned.none.fl_str_mv 2021-09-24T03:03:25Z
dc.date.available.none.fl_str_mv 2021-09-24T03:03:25Z
dc.date.issued.none.fl_str_mv 2021-09-22
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/80288
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/80288
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
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spelling Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Lopez, Martha Cristina770a68dded30d60f0f05ecf2ad643689Oviedo Cancino, Alejandrae1e4e5eb5719a3ea3a8c870f20d9ed2aLeal Aura LuciaDelgado Morales Rocio del PilarReguero Maria TeresaResiliencia y Saneamiento, RESA2021-09-24T03:03:25Z2021-09-24T03:03:25Z2021-09-22https://repositorio.unal.edu.co/handle/unal/80288Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/fotografías a color, gráficas, ilustraciones, tablasEl presente trabajo se basó inicialmente en la caracterización fisicoquímica y microbiológica del agua de uso agrícola en la zona occidental de la Sabana de Cundinamarca, conocida como distrito de riego la Ramada, donde se midieron parámetros como pH, conductividad, temperatura, oxígeno disuelto (OD), demanda química de oxígeno (DQO), demanda biológica de oxígeno (DBO5), carbono orgánico total (COT) y sólidos suspendidos totales (S.S.T.) y parámetros microbiológicos como recuento total de Coliformes Totales y Escherichia coli. Los muestreos se llevaron a cabo en seis puntos diferentes de la Ramada, donde el agua recolectada se analizó en el laboratorio de Ingeniería Ambiental de la Universidad Nacional de Colombia. Cabe mencionar, que los parámetros microbiológicos en las muestras de agua se analizaron mediante dos técnicas microbiológicas; la primera para establecer un recuento de la población total (NMP/100mL) y comparar los resultados con la normativa colombiana vigente (Decreto 1594 de 1984) para determinar si es apta para riego agrícola, y finalmente la técnica de filtración por membrana (UFC/100 mL) para obtener colonias aisladas de bacterias Gram negativas, que son de interés en este estudio; a las cuales se les determino el perfil de resistencia a antibióticos betalactámicos. Para llevar a cabo esto, inicialmente se realizó un pase de las colonias aisladas en Chromagares (ESBL – CARBA SMART) con el objetivo de seleccionarlas e identificarlas, para que, mediante el uso de herramientas automatizadas, se observará su perfil de sensibilidad. Por otro lado, para determinar la presencia de antibióticos en estas aguas, se realizó una extracción en fase sólida mediante el uso de cartuchos de extracción OASIS HLA (60mg/3cc), para finalmente analizar las muestras mediante metodologías de residuos múltiples como cromatografía líquida acoplada a espectrometría de masas (LC-MS / MS), con el objetivo de cuantificar los analitos en estudio. Teniendo en cuenta este panorama, se decidió caracterizar e identificar si hay presencia de microorganismos resistentes a antibióticos en aguas de uso agrícola del distrito la Ramada, Cundinamarca. En la caracterización fisicoquímica y microbiológica del agua agrícola, se pudo observar que, parámetros como DQO arrojaron resultados que están entre rangos de 101 mg/L a 1276 mg/L para temporada lluvia, mientras que para temporada seca los rangos oscilaron 102 mg/L a 1301 mg/L, en cambio para DBO5 los parámetros oscilaron 34 mg/L a 390 mg/L en temporada lluvia y para temporada seca fueron de 58 mg/L a 830 mg/L. Igualmente, los recuentos de bacterias como E. coli fueron mayores de 5000 NMP Log/100mL en el sitio 4 y sitio 6 en ambas temporadas. Por su parte, se observó como en estas aguas agrícolas hubo presencia de antibióticos como clindamicina, obteniendo valores mínimos de 1.20 ng/L a 42 ng/L en ambas temporadas, azitromicina con valores máximos de 5550 ng/L y trimetropim con rangos entre 82 ng/L a 339.23 ng/L en temporada seca, mientras que para temporada lluvia oscilaron entre los 45 ng/L a 606.48 ng/L y a su vez, como en el sitio 6 el promedio para este antibiótico fue de 1418.24 ng/L, registrando la presencia de fármacos en aguas para fines agrícolas. Igualmente, la identificación mediante técnicas automatizadas arrojó resultados interesantes, encontrando bacterias resistentes a antibióticos betalactámicos como E. coli, y Klepsiella sp., las cuales pueden causar enfermedades y ser relevantes en el ambiente clínico por su importancia para generar resistencia en antibióticos. (Texto tomado de la fuente)The present work was initially based on the physicochemical and microbiological characterization of water for agricultural use in the western zone of the Cundinamarca Plains, known as the Ramada irrigation district. Parameters such as pH, conductivity, temperature, dissolved oxygen (DO), chemical oxygen demand (COD), biological oxygen demand (BOD5), total organic carbon (TOC) and total suspended solids (TSS) and microbiological parameters such as total coliforms and Escherichia coli count were measured. The samplings were carried out in six different points of the Ramada district, which were: Site 1, Site 2, Site 3, Site 4, Site 5, and Site 6; the collected water was analyzed in the Environmental Engineering laboratory of the Universidad Nacional de Colombia. It is worth mentioning that the microbiological parameters in the water samples were analyzed using two microbiological techniques; the first to establish a count of the total population (MPN / 100mL) and compare the results with the current Colombian regulations (Decree 1594 of 1984) and determine if it is suitable for agricultural irrigation, and finally the membrane filtration technique (CFU/100 mL) to obtain isolated colonies of Gram negative bacteria, which are of interest in this study; to which resistance to beta-lactam antibiotics was evaluated; these were contacted with Chromagares (ESBL - CARBA SMART) in order to select and identify them, so that, through the use of automated tools, their sensitivity profile could be observed. On the other hand, to determine the presence of antibiotics in these waters, a solid phase extraction was carried out using OASIS HLA extraction cartridges (60mg / 3cc), to finally analyze the samples using multiple residue methodologies such as coupled liquid chromatography to mass spectrometry (LC-MS / MS), in order to quantify the analytes under study. Taking this scenario into account, it was decided to characterize and identify whether there is the presence of multi-resistant microorganisms to antibiotics in waters for agricultural use in the La Ramada district, Cundinamarca. It was observed that in these agricultural waters there was presence of antibiotics such as clindamycin, obtaining minimum values of 1.20 ng/L to 42 ng/L in both seasons, azithromycin with maximum values of 5550 ng/L and trimethoprim with ranges between 82 ng/L to 339.23 ng/L in the dry season, while for the rainy season they ranged from 45 ng/L to 606.48 ng/L and in turn, as in site 6, the average for this antibiotic was 1418.24 ng/L, recording the presence of drugs in waters for agricultural purposes. In the physicochemical and microbiological characterization of agricultural water, it could be observed that parameters such as COD yielded results ranging from 101 mg/L to 1276 mg/L for the rainy season, while for the dry season the ranges ranged from 102 mg/L at 1301 mg/L, on the other hand for BOD5 the parameters ranged from 34 mg/L to 390 mg/L in the rainy season and for the dry season they were from 58 mg/L to 830 mg/L. Likewise, the counts of bacteria such as E. coli were greater than 5 MPN Log/100mL in both seasons, whereas for site 6 the limits exceed values of 7 MPN Log/100mL. Likewise, the identification using automated techniques yielded interesting results, finding bacteria such as E. coli, Citrobacter freundii, Enterobacter cloacae and Klepsiella spp., Which can cause diseases and be relevant in the clinical environment due to their importance in generating antibiotic resistance.AgrosaviaUniversidad NacionalLaboratorio de Ingenieria AmbientalMaestríaLínea de Investigación en Contaminantes Emergentesxx, 114 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias - MicrobiologíaInstituto de Biotecnología (IBUN)Facultad de CienciasBogotá - ColombiaUniversidad Nacional de Colombia - Sede BogotáIdentificación de bacterias resistentes a betalactámicos en aguas para riego agrícola en la Ramada, Cundinamarca.Identification of bacteria resistant to beta-lactams in water for agricultural irrigation in La Ramada, Cundinamarca.Trabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMAcevedo Barrios, R. 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American Society for Microbiology, 5(33), 4–5. doi: 10.1128/genomeA.00842-17Aguas agrícolasResistencia antibióticosEnterobacteriasPerfil de susceptibilidadDetección de antibióticosAgricultural watersResistanceAntibioticsSensitivity profileIdentificación de contaminantes emergentes y microbiológicos, análisis metagenómico bacteriano y perfil de resistencia a antibióticos en aguas de riego y hortalizas de la Sabana occidental de CundinamarcaMinisterio de Ciencia y TecnologíaPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-83964https://repositorio.unal.edu.co/bitstream/unal/80288/1/license.txtcccfe52f796b7c63423298c2d3365fc6MD51ORIGINAL1032442709.2021.pdf1032442709.2021.pdfTesis de Mestría en Ciencias Microbiologíaapplication/pdf3951195https://repositorio.unal.edu.co/bitstream/unal/80288/2/1032442709.2021.pdfa1c54f6d6fe7fde9dd0fd4328322bb92MD52THUMBNAIL1032442709.2021.pdf.jpg1032442709.2021.pdf.jpgGenerated 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GVyZWNob3MgZGUgYXV0b3IgcXVlIGNvbmxsZXZlIGxhIGRpc3RyaWJ1Y2nDs24gZGUgZXN0b3MgYXJjaGl2b3MgeSBtZXRhZGF0b3MuCkFsIGhhY2VyIGNsaWMgZW4gZWwgc2lndWllbnRlIGJvdMOzbiwgdXN0ZWQgaW5kaWNhIHF1ZSBlc3TDoSBkZSBhY3VlcmRvIGNvbiBlc3RvcyB0w6lybWlub3MuCgpVTklWRVJTSURBRCBOQUNJT05BTCBERSBDT0xPTUJJQSAtIMOabHRpbWEgbW9kaWZpY2FjacOzbiAyNy8yMC8yMDIwCg==

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