Exploration of hybrid simulation methodologies for the computational study of fluid flow phenomena in airways

ilustraciones, diagramas, gráficas, tablas

Autores:
Espinosa Moreno, Andres Santiago
Tipo de recurso:
Fecha de publicación:
2022
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
eng
OAI Identifier:
oai:repositorio.unal.edu.co:unal/82936
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/82936
https://repositorio.unal.edu.co/
Palabra clave:
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
Fenómenos Fisiológicos Circulatorios y Respiratorios
Circulatory and Respiratory Physiological Phenomena
Computational Fluid Dynamics (CFD)
Hybrid Numerical Simulation
Lower Airways
Homothety ratios
Real Airway Patient-Specific
Synthetic Airway Models
Dinámica de fluidos computacional (CFD)
Simulación numérica híbrida
Vías respiratorias inferiores
Factores homotéticos
Modelos de vías respiratorias reales de paciente especifico
Modelos sintéticos de vías respiratorias
Mecánica de fluidos
Rights
openAccess
License
Reconocimiento 4.0 Internacional
id UNACIONAL2_bf54cb15c3b8f4f9cf4e6a370c5e34c1
oai_identifier_str oai:repositorio.unal.edu.co:unal/82936
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.eng.fl_str_mv Exploration of hybrid simulation methodologies for the computational study of fluid flow phenomena in airways
dc.title.translated.spa.fl_str_mv Exploración de metodologías de simulación híbridas para el estudio computacional de fenómenos de flujos de fluidos en vías respiratorias
title Exploration of hybrid simulation methodologies for the computational study of fluid flow phenomena in airways
spellingShingle Exploration of hybrid simulation methodologies for the computational study of fluid flow phenomena in airways
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
Fenómenos Fisiológicos Circulatorios y Respiratorios
Circulatory and Respiratory Physiological Phenomena
Computational Fluid Dynamics (CFD)
Hybrid Numerical Simulation
Lower Airways
Homothety ratios
Real Airway Patient-Specific
Synthetic Airway Models
Dinámica de fluidos computacional (CFD)
Simulación numérica híbrida
Vías respiratorias inferiores
Factores homotéticos
Modelos de vías respiratorias reales de paciente especifico
Modelos sintéticos de vías respiratorias
Mecánica de fluidos
title_short Exploration of hybrid simulation methodologies for the computational study of fluid flow phenomena in airways
title_full Exploration of hybrid simulation methodologies for the computational study of fluid flow phenomena in airways
title_fullStr Exploration of hybrid simulation methodologies for the computational study of fluid flow phenomena in airways
title_full_unstemmed Exploration of hybrid simulation methodologies for the computational study of fluid flow phenomena in airways
title_sort Exploration of hybrid simulation methodologies for the computational study of fluid flow phenomena in airways
dc.creator.fl_str_mv Espinosa Moreno, Andres Santiago
dc.contributor.advisor.none.fl_str_mv Duque Daza, Carlos Alberto
dc.contributor.author.none.fl_str_mv Espinosa Moreno, Andres Santiago
dc.contributor.researchgroup.spa.fl_str_mv Gnum Grupo de Modelado y Métodos Numericos en Ingeniería
dc.contributor.orcid.spa.fl_str_mv Espinosa Moreno, Andres Santiago [0000-0002-3562-6658]
dc.contributor.cvlac.spa.fl_str_mv Espinosa Moreno, Andres Santiago [0001619872]
dc.contributor.researchgate.spa.fl_str_mv Espinosa Moreno, Andres Santiago [Andres-Espinosa-Moreno]
dc.contributor.googlescholar.spa.fl_str_mv Espinosa Moreno, Andres Santiago [HCrJtfwAAAAJ&hl=es]
dc.subject.ddc.spa.fl_str_mv 620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
topic 620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
Fenómenos Fisiológicos Circulatorios y Respiratorios
Circulatory and Respiratory Physiological Phenomena
Computational Fluid Dynamics (CFD)
Hybrid Numerical Simulation
Lower Airways
Homothety ratios
Real Airway Patient-Specific
Synthetic Airway Models
Dinámica de fluidos computacional (CFD)
Simulación numérica híbrida
Vías respiratorias inferiores
Factores homotéticos
Modelos de vías respiratorias reales de paciente especifico
Modelos sintéticos de vías respiratorias
Mecánica de fluidos
dc.subject.decs.spa.fl_str_mv Fenómenos Fisiológicos Circulatorios y Respiratorios
dc.subject.decs.eng.fl_str_mv Circulatory and Respiratory Physiological Phenomena
dc.subject.proposal.eng.fl_str_mv Computational Fluid Dynamics (CFD)
Hybrid Numerical Simulation
Lower Airways
Homothety ratios
Real Airway Patient-Specific
Synthetic Airway Models
dc.subject.proposal.spa.fl_str_mv Dinámica de fluidos computacional (CFD)
Simulación numérica híbrida
Vías respiratorias inferiores
Factores homotéticos
Modelos de vías respiratorias reales de paciente especifico
Modelos sintéticos de vías respiratorias
dc.subject.spines.spa.fl_str_mv Mecánica de fluidos
description ilustraciones, diagramas, gráficas, tablas
publishDate 2022
dc.date.issued.none.fl_str_mv 2022
dc.date.accessioned.none.fl_str_mv 2023-01-16T15:04:08Z
dc.date.available.none.fl_str_mv 2023-01-16T15:04:08Z
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/82936
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/82936
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv eng
language eng
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rights_invalid_str_mv Reconocimiento 4.0 Internacional
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dc.format.extent.spa.fl_str_mv xiii, 119 páginas
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dc.publisher.faculty.spa.fl_str_mv Facultad de Ingeniería
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dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá
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spelling Reconocimiento 4.0 InternacionalDerechos reservados al autor, 2022http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Duque Daza, Carlos Alberto2af3fa9fc1551951a8ddefbc637c4cd8Espinosa Moreno, Andres Santiagoccaa8f6e08a36e057426b34bc12341f2Gnum Grupo de Modelado y Métodos Numericos en IngenieríaEspinosa Moreno, Andres Santiago [0000-0002-3562-6658]Espinosa Moreno, Andres Santiago [0001619872]Espinosa Moreno, Andres Santiago [Andres-Espinosa-Moreno]Espinosa Moreno, Andres Santiago [HCrJtfwAAAAJ&hl=es]2023-01-16T15:04:08Z2023-01-16T15:04:08Z2022https://repositorio.unal.edu.co/handle/unal/82936Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramas, gráficas, tablasIn recent years, numerical simulation has emerged as a robust tool for the analysis of physiological phenomena. The application of computational fluid dynamics (CFD) techniques to the study of biofluids is a constantly growing field, especially the focus given to simulations of blood through the circulatory system and air within the human airways. A high complexity arises in the analysis of these systems. On the one hand, the extension and configuration of the geometrical model (branches, networks), and on the other hand, the multiphysics nature of many of these phenomena. This research work was developed with the aim of exploring methodologies that help to simplify the complexity of simulations associated with biofluids, particularly in human airways. In the first part, a specification of the basic concepts was developed, focusing on the description of the airways and the fluid dynamics associated with air transport in the respiratory system. In turn, a background of numerical simulation applied to biofluids, and a classification of the hybrid simulation methodologies was discussed. In the second part, a first simplification strategy was studied, specifically the use of synthetic airway models. For this purpose, a comparison study of the use of these models vs real patient-specific models was carried out. In addition, a study of the effect of the variation of some morphological parameters on the flow, such as bifurcation angle and carina radius rounding, was developed. In the third part, the implementation and validation of a hybrid simulation methodology was performed, based on a dimensional reduction from the airway homothety ratios. A boundary condition for the pressure, which is the result of this methodology, was implemented in a open source, and tested with two application cases: a study of airways in asthma condition and a study of branch collapse. Finally, general conclusions about the application of the spatial simplification strategy and the use of the hybrid simulation methodology were detailed, as well as recommendations and future work.En los últimos años, la simulación numérica se ha potenciado como una herramienta robusta para el análisis de fenómenos fisiológicos. La aplicación de técnicas de dinámica de fluidos computacional (CFD) para el estudio de bio-fluidos es un campo en constante crecimiento, en especial, el enfoque dado a las simulaciones de sangre a través del sistema circulatorio y de aire a través de las vías respiratorias. Una elevada complejidad surge en el análisis de estos sistemas. Por un lado, la extensión y la configuración del modelo geométrico (ramificaciones, redes), y por otro, la naturaleza multi-física de muchos fenómenos. Este trabajo de investigación fue desarrollado con la intención de explorar metodologías que ayuden a simplificar la complejidad de las simulaciones asociadas a bio-fluidos, particularmente en vías respiratorias humanas. En la primera parte, una especificación de los conceptos básicos fue desarrollada, centrándose en la descripción de las vías respiratorias y la dinámica de fluidos asociada al transporte de aire en el sistema respiratorio. A su vez, un background de la simulación numérica aplicada a bio-fluidos, y la consecución de una clasificación de las metodologías de simulación híbridas, fue discutido. En la segunda parte, una primera estrategia de simplificación fue estudiada, específicamente el uso de modelos sintéticos de vías respiratorias. Para esto, un estudio de comparación del uso de estos modelos contra los modelos reales específicos de paciente fue llevado a cabo. Ademas, un estudio del efecto de la variación de algunos parámetros morfológicos sobre el flujo, como lo son el ángulo de bifurcación y el redondeo de radio de carina, fue desarrollado. En la tercera parte, la implementación y validación de una metodología de simulación híbrida fue realizada, basados en una reducción dimensional a partir de los factores homotéticos de vías respiratorias. Una condición de frontera para la presión, la cual es el resultado de dicha metodología, fue implementada en un software libre, y puesta a prueba con dos casos aplicativos: un estudio de vías respiratorias en condición de asma y un estudio de colapso de ramificaciones. Finalmente, las conclusiones generales acerca de la aplicación de la estrategia de simplificación espacial y del uso de la metodología de simulación híbrida fueron detalladas, así como las debidas recomendaciones y trabajos futuros. (Texto tomado de la fuente)MaestríaMagíster en Ingeniería - Ingeniería MecánicaThermal and fluid sciencesxiii, 119 páginasapplication/pdfengUniversidad Nacional de ColombiaBogotá - Ingeniería - Maestría en Ingeniería - Ingeniería MecánicaFacultad de IngenieríaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingenieríaFenómenos Fisiológicos Circulatorios y RespiratoriosCirculatory and Respiratory Physiological PhenomenaComputational Fluid Dynamics (CFD)Hybrid Numerical SimulationLower AirwaysHomothety ratiosReal Airway Patient-SpecificSynthetic Airway ModelsDinámica de fluidos computacional (CFD)Simulación numérica híbridaVías respiratorias inferioresFactores homotéticosModelos de vías respiratorias reales de paciente especificoModelos sintéticos de vías respiratoriasMecánica de fluidosExploration of hybrid simulation methodologies for the computational study of fluid flow phenomena in airwaysExploración de metodologías de simulación híbridas para el estudio computacional de fenómenos de flujos de fluidos en vías respiratoriasTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMKatrin Adler and Christoph Brücker. 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Journal of biomechanical engineering, 116(4):488–496, 1994.EstudiantesInvestigadoresPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/82936/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1073164931.2022.pdf1073164931.2022.pdfTesis de Maestría en Ingeniería Mecánicaapplication/pdf20520411https://repositorio.unal.edu.co/bitstream/unal/82936/2/1073164931.2022.pdf12684869e1fd20a2ed4ccea3f738aaa5MD52THUMBNAIL1073164931.2022.pdf.jpg1073164931.2022.pdf.jpgGenerated Thumbnailimage/jpeg4560https://repositorio.unal.edu.co/bitstream/unal/82936/3/1073164931.2022.pdf.jpgea85873bdab87dbeebb3862720baa3cbMD53unal/82936oai:repositorio.unal.edu.co:unal/829362024-08-14 23:42:25.919Repositorio Institucional Universidad Nacional de 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