Effectiveness of lyophilized amniotic membrane as barrier in guided bone regeneration in rabbit tibias

This study aimed to determine the effect of lyophilized amniotic membrane used as a biological barrier in the process of guided bone regeneration in rabbit tibias. Materials and Methods: Were used 10 New Zealand white rabbits of 2 to 2.5 Kg and 4-6 months of age; in which circular bone defects of 4mm in diameter were created in the lower region of the rabbit hind limb (tibias). 2 groups were formed: a control group (no membranewas placed) and the experimental group (lyophilized amniotic membrane was placed as a barrier). The animals were sacrificed at 6 weeks after surgery, performing a clinical, radiological and histological analysis of the area where the bone defects were created. Results: Clinically was found an absence of inflammatory reaction (100%) and absence of infectious processes (100%), in the histological examination, 87.5% of the samples of the study group showed the presence of mature compact bone while in the group control reported a 100% absence. Conclusion: We concluded that bone regenerationwas significantly higher in the defects covered with lyophilized amniotic membrane compared with the samples from the control group.

• Autores: Yábar Condori, Jusef; Castro Rodríguez, Yuri; Grados Pomarino, Sixto; Medina Calderón, Katia; Castro Gamero, Emma
• Tipo de recurso: Article of journal
• Fecha de publicación: 2014
• Institución: Universidad Nacional de Colombia
• Repositorio: Universidad Nacional de Colombia
• Idioma: spa
• OAI Identifier: oai:repositorio.unal.edu.co:unal/49178
• Acceso en línea: https://repositorio.unal.edu.co/handle/unal/49178; http://bdigital.unal.edu.co/42635/
• Palabra clave: Regeneración ósea guiada; membrana amniótica humana; defectos óseos.; Guided bone regeneration; human amniotic membrane; bone defects.
• Rights: openAccess
• License: Atribución-NoComercial 4.0 Internacional