Coocurrencia de anemia y prueba antiglobulínica directa (PAD) positiva en pacientes hospitalizados por COVID-19

ilustraciones

Autores:
Burbano Gutiérrez, Juan Felipe
Tipo de recurso:
Fecha de publicación:
2021
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/80841
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/80841
https://repositorio.unal.edu.co/
Palabra clave:
610 - Medicina y salud::616 - Enfermedades
Infecciones por Coronavirus
Coronavirus Infections
Anemia
Anemia Hemolítica Autoinmune
Anemia, Hemolytic, Autoimmune
COVID-19
SARS-CoV-2
Anemia
Anemia hemolítica autoinmune
Prueba antiglobulínica directa
Autoimmune hemolytic anemia
Direct antiglobulin test
Rights
openAccess
License
Atribución-NoComercial-CompartirIgual 4.0 Internacional
id UNACIONAL2_bbef065415634b3e3034d16355e2f2f1
oai_identifier_str oai:repositorio.unal.edu.co:unal/80841
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Coocurrencia de anemia y prueba antiglobulínica directa (PAD) positiva en pacientes hospitalizados por COVID-19
dc.title.translated.eng.fl_str_mv Prevalence of anemia and positive direct antiglobulin test (DAT) in hospitalized patients with COVID-19
title Coocurrencia de anemia y prueba antiglobulínica directa (PAD) positiva en pacientes hospitalizados por COVID-19
spellingShingle Coocurrencia de anemia y prueba antiglobulínica directa (PAD) positiva en pacientes hospitalizados por COVID-19
610 - Medicina y salud::616 - Enfermedades
Infecciones por Coronavirus
Coronavirus Infections
Anemia
Anemia Hemolítica Autoinmune
Anemia, Hemolytic, Autoimmune
COVID-19
SARS-CoV-2
Anemia
Anemia hemolítica autoinmune
Prueba antiglobulínica directa
Autoimmune hemolytic anemia
Direct antiglobulin test
title_short Coocurrencia de anemia y prueba antiglobulínica directa (PAD) positiva en pacientes hospitalizados por COVID-19
title_full Coocurrencia de anemia y prueba antiglobulínica directa (PAD) positiva en pacientes hospitalizados por COVID-19
title_fullStr Coocurrencia de anemia y prueba antiglobulínica directa (PAD) positiva en pacientes hospitalizados por COVID-19
title_full_unstemmed Coocurrencia de anemia y prueba antiglobulínica directa (PAD) positiva en pacientes hospitalizados por COVID-19
title_sort Coocurrencia de anemia y prueba antiglobulínica directa (PAD) positiva en pacientes hospitalizados por COVID-19
dc.creator.fl_str_mv Burbano Gutiérrez, Juan Felipe
dc.contributor.advisor.none.fl_str_mv Grajales Buitrago, Marco Antonio
Camacho Rodríguez, Bernardo Armando
Angarita de Botero, María del Pilar
Sánchez Pedraza, Ricardo
dc.contributor.author.none.fl_str_mv Burbano Gutiérrez, Juan Felipe
dc.contributor.researcher.none.fl_str_mv Amador Rodríguez, Mónica Patricia
Gaviria García, Paula Andrea
Grass Guáqueta, Jeser Santiago
Deantonio Paéz, Danna Valentina
dc.subject.ddc.spa.fl_str_mv 610 - Medicina y salud::616 - Enfermedades
topic 610 - Medicina y salud::616 - Enfermedades
Infecciones por Coronavirus
Coronavirus Infections
Anemia
Anemia Hemolítica Autoinmune
Anemia, Hemolytic, Autoimmune
COVID-19
SARS-CoV-2
Anemia
Anemia hemolítica autoinmune
Prueba antiglobulínica directa
Autoimmune hemolytic anemia
Direct antiglobulin test
dc.subject.other.none.fl_str_mv Infecciones por Coronavirus
Coronavirus Infections
Anemia
Anemia Hemolítica Autoinmune
Anemia, Hemolytic, Autoimmune
dc.subject.proposal.spa.fl_str_mv COVID-19
SARS-CoV-2
Anemia
Anemia hemolítica autoinmune
Prueba antiglobulínica directa
dc.subject.proposal.eng.fl_str_mv Autoimmune hemolytic anemia
Direct antiglobulin test
description ilustraciones
publishDate 2021
dc.date.issued.none.fl_str_mv 2021
dc.date.accessioned.none.fl_str_mv 2022-02-01T19:45:25Z
dc.date.available.none.fl_str_mv 2022-02-01T19:45:25Z
dc.type.spa.fl_str_mv Trabajo de grado - Especialidad Médica
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/80841
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/80841
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.indexed.spa.fl_str_mv LaReferencia
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spelling Atribución-NoComercial-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Grajales Buitrago, Marco Antonioda903ef0eeb60966d23123b80a9b46f2Camacho Rodríguez, Bernardo Armando41a1d3fa4dfecadc930167e941dd257cAngarita de Botero, María del Pilar6fa4e19ac187be4ac1ab42426687f76dSánchez Pedraza, Ricardo71d39599cff2e2eb6af28ec7d259fc60Burbano Gutiérrez, Juan Felipe9af9404ad33bcba40915e9a4cb136afeAmador Rodríguez, Mónica PatriciaGaviria García, Paula AndreaGrass Guáqueta, Jeser SantiagoDeantonio Paéz, Danna Valentina2022-02-01T19:45:25Z2022-02-01T19:45:25Z2021https://repositorio.unal.edu.co/handle/unal/80841Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustracionesLa infección por SARSCoV-2 causa la enfermedad por coronavirus del 2019 (COVID-19), considerada como pandemia, con complicaciones hematológicas derivadas de síndromes hiperinflamatorios y autoinmunidad en pacientes de alto riesgo y ancianos que desarrollan una infección grave por COVID-19. Una de las complicaciones documentadas es la anemia hemolítica autoinmune (AHAI), que está mediada por la emergencia de autoanticuerpos contra los eritrocitos del huésped. El diagnóstico de AHAI a menudo no se realiza, lo que conduce a resultados clínicos deficientes debido a anemia, disfunción endotelial e hipoperfusión tisular. Se realizó un estudio observacional de corte transversal por período para evaluar la coocurrencia de anemia y prueba de antiglobulina directa (PAD) positiva, en pacientes hospitalizados por COVID-19 en dos hospitales de Bogotá, Colombia, del 18 de marzo al 29 de abril. 2021. La asociación sustantiva entre anemia y PAD positiva se estimó por medio del coeficiente de agrupamiento o de cluster; Las variables de confusión que se sabe están asociadas con la anemia y PAD (p. ej., inflamación, gravedad de COVID-19, sangrado mayor y tratamiento con antibióticos) se controlaron mediante regresión logística multivariable. Se evaluaron 185 pacientes, 84 (45,4%) eran mujeres y la edad media fue 59,7 ± 14,7. Cien (54,1%) ingresaron a la unidad de cuidados intensivos, 67 (36,2%) con disfunción multiorgánica (medida por qSOFA ≥2). La prevalencia de anemia y PAD positiva fue del 19,4% (intervalo de confianza [IC] del 95%, 13,8 a 25,2). El coeficiente de cluster fue de 1,55, lo que demuestra una asociación sustancial no coincidencial. La disfunción multiorgánica, la PAD positiva y la terapia con antibióticos se asociaron significativamente con anemia durante la hospitalización (OR: 5,11 (IC 95%: 2,46 - 10,60), 2,72 (IC 95%: 1,32 – 5,60) y 2,48 (IC 95% 1,10 - 5,57), respectivamente. En conclusión, la coocurrencia de anemia y PAD positiva en pacientes hospitalizados con infección por SARS-CoV-2 no es una coincidencia y se asocia a insuficiencia multiorgánica y terapia con antibióticos. Para el médico, la anemia de nueva aparición después o durante la hospitalización debido a un COVID-19 grave debe despertar sospechas de AHAI. (texto tomado de la fuente)Hematologic complications derived from hyperinflammatory syndromes and autoimmunity can be seen in high-risk and elderly patients who develop severe COVID-19 infection. One of the reported complications is autoimmune hemolytic anemia (AIHA), which is mediated by the emergency of autoantibodies against host erythrocytes. The diagnosis of AIHA is often unrecognized leading to poor clinical outcomes due to anemia, endothelial dysfunction, and tissue hypoperfusion. Herein, we conducted a cross-sectional, observational study to evaluate the prevalence of anemia and a positive Direct Antiglobulin Test (DAT), among hospitalized patients with COVID-19 in two hospitals in Bogota, Colombia during COVID surge from March 18 to April 29, 2021. The association between anemia and a positive DAT was estimated by cluster coefficient; confounding variables known to be associated with anemia (eg, inflammation, COVID-19 severity, mayor bleeding and antibiotic therapy) were controlled by multivariate logistic regression. One hundred and eighty-five patients were evaluated, 84 (45,4%) were female, and the mean age was 59,7 ± 14,7. One hundred (54,1%) were admitted to intensive care unit, 67 (36,2%) with multi-organ dysfunction (measured by qSOFA ≥2). The prevalence of anemia and positive DAT was 19.4% (95% confidence interval [CI], 13.8 to 25.2). Cluster coefficient was 1.55 showing a substantive non coincidental association. Multi-organic dysfunction, positive DAT and antibiotic therapy were significantly associated with anemia that occurred during hospitalization (OR:5,11 (95% CI 2,46 – 10,60), 2,72 (95% CI 1,32 – 5,60) and 2,48 (95% CI 1,10 – 5,57), respectively In summary, the prevalence of anemia and positive DAT in hospitalized patients with SARS-CoV-2 infection is not coincidental and it is associated to multiple organ failure and antibiotic therapy. For the clinician, new onset anemia following hospitalization due to severe COVID-19 should raise suspicion for AIHA.Especialidades MédicasEspecialista en HematologíaHematologíaapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Especialidad en HematologíaDepartamento de Medicina InternaFacultad de MedicinaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::616 - EnfermedadesInfecciones por CoronavirusCoronavirus InfectionsAnemiaAnemia Hemolítica AutoinmuneAnemia, Hemolytic, AutoimmuneCOVID-19SARS-CoV-2AnemiaAnemia hemolítica autoinmunePrueba antiglobulínica directaAutoimmune hemolytic anemiaDirect antiglobulin testCoocurrencia de anemia y prueba antiglobulínica directa (PAD) positiva en pacientes hospitalizados por COVID-19Prevalence of anemia and positive direct antiglobulin test (DAT) in hospitalized patients with COVID-19Trabajo de grado - Especialidad Médicainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMLaReferencia1. 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Hematology. 2010;2010(1):276-280. doi:10.1182/asheducation-2010.1.276EstudiantesInvestigadoresPúblico generalORIGINALBurbano hematologia 2021 - Juan Felipe Burbano Gutierrez.pdfBurbano hematologia 2021 - Juan Felipe Burbano Gutierrez.pdfTesis de especialidad medica en Hematologíaapplication/pdf1258439https://repositorio.unal.edu.co/bitstream/unal/80841/1/Burbano%20hematologia%202021%20-%20Juan%20Felipe%20Burbano%20Gutierrez.pdf2010702fb46f91c933a4b83f6a0b9d38MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-84074https://repositorio.unal.edu.co/bitstream/unal/80841/2/license.txt8153f7789df02f0a4c9e079953658ab2MD52THUMBNAILBurbano hematologia 2021 - Juan Felipe Burbano Gutierrez.pdf.jpgBurbano hematologia 2021 - Juan Felipe Burbano Gutierrez.pdf.jpgGenerated 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EVESURBIFBPUiBMQSBTRUNSRVRBUsONQSBHRU5FUkFMLiAqTEEgVEVTSVMgQSBQVUJMSUNBUiBERUJFIFNFUiBMQSBWRVJTScOTTiBGSU5BTCBBUFJPQkFEQS4gCgpBbCBoYWNlciBjbGljIGVuIGVsIHNpZ3VpZW50ZSBib3TDs24sIHVzdGVkIGluZGljYSBxdWUgZXN0w6EgZGUgYWN1ZXJkbyBjb24gZXN0b3MgdMOpcm1pbm9zLiBTaSB0aWVuZSBhbGd1bmEgZHVkYSBzb2JyZSBsYSBsaWNlbmNpYSwgcG9yIGZhdm9yLCBjb250YWN0ZSBjb24gZWwgYWRtaW5pc3RyYWRvciBkZWwgc2lzdGVtYS4KClVOSVZFUlNJREFEIE5BQ0lPTkFMIERFIENPTE9NQklBIC0gw5psdGltYSBtb2RpZmljYWNpw7NuIDE5LzEwLzIwMjEK

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