Rifaximina en enfermedad diverticular sintomática no complicada. Revisión sistemática de la literatura

ilustraciones, gráficas, tablas

Autores:
Bastidas Riascos, Melissa del Rosario
Tipo de recurso:
Fecha de publicación:
2021
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/80996
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/80996
https://repositorio.unal.edu.co/
Palabra clave:
610 - Medicina y salud
Divertículo
Revisión Sistemática
Rifaximina
Diverticulum
Systematic Review
Rifaximin
Rifaximina
Enfermedad diverticular no complicada
Rifaximin
Rifaximin
Uncomplicated diverticular disease
Rifaximine
Rights
openAccess
License
Atribución-SinDerivadas 4.0 Internacional
id UNACIONAL2_b93b5274c555674fdbc3cf82683faa88
oai_identifier_str oai:repositorio.unal.edu.co:unal/80996
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Rifaximina en enfermedad diverticular sintomática no complicada. Revisión sistemática de la literatura
dc.title.translated.eng.fl_str_mv Rifaximin in symptomatic uncomplicated diverticular disease. Systematic review of the literature
title Rifaximina en enfermedad diverticular sintomática no complicada. Revisión sistemática de la literatura
spellingShingle Rifaximina en enfermedad diverticular sintomática no complicada. Revisión sistemática de la literatura
610 - Medicina y salud
Divertículo
Revisión Sistemática
Rifaximina
Diverticulum
Systematic Review
Rifaximin
Rifaximina
Enfermedad diverticular no complicada
Rifaximin
Rifaximin
Uncomplicated diverticular disease
Rifaximine
title_short Rifaximina en enfermedad diverticular sintomática no complicada. Revisión sistemática de la literatura
title_full Rifaximina en enfermedad diverticular sintomática no complicada. Revisión sistemática de la literatura
title_fullStr Rifaximina en enfermedad diverticular sintomática no complicada. Revisión sistemática de la literatura
title_full_unstemmed Rifaximina en enfermedad diverticular sintomática no complicada. Revisión sistemática de la literatura
title_sort Rifaximina en enfermedad diverticular sintomática no complicada. Revisión sistemática de la literatura
dc.creator.fl_str_mv Bastidas Riascos, Melissa del Rosario
dc.contributor.advisor.spa.fl_str_mv Otero Regino, William Alberto
Estrada Orozco, Kelly
dc.contributor.author.spa.fl_str_mv Bastidas Riascos, Melissa del Rosario
dc.subject.ddc.spa.fl_str_mv 610 - Medicina y salud
topic 610 - Medicina y salud
Divertículo
Revisión Sistemática
Rifaximina
Diverticulum
Systematic Review
Rifaximin
Rifaximina
Enfermedad diverticular no complicada
Rifaximin
Rifaximin
Uncomplicated diverticular disease
Rifaximine
dc.subject.decs.spa.fl_str_mv Divertículo
Revisión Sistemática
Rifaximina
dc.subject.decs.eng.fl_str_mv Diverticulum
Systematic Review
Rifaximin
dc.subject.proposal.spa.fl_str_mv Rifaximina
Enfermedad diverticular no complicada
Rifaximin
dc.subject.proposal.eng.fl_str_mv Rifaximin
Uncomplicated diverticular disease
Rifaximine
description ilustraciones, gráficas, tablas
publishDate 2021
dc.date.issued.none.fl_str_mv 2021
dc.date.accessioned.none.fl_str_mv 2022-02-16T17:11:49Z
dc.date.available.none.fl_str_mv 2022-02-16T17:11:49Z
dc.type.spa.fl_str_mv Trabajo de grado - Especialidad Médica
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/80996
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/80996
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.indexed.spa.fl_str_mv Bireme
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dc.format.extent.spa.fl_str_mv xi, 55, 7 páginas
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dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv Bogotá - Medicina - Especialidad en Gastroenterología
dc.publisher.department.spa.fl_str_mv Departamento de Medicina Interna
dc.publisher.faculty.spa.fl_str_mv Facultad de Medicina
dc.publisher.place.spa.fl_str_mv Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá
institution Universidad Nacional de Colombia
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spelling Atribución-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Otero Regino, William Albertod36a8f6432b282112dd921f6c1e74488600Estrada Orozco, Kellyeba696de6082d777f9028dab0dac253c600Bastidas Riascos, Melissa del Rosario2c09c5cf8a13d2400c5a1adedbedca816002022-02-16T17:11:49Z2022-02-16T17:11:49Z2021https://repositorio.unal.edu.co/handle/unal/80996Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, gráficas, tablasRifaximina en enfermedad diverticular sintomática no complicada. Revisión sistemática de la literatura Introducción: La rifaximina es un antibiótico que inhibe la síntesis del ARN bacteriano y se ha propuesto en el tratamiento de enfermedad diverticular sintomática no complicada (EDSNC), pero hay controversia sobre su utilidad. Objetivo: Determinar la efectividad y seguridad de la rifaximina frente a otras intervenciones o no intervención en la mejoría de los síntomas de pacientes con EDSNC. Materiales y métodos: Investigamos en todas las bases de datos hasta Julio 2021 para identificar experimentos clínicos, otros estudios de intervención, cohortes o casos y controles que evaluaran la efectividad y seguridad de la rifaximina frente a otras intervenciones o no intervención en la mejoría de los síntomas de pacientes con EDSNC. La calidad metodológica de los estudios incluidos se evaluó de acuerdo al tipo de diseño. Se realizó síntesis cualitativa. Resultados: se tamizaron 1489 referencias. Se revisaron 18 referencias en texto completo, de las cuales se excluyeron siete. 11 estudios cumplieron criterios de inclusión y exclusión. En los ECA (ensayos clínicos) existió mejoría en el score global sintomático a 14+/-2 días p<0.005, 6 meses (p<0.001), 12 meses (p<0.001), 24 meses (p<0.001) con diferencias estadísticamente significativa. En el estudio cuasiexperimetal y en los estudios observacionales también existió reducción significativa a los 3 meses (p<0.001) 6 meses p (0,0001), 8 años (p<0.001). Los efectos adversos, fueron menor al 1%, y no tienen diferencias significativas (NS) en relación al grupo comparador. Rifaximina no tiene utilidad en la prevención de complicaciones (NS). La heterogeneidad clínica y metodológica debido a las diferentes mediciones de los desenlaces y definiciones del score sintomático, no permite establecer medidas combinadas del efecto. Conclusiones: Rifaximina es mejor que la fibra (glucomanano solo), superior a placebo en mejoria de los síntomas. Se requieren más estudios para confirmar estos hallazgos. Se recomienda realizar ECA bien diseñados para establecer el impacto de la rifaximina en EDSNC. (Texto tomado de la fuente).Rifaximin in uncomplicated symptomatic diverticular disease. Systematic review of the literature Introduction: Rifaximin is an antibiotic that inhibits bacterial RNA synthesis and has been proposed for the treatment of uncomplicated symptomatic diverticular disease (NCSD), but there is controversy about its usefulness. Objective: To determine the effectiveness and safety of rifaximin compared to other interventions or no intervention in improving the symptoms of patients with EDSNC. Materials and methods: We searched all databases up to July 2021 to identify clinical trials, other intervention studies, cohorts, or cases and controls that evaluated the effectiveness and safety of rifaximin versus other interventions or no intervention in improving symptoms. symptoms of patients with EDSNC. The methodological quality of the included studies was assessed according to the type of design. Qualitative synthesis was performed. Results: 1489 references were screened. Eighteen full-text references were reviewed, of which seven were excluded. 11 studies met inclusion and exclusion criteria. In the RCTs (clinical trials) there was an improvement in the global symptomatic score at 14+/-2 days p<0.005, 6 months (p<0.001), 12 months (p<0.001), 24 months (p<0.001) with differences statistically significant. In the quasi-experimental study and in the observational studies there was also a significant reduction at 3 months (p<0.001), 6 months p (0.0001), 8 years (p<0.001). Adverse effects were less than 1%, and have no significant differences (NS) in relation to the comparator group. Rifaximin has no utility in the prevention of complications (NS). The clinical and methodological heterogeneity due to the different measurements of the outcomes and definitions of the symptom score, does not allow to establish combined measures of the effect. Conclusions: Rifaximin is better than fiber (glucomannan alone), superior to placebo in symptom improvement. Further studies are required to confirm these findings. Well-designed RCTs are recommended to establish the impact of rifaximin on EDSNC.Incluye anexosEspecialidades MédicasEspecialista en Gastroenterologíaxi, 55, 7 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Especialidad en GastroenterologíaDepartamento de Medicina InternaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y saludDivertículoRevisión SistemáticaRifaximinaDiverticulumSystematic ReviewRifaximinRifaximinaEnfermedad diverticular no complicadaRifaximinRifaximinUncomplicated diverticular diseaseRifaximineRifaximina en enfermedad diverticular sintomática no complicada. Revisión sistemática de la literaturaRifaximin in symptomatic uncomplicated diverticular disease. Systematic review of the literatureTrabajo de grado - Especialidad Médicainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBireme1. Tursi A, Papa A, Danese S. 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Polski Przeglad Chirurgiczny/ Polish Journal of Surgery. 2019;91(4):1–8.BibliotecariosEstudiantesGrupos comunitariosInvestigadoresMaestrosMedios de comunicaciónPersonal de apoyo escolarPúblico generalORIGINAL1085286671.2021.pdf1085286671.2021.pdfTesis de Especialidad en Gastroenterologíaapplication/pdf776058https://repositorio.unal.edu.co/bitstream/unal/80996/1/1085286671.2021.pdfb1560d0242b81e6704206ac5974a7975MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-84074https://repositorio.unal.edu.co/bitstream/unal/80996/2/license.txt8153f7789df02f0a4c9e079953658ab2MD52THUMBNAIL1085286671.2021.pdf.jpg1085286671.2021.pdf.jpgGenerated Thumbnailimage/jpeg4734https://repositorio.unal.edu.co/bitstream/unal/80996/3/1085286671.2021.pdf.jpgb69ed379b1ecd742d11e4ec204969d5aMD53unal/80996oai:repositorio.unal.edu.co:unal/809962023-08-01 23:03:59.996Repositorio Institucional Universidad Nacional de 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EVESURBIFBPUiBMQSBTRUNSRVRBUsONQSBHRU5FUkFMLiAqTEEgVEVTSVMgQSBQVUJMSUNBUiBERUJFIFNFUiBMQSBWRVJTScOTTiBGSU5BTCBBUFJPQkFEQS4gCgpBbCBoYWNlciBjbGljIGVuIGVsIHNpZ3VpZW50ZSBib3TDs24sIHVzdGVkIGluZGljYSBxdWUgZXN0w6EgZGUgYWN1ZXJkbyBjb24gZXN0b3MgdMOpcm1pbm9zLiBTaSB0aWVuZSBhbGd1bmEgZHVkYSBzb2JyZSBsYSBsaWNlbmNpYSwgcG9yIGZhdm9yLCBjb250YWN0ZSBjb24gZWwgYWRtaW5pc3RyYWRvciBkZWwgc2lzdGVtYS4KClVOSVZFUlNJREFEIE5BQ0lPTkFMIERFIENPTE9NQklBIC0gw5psdGltYSBtb2RpZmljYWNpw7NuIDE5LzEwLzIwMjEK

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