Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática
ilustraciones
- Autores:
-
Romero Fonseca, Adriana Zuleny
- Tipo de recurso:
- Fecha de publicación:
- 2023
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/83699
- Palabra clave:
- 610 - Medicina y salud
Periodontitis crónica
Control de infección dental
Chronic Periodontitis
Infection Control, Dental
TNF-α
HLA
SNV
Linkage disequilibrium
Periodontitis cronica
Periodontitis agresiva
Desequilibrio de ligamiento
Chronic periodontitis
Aggressive periodontitis
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática |
| dc.title.translated.eng.fl_str_mv |
Gene variants in the Human Leukocyte Antigen (HLA) system and TNF alpha in chronic and aggressive periodontitis phenotypes: a systematic review |
| title |
Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática |
| spellingShingle |
Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática 610 - Medicina y salud Periodontitis crónica Control de infección dental Chronic Periodontitis Infection Control, Dental TNF-α HLA SNV Linkage disequilibrium Periodontitis cronica Periodontitis agresiva Desequilibrio de ligamiento Chronic periodontitis Aggressive periodontitis |
| title_short |
Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática |
| title_full |
Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática |
| title_fullStr |
Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática |
| title_full_unstemmed |
Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática |
| title_sort |
Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática |
| dc.creator.fl_str_mv |
Romero Fonseca, Adriana Zuleny |
| dc.contributor.advisor.none.fl_str_mv |
Rey Buitrago, Mauricio |
| dc.contributor.author.none.fl_str_mv |
Romero Fonseca, Adriana Zuleny |
| dc.contributor.researchgroup.spa.fl_str_mv |
Genética clínica |
| dc.subject.ddc.spa.fl_str_mv |
610 - Medicina y salud |
| topic |
610 - Medicina y salud Periodontitis crónica Control de infección dental Chronic Periodontitis Infection Control, Dental TNF-α HLA SNV Linkage disequilibrium Periodontitis cronica Periodontitis agresiva Desequilibrio de ligamiento Chronic periodontitis Aggressive periodontitis |
| dc.subject.decs.spa.fl_str_mv |
Periodontitis crónica Control de infección dental |
| dc.subject.decs.eng.fl_str_mv |
Chronic Periodontitis Infection Control, Dental |
| dc.subject.proposal.none.fl_str_mv |
TNF-α HLA SNV Linkage disequilibrium |
| dc.subject.proposal.spa.fl_str_mv |
Periodontitis cronica Periodontitis agresiva Desequilibrio de ligamiento |
| dc.subject.proposal.eng.fl_str_mv |
Chronic periodontitis Aggressive periodontitis |
| description |
ilustraciones |
| publishDate |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2023-04-12T16:20:59Z |
| dc.date.available.none.fl_str_mv |
2023-04-12T16:20:59Z |
| dc.date.issued.none.fl_str_mv |
2023-04-11 |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Maestría |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/masterThesis |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
| dc.type.content.spa.fl_str_mv |
Text |
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http://purl.org/redcol/resource_type/TM |
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acceptedVersion |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.unal.edu.co/handle/unal/83699 |
| dc.identifier.instname.spa.fl_str_mv |
Universidad Nacional de Colombia |
| dc.identifier.reponame.spa.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
| dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.unal.edu.co/ |
| url |
https://repositorio.unal.edu.co/handle/unal/83699 https://repositorio.unal.edu.co/ |
| identifier_str_mv |
Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
| dc.language.iso.spa.fl_str_mv |
spa |
| language |
spa |
| dc.relation.references.spa.fl_str_mv |
Aguillón G, Juan C, Cruzat C, Andrea, Cuenca M, Jimena, & Cuchacovich T, Miguel. (2002). El polimorfismo genético del factor de necrosis tumoral alfa como factor de riesgo en patología. Revista médica de Chile, 130(9), 1043-1050. https://dx.doi.org/10.4067/S0034-98872002000900013 Arrunategui, Ana María, Villegas, Adriana, Ocampo, Luz Ángela, Rodríguez, Libia María, & Badih, Abdelmounim. (2013). Frecuencias alélicas, genotípicas y haplotípicas del sistema HLA clase I y II en donantes de una población del suroccidente colombiano. Acta Medica Colombiana, 38(1), 16-21. Retrieved March 30, 2023, from http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-24482013000100006&lng=en&tlng=es. Babel, N., Cherepnev, G.,Babel, D., Tropmann Alla and Hammer, M., Volk, H.-D., & Reinke, P. (2006). Analysis of tumor necrosis factor-alpha, transforming growth factor-beta, interleukin-10, IL-6, and interferon-gamma gene polymorphisms in patients with chronic periodontitis. JOURNAL OF PERIODONTOLOGY, 77(12), 1978–1983. https://doi.org/10.1902/jop.2006.050315 Barnea, T. V., Sava, A., Gentimir, C., Goriuc, A., Boisteanu, O., Chelaru, L., Iancu, R. I., Avram, C. A., Acatrinei, D. D., Bogza, E. G., Raducanu, O. C., Cioloca, D. P., Vasincu, D., & Costuleanu, M. (2015). Genetic polymorphisms of TNFA and IL-1A and generalized aggressive periodontitis. ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY, 56(2), 459–464 Batool, A.-G. H., Saif, S. S., Raad, A.-A. S., & Ahmed, A. A. (2017a). Analysis of HLA-DQB1 Alleles Frequency in Patients with Chronic Periodontitis. International Journal of Medical Research & Health Sciences, 6(8), 12–16. Berker, E., Eratalay, K., & Tepe, E. (2015). Analysis of TNF- a ( -308 ) polymorphism and gingival crevicular fluid TNF- a levels in aggressive and chronic periodontitis : A preliminary report. Cytokine, 72, 173–177. https://doi.org/10.1016/j.cyto.2015.01.001 Brett, P. M., Zygogianni, P., Griffiths, G. S., Tomaz, M., Parkar, M., D’Aiuto, F., & Tonetti, M. (2005). Functional Gene Polymorphisms in Aggressive and Chronic Periodontitis. JOURNAL OF DENTAL RESEARCH, 12, 1149–1153. https://doi.org/10.1177/154405910508401211 Cardoso, E. M., Reis, C., & Manzanares-Céspedes, M. C. (2018). Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases. In Postgraduate Medicine (Vol. 130, Issue 1, pp. 98–104). Taylor and Francis Inc. https://doi.org/10.1080/00325481.2018.1396876 Cao Jea. Hyaluronan Increases RANKL Expression in Bone Marrow Stromal Cells Through CD44. J Bone Miner Res. 2005; 20(1) Costa, A. M., Guimaraes, M. C. M., Souza, E. R. de, & Nobrega, O. T. (2010). Interleukin-6 ( G-174C ) and tumour necrosis factor-alpha ( G-308A ) gene polymorphisms in geriatric patients with chronic periodontitis. Gerodontology, 27, 70–75. https://doi.org/10.1111/j.1741-2358.2009.00291.x Craandijk, J., van Krugten, M. v, Verweij, C. L., van der Velden, U., & Loos, B. G. (2002). Tumor necrosis factor- a gene polymorphisms in relation to periodontitis. J Clin Periodontol, 29, 28–34 Craandijk, J., van Krugten, M. v, Verweij, C. L., & van der Velden U and Loos, B. G. (2002). Tumor necrosis factor-alpha gene polymorphisms in relation to periodontitis. JOURNAL OF CLINICAL PERIODONTOLOGY, 29(1), 28–34. https://doi.org/10.1034/j.1600-051x.2002.290105.x Darvishi, E., Yari, K., Kahrizi, D., & Karim, H. A. (2016). Lack of association between the TNF-α-1031 genotypes and generalized aggressive periodontitis disease. Cell. Mol. Biol, 62(11), 62–65. https://doi.org/10.14715/cmb/ Donati, M., Berglundh, T., Hytonen, A. M., Hahn-Zoric, M., Hanson, L., & Padyukov, L. (2005). Association of the-159 CD14 gene polymorphism and lack of association of the-308 TNFA and Q551R IL-4RA polymorphisms with severe chronic periodontitis in Swedish Caucasians. JOURNAL OF CLINICAL PERIODONTOLOGY, 32(5), 474–479. https://doi.org/10.1111/j.1600-051X.2005.00697.x Dosseva-Panova, V., Mlachkova, A., Popova, C., & Kicheva, M. (2015). Evaluation of Interleukin-6, Lymphotoxin-Α and Tnf-Α Gene Polymorphisms in Chronic Periodontitis. Journal of IMAB - Annual Proceeding (Scientific Papers), 21(3), 868–875. https://doi.org/10.5272/jimab.2015213.868 Ebadian, A. R., Radvar, M., Afshari, J. T., Sargolzaee, N., Brook, A., Ganjali, R., Tamizi, M., & Arab, H. R. (2013). Gene Polymorphisms of TNF-alpha and IL-1 beta Are Not Associated with Generalized Aggressive Periodontitis in an Iranian Subpopulation. IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY, 12(4), 345–351 Endo, M., Tai, H., Tabeta, K., Kobayashi, T., Yamazaki, K., & Yoshie, H. (2001). Analysis of single nucleotide polymorphisms in the 5’-flanking region of tumor necrosis factor-alpha gene in Japanese patients with early-onset periodontitis. JOURNAL OF PERIODONTOLOGY, 72(11), 1554–1559. https://doi.org/10.1902/jop.2001.72.11.1554 Fassmann, A., Holla, L. I., Buckova, D., Vasku, A., Znojil, V., & Vanek, J. (2003). Polymorphisms in the+252(A/G) lymphotoxin-alpha and the-308(A/G) tumor necrosis factor-alpha genes and susceptibility to chronic periodontitis in a Czech population. JOURNAL OF PERIODONTAL RESEARCH, 38(4), 394–399. https://doi.org/10.1034/j.1600-0765.2003.00661.x Feuk, L., Carson, A., & Scherer, S. (2006). Structural variation in the human genome. Nat Rev Genet., 7(2), 85‐97. Figueredo, C. M., Lira-Junior, R., & Love, R. M. (2019). T and B Cells in Periodontal Disease: New Functions in A Complex Scenario. . International journal of molecular sciences, 20(16), 3949. doi:doi:10.3390/ijms20163949 Folwaczny, M., Glas, J., Torok, H. P., Mende, M., & Folwaczny, C. (2004). Lack of association between the TNF alpha G-308 A promoter polymorphism and periodontal disease. JOURNAL OF CLINICAL PERIODONTOLOGY, 31(6), 449–453. https://doi.org/10.1111/j.1600-051X.2004.00499.x Galbraith, G. M. P., Hendley, T. M., Sanders, J. J., Palesch, Y., & Pandey, J. P. (1999). Polymorphic cytokine genotypes as markers of disease severity in adult periodontitis. JOURNAL OF CLINICAL PERIODONTOLOGY, 26(11), 705–709. Galbraith, G. M. P., Steed, R. B., Sanders, J. J., & Pandey, J. P. (1998). Tumor necrosis factor alpha production by oral leukocytes: Influence of tumor necrosis factor genotype. JOURNAL OF PERIODONTOLOGY, 69(4), 428–433. https://doi.org/10.1902/jop.1998.69.4.428 Giovannetti de Menezes, N., & Colombo Vieira, A. P. (2008). Lack of association between the TNF- α -308 ( G / A ) genetic polymorphism and periodontal disease in Brazilians. Braz Oral Res, 22(4), 322–327 Gutiérrez, Iván Aurelio Páez; Hernández, David; Lozano, Diana María Vanegas; Rodríguez, Bernardo Armando Camacho; Arciniegas, Ana María Perdomo (2019). HLA-A, -B, -C, -DRB1 and –DQB1 allele and haplotype frequencies of 1463 umbilical cord blood units typed in high resolution from Bogotá, Colombia. Human Immunology, (), S0198885918309960–. doi:10.1016/j.humimm.2019.03.006 Hajeer, A., & Hutchinson, I. (2000). TNF-a Gene Polymorphism: Clinical and Biological Implications. Microsc. Res. Tech., 50 , 216-228. Hajeer, H., & Hutchinson, I. (2001). Human Immunology, 62, 1191-1199. Havlíček, J., Winternitz, J., & Craig Roberts. (2020). Jan Havlíček, JamieMajor histocompatibility complex-associated odour preferences and human mate choice: near and far horizons. Phil. Trans. R. Soc. Highfield, J. (2009). Diagnosis and classification of periodontal disease. Australian Dental Journal, S11-S26. Ho, Y.-P., Lin, Y.-C., Yang, Y.-H., Chou, Y.-H., Ho, K.-Y., Wu, Y.-M., & Tsai, C.-C. (2015). Analysis of tumor necrosis factor-alpha(-308) and lymphotoxin-alpha(+252) gene polymorphisms in Taiwanese patients with periodontitis. JOURNAL OF DENTAL SCIENCES, 10(3), 316–322. https://doi.org/10.1016/j.jds.2015.03.003 Ianni, M., Bruzzesi, G., Pugliese, D., Porcellini, E., Carbone, I., Schiavone, A., & Licastro, F. (2013). Variations in inflammatory genes are associated with periodontitis. IMMUNITY & AGEING, 10(39). https://doi.org/10.1186/1742-4933-10-39 Jaago M, Pupina N, Rähni A, Pihlak A, Sadam H, Vrana NE, Sinisalo J, Pussinen P, Palm K. Antibody response to oral biofilm is a biomarker for acute coronary syndrome in periodontal disease. Commun Biol. 2022 Mar 4;5(1):205. doi: 10.1038/s42003-022-03122-4. PMID: 35246599; PMCID: PMC8897497. Kazazoglu, E., & Korachi, M. (2011). A Comparative Study of the Role of Cytokine Polymorphisms Interleukin-10 and Tumor Necrosis Factor Alpha in Susceptibility to Implant Failure and Chronic Periodontitis. The International Journal of Oral & Maxillofacial Implants, 26(5), 955–960 Khammissa, R., Ballyram, R., Jadwat, Y., Fourie, J., Lemmer, J., & Feller, F. (octubre de 2018). Vitamin D Deficiency as It Relates to Oral Immunity and Chronic Periodontitis. Int J Dent. Kim, H., Ae, E. K., Park, K., Shin, Y., Kang, J., Lim, J., Bhak, J., Lee, J., Chul, B., & Joo, K. J. (2020). Detection of association between periodontitis and polymorphisms of IL-1 β + 3954 and TNF- α -863 in the Korean population after controlling for confounding risk factors. J Periodont Res. 2020, 55, 905–917. https://doi.org/10.1111/jre.12783 Kumar, N., Kaur, G., Tandon, N., & Mehra, N. (2012). Tumor necrosis factor–associated susceptibility to type 1 diabetes is caused by linkage disequilibrium with HLA-DR3 haplotypes. Human Immunology, 566-573 Kumar, S. (2019). Evidence-Based Update on Diagnosis and Management of Gingivitis and Periodontitis. In Dental Clinics of North America (Vol. 63, Issue 1, pp. 69–81). W.B. Saunders. https://doi.org/10.1016/j.cden.2018.08.005 Laine, M. L., Moustakis, V., Koumakis, L., Potamias, G., & Loos, B. G. (2013). Modeling Susceptibility to Periodontitis. J DENT RES, 92(1), 45–50. https://doi.org/10.1177/0022034512465435 Lavu, V., Venkatesan, V., Bhaskar, L., Priyanka, V., Durairaj Pau, S. F., & Rao, S. R. (2016). Polymorphic Regions in Fcgr and Tnf Alpha Genes and Susceptibility to Chronic Periodontitis in a Cohort From South India. JOURNAL OF PERIODONTOLOGY, 1–15. https://doi.org/10.1902/jop.2016.150743 Lavu, V., Venkatesan, V., Venugopal, P., Lakkakula, B. V. K. S., Paul, S. F. D., Peria, K., & Rao, S. R. (2017). Clinical Relevance of Cytokines Gene Polymorphisms and Protein Levels in Gingival Cervical Fluid from Chronic Periodontitis Patients. IRANIAN JOURNAL OF IMMUNOLOGY, 14(1), 51–58 Libeth Criado; Oscar Flórez; Javier Martín; Clara Isabel González (2012). Genetic polymorphisms in TNFA/TNFR2 genes and Chagas disease in a Colombian endemic population. , 57(3), 0–401. doi:10.1016/j.cyto.2011.12.007 Loo, W. T. Y., Fan, C., Bai, L., Yue, Y., Dou, Y., Wang, M., Liang, H., Cheung, M. N. B., Chow, L. W. C., Li, J., Tian, Y., & Qing, L. (2012). Gene polymorphism and protein of human pro- and anti-inflammatory cytokines in Chinese healthy subjects and chronic periodontitis patients. Journal of Translational Medicine, 10(suppl 1), S8. https://doi.org/10.1186/1479-5876-10-S1-S8 Loos, B. G., John, R. P., & Laine, M. L. (2005). Identification of genetic risk factors for periodontitis and possible mechanisms of action. Journal of Clinical Periodontology, 36, 159–179 Lundmark, A., Hu, Y., Huss, M., Johannsen, G., Andersson, A. F., & & Yucel-Lindberg, T. (2019). Identification of Salivary Microbiota and Its Association With Host Inflammatory Mediators in Periodontitis. 9(216). Majumder, P., Thou, K., Bhattacharya, M., Nair, V., Ghosh, S., & Dey, S. K. (2018). Association of tumor necrosis factor-alpha (TNF-alpha) gene promoter polymorphisms with aggressive and chronic periodontitis in the eastern Indian population. BIOSCIENCE REPORTS, 38(4), 1–14. https://doi.org/10.1042/BSR20171212 ministerio de salud . (2012). Obtenido de ministerio de salud : https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/ENSAB-IV-Situacion-Bucal-Actual.pdf Moreira, P. R., Costa, J. E., Gomez, R. S., Gollob, K. J., & Dutra, W. O. (2009). TNFA and IL10 Gene Polymorphisms are not Associated with Periodonti- tis in Brazilians. The Open Dentistry Journal, 3, 184–190 Mousavi Jazi, M., Solgi, G., Asl Roosta, H., Noshad, S., Moslemi, N., Sadrimanesh, R., Moradi, B., & Amirzargar, A. (2013). HLA-DRB and HLA-DQA / HLA-DQB allele and haplotype frequencies in Iranian patients with aggressive periodontitis. J Periodont Res, 48, 533–539. https://doi.org/10.1111/jre.12043 Moutsopoulos, N. M., Kling', H. M., Angelov, N., Jin, W., Palmer, R. J., Nares, S., . . . Wahl, S. M. (diciembre de 2012). P. gingivalis promotes Th17 inducing pathways in chronic periodontitis. J Autoimmun., 39(4), 294–303 Mysak, J., Podzimek, S., Sommerova, P., Lyuya-Mi, Y., Bartova, J., Janatova, T., Prochazkova, J., & Duskova, J. (2014). Porphyromonas gingivalis: Major periodontopathic pathogen overview. In Journal of Immunology Research (Vol. 2014). Hindawi Publishing Corporation. https://doi.org/10.1155/2014/476068 Ohyama, H., Takashiba, S., Oyaizu, K., Nagai, A., Naruse, T., Inoko, H., Kurihara, H., & Murayama, Y. (1996). HLA class II genotypes associated with early-onset periodontitis: DQB1 molecule primarily confers susceptibility to the disease. JOURNAL OF PERIODONTOLOGY, 67(9), 888–894. https://doi.org/10.1902/jop.1996.67.9.888 Pan, W., Wang, Q., & Chen, Q. (2019). The cytokine network involved in the host immune response to periodontitis. In International Journal of Oral Science (Vol. 11, Issue 3). Springer Nature. https://doi.org/10.1038/s41368-019-0064-z Reichert, S., Altermann, W., Stein, J. M., Schaller, H.-G., Machulla, H. K. G., & Schulz, S. (2013). Individual Composition of Human Leukocyte Antigens and Periodontopathogens in the Background of Periodontitis. Journal of Periodontology, 84(1), 100–109. https://doi.org/10.1902/jop.2012.110545 Romero-Sánchez C, Hernández N, Chila-Moreno L, Jiménez K, Padilla D, Bello-Gualtero JM, Bautista-Molano W. HLA-B Allele, Genotype, and Haplotype Frequencies in a Group of Healthy Individuals in Colombia. J Clin Rheumatol. 2021 Sep 1;27(6S):S148-S152. doi: 10.1097/RHU.0000000000001671. PMID: 33790206. Sakellari, D., Katsares, V., Georgiadou, M., Kouvatsi, A., Arsenakis, M., & Konstantinidis, A. (2006). No correlation of five gene polymorphisms with periodontal conditions in a Greek population. JOURNAL OF CLINICAL PERIODONTOLOGY, 33(11), 765–770. https://doi.org/10.1111/j.1600-051X.2006.00983.x Schulz, S., Machulla, H., Altermann, W., Klapproth, J., Zimmermann, U., Glaser, C., Kluttig, A., Stein, J., Schaller, H.-G., & Reichert, S. G. (2008). Genetic markers of tumour necrosis factor a in aggressive and chronic periodontitis. J Clin Periodontol, 35, 493–500. https://doi.org/10.1111/j.1600-051X.2008.01226.x Shapira, L., Stabholz, A., Rieckmann, P., & Kruse, N. (2001). Genetic polymorphism of the tumor necrosis factor ( TNF ) - a promoter region in families with localized early-onset periodontitis. J Periodont Res, 36(3), 183–186. Soga, Y., Nishimura, F., Ohyama, H., Maeda, H., Takashiba, S., & Murayama, Y. (2003). Tumor necrosis factor-alpha gene (TNF-alpha)-1031/-863,-857 single-nucleotide polymorphisms (SNPs) are associated with severe adult periodontitis in Japanese. JOURNAL OF CLINICAL PERIODONTOLOGY, 30(6), 524–531. https://doi.org/10.1034/j.1600-051X.2003.00287.x Sodek J, Mckee M. Molecular and cellular biology of alveolar bone. preiodontology 2000. 2000; 24(2): p. 99-126. Stabholz, A., aubrey soskolne, W., & shapira, ,. (2010). Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis. Periodontology 2000, 53, 138-153. Stein, J., Reichert, S., Gautsch, A., & Machulla, H. K. G. (2003). Are there HLA combinations typical supporting for or making resistant against aggressive and/or chronic periodontitis? Journal of Periodontal Research, 38(5), 508–517. https://doi.org/10.1034/j.1600-0765.2003.00683.x Takashiba, S., Noji, S., Nishimura, F., Ohyama, H., Kurihara, H., Nomura, Y., Taniguchi, S., & Murayama, Y. (1994). Unique Intronic Variations of HLA- DQß Gene in Early-Onset Periodontitis. J Periodontol, 65(5), 379–386. Trevilatto, P., Tramontina, V., Machado, M., Gonzalves, R., & Sallum, A. (2002). Clinical , genetic and microbiological findings in a Brazilian family with aggressive periodontitis. J Clin Periodontol, 29, 233–239 Yang, W., Jia, Y., & Wu, H. (2013). Four tumor necrosis factor alpha genes polymorphisms and periodontitis risk in a Chinese population. HUMAN IMMUNOLOGY, 74(12), 1684–1687. https://doi.org/10.1016/j.humimm.2013.08.009 Yucel-Lindberg, T., & Båge, T. (2015). Inflammatory mediators in the pathogenesis of periodontitis. Expert Reviews in Molecular Medicine, 15. Zhou M,Graves DT. Impact of the host response and osteoblast lineage cells on periodontal disease. Front Immunol. 2022 Oct 11;13:998244. doi: 10.3389/fimmu.2022.998244. PMID: 36304447; PMCID: PMC9592920. |
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Universidad Nacional de Colombia |
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Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Rey Buitrago, Mauricio6901d8aa13d0a96f75a55e493dcbf73cRomero Fonseca, Adriana Zulenye3803b5c7c4307d12e6a1ce250bce8daGenética clínica2023-04-12T16:20:59Z2023-04-12T16:20:59Z2023-04-11https://repositorio.unal.edu.co/handle/unal/83699Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustracionesRevisión sistemática de la literatura donde se reporta el resultado de la búsqueda de variantes en genes del Sistema Antígeno Leucocitario Humano y TNF- α asociadas a los fenotipos periodontitis crónica y agresiva, y su posible desequilibrio de ligamiento. La periodontitis es una enfermedad infecciosa que afecta los tejidos de soporte del diente (hueso y encía), dentro de sus presentaciones más comunes se encuentran la periodontitis crónica y la periodontitis agresiva. El TNF-α es una citoquina involucrada en el desarrollo y progresión de la enfermedad periodontal tanto crónica como agresiva; el gen del TNF-α se encuentra dentro de los genes HLA III en el cromosoma 6, dichos genes son heredados en bloque junto con HLA I y HLA II (desequilibrio de ligamiento). Debido a su papel en el desarrollo de la enfermedad periodontal las variantes de TNF-α, HLA I y II pueden llegar a ser indicativos de susceptibilidad a padecer enfermedad periodontal. (Texto tomado de la fuente)Systematic review of the literature where the results of the search for variants in genes of the Human Leukocyte Antigen System and TNF-α associated with the chronic and aggressive periodontitis phenotypes, and their possible linkage disequilibrium, are reported. Periodontitis is an infectious disease that affects the supporting tissues of the tooth (bone and gum), among its most common presentations are chronic periodontitis and aggressive periodontitis. TNF-α is a cytokine involved in the development and progression of both chronic and aggressive periodontal disease; the TNF-α gene is found within the HLA III genes on chromosome 6, these genes are inherited en bloc along with HLA I and HLA II (linkage disequilibrium). Due to their role in the development of periodontal disease, TNF-α, HLA I and II variants may become indicative of susceptibility to periodontal disease.MaestríaMagíster en InmunologíaSe realizó una búsqueda de artículos (Pubmed, Wiley online library, Web of science); se tuvo como criterio de inclusión el uso de criterios para el diagnóstico de enfermedad periodontal según la clasificación de 1999 y la determinación y/o análisis de variantes en genes HLA, TNF o en todo el grupo de genes MHC evaluando su asociación con enfermedad periodontal; se excluyeron artículos que no estuviesen escritos en inglés o español, revisiones sistemáticas y/o metaanálisis, estudios en animales, evaluación de periodontitis apical o enfermedad peri-implantar, workshops o abstracts. La determinación del riesgo de sesgo se realizó a través de New Castle Otawa Scale. Para la determinación de la asociación se tomó como variable independiente el polimorfismo estudiado en cada uno de los estudios, la variable dependiente es el estado de salud periodontal. Las medidas de asociación debieron determinarse por pruebas estadísticas validadas para dicho fin (chi cuadrado, prueba de Fisher) y se reconoció entonces el valor p, en adición el valor de OR/RR: mayor a 1 se consideró como una asociación positiva y los valores menores a 1 con asociación negativa. La síntesis de datos se realizó basado en la presentación o no de la variante de TNF-A o de HLA, según esta variante se examinó la relación con los fenotipos de enfermedad periodontal (crónica y agresiva), para el desequilibrio de ligamiento se revisaron las asociaciones múltiples.xv, 34 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Maestría en InmunologíaFacultad de MedicinaBogotá,ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y saludPeriodontitis crónicaControl de infección dentalChronic PeriodontitisInfection Control, DentalTNF-αHLASNVLinkage disequilibriumPeriodontitis cronicaPeriodontitis agresivaDesequilibrio de ligamientoChronic periodontitisAggressive periodontitisVariantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemáticaGene variants in the Human Leukocyte Antigen (HLA) system and TNF alpha in chronic and aggressive periodontitis phenotypes: a systematic reviewTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMAguillón G, Juan C, Cruzat C, Andrea, Cuenca M, Jimena, & Cuchacovich T, Miguel. (2002). El polimorfismo genético del factor de necrosis tumoral alfa como factor de riesgo en patología. Revista médica de Chile, 130(9), 1043-1050. https://dx.doi.org/10.4067/S0034-98872002000900013Arrunategui, Ana María, Villegas, Adriana, Ocampo, Luz Ángela, Rodríguez, Libia María, & Badih, Abdelmounim. (2013). Frecuencias alélicas, genotípicas y haplotípicas del sistema HLA clase I y II en donantes de una población del suroccidente colombiano. Acta Medica Colombiana, 38(1), 16-21. Retrieved March 30, 2023, from http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-24482013000100006&lng=en&tlng=es.Babel, N., Cherepnev, G.,Babel, D., Tropmann Alla and Hammer, M., Volk, H.-D., & Reinke, P. (2006). Analysis of tumor necrosis factor-alpha, transforming growth factor-beta, interleukin-10, IL-6, and interferon-gamma gene polymorphisms in patients with chronic periodontitis. JOURNAL OF PERIODONTOLOGY, 77(12), 1978–1983. https://doi.org/10.1902/jop.2006.050315Barnea, T. V., Sava, A., Gentimir, C., Goriuc, A., Boisteanu, O., Chelaru, L., Iancu, R. I., Avram, C. A., Acatrinei, D. D., Bogza, E. G., Raducanu, O. C., Cioloca, D. P., Vasincu, D., & Costuleanu, M. (2015). Genetic polymorphisms of TNFA and IL-1A and generalized aggressive periodontitis. ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY, 56(2), 459–464Batool, A.-G. H., Saif, S. S., Raad, A.-A. S., & Ahmed, A. A. (2017a). Analysis of HLA-DQB1 Alleles Frequency in Patients with Chronic Periodontitis. International Journal of Medical Research & Health Sciences, 6(8), 12–16.Berker, E., Eratalay, K., & Tepe, E. (2015). Analysis of TNF- a ( -308 ) polymorphism and gingival crevicular fluid TNF- a levels in aggressive and chronic periodontitis : A preliminary report. Cytokine, 72, 173–177. https://doi.org/10.1016/j.cyto.2015.01.001Brett, P. M., Zygogianni, P., Griffiths, G. S., Tomaz, M., Parkar, M., D’Aiuto, F., & Tonetti, M. (2005). Functional Gene Polymorphisms in Aggressive and Chronic Periodontitis. JOURNAL OF DENTAL RESEARCH, 12, 1149–1153. https://doi.org/10.1177/154405910508401211Cardoso, E. M., Reis, C., & Manzanares-Céspedes, M. C. (2018). Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases. In Postgraduate Medicine (Vol. 130, Issue 1, pp. 98–104). Taylor and Francis Inc. https://doi.org/10.1080/00325481.2018.1396876Cao Jea. Hyaluronan Increases RANKL Expression in Bone Marrow Stromal Cells Through CD44. J Bone Miner Res. 2005; 20(1)Costa, A. M., Guimaraes, M. C. M., Souza, E. R. de, & Nobrega, O. T. (2010). Interleukin-6 ( G-174C ) and tumour necrosis factor-alpha ( G-308A ) gene polymorphisms in geriatric patients with chronic periodontitis. Gerodontology, 27, 70–75. https://doi.org/10.1111/j.1741-2358.2009.00291.xCraandijk, J., van Krugten, M. v, Verweij, C. L., van der Velden, U., & Loos, B. G. (2002). Tumor necrosis factor- a gene polymorphisms in relation to periodontitis. J Clin Periodontol, 29, 28–34Craandijk, J., van Krugten, M. v, Verweij, C. L., & van der Velden U and Loos, B. G. (2002). Tumor necrosis factor-alpha gene polymorphisms in relation to periodontitis. JOURNAL OF CLINICAL PERIODONTOLOGY, 29(1), 28–34. https://doi.org/10.1034/j.1600-051x.2002.290105.xDarvishi, E., Yari, K., Kahrizi, D., & Karim, H. A. (2016). Lack of association between the TNF-α-1031 genotypes and generalized aggressive periodontitis disease. Cell. Mol. Biol, 62(11), 62–65. https://doi.org/10.14715/cmb/Donati, M., Berglundh, T., Hytonen, A. M., Hahn-Zoric, M., Hanson, L., & Padyukov, L. (2005). Association of the-159 CD14 gene polymorphism and lack of association of the-308 TNFA and Q551R IL-4RA polymorphisms with severe chronic periodontitis in Swedish Caucasians. JOURNAL OF CLINICAL PERIODONTOLOGY, 32(5), 474–479. https://doi.org/10.1111/j.1600-051X.2005.00697.xDosseva-Panova, V., Mlachkova, A., Popova, C., & Kicheva, M. (2015). Evaluation of Interleukin-6, Lymphotoxin-Α and Tnf-Α Gene Polymorphisms in Chronic Periodontitis. Journal of IMAB - Annual Proceeding (Scientific Papers), 21(3), 868–875. https://doi.org/10.5272/jimab.2015213.868Ebadian, A. R., Radvar, M., Afshari, J. T., Sargolzaee, N., Brook, A., Ganjali, R., Tamizi, M., & Arab, H. R. (2013). Gene Polymorphisms of TNF-alpha and IL-1 beta Are Not Associated with Generalized Aggressive Periodontitis in an Iranian Subpopulation. IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY, 12(4), 345–351Endo, M., Tai, H., Tabeta, K., Kobayashi, T., Yamazaki, K., & Yoshie, H. (2001). Analysis of single nucleotide polymorphisms in the 5’-flanking region of tumor necrosis factor-alpha gene in Japanese patients with early-onset periodontitis. JOURNAL OF PERIODONTOLOGY, 72(11), 1554–1559. https://doi.org/10.1902/jop.2001.72.11.1554Fassmann, A., Holla, L. I., Buckova, D., Vasku, A., Znojil, V., & Vanek, J. (2003). Polymorphisms in the+252(A/G) lymphotoxin-alpha and the-308(A/G) tumor necrosis factor-alpha genes and susceptibility to chronic periodontitis in a Czech population. JOURNAL OF PERIODONTAL RESEARCH, 38(4), 394–399. https://doi.org/10.1034/j.1600-0765.2003.00661.xFeuk, L., Carson, A., & Scherer, S. (2006). Structural variation in the human genome. Nat Rev Genet., 7(2), 85‐97.Figueredo, C. M., Lira-Junior, R., & Love, R. M. (2019). T and B Cells in Periodontal Disease: New Functions in A Complex Scenario. . International journal of molecular sciences, 20(16), 3949. doi:doi:10.3390/ijms20163949Folwaczny, M., Glas, J., Torok, H. P., Mende, M., & Folwaczny, C. (2004). Lack of association between the TNF alpha G-308 A promoter polymorphism and periodontal disease. JOURNAL OF CLINICAL PERIODONTOLOGY, 31(6), 449–453. https://doi.org/10.1111/j.1600-051X.2004.00499.xGalbraith, G. M. P., Hendley, T. M., Sanders, J. J., Palesch, Y., & Pandey, J. P. (1999). Polymorphic cytokine genotypes as markers of disease severity in adult periodontitis. JOURNAL OF CLINICAL PERIODONTOLOGY, 26(11), 705–709.Galbraith, G. M. P., Steed, R. B., Sanders, J. J., & Pandey, J. P. (1998). Tumor necrosis factor alpha production by oral leukocytes: Influence of tumor necrosis factor genotype. JOURNAL OF PERIODONTOLOGY, 69(4), 428–433. https://doi.org/10.1902/jop.1998.69.4.428Giovannetti de Menezes, N., & Colombo Vieira, A. P. (2008). Lack of association between the TNF- α -308 ( G / A ) genetic polymorphism and periodontal disease in Brazilians. Braz Oral Res, 22(4), 322–327Gutiérrez, Iván Aurelio Páez; Hernández, David; Lozano, Diana María Vanegas; Rodríguez, Bernardo Armando Camacho; Arciniegas, Ana María Perdomo (2019). HLA-A, -B, -C, -DRB1 and –DQB1 allele and haplotype frequencies of 1463 umbilical cord blood units typed in high resolution from Bogotá, Colombia. Human Immunology, (), S0198885918309960–. doi:10.1016/j.humimm.2019.03.006Hajeer, A., & Hutchinson, I. (2000). TNF-a Gene Polymorphism: Clinical and Biological Implications. Microsc. Res. Tech., 50 , 216-228.Hajeer, H., & Hutchinson, I. (2001). Human Immunology, 62, 1191-1199.Havlíček, J., Winternitz, J., & Craig Roberts. (2020). Jan Havlíček, JamieMajor histocompatibility complex-associated odour preferences and human mate choice: near and far horizons. Phil. Trans. R. Soc.Highfield, J. (2009). Diagnosis and classification of periodontal disease. Australian Dental Journal, S11-S26.Ho, Y.-P., Lin, Y.-C., Yang, Y.-H., Chou, Y.-H., Ho, K.-Y., Wu, Y.-M., & Tsai, C.-C. (2015). Analysis of tumor necrosis factor-alpha(-308) and lymphotoxin-alpha(+252) gene polymorphisms in Taiwanese patients with periodontitis. JOURNAL OF DENTAL SCIENCES, 10(3), 316–322. https://doi.org/10.1016/j.jds.2015.03.003Ianni, M., Bruzzesi, G., Pugliese, D., Porcellini, E., Carbone, I., Schiavone, A., & Licastro, F. (2013). Variations in inflammatory genes are associated with periodontitis. IMMUNITY & AGEING, 10(39). https://doi.org/10.1186/1742-4933-10-39Jaago M, Pupina N, Rähni A, Pihlak A, Sadam H, Vrana NE, Sinisalo J, Pussinen P, Palm K. Antibody response to oral biofilm is a biomarker for acute coronary syndrome in periodontal disease. Commun Biol. 2022 Mar 4;5(1):205. doi: 10.1038/s42003-022-03122-4. PMID: 35246599; PMCID: PMC8897497.Kazazoglu, E., & Korachi, M. (2011). A Comparative Study of the Role of Cytokine Polymorphisms Interleukin-10 and Tumor Necrosis Factor Alpha in Susceptibility to Implant Failure and Chronic Periodontitis. The International Journal of Oral & Maxillofacial Implants, 26(5), 955–960Khammissa, R., Ballyram, R., Jadwat, Y., Fourie, J., Lemmer, J., & Feller, F. (octubre de 2018). Vitamin D Deficiency as It Relates to Oral Immunity and Chronic Periodontitis. Int J Dent.Kim, H., Ae, E. K., Park, K., Shin, Y., Kang, J., Lim, J., Bhak, J., Lee, J., Chul, B., & Joo, K. J. (2020). Detection of association between periodontitis and polymorphisms of IL-1 β + 3954 and TNF- α -863 in the Korean population after controlling for confounding risk factors. J Periodont Res. 2020, 55, 905–917. https://doi.org/10.1111/jre.12783Kumar, N., Kaur, G., Tandon, N., & Mehra, N. (2012). Tumor necrosis factor–associated susceptibility to type 1 diabetes is caused by linkage disequilibrium with HLA-DR3 haplotypes. Human Immunology, 566-573Kumar, S. (2019). Evidence-Based Update on Diagnosis and Management of Gingivitis and Periodontitis. In Dental Clinics of North America (Vol. 63, Issue 1, pp. 69–81). W.B. Saunders. https://doi.org/10.1016/j.cden.2018.08.005Laine, M. L., Moustakis, V., Koumakis, L., Potamias, G., & Loos, B. G. (2013). Modeling Susceptibility to Periodontitis. J DENT RES, 92(1), 45–50. https://doi.org/10.1177/0022034512465435Lavu, V., Venkatesan, V., Bhaskar, L., Priyanka, V., Durairaj Pau, S. F., & Rao, S. R. (2016). Polymorphic Regions in Fcgr and Tnf Alpha Genes and Susceptibility to Chronic Periodontitis in a Cohort From South India. JOURNAL OF PERIODONTOLOGY, 1–15. https://doi.org/10.1902/jop.2016.150743Lavu, V., Venkatesan, V., Venugopal, P., Lakkakula, B. V. K. S., Paul, S. F. D., Peria, K., & Rao, S. R. (2017). Clinical Relevance of Cytokines Gene Polymorphisms and Protein Levels in Gingival Cervical Fluid from Chronic Periodontitis Patients. IRANIAN JOURNAL OF IMMUNOLOGY, 14(1), 51–58Libeth Criado; Oscar Flórez; Javier Martín; Clara Isabel González (2012). Genetic polymorphisms in TNFA/TNFR2 genes and Chagas disease in a Colombian endemic population. , 57(3), 0–401. doi:10.1016/j.cyto.2011.12.007Loo, W. T. Y., Fan, C., Bai, L., Yue, Y., Dou, Y., Wang, M., Liang, H., Cheung, M. N. B., Chow, L. W. C., Li, J., Tian, Y., & Qing, L. (2012). Gene polymorphism and protein of human pro- and anti-inflammatory cytokines in Chinese healthy subjects and chronic periodontitis patients. Journal of Translational Medicine, 10(suppl 1), S8. https://doi.org/10.1186/1479-5876-10-S1-S8Loos, B. G., John, R. P., & Laine, M. L. (2005). Identification of genetic risk factors for periodontitis and possible mechanisms of action. Journal of Clinical Periodontology, 36, 159–179Lundmark, A., Hu, Y., Huss, M., Johannsen, G., Andersson, A. F., & & Yucel-Lindberg, T. (2019). Identification of Salivary Microbiota and Its Association With Host Inflammatory Mediators in Periodontitis. 9(216).Majumder, P., Thou, K., Bhattacharya, M., Nair, V., Ghosh, S., & Dey, S. K. (2018). Association of tumor necrosis factor-alpha (TNF-alpha) gene promoter polymorphisms with aggressive and chronic periodontitis in the eastern Indian population. BIOSCIENCE REPORTS, 38(4), 1–14. https://doi.org/10.1042/BSR20171212ministerio de salud . (2012). Obtenido de ministerio de salud : https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/ENSAB-IV-Situacion-Bucal-Actual.pdfMoreira, P. R., Costa, J. E., Gomez, R. S., Gollob, K. J., & Dutra, W. O. (2009). TNFA and IL10 Gene Polymorphisms are not Associated with Periodonti- tis in Brazilians. The Open Dentistry Journal, 3, 184–190Mousavi Jazi, M., Solgi, G., Asl Roosta, H., Noshad, S., Moslemi, N., Sadrimanesh, R., Moradi, B., & Amirzargar, A. (2013). HLA-DRB and HLA-DQA / HLA-DQB allele and haplotype frequencies in Iranian patients with aggressive periodontitis. J Periodont Res, 48, 533–539. https://doi.org/10.1111/jre.12043Moutsopoulos, N. M., Kling', H. M., Angelov, N., Jin, W., Palmer, R. J., Nares, S., . . . Wahl, S. M. (diciembre de 2012). P. gingivalis promotes Th17 inducing pathways in chronic periodontitis. J Autoimmun., 39(4), 294–303Mysak, J., Podzimek, S., Sommerova, P., Lyuya-Mi, Y., Bartova, J., Janatova, T., Prochazkova, J., & Duskova, J. (2014). Porphyromonas gingivalis: Major periodontopathic pathogen overview. In Journal of Immunology Research (Vol. 2014). Hindawi Publishing Corporation. https://doi.org/10.1155/2014/476068Ohyama, H., Takashiba, S., Oyaizu, K., Nagai, A., Naruse, T., Inoko, H., Kurihara, H., & Murayama, Y. (1996). HLA class II genotypes associated with early-onset periodontitis: DQB1 molecule primarily confers susceptibility to the disease. JOURNAL OF PERIODONTOLOGY, 67(9), 888–894. https://doi.org/10.1902/jop.1996.67.9.888Pan, W., Wang, Q., & Chen, Q. (2019). The cytokine network involved in the host immune response to periodontitis. In International Journal of Oral Science (Vol. 11, Issue 3). Springer Nature. https://doi.org/10.1038/s41368-019-0064-zReichert, S., Altermann, W., Stein, J. M., Schaller, H.-G., Machulla, H. K. G., & Schulz, S. (2013). Individual Composition of Human Leukocyte Antigens and Periodontopathogens in the Background of Periodontitis. Journal of Periodontology, 84(1), 100–109. https://doi.org/10.1902/jop.2012.110545Romero-Sánchez C, Hernández N, Chila-Moreno L, Jiménez K, Padilla D, Bello-Gualtero JM, Bautista-Molano W. HLA-B Allele, Genotype, and Haplotype Frequencies in a Group of Healthy Individuals in Colombia. J Clin Rheumatol. 2021 Sep 1;27(6S):S148-S152. doi: 10.1097/RHU.0000000000001671. PMID: 33790206.Sakellari, D., Katsares, V., Georgiadou, M., Kouvatsi, A., Arsenakis, M., & Konstantinidis, A. (2006). No correlation of five gene polymorphisms with periodontal conditions in a Greek population. JOURNAL OF CLINICAL PERIODONTOLOGY, 33(11), 765–770. https://doi.org/10.1111/j.1600-051X.2006.00983.xSchulz, S., Machulla, H., Altermann, W., Klapproth, J., Zimmermann, U., Glaser, C., Kluttig, A., Stein, J., Schaller, H.-G., & Reichert, S. G. (2008). Genetic markers of tumour necrosis factor a in aggressive and chronic periodontitis. J Clin Periodontol, 35, 493–500. https://doi.org/10.1111/j.1600-051X.2008.01226.xShapira, L., Stabholz, A., Rieckmann, P., & Kruse, N. (2001). Genetic polymorphism of the tumor necrosis factor ( TNF ) - a promoter region in families with localized early-onset periodontitis. J Periodont Res, 36(3), 183–186.Soga, Y., Nishimura, F., Ohyama, H., Maeda, H., Takashiba, S., & Murayama, Y. (2003). Tumor necrosis factor-alpha gene (TNF-alpha)-1031/-863,-857 single-nucleotide polymorphisms (SNPs) are associated with severe adult periodontitis in Japanese. JOURNAL OF CLINICAL PERIODONTOLOGY, 30(6), 524–531. https://doi.org/10.1034/j.1600-051X.2003.00287.xSodek J, Mckee M. Molecular and cellular biology of alveolar bone. preiodontology 2000. 2000; 24(2): p. 99-126.Stabholz, A., aubrey soskolne, W., & shapira, ,. (2010). Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis. Periodontology 2000, 53, 138-153.Stein, J., Reichert, S., Gautsch, A., & Machulla, H. K. G. (2003). Are there HLA combinations typical supporting for or making resistant against aggressive and/or chronic periodontitis? Journal of Periodontal Research, 38(5), 508–517. https://doi.org/10.1034/j.1600-0765.2003.00683.xTakashiba, S., Noji, S., Nishimura, F., Ohyama, H., Kurihara, H., Nomura, Y., Taniguchi, S., & Murayama, Y. (1994). Unique Intronic Variations of HLA- DQß Gene in Early-Onset Periodontitis. J Periodontol, 65(5), 379–386.Trevilatto, P., Tramontina, V., Machado, M., Gonzalves, R., & Sallum, A. (2002). Clinical , genetic and microbiological findings in a Brazilian family with aggressive periodontitis. J Clin Periodontol, 29, 233–239Yang, W., Jia, Y., & Wu, H. (2013). Four tumor necrosis factor alpha genes polymorphisms and periodontitis risk in a Chinese population. HUMAN IMMUNOLOGY, 74(12), 1684–1687. https://doi.org/10.1016/j.humimm.2013.08.009Yucel-Lindberg, T., & Båge, T. (2015). Inflammatory mediators in the pathogenesis of periodontitis. Expert Reviews in Molecular Medicine, 15.Zhou M,Graves DT. Impact of the host response and osteoblast lineage cells on periodontal disease. Front Immunol. 2022 Oct 11;13:998244. doi: 10.3389/fimmu.2022.998244. PMID: 36304447; PMCID: PMC9592920.Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemáticaTHUMBNAIL1013637179.2023.pdf.jpg1013637179.2023.pdf.jpgGenerated Thumbnailimage/jpeg5706https://repositorio.unal.edu.co/bitstream/unal/83699/3/1013637179.2023.pdf.jpg4021c3c4651333b0013c730d8bcd4e3fMD53ORIGINAL1013637179.2023.pdf1013637179.2023.pdfTesis de Maestría en Inmunologíaapplication/pdf895846https://repositorio.unal.edu.co/bitstream/unal/83699/2/1013637179.2023.pdfecdd72f5f5b89a712ad3ac420d580addMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/83699/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51unal/83699oai:repositorio.unal.edu.co:unal/836992023-08-01 23:03:28.221Repositorio Institucional Universidad Nacional de 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