Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática

ilustraciones

Autores:: Romero Fonseca, Adriana Zuleny

Tipo de recurso:

Fecha de publicación:: 2023

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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dc.title.spa.fl_str_mv	Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática
dc.title.translated.eng.fl_str_mv	Gene variants in the Human Leukocyte Antigen (HLA) system and TNF alpha in chronic and aggressive periodontitis phenotypes: a systematic review
title	Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática
spellingShingle	Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática 610 - Medicina y salud Periodontitis crónica Control de infección dental Chronic Periodontitis Infection Control, Dental TNF-α HLA SNV Linkage disequilibrium Periodontitis cronica Periodontitis agresiva Desequilibrio de ligamiento Chronic periodontitis Aggressive periodontitis
title_short	Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática
title_full	Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática
title_fullStr	Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática
title_full_unstemmed	Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática
title_sort	Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática
dc.creator.fl_str_mv	Romero Fonseca, Adriana Zuleny
dc.contributor.advisor.none.fl_str_mv	Rey Buitrago, Mauricio
dc.contributor.author.none.fl_str_mv	Romero Fonseca, Adriana Zuleny
dc.contributor.researchgroup.spa.fl_str_mv	Genética clínica
dc.subject.ddc.spa.fl_str_mv	610 - Medicina y salud
topic	610 - Medicina y salud Periodontitis crónica Control de infección dental Chronic Periodontitis Infection Control, Dental TNF-α HLA SNV Linkage disequilibrium Periodontitis cronica Periodontitis agresiva Desequilibrio de ligamiento Chronic periodontitis Aggressive periodontitis
dc.subject.decs.spa.fl_str_mv	Periodontitis crónica Control de infección dental
dc.subject.decs.eng.fl_str_mv	Chronic Periodontitis Infection Control, Dental
dc.subject.proposal.none.fl_str_mv	TNF-α HLA SNV Linkage disequilibrium
dc.subject.proposal.spa.fl_str_mv	Periodontitis cronica Periodontitis agresiva Desequilibrio de ligamiento
dc.subject.proposal.eng.fl_str_mv	Chronic periodontitis Aggressive periodontitis
description	ilustraciones
publishDate	2023
dc.date.accessioned.none.fl_str_mv	2023-04-12T16:20:59Z
dc.date.available.none.fl_str_mv	2023-04-12T16:20:59Z
dc.date.issued.none.fl_str_mv	2023-04-11
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/83699
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/83699 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
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spelling	Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Rey Buitrago, Mauricio6901d8aa13d0a96f75a55e493dcbf73cRomero Fonseca, Adriana Zulenye3803b5c7c4307d12e6a1ce250bce8daGenética clínica2023-04-12T16:20:59Z2023-04-12T16:20:59Z2023-04-11https://repositorio.unal.edu.co/handle/unal/83699Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustracionesRevisión sistemática de la literatura donde se reporta el resultado de la búsqueda de variantes en genes del Sistema Antígeno Leucocitario Humano y TNF- α asociadas a los fenotipos periodontitis crónica y agresiva, y su posible desequilibrio de ligamiento. La periodontitis es una enfermedad infecciosa que afecta los tejidos de soporte del diente (hueso y encía), dentro de sus presentaciones más comunes se encuentran la periodontitis crónica y la periodontitis agresiva. El TNF-α es una citoquina involucrada en el desarrollo y progresión de la enfermedad periodontal tanto crónica como agresiva; el gen del TNF-α se encuentra dentro de los genes HLA III en el cromosoma 6, dichos genes son heredados en bloque junto con HLA I y HLA II (desequilibrio de ligamiento). Debido a su papel en el desarrollo de la enfermedad periodontal las variantes de TNF-α, HLA I y II pueden llegar a ser indicativos de susceptibilidad a padecer enfermedad periodontal. (Texto tomado de la fuente)Systematic review of the literature where the results of the search for variants in genes of the Human Leukocyte Antigen System and TNF-α associated with the chronic and aggressive periodontitis phenotypes, and their possible linkage disequilibrium, are reported. Periodontitis is an infectious disease that affects the supporting tissues of the tooth (bone and gum), among its most common presentations are chronic periodontitis and aggressive periodontitis. TNF-α is a cytokine involved in the development and progression of both chronic and aggressive periodontal disease; the TNF-α gene is found within the HLA III genes on chromosome 6, these genes are inherited en bloc along with HLA I and HLA II (linkage disequilibrium). Due to their role in the development of periodontal disease, TNF-α, HLA I and II variants may become indicative of susceptibility to periodontal disease.MaestríaMagíster en InmunologíaSe realizó una búsqueda de artículos (Pubmed, Wiley online library, Web of science); se tuvo como criterio de inclusión el uso de criterios para el diagnóstico de enfermedad periodontal según la clasificación de 1999 y la determinación y/o análisis de variantes en genes HLA, TNF o en todo el grupo de genes MHC evaluando su asociación con enfermedad periodontal; se excluyeron artículos que no estuviesen escritos en inglés o español, revisiones sistemáticas y/o metaanálisis, estudios en animales, evaluación de periodontitis apical o enfermedad peri-implantar, workshops o abstracts. La determinación del riesgo de sesgo se realizó a través de New Castle Otawa Scale. Para la determinación de la asociación se tomó como variable independiente el polimorfismo estudiado en cada uno de los estudios, la variable dependiente es el estado de salud periodontal. Las medidas de asociación debieron determinarse por pruebas estadísticas validadas para dicho fin (chi cuadrado, prueba de Fisher) y se reconoció entonces el valor p, en adición el valor de OR/RR: mayor a 1 se consideró como una asociación positiva y los valores menores a 1 con asociación negativa. La síntesis de datos se realizó basado en la presentación o no de la variante de TNF-A o de HLA, según esta variante se examinó la relación con los fenotipos de enfermedad periodontal (crónica y agresiva), para el desequilibrio de ligamiento se revisaron las asociaciones múltiples.xv, 34 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Maestría en InmunologíaFacultad de MedicinaBogotá,ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y saludPeriodontitis crónicaControl de infección dentalChronic PeriodontitisInfection Control, DentalTNF-αHLASNVLinkage disequilibriumPeriodontitis cronicaPeriodontitis agresivaDesequilibrio de ligamientoChronic periodontitisAggressive periodontitisVariantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemáticaGene variants in the Human Leukocyte Antigen (HLA) system and TNF alpha in chronic and aggressive periodontitis phenotypes: a systematic reviewTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMAguillón G, Juan C, Cruzat C, Andrea, Cuenca M, Jimena, & Cuchacovich T, Miguel. (2002). El polimorfismo genético del factor de necrosis tumoral alfa como factor de riesgo en patología. Revista médica de Chile, 130(9), 1043-1050. https://dx.doi.org/10.4067/S0034-98872002000900013Arrunategui, Ana María, Villegas, Adriana, Ocampo, Luz Ángela, Rodríguez, Libia María, & Badih, Abdelmounim. (2013). Frecuencias alélicas, genotípicas y haplotípicas del sistema HLA clase I y II en donantes de una población del suroccidente colombiano. Acta Medica Colombiana, 38(1), 16-21. Retrieved March 30, 2023, from http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-24482013000100006&lng=en&tlng=es.Babel, N., Cherepnev, G.,Babel, D., Tropmann Alla and Hammer, M., Volk, H.-D., & Reinke, P. (2006). Analysis of tumor necrosis factor-alpha, transforming growth factor-beta, interleukin-10, IL-6, and interferon-gamma gene polymorphisms in patients with chronic periodontitis. JOURNAL OF PERIODONTOLOGY, 77(12), 1978–1983. https://doi.org/10.1902/jop.2006.050315Barnea, T. 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(2015). Inflammatory mediators in the pathogenesis of periodontitis. Expert Reviews in Molecular Medicine, 15.Zhou M,Graves DT. Impact of the host response and osteoblast lineage cells on periodontal disease. Front Immunol. 2022 Oct 11;13:998244. doi: 10.3389/fimmu.2022.998244. PMID: 36304447; PMCID: PMC9592920.Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemáticaTHUMBNAIL1013637179.2023.pdf.jpg1013637179.2023.pdf.jpgGenerated Thumbnailimage/jpeg5706https://repositorio.unal.edu.co/bitstream/unal/83699/3/1013637179.2023.pdf.jpg4021c3c4651333b0013c730d8bcd4e3fMD53ORIGINAL1013637179.2023.pdf1013637179.2023.pdfTesis de Maestría en Inmunologíaapplication/pdf895846https://repositorio.unal.edu.co/bitstream/unal/83699/2/1013637179.2023.pdfecdd72f5f5b89a712ad3ac420d580addMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/83699/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51unal/83699oai:repositorio.unal.edu.co:unal/836992023-08-01 23:03:28.221Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.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Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática

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