Asociación entre disminución de la sensibilidad parasitaria in vitro y respuesta terapéutica en pacientes con Leishmaniasis cutánea tratados en el centro dermatológico Federico Lleras Acosta de la ciudad de Bogotá entre 2006 y 2012

Cutaneous leishmaniasis is a neglected tropical disease, broadly distributed in the planet and with high incidence among socially vulnerable persons. It has been underestimated by healthcare systems and society, with a great burden of disease. Despite an available effective and well established trea...

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Autores:
Zapata Pinillos, Erik
Tipo de recurso:
Fecha de publicación:
2021
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
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oai:repositorio.unal.edu.co:unal/80048
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/80048
https://repositorio.unal.edu.co/
Palabra clave:
610 - Medicina y salud::616 - Enfermedades
Leishmaniasis
Miltefosine
Resistencia a drogas
Antimoniato de meglumina
Pentamidina
Leishmaniasis cutánea
resistencia a drogas
Leishmaniasis
Miltefosine
Drug resistance
Meglumine antimoniate
Pentamidine
Cutaneous leishmaniasis
Miltefosine
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openAccess
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Reconocimiento 4.0 Internacional
id UNACIONAL2_b6c56cd493fe640e9f087c849bd4b3d8
oai_identifier_str oai:repositorio.unal.edu.co:unal/80048
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.none.fl_str_mv Asociación entre disminución de la sensibilidad parasitaria in vitro y respuesta terapéutica en pacientes con Leishmaniasis cutánea tratados en el centro dermatológico Federico Lleras Acosta de la ciudad de Bogotá entre 2006 y 2012
dc.title.translated.eng.fl_str_mv Association between reduced in vitro susceptibility and response to treatment in cutaneous leishmaniasis patients treated in the dermatologic centre Federico Lleras Acosta in Bogota between 2006 and 2012
title Asociación entre disminución de la sensibilidad parasitaria in vitro y respuesta terapéutica en pacientes con Leishmaniasis cutánea tratados en el centro dermatológico Federico Lleras Acosta de la ciudad de Bogotá entre 2006 y 2012
spellingShingle Asociación entre disminución de la sensibilidad parasitaria in vitro y respuesta terapéutica en pacientes con Leishmaniasis cutánea tratados en el centro dermatológico Federico Lleras Acosta de la ciudad de Bogotá entre 2006 y 2012
610 - Medicina y salud::616 - Enfermedades
Leishmaniasis
Miltefosine
Resistencia a drogas
Antimoniato de meglumina
Pentamidina
Leishmaniasis cutánea
resistencia a drogas
Leishmaniasis
Miltefosine
Drug resistance
Meglumine antimoniate
Pentamidine
Cutaneous leishmaniasis
Miltefosine
title_short Asociación entre disminución de la sensibilidad parasitaria in vitro y respuesta terapéutica en pacientes con Leishmaniasis cutánea tratados en el centro dermatológico Federico Lleras Acosta de la ciudad de Bogotá entre 2006 y 2012
title_full Asociación entre disminución de la sensibilidad parasitaria in vitro y respuesta terapéutica en pacientes con Leishmaniasis cutánea tratados en el centro dermatológico Federico Lleras Acosta de la ciudad de Bogotá entre 2006 y 2012
title_fullStr Asociación entre disminución de la sensibilidad parasitaria in vitro y respuesta terapéutica en pacientes con Leishmaniasis cutánea tratados en el centro dermatológico Federico Lleras Acosta de la ciudad de Bogotá entre 2006 y 2012
title_full_unstemmed Asociación entre disminución de la sensibilidad parasitaria in vitro y respuesta terapéutica en pacientes con Leishmaniasis cutánea tratados en el centro dermatológico Federico Lleras Acosta de la ciudad de Bogotá entre 2006 y 2012
title_sort Asociación entre disminución de la sensibilidad parasitaria in vitro y respuesta terapéutica en pacientes con Leishmaniasis cutánea tratados en el centro dermatológico Federico Lleras Acosta de la ciudad de Bogotá entre 2006 y 2012
dc.creator.fl_str_mv Zapata Pinillos, Erik
dc.contributor.advisor.none.fl_str_mv Saavedra Trujillo, Carlos Humberto
Echeverry Gaitan, Maria Clara
dc.contributor.author.none.fl_str_mv Zapata Pinillos, Erik
dc.subject.ddc.spa.fl_str_mv 610 - Medicina y salud::616 - Enfermedades
topic 610 - Medicina y salud::616 - Enfermedades
Leishmaniasis
Miltefosine
Resistencia a drogas
Antimoniato de meglumina
Pentamidina
Leishmaniasis cutánea
resistencia a drogas
Leishmaniasis
Miltefosine
Drug resistance
Meglumine antimoniate
Pentamidine
Cutaneous leishmaniasis
Miltefosine
dc.subject.proposal.spa.fl_str_mv Leishmaniasis
Miltefosine
Resistencia a drogas
Antimoniato de meglumina
Pentamidina
Leishmaniasis cutánea
resistencia a drogas
dc.subject.proposal.eng.fl_str_mv Leishmaniasis
Miltefosine
Drug resistance
Meglumine antimoniate
Pentamidine
Cutaneous leishmaniasis
Miltefosine
description Cutaneous leishmaniasis is a neglected tropical disease, broadly distributed in the planet and with high incidence among socially vulnerable persons. It has been underestimated by healthcare systems and society, with a great burden of disease. Despite an available effective and well established treatment since the 50’s, it has been documented an increasing rate of resistance and treatment failure. Reports in Latin America, show resistance rates between 10-20% and 25% of subjects with treatment failure using first line drugs. Nevertheless, there is no clear association between reduced in vitro susceptibility from the parasite and treatment response. This case control study with 34 subjects in a reference center in Bogotá, aimed to establish an association between reduced in vitro susceptibility and response to treatment. The results showed an OR 0.71 (IC 95% 0.085 – 9.39), which possibly means that there is no relation among the mentioned variables. These results suggest that susceptibility testing would not impact clinical decision making as treatment failure predictors, therefore limiting its systematic use
publishDate 2021
dc.date.accessioned.none.fl_str_mv 2021-08-27T22:52:33Z
dc.date.available.none.fl_str_mv 2021-08-27T22:52:33Z
dc.date.issued.none.fl_str_mv 2021-07-26
dc.type.spa.fl_str_mv Trabajo de grado - Especialidad Médica
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/80048
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/80048
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
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spelling Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Saavedra Trujillo, Carlos Humberto08c609ca0fa0817e557a78e527acaa4fEcheverry Gaitan, Maria Clarab92a66f8bde4778de4953033bae69422Zapata Pinillos, Erik71bc9c2dc11baf63ef17c81bc5cd486c2021-08-27T22:52:33Z2021-08-27T22:52:33Z2021-07-26https://repositorio.unal.edu.co/handle/unal/80048Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/Cutaneous leishmaniasis is a neglected tropical disease, broadly distributed in the planet and with high incidence among socially vulnerable persons. It has been underestimated by healthcare systems and society, with a great burden of disease. Despite an available effective and well established treatment since the 50’s, it has been documented an increasing rate of resistance and treatment failure. Reports in Latin America, show resistance rates between 10-20% and 25% of subjects with treatment failure using first line drugs. Nevertheless, there is no clear association between reduced in vitro susceptibility from the parasite and treatment response. This case control study with 34 subjects in a reference center in Bogotá, aimed to establish an association between reduced in vitro susceptibility and response to treatment. The results showed an OR 0.71 (IC 95% 0.085 – 9.39), which possibly means that there is no relation among the mentioned variables. These results suggest that susceptibility testing would not impact clinical decision making as treatment failure predictors, therefore limiting its systematic useLa leishmaniasis cutánea es considerada una enfermedad tropical desatendida, con una amplia distribución geográfica en el mundo e incidencia importante en población socialmente vulnerable. Tiene un impacto infravalorado por la sociedad y los sistemas de salud, con una carga de enfermedad no despreciable. A pesar de disponer de esquemas terapéuticos desde hace 70 años, en las ultimas décadas se ha venido documentando resistencia creciente por parte del parásito a las primeras líneas de tratamiento y altos índices de falla terapéutica. Trabajos realizados en América Latina reportan resistencia entre el 10-20% y tasas de falla terapéutica a la primera línea de tratamiento del 25%. Sin embargo, no es clara la correlación entre la disminución de la sensibilidad parasitaria in vitro y la respuesta terapéutica. Se realizó un estudio de casos y controles, con un total de 34 pacientes en un centro de referencia de Bogotá para determinar la asociación entre la sensibilidad in vitro disminuida y la respuesta clínica al tratamiento. Se obtuvo un OR 0.71 (IC 95% 0.085 – 9.39) con lo cual posiblemente no existe relación entre las variables. Estos resultados sugieren que las pruebas de sensibilidad disminuidas in vitro no impactan en la toma de decisiones en la practica clínica, como posibles predictores de falla al tratamiento por lo cual el papel en el uso sistemático de ellas es limitado.Especialidades MédicasEspecialista en medicina internaDesarrollo de métodos diagnósticos en enfermedades de transmisión vectorial43 páginasapplication/pdf610 - Medicina y salud::616 - EnfermedadesLeishmaniasisMiltefosineResistencia a drogasAntimoniato de megluminaPentamidinaLeishmaniasis cutánearesistencia a drogasLeishmaniasisMiltefosineDrug resistanceMeglumine antimoniatePentamidineCutaneous leishmaniasisMiltefosineAsociación entre disminución de la sensibilidad parasitaria in vitro y respuesta terapéutica en pacientes con Leishmaniasis cutánea tratados en el centro dermatológico Federico Lleras Acosta de la ciudad de Bogotá entre 2006 y 2012Association between reduced in vitro susceptibility and response to treatment in cutaneous leishmaniasis patients treated in the dermatologic centre Federico Lleras Acosta in Bogota between 2006 and 2012Trabajo de grado - Especialidad Médicainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBogotá - Medicina - Especialidad en Medicina InternaDepartamento de Medicina InternaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá1. 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Sensitivity of Leishmania braziliensis promastigotes to meglumine antimoniate (glucantime) is higher than that of other Leishmania species and correlates with response to therapy in American tegumentary leishmaniasis. J Parasitol. 2007 Jun;93(3):688-693LICENSElicense.txtlicense.txttext/plain; charset=utf-83964https://repositorio.unal.edu.co/bitstream/unal/80048/1/license.txtcccfe52f796b7c63423298c2d3365fc6MD51ORIGINAL1140834196.2021.pdf1140834196.2021.pdfTesis de Especialización en Medicina Internaapplication/pdf923720https://repositorio.unal.edu.co/bitstream/unal/80048/2/1140834196.2021.pdffbe2f89c53e6f23ae7861ae69bbe8954MD52CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8908https://repositorio.unal.edu.co/bitstream/unal/80048/3/license_rdf0175ea4a2d4caec4bbcc37e300941108MD53THUMBNAIL1140834196.2021.pdf.jpg1140834196.2021.pdf.jpgGenerated Thumbnailimage/jpeg3935https://repositorio.unal.edu.co/bitstream/unal/80048/4/1140834196.2021.pdf.jpgb322cbd44ebcc81745d6e348ef01bb06MD54unal/80048oai:repositorio.unal.edu.co:unal/800482023-07-26 23:04:15.032Repositorio Institucional Universidad Nacional de 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GVyZWNob3MgZGUgYXV0b3IgcXVlIGNvbmxsZXZlIGxhIGRpc3RyaWJ1Y2nDs24gZGUgZXN0b3MgYXJjaGl2b3MgeSBtZXRhZGF0b3MuCkFsIGhhY2VyIGNsaWMgZW4gZWwgc2lndWllbnRlIGJvdMOzbiwgdXN0ZWQgaW5kaWNhIHF1ZSBlc3TDoSBkZSBhY3VlcmRvIGNvbiBlc3RvcyB0w6lybWlub3MuCgpVTklWRVJTSURBRCBOQUNJT05BTCBERSBDT0xPTUJJQSAtIMOabHRpbWEgbW9kaWZpY2FjacOzbiAyNy8yMC8yMDIwCg==

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