Sistema aplicador de campo electromagnético para el tratamiento del melanoma usando hipertermia local

ilustraciones, diagramas

Autores:: Duque Muñoz, José Luis

Tipo de recurso:

Fecha de publicación:: 2024

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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repository_id_str
dc.title.spa.fl_str_mv	Sistema aplicador de campo electromagnético para el tratamiento del melanoma usando hipertermia local
dc.title.translated.eng.fl_str_mv	Electromagnetic field applicator system for the treatment of melanoma using local hyperthermia
title	Sistema aplicador de campo electromagnético para el tratamiento del melanoma usando hipertermia local
spellingShingle	Sistema aplicador de campo electromagnético para el tratamiento del melanoma usando hipertermia local 530 - Física::537 - Electricidad y electrónica 610 - Medicina y salud::616 - Enfermedades 610 - Medicina y salud::615 - Farmacología y terapéutica Melanoma/terapia Hipertermia Equipos y Suministros Eléctricos Melanoma/therapy Hyperthermia Electrical Equipment and Supplies Aplicador Fantoma Hipertermia Melanoma SAR Applicator Phantom Hyperthermia Melanoma SAR
title_short	Sistema aplicador de campo electromagnético para el tratamiento del melanoma usando hipertermia local
title_full	Sistema aplicador de campo electromagnético para el tratamiento del melanoma usando hipertermia local
title_fullStr	Sistema aplicador de campo electromagnético para el tratamiento del melanoma usando hipertermia local
title_full_unstemmed	Sistema aplicador de campo electromagnético para el tratamiento del melanoma usando hipertermia local
title_sort	Sistema aplicador de campo electromagnético para el tratamiento del melanoma usando hipertermia local
dc.creator.fl_str_mv	Duque Muñoz, José Luis
dc.contributor.advisor.spa.fl_str_mv	Araque Quijano, Javier Leonardo
dc.contributor.author.spa.fl_str_mv	Duque Muñoz, José Luis
dc.contributor.researchgroup.spa.fl_str_mv	Grupo de Investigación en Electrónica de Alta Frecuencia y Telecomunicaciones (Cmun)
dc.subject.ddc.spa.fl_str_mv	530 - Física::537 - Electricidad y electrónica 610 - Medicina y salud::616 - Enfermedades 610 - Medicina y salud::615 - Farmacología y terapéutica
topic	530 - Física::537 - Electricidad y electrónica 610 - Medicina y salud::616 - Enfermedades 610 - Medicina y salud::615 - Farmacología y terapéutica Melanoma/terapia Hipertermia Equipos y Suministros Eléctricos Melanoma/therapy Hyperthermia Electrical Equipment and Supplies Aplicador Fantoma Hipertermia Melanoma SAR Applicator Phantom Hyperthermia Melanoma SAR
dc.subject.decs.spa.fl_str_mv	Melanoma/terapia Hipertermia Equipos y Suministros Eléctricos
dc.subject.decs.eng.fl_str_mv	Melanoma/therapy Hyperthermia Electrical Equipment and Supplies
dc.subject.proposal.spa.fl_str_mv	Aplicador Fantoma Hipertermia Melanoma SAR
dc.subject.proposal.eng.fl_str_mv	Applicator Phantom Hyperthermia Melanoma SAR
description	ilustraciones, diagramas
publishDate	2024
dc.date.accessioned.none.fl_str_mv	2024-07-17T13:55:47Z
dc.date.available.none.fl_str_mv	2024-07-17T13:55:47Z
dc.date.issued.none.fl_str_mv	2024
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/86513
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/86513 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.indexed.spa.fl_str_mv	Bireme
dc.relation.references.spa.fl_str_mv	“IEC/IEEE International Standard - Measurement procedure for the assessment of specific absorption rate of human exposure to radio frequency fields from hand-held and body-mounted wireless communication devices – Part 1528: Human models, instrumentation, and procedures (Frequency range of 4 MHz to 10 GHz),” IEC/IEEE 62209-1528:2020, pp. 1–284, 2020. PDQ® Adult Treatment Editorial Board, “Melanoma Treatment,” Bethesda, MD: National Cancer Institute, 2023. [Online]. Available: https://www.cancer.gov/types/skin/patient/melanoma-treatment-pdq D. S. Rigel, J. Russak, and R. Friedman, “The evolution of melanoma diagnosis: 25 years beyond the abcds,” CA: A Cancer Journal for Clinicians, vol. 60, no. 5, pp. 301–316, 2010. [Online]. Available: https://acsjournals.onlinelibrary.wiley.com/doi/abs/10.3322/caac.20074 PDQ® Adult Treatment Editorial Board, “PDQ Skin Cancer Treatment,” Bethesda, MD: National Cancer Institute, 2023. [Online]. Available: https://www.cancer.gov/types/skin/patient/skin-treatment-pdq “Glossary,” International Journal of Hyperthermia, vol. 19, no. 3, pp. 385–390, 2003. [Online]. Available: https://doi.org/10.1080/0265673031000090710 A. Januszewski and J. Stebbing, “Hyperthermia in cancer: is it coming of age?” The Lancet Oncology, vol. 15, no. 6, pp. 565–566, 2014. [Online]. Available: https://doi.org/10.1016/S1470-2045(14)70207-4 M. H. Falk and R. D. Issels, “Hyperthermia in oncology,” International Journal of Hyperthermia, vol. 17, no. 1, pp. 1–18, 2001. [Online]. Available: https://doi.org/10.1080/02656730118511 J. van der Zee, “Heating the patient: a promising approach?” TAnnals of Oncology, vol. 13, no. 8, pp. 1173–1184, 2002. [Online]. Available: https: //doi.org/10.1093/annonc/mdf280 P. Wust, B. Hildebrandt, G. Sreenivasa, B. Rau, J. Gellermann, H. Riess, R. Felix, and P. M. Schlag, “Hyperthermia in combined treatment of cancer,” The Lancet Oncology, vol. 3, no. 8, pp. 487–497, 2002. [Online]. Available: https://doi.org/10.1016/S1470-2045(02)00818-5 N. Cihoric, A. Tsikkinis, G. van Rhoon, H. Crezee, D. M. Aebersold, S. Bodis, M. Beck, J. Nadobny, V. Budach, P. Wust, and P. Ghadjar, “Hyperthermia-related clinical trials on cancer treatment within the clinicaltrials.gov registry,” International Journal of Hyperthermia, vol. 31, no. 6, pp. 609–614, 2015. [Online]. Available: https://doi.org/10.3109/02656736.2015.1040471 M. B. Lodi, G. Muntoni, A. Ruggeri, A. Fanti, G. Montisci, and G. Mazzarella, “Towards the Robust and Effective Design of Hyperthermic Devices: Case Study of Abdominal Rhabdomyosarcoma with 3D Perfusion,” IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology, pp. 1–1, 2020. G. Muntoni, A. Fanti, G. Montisci, and M. Muntoni, “A Blood Perfusion Model of a RMS Tumor in a Local Hyperthermia Multi-Physic Scenario: A Preliminary Study,” IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology, vol. 3, no. 1, pp. 71–78, 2019. G. Muntoni, A. Fanti, M. B. Lodi, and G. Montisci, “Optimum Design of Superficial Microwave Hyperthermia Treatment,” in 2019 IEEE MTT-S International Conference on Numerical Electromagnetic and Multiphysics Modeling and Optimization (NEMO), 2019, pp. 1–3. X. He, W. Geyi, and S. Wang, “A Hexagonal Focused Array for Microwave Hyperthermia: Optimal Design and Experiment,” IEEE Antennas and Wireless Propagation Let ters, vol. 15, pp. 56–59, 2016. G. C. V. Rhoon, P. J. M. Rietveld, and J. V. D. Zee, “A 433 MHz Lucite Cone waveguide applicator for superficial hyperthermia,” International Journal of Hyperthermia, vol. 14, no. 1, pp. 13–27, 1998. [Online]. Available: https://doi.org/10.3109/02656739809018211 P. Takook, M. Persson, and H. D. Trefná, “Performance Evaluation of Hyperthermia Applicators to Heat Deep-Seated Brain Tumors,” IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology, vol. 2, no. 1, pp. 18–24, 2018. J. Ferlay, M. Ervik, F. Lam, M. Colombet, L. Mery, M. Piñeros, A. Znaor, I. Soerjomataram, and F. Bray, “Global cancer observatory: Cancer today,” International Agency for Research on Cancer, Lyon, France, 2020. [Online]. Available: https://gco.iarc.fr/today A. Chichel, J. Skowronek, M. Kubaszewska, and M. Kanikowski, “Hyperthermia – description of a method and a review of clinical applications,” Reports of Practical Oncology & Radiotherapy, vol. 12, no. 5, pp. 267–275, 2007. [Online]. Available: https://www.sciencedirect.com/science/article/pii/S150713671060065X P. T. Nguyen, A. Abbosh, and S. Crozier, “Three-Dimensional Microwave Hyperthermia for Breast Cancer Treatment in a Realistic Environment Using Particle Swarm Optimization,” IEEE Transactions on Biomedical Engineering, vol. 64, no. 6, pp. 1335–1344, 2017. H. F. Guarnizo Mendez, M. A. Polochè Arango, J. J. Pantoja Acosta, J. F. Coronel Rico, and J. S. Amaya Opayome, “Hyperthermia study in breast cancer treatment using three applicators,” in Applied Computer Sciences in Engineering, J. C. Figueroa-García, M. Duarte-González, S. Jaramillo-Isaza, A. D. Orjuela-Cañon, and Y. Díaz-Gutierrez, Eds. Cham: Springer International Publishing, 2019, pp. 416–427. W. C. Choi, S. Lim, and Y. J. Yoon, “Design of Noninvasive Hyperthermia System Using Transmit-Array Lens Antenna Configuration,” IEEE Antennas and Wireless Propagation Letters, vol. 15, pp. 857–860, 2016. K. T. Karathanasis, I. A. Gouzouasis, I. S. Karanasiou, and N. K. Uzunoglu, “Experi mental Study of a Hybrid Microwave Radiometry—Hyperthermia Apparatus With the Use of an Anatomical Head Phantom,” IEEE Transactions on Information Technology in Biomedicine, vol. 16, no. 2, pp. 241–247, 2012. "IEEE Standard for Validation of Computational Electromagnetics Computer Modeling and Simulations,” IEEE Std 1597.1-2022 (Revision of IEEE Std 1597.1-2008), pp. 1–52, 2022 X.-Q. Sheng and W. Song, Finite-Difference Time-Domain Method, 2012, pp. 207–241. “IEEE Recommended Practice for Measurements and Computations of Electric, Magnetic, and Electromagnetic Fields with Respect to Human Exposure to Such Fields, 0 Hz to 300 GHz,” IEEE Std C95.3-2021 (Revision of IEEE Std C95.3-2002 and IEEE Std C95.3.1-2010), pp. 1–240, 2021. Sim4Life por ZMT. [Online]. Available: https://zmt.swiss/ CST Studio Suite por 3DS. [Online]. Available: https://www.3ds.com/ SEMCAD X por SPEAG. [Online]. Available: https://speag.swiss/ XFDTD por REMCOM. [Online]. Available: https://www.remcom.com/ K. Yee, “Numerical solution of initial boundary value problems involving maxwell’s equations in isotropic media,” IEEE Transactions on Antennas and Propagation, vol. 14, no. 3, pp. 302–307, 1966. X.-Q. Sheng and W. Song, Mathematical Formulations for Electromagnetic Fields, 2012, pp. 1–28. P. A. Hasgall, F. Di Gennaro, C. Baumgartner, E. Neufeld, B. Lloyd, M. C. Gosselin, D. Payne, A. Klingenb¨ock, and N. Kuster, “IT’IS Database for thermal and electromagnetic parameters of biological tissues,” 2022. [Online]. Available: itis.swiss/database A. Peyman and C. Gabriel, “Dielectric properties of porcine glands, gonads and body fluids,” Physics in Medicine Biology, vol. 57, no. 19, p. N339, sep 2012. [Online]. Available: https://dx.doi.org/10.1088/0031-9155/57/19/N339 S. Gabriel, R. W. Lau, and C. Gabriel, “The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues,” Physics in Medicine Biology, vol. 41, no. 11, p. 2271, nov 1996. [Online]. Available: https://dx.doi.org/10.1088/0031-9155/41/11/003 G. Hartsgrove, A. Kraszewski, and A. Surowiec, “Simulated Biological Materials for Electromagnetic Radiation Absorption Studies,” Bioelectromagnetics, vol. 5, pp. 29–36, 1984. C. Chou, G. Chen, A. W. Guy, and K. H. Luk, “Formulas for Preparing Phantom Muscle Tissue at Various Radiofrequencies,” Bioelectromagnetics, vol. 5, pp. 435–441, 1984. C. Ianniello, J. A. de Zwart, Q. Duan, C. M. Deniz, L. Alon, J. S. Lee, R. Lattanzi, and R. Brown, “Synthesized tissue-equivalent dielectric phantoms using salt and polyvinylpyrrolidone solutions,” Magnetic Resonance in Medicine, vol. 81, no. 1, pp. 413–9, 2018. L. Farina, K. Sumser, G. van Rhoon, and S. Curto, “Thermal characterization of phantoms used for quality assurance of deep hyperthermia systems,” Sensors, vol. 20, 2020. B. G. Loader, A. P. Gregory, and R. Mouthaan, “Formulation and properties of liquid phantoms, 1 MHz to 10 GHz,” NPL Report, May 2018. [Online]. Available: http://eprintspublications.npl.co.uk/7946/ S. Rodríguez, A. Gallego, E. Pineda, J. Vargas, M. Perez, F. Román, and J. Araque, “Low-cost Setup for Electromagnetic SAR Evaluation in a Human Phantom,” in 2022 16th European Conference on Antennas and Propagation (EuCAP), 2022, pp. 1–5. “Señales de Radio 5G y Salud Humana en el Contexto Colombiano,” Agencia Nacional del Espectro (ANE), 2022. [Online]. Available: https: //www.ane.gov.co/Sliders/archivos/gestionConocimiento/Resultados%20proyectos% 20de%20investigaci%C%B3n/ANE%20Efectos5G%20Salud%20-%20Nov2022.pdf J. F. González, J. L. Duque, and J. L. Araque, “Low-Cost Freehand System for Measuring the E-Field Spatial Distribution for Antenna Diagnosis in Microwaves,” in Accepted to: 2024 IEEE International Symposium on Antennas and Propagation and USNC-URSI Radio Science Meeting (USNC-URSI), 2024. A. Gallego, E. Pineda, M. Pérez, F. Román, and J. Araque, “Low-cost system for electromagnetic SAR evaluation in a human phantom,” in 2022 IEEE USNC-URSI Radio Science Meeting (Joint with AP-S Symposium), 2022, pp. 23–24. J. González, G. Ramírez, and J. Araque, “Isotropic Magnetic Field Probe with ICNIRP 2020 Frequency Shaping in the Band up to 400 MHz,” in 2023 17th European Conference on Antennas and Propagation (EuCAP), Florence, Italy, march 2023. OptiTrack por NaturalPoint. [Online]. Available: https://optitrack.com/
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dc.rights.license.spa.fl_str_mv	Atribución-NoComercial-CompartirIgual 4.0 Internacional
dc.rights.uri.spa.fl_str_mv	http://creativecommons.org/licenses/by-nc-sa/4.0/
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dc.format.extent.spa.fl_str_mv	xii, 36 páginas
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv	Bogotá - Ingeniería - Maestría en Ingeniería - Ingeniería Electrónica
dc.publisher.faculty.spa.fl_str_mv	Facultad de Ingeniería
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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spelling	Atribución-NoComercial-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Araque Quijano, Javier Leonardof7c02a672bb89500556ed95cc7d915ec600Duque Muñoz, José Luis6ad6cdd78db42ffd5873e5910b51e683Grupo de Investigación en Electrónica de Alta Frecuencia y Telecomunicaciones (Cmun)2024-07-17T13:55:47Z2024-07-17T13:55:47Z2024https://repositorio.unal.edu.co/handle/unal/86513Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasEl objetivo de este estudio fue diseñar, simular y caracterizar un sistema radiante apropiado para el tratamiento del melanoma con hipertermia a 2.45 GHz. El melanoma es el cáncer de piel con mayor mortalidad, y su principal tratamiento es la cirugía, sin embargo, en casos donde no se pueda realizar, es necesario acudir a otras alternativas como lo es la hipertermia. La hipertermia junto a otros tratamientos como la quimioterapia o radioterapia, ha demostrado mejorar la efectividad de estos. Primeramente, se verificó en estándares internacionales el procedimiento para validar el funcionamiento del aplicador usando la distribución de la tasa de absorción específica (SAR) en un fantoma. Posteriormente, se realizó un montaje experimental siguiendo las indicaciones y procedimientos del estándar IEC/IEEE 62209-1528:2020, además se diseñó y construyó una antena tipo dipolo doblado, para finalmente comparar los resultados de simulación con los resultados de las mediciones experimentales. Se evidenció de las mediciones experimentales, un alto enfoque de la distribución del campo eléctrico y la SAR, lo que sugiere una huella térmica compatible al melanoma. (Texto tomado de la fuente).The goal of the study was to develop, model, and describe a radiant system suitable for treating melanoma at 2.45GHz. The most deadly type of skin cancer is melanoma, and surgery is the primary treatment for it. If it isn’t possible, though, there are other options that must be considered, such hyperthermia. It has been demonstrated that combining hyperthermia with other treatments like radiation or chemotherapy increases their efficacy. First, the distribution of the specific absorption rate (SAR) in a phantom was used to validate the applicator’s operation in accordance with international standards. To ultimately compare the findings of the simulation and the experimental observations, an experimental setup was completed in accordance with the guidelines and protocols of the IEC/IEEE 62209-1528:2020 standard. Additionally, a folded dipole-type antenna was designed and constructed. The experimental observations showed a high focus of the electric field distribution and SAR, indicating a thermal signature consistent with melanoma.MaestríaMagíster en Ingeniería - Ingeniería ElectrónicaAntenas y propagaciónxii, 36 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ingeniería - Maestría en Ingeniería - Ingeniería ElectrónicaFacultad de IngenieríaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá530 - Física::537 - Electricidad y electrónica610 - Medicina y salud::616 - Enfermedades610 - Medicina y salud::615 - Farmacología y terapéuticaMelanoma/terapiaHipertermiaEquipos y Suministros EléctricosMelanoma/therapyHyperthermiaElectrical Equipment and SuppliesAplicadorFantomaHipertermiaMelanomaSARApplicatorPhantomHyperthermiaMelanomaSARSistema aplicador de campo electromagnético para el tratamiento del melanoma usando hipertermia localElectromagnetic field applicator system for the treatment of melanoma using local hyperthermiaTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBireme“IEC/IEEE International Standard - Measurement procedure for the assessment of specific absorption rate of human exposure to radio frequency fields from hand-held and body-mounted wireless communication devices – Part 1528: Human models, instrumentation, and procedures (Frequency range of 4 MHz to 10 GHz),” IEC/IEEE 62209-1528:2020, pp. 1–284, 2020.PDQ® Adult Treatment Editorial Board, “Melanoma Treatment,” Bethesda, MD: National Cancer Institute, 2023. [Online]. Available: https://www.cancer.gov/types/skin/patient/melanoma-treatment-pdqD. S. Rigel, J. Russak, and R. Friedman, “The evolution of melanoma diagnosis: 25 years beyond the abcds,” CA: A Cancer Journal for Clinicians, vol. 60, no. 5, pp. 301–316, 2010. [Online]. Available: https://acsjournals.onlinelibrary.wiley.com/doi/abs/10.3322/caac.20074PDQ® Adult Treatment Editorial Board, “PDQ Skin Cancer Treatment,” Bethesda, MD: National Cancer Institute, 2023. [Online]. Available: https://www.cancer.gov/types/skin/patient/skin-treatment-pdq“Glossary,” International Journal of Hyperthermia, vol. 19, no. 3, pp. 385–390, 2003. [Online]. Available: https://doi.org/10.1080/0265673031000090710A. Januszewski and J. Stebbing, “Hyperthermia in cancer: is it coming of age?” The Lancet Oncology, vol. 15, no. 6, pp. 565–566, 2014. [Online]. Available: https://doi.org/10.1016/S1470-2045(14)70207-4M. H. Falk and R. D. Issels, “Hyperthermia in oncology,” International Journal of Hyperthermia, vol. 17, no. 1, pp. 1–18, 2001. [Online]. Available: https://doi.org/10.1080/02656730118511J. van der Zee, “Heating the patient: a promising approach?” TAnnals of Oncology, vol. 13, no. 8, pp. 1173–1184, 2002. [Online]. Available: https: //doi.org/10.1093/annonc/mdf280P. Wust, B. Hildebrandt, G. Sreenivasa, B. Rau, J. Gellermann, H. Riess, R. Felix, and P. M. Schlag, “Hyperthermia in combined treatment of cancer,” The Lancet Oncology, vol. 3, no. 8, pp. 487–497, 2002. [Online]. Available: https://doi.org/10.1016/S1470-2045(02)00818-5N. Cihoric, A. Tsikkinis, G. van Rhoon, H. Crezee, D. M. Aebersold, S. Bodis, M. Beck, J. Nadobny, V. Budach, P. Wust, and P. Ghadjar, “Hyperthermia-related clinical trials on cancer treatment within the clinicaltrials.gov registry,” International Journal of Hyperthermia, vol. 31, no. 6, pp. 609–614, 2015. [Online]. Available: https://doi.org/10.3109/02656736.2015.1040471M. B. Lodi, G. Muntoni, A. Ruggeri, A. Fanti, G. Montisci, and G. Mazzarella, “Towards the Robust and Effective Design of Hyperthermic Devices: Case Study of Abdominal Rhabdomyosarcoma with 3D Perfusion,” IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology, pp. 1–1, 2020.G. Muntoni, A. Fanti, G. Montisci, and M. Muntoni, “A Blood Perfusion Model of a RMS Tumor in a Local Hyperthermia Multi-Physic Scenario: A Preliminary Study,” IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology, vol. 3, no. 1, pp. 71–78, 2019.G. Muntoni, A. Fanti, M. B. Lodi, and G. Montisci, “Optimum Design of Superficial Microwave Hyperthermia Treatment,” in 2019 IEEE MTT-S International Conference on Numerical Electromagnetic and Multiphysics Modeling and Optimization (NEMO), 2019, pp. 1–3.X. He, W. Geyi, and S. Wang, “A Hexagonal Focused Array for Microwave Hyperthermia: Optimal Design and Experiment,” IEEE Antennas and Wireless Propagation Let ters, vol. 15, pp. 56–59, 2016.G. C. V. Rhoon, P. J. M. Rietveld, and J. V. D. Zee, “A 433 MHz Lucite Cone waveguide applicator for superficial hyperthermia,” International Journal of Hyperthermia, vol. 14, no. 1, pp. 13–27, 1998. [Online]. Available: https://doi.org/10.3109/02656739809018211P. Takook, M. Persson, and H. D. Trefná, “Performance Evaluation of Hyperthermia Applicators to Heat Deep-Seated Brain Tumors,” IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology, vol. 2, no. 1, pp. 18–24, 2018.J. Ferlay, M. Ervik, F. Lam, M. Colombet, L. Mery, M. Piñeros, A. Znaor, I. Soerjomataram, and F. Bray, “Global cancer observatory: Cancer today,” International Agency for Research on Cancer, Lyon, France, 2020. [Online]. Available: https://gco.iarc.fr/todayA. Chichel, J. Skowronek, M. Kubaszewska, and M. Kanikowski, “Hyperthermia – description of a method and a review of clinical applications,” Reports of Practical Oncology & Radiotherapy, vol. 12, no. 5, pp. 267–275, 2007. [Online]. Available: https://www.sciencedirect.com/science/article/pii/S150713671060065XP. T. Nguyen, A. Abbosh, and S. Crozier, “Three-Dimensional Microwave Hyperthermia for Breast Cancer Treatment in a Realistic Environment Using Particle Swarm Optimization,” IEEE Transactions on Biomedical Engineering, vol. 64, no. 6, pp. 1335–1344, 2017.H. F. Guarnizo Mendez, M. A. Polochè Arango, J. J. Pantoja Acosta, J. F. Coronel Rico, and J. S. Amaya Opayome, “Hyperthermia study in breast cancer treatment using three applicators,” in Applied Computer Sciences in Engineering, J. C. Figueroa-García, M. Duarte-González, S. Jaramillo-Isaza, A. D. Orjuela-Cañon, and Y. Díaz-Gutierrez, Eds. Cham: Springer International Publishing, 2019, pp. 416–427.W. C. Choi, S. Lim, and Y. J. 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