Implementación de tratamientos de radiocirugía en un acelerador lineal clínico de un hospital público de mediana y alta complejidad en el Valle del Cauca, 2021

ilustraciones, fotografías a blanco y negro, fotografías a color, gráficas

Autores:
Herrera Alvarez , Sergio Esteban
Tipo de recurso:
Fecha de publicación:
2022
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/82567
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/82567
https://repositorio.unal.edu.co/
Palabra clave:
610 - Medicina y salud
Cancer - cirugía
Cancer tratamiento
Cancer-surgery
Cancer-treatment
Radioterapia
Implementación
Radiocirugía estereotáxica
Radiotherapy
Stereotactic radiosurgery
Implementation
Rights
openAccess
License
Reconocimiento 4.0 Internacional
id UNACIONAL2_b2ecb46ff5b33a78279fc9e3764bb8fe
oai_identifier_str oai:repositorio.unal.edu.co:unal/82567
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Implementación de tratamientos de radiocirugía en un acelerador lineal clínico de un hospital público de mediana y alta complejidad en el Valle del Cauca, 2021
dc.title.translated.eng.fl_str_mv Implementation of radiosurgery treatments in a clinical linear accelerator of a public hospital of medium and high complexity in Valle del Cauca, 2021
title Implementación de tratamientos de radiocirugía en un acelerador lineal clínico de un hospital público de mediana y alta complejidad en el Valle del Cauca, 2021
spellingShingle Implementación de tratamientos de radiocirugía en un acelerador lineal clínico de un hospital público de mediana y alta complejidad en el Valle del Cauca, 2021
610 - Medicina y salud
Cancer - cirugía
Cancer tratamiento
Cancer-surgery
Cancer-treatment
Radioterapia
Implementación
Radiocirugía estereotáxica
Radiotherapy
Stereotactic radiosurgery
Implementation
title_short Implementación de tratamientos de radiocirugía en un acelerador lineal clínico de un hospital público de mediana y alta complejidad en el Valle del Cauca, 2021
title_full Implementación de tratamientos de radiocirugía en un acelerador lineal clínico de un hospital público de mediana y alta complejidad en el Valle del Cauca, 2021
title_fullStr Implementación de tratamientos de radiocirugía en un acelerador lineal clínico de un hospital público de mediana y alta complejidad en el Valle del Cauca, 2021
title_full_unstemmed Implementación de tratamientos de radiocirugía en un acelerador lineal clínico de un hospital público de mediana y alta complejidad en el Valle del Cauca, 2021
title_sort Implementación de tratamientos de radiocirugía en un acelerador lineal clínico de un hospital público de mediana y alta complejidad en el Valle del Cauca, 2021
dc.creator.fl_str_mv Herrera Alvarez , Sergio Esteban
dc.contributor.advisor.none.fl_str_mv Orejuela Mosquera, Diego Mauricio
Plazas de Pinzon, Maria Cristina
dc.contributor.author.none.fl_str_mv Herrera Alvarez , Sergio Esteban
dc.subject.ddc.spa.fl_str_mv 610 - Medicina y salud
topic 610 - Medicina y salud
Cancer - cirugía
Cancer tratamiento
Cancer-surgery
Cancer-treatment
Radioterapia
Implementación
Radiocirugía estereotáxica
Radiotherapy
Stereotactic radiosurgery
Implementation
dc.subject.lemb.spa.fl_str_mv Cancer - cirugía
Cancer tratamiento
dc.subject.lemb.eng.fl_str_mv Cancer-surgery
Cancer-treatment
dc.subject.proposal.spa.fl_str_mv Radioterapia
Implementación
Radiocirugía estereotáxica
dc.subject.proposal.eng.fl_str_mv Radiotherapy
Stereotactic radiosurgery
Implementation
description ilustraciones, fotografías a blanco y negro, fotografías a color, gráficas
publishDate 2022
dc.date.accessioned.none.fl_str_mv 2022-10-31T15:51:22Z
dc.date.available.none.fl_str_mv 2022-10-31T15:51:22Z
dc.date.issued.none.fl_str_mv 2022-09
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/82567
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/82567
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.indexed.spa.fl_str_mv RedCol
LaReferencia
dc.relation.references.spa.fl_str_mv Instituto Nacional del Cancer, «cancer.gov.co,» [En línea]. Available: https://www.cancer.gov/espanol/cancer/tratamiento/tipos. [Último acceso: 03 Septiembre 2021].
A. Brosed Serrata y M. C. Lizuain Arroyo, Fundamentos de Fisica Medica, Volumen 3., 2012.
Varian, [En línea]. Available: https://www.varian.com/es/products/radiotherapy/treatment-planning/eclipse. [Último acceso: 23 07 2021].
Varian, «varian.com,» [En línea]. Available: https://varian.widen.net/view/pdf/xo1pmzdzjb/Acuros_ClinicalPerspectives_RAD10156A_April2015.pdf?u=wefire. [Último acceso: 23 07 2021]
S. R. Cherry, «Multimodality Imaging: Beyond PET/CT and SPECT/CT,» Seminars in Nuclear Medicine, vol. 39, nº 5, pp. 348-353, 2009.
j. A. Kennedy, O. Israel, A. Frenkel, R. Bar-Shalom y H. Azhari, «Improved Image Fusion in PET/CT Using Hybrid Image Reconstruction and Super-Resolution,» International Journal of Biomedical Imaging, p. 10, 2007.
AAPM, «Accelerator beam data commissioning equipment and procedures: report of the TG-106 of the Therapy Physics Committee of the AAPM,» Medical Physcs, vol. 35, pp. 4186-4215, 2008.
Ravinder Nath, P. J. Biggs, F. J. Bova, C. Ling, C, J. A. Purdy, J. van de Geijn y M. S. Weinhous, «AAPM code of practice for radiotherapy accelerators: Report of AAPM Radiation Therapy Task Group No. 45,» Medical Physics, 1994.
INTERNATIONAL AGENCY ATOMIC ENERGY (IAEA), «Commissioning and comprehensive quality assurance of commercial 3D treatment planning system using IAEA Technical Report Series—430,» Vienna, 2008.
P. P. Almond, P. J. Biggs, B. M. Coursey, W. F. Hanson, M. S. Huq, R. Nath y D. W. O. Rogers, «AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams,» Medical Physics, 1999
INTERNATIONAL AGENCY ATOMIC ENERGY (IAEA), «Absorbed Dose Determination in External Beam Radiotherapy,» Vienna, 2001.
INTERNATIONAL AGENCY ATOMIC ENERGY (IAEA), «Dosimetry of Small Static Fields Used in External Beam Radiotherapy. An International Code of Practice for Reference and Relative Dose Determination.,» Vienna, 2017.
OMS, 2020. [En línea]. Available: https://www.who.int/es/news-room/fact-sheets/detail/cancer.
L. E. Bravo y N. Muñoz, «Epidemiologia del cáncer en Colombia,» Colombia Médica, vol. 49, nº 1, 2018.
L. M. Mayorga Fierro, «Factores de riesgo y detección precoz por pruebas de laboratorio de cáncer cervicouterino, en el Hospital Teodoro Maldonado Carbo durante el período 2010-2014,» Facultad de Ciencias Medicas, 2015.
S. Mariacarmela, A. Liguori, A. D'Aveni, N. Karachaliou, M. Gonzales-Cao, M. Grazia Daffina, C. Lazarri, G. Altavilla y R. Rossel, «Liquid biopsy for lung cancer early detection,» Journal of Thoracic Disease, nº 10, 2018.
E. Heitzer, S. Perakis, J. B. Geigl y M. R. Speicher, «The potential of liquid biopsies for the early detection of cancer,» Precision Oncology, nº 17, 2017.
S. Kato y K. Honda, «Use of Biomarkers and Imaging for Early Detection of Pancreatic Cancer,» Cancers, vol. 12, nº 7, 2020.
M. Perera, N. Papa, M. Roberts, M. Williams, C. Udovicich, I. Vela, D. Christiditis, D. Bolton, M. S. Hof,am, N. Lawrentschuk y D. Murphy, «Gallium-68 Prostate-specific Membrane Antigen Positron Emission Tomography in Advanced Prostate Cancer—Updated Diagnostic Utility, Sensitivity, Specificity, and Distribution of Prostate-specific Membrane Antigen-avid Lesions: A Systematic Review and Meta-,» European Urology, vol. 77, nº 4, pp. 403-417, 2020.
P. Li y D. Sun, «Advanced diagnostic imaging of sentinel lymph node in early stage breast cancer,» Journal of clinical ultrasond, 2022.
IAEA- AAPM, «Dosimetry of Small Static Fields Used in External Beam Radiotherapy- An International Code of Practice for Reference and Relative Dose Determination,» 2017.
AAPM, «TG-119 IMRT Commissioning Tests Instructions for Planning, Measurement, and Analysis,» 2009.
D. K. Mynampati, R. Yaparpalvi, L. Hong, . H.-C. Kuo y D. Mah, «Application of AAPM TG 119 to volumetric arc therapy (VMAT),» Radiation Oncology Physics, vol. 13, nº 5, pp. 108-116, 2012.
C.-H. Yao, T.-H. Chang, C.-C. Lin, Y.-C. Lai, C.-H. Chen y Y.-J. Chang, «Three-dimensional dose comparison of flattening filter (FF) and flattening filter-free (FFF) radiation therapy by using NIPAM gel dosimetry,» Plos One, 2019.
Y. Wang, M. K. Khan, J. Y. Ting y S. B. Easterling, «Surface dose investigation of the flattening filter free photon beams,» Int. J. Radiat. Oncol. Biol. Phys. , vol. 83, nº 2, pp. e281-e285, 2012.
J. E. Lye, D. J. Butler, C. P. Oliver, A. Alves, J. Gibbons, F. P. Gibbons y I. M. Williams, «Comparison between the TRS-398 code of practice and the TG-51 dosimetry,» Phys. Med. Biol, vol. 61, nº 14, pp. 362-372, 2016.
Y. Yan, P. Yadav, M. Bassetti, K. Du, D. Saenz, P. Harari y B. R. Paliwal, «Dosimetric differences in flattened and flattening filter-free beam treatment plans,» Journal Medical Physics, vol. 41, nº 2, pp. 92-99, 2016.
C. Ma, M. Chen, T. Long, D. Parsons, X. Gu, S. Jiang, Q. Hou y W. Lu, «Flattening filter free in intensity-modulated radiotherapy (IMRT) – Theoretical modeling with delivery efficiency analysis,» Medical Physics, vol. 46, nº 1, pp. 34-44, 2018.
G. Reggiori, P. Mancosu , S. Castiglioni, F. Alongi, C. Pellegrini, F. Lobefalo, M. Catalano y A. Fogliata , «Can volumetric modulated arc therapy with flattening filter free beams play a role in stereotactic body radiotherapy for liver lesions? A volume-based analysis,» Radiation Therapy Physics, vol. 39, nº 2, pp. 1112-1118, 2012.
P. Navarria, A. M. Ascolese, P. Mancosu, L. Cozzi, E. Morenghi, M. Scorsetti, F. Alongi, E. Clerici, A. Tozzi, C. Iftode y G. Reggiori, «Volumetric modulated arc therapy with flattening filter free (FFF) beams for stereotactic body radiation therapy (SBRT) in patients with medically inoperable early stage non small cell lung cancer (NSCLC),» Radiotherapya & Oncology, vol. 107, nº 3, pp. 414-418, 2013.
L. Vieillevigne, S. Bessieres, M. Quali y C. Lanaspeze, «Dosimetric comparison of flattened and unflattened beams for stereotactic body radiation therapy: Impact of the size of the PTV on dynamic conformal arc and volumetric modulated arc therapy,» European Journal of Medical Physics, vol. 32, nº 11, pp. 1405-1014, 2016.
L. Irazola, B. Sanchez- Nieto, M. Garcia- Hernandez, J. A. Terron, J. Rosello, M. Ortiz- Seidel, M. Bejar, R. Linares , S. Velazquez y F. Sanchez Doblado, «10-MV SBRT FFF IRRADIATION TECHNIQUE IS ASSOCIATED TO THE LOWEST PERIPHERAL DOSE: THE OUTCOME OF 142 TREATMENT PLANS FOR THE 10 MOST COMMON TUMOUR LOCATIONS,» Radiation Protection Dosimetry, pp. 183-195, 2019.
AAPM, «AAPM-RSS Medical Physics Practice Guideline 9.a. forSRS-SBRT,» AAPM REPORTS & DOCUMENTS, vol. 18, nº 5, pp. 10-21, 2017.
G. Kim, J. Lawson, K. Murphy y T. Pawlicki, «Stereotactic Radiosurgery With FFF Mode Photon Beams,» Radiation Oncology Biology Physics, vol. 84, nº 3, 2012.
Y. Lai, S. Chen, C. Xu, L. Shi, L. Fu, H. Ha, Q. Lin y Z. Zhang, « Dosimetric superiority of flattening filter free beams for single-fraction stereotactic radiosurgery in single brain metastasis,» Oncotarget, vol. 8, nº 21, pp. 35272-35279, 2017.
S. Laoui, D. E. Roa, J. Kuo, M. Baldytchev, J. Gonzales y S. Dietrich, « Flattening filter free beam energy selection and its impact in multitarget intracranial stereotactic radiosurgery treatments,» Med Dosim, vol. 45, nº 4, pp. 363-367, 2020.
AAPMA, «Tolerance Limits and Methodologies for IMRT Measurement-Based Verification QA: Recommendations of AAPM Task Group No. 218,» Medical Physics, 2018.
Y. Xia, J. Adamson, Y. Zlateva y W. Giles, «Application of TG-218 action limits to SRS and SBRT pre-treatment patient specific QA,» Journal Radiosurgery SBRT, vol. 7, nº 2, pp. 135-147, 2020.
Y. C. Lee y Y. Kim, «A patient-specific QA comparison between 2D and 3D diode arrays for single-lesion SRS and SBRT treatments,» Journal Radiosurgery SBRT, vol. 7, nº 4, pp. 295-307, 2021.
J. C. Ramirez Giraldo, C. Arboleda Clavijo y C. H. McCollough, «Tomografía computarizada por rayos X: fundamentos y actualidad,» Revista Ingenieria Biomedica, 2008.
INTERNATIONAL AGENCY ATOMIC ENERGY (IAEA), Radiation Oncology Physics: A Handbook for Teachers and Students, Vienna: IAEA Vienna, 2005.
Varian , Eclipse Photon and Electron Algorithms Reference - EclipseAlgorithms13.6_RefGuide.pdf, Varian Medical Systems, 2015.
H. E. Romejin, R. K. Ahuja, J. Dempsey y A. Kumar, «A Column Generation Approach to Radiation Therapy Treatment Planning Using Aperture Modulation,» SIAM Journal on Optimization, vol. 15, nº 3, pp. 838-862, 2005
W. Parwaie, S. Refahi y B. Farhood, «Different Dosimeters/Detectors Used in Small-Field Dosimetry: Pros and Cons,» Journal of Medical Signals And Sensors, 2018.
S. E. Order, «Radiation Therapy of Benign Diseases,» 1990.
S. Mckewon, P. Haltfield, R. J. Prestwich, R. E. Shaffer y R. . E. Taylor, «Radiotherapy for benign disease; assessing the risk of radiation-induced cancer following exposure to intermediate dose radiation,» The british Journal of Radiology, vol. 88, nº 1056, 2015.
M. Solans, C. Almazaán y J. Espinás, «La protonterapia en el tratamiento del cancer,» Agència de Qualitat i Avaluació Sanitàries de Catalunya; 2, Barcelona, 2014.
L. N. Burigo, «Hadronterapia : simulações da contribuição de processos nucleares para o tratamento de tumores,» 2011.
I. C. O. R. U. A. MEASUREMENTS, «Prescribing, Recording, and Reporting Photon-Beam Intensity- Modulated Radiation Therapy (IMRT),» OXFORD UNIVERSITY PRESS, 2010.
S. N. Salva Camaño, «Historia de la estereotaxia, la braquiterapia y la radiocirugía en Cuba,» Revista Medica Electronica, vol. 33, 2011.
S. H. Benedict, K. M. Yenice, D. Followill, J. M. Galvin, W. Hinson, B. Kavanagh, P. Keall, M. Lovelock, S. Meeks, L. Papiez, T. Purdie, R. Sadagopan, M. C. Schell y B. S. Salter, «Stereotactic body radiation therapy: The report of AAPM Task Group 101,» Medical Physics, nº 37, pp. 4078-4101, 2010.
H. U. d. Valle, «HUV,» [En línea]. Available: https://huv.gov.co/index.php/quienes-somos/. [Último acceso: 11 02 2022].
I. T. Castro, «PLAN OPERATIVO ANUAL Y EL PLAN OPERATIVO ANUAL DE INVERSIONES,» Santiago de Cali, 2021.
M. d. S. y. P. Social, «GUÍA INSTRUCTIVA PARA LICENCIAMIENTO DE EQUIPOS GENERADORES DE RADIACIÓN IONIZANTE EN RADIOTERAPIA,» Bogota, 2018.
P. Andreo, D. Burns, R. Kapsch, M. McEwen, S. Vatnitsky, C. Andersen y B. F, «Determination of consensus k Q values for megavoltage photon beams for the update of IAEA TRS-398,» Phys Med Biol, 2020.
A. Fogliata, R. Garcia, T. Knoos, G. Nicolini, A. Clivio, E. Vanetti, C. Khampan y L. Cozzi, «Definition of parameters for quality assurance of flattening filter free (FFF) photon beams in radiation therapy,» Medical Physics, vol. 39, nº 10, pp. 6455-6464, 2012.
A. Fogliata , J. Fleckensteina, F. Schneider, M. Pachoud, S. Ghandour, H. Frauss, G. Reggiori , Stravato Antonella, F. Lohr, L. Cozzi y M. Scorsetti, «Flattening filter free brams from TrueBeam and Versa HD units: Evaluation of the parameter for quality assurance,» Med Phys, vol. 1, 2016.
M. Hussein, C. H. Clark y A. Nisbet, «Challenges in calculation of the gamma index in radiotherapy – Towards good practice,» Physica Medica, vol. 36, pp. 1-11, 2017.
A. Farias, M. Martin-Landrove y R. Alfonso, «Puesta en Marcha de Sistema para la Garantía de Calidad Paciente Específico en Radioterapia de Intensidad Modulada,» 2017.
A. Clivio, M. F. Belosi, L. Cozzi, N. Giorgia, E. Vanetti, G. Bolard, P. Fenoglietto, H. Krauss y A. Fogliata, «On the determination of reference levels for quality assurance of flattening filter free photon beams in radiation therapy,» Medical Physics, vol. 39, nº 10, pp. 6455-6464, 2014.
M. Miften, A. Olch, D. Mihailidis, J. Moran, T. Pawlicki, A. Molineu, H. Li, K. Wijesooriya, J. Shi, P. Xia , N. Papanikolaou y D. A. Low, «Tolerance limits and methodologies for IMRT measurement-based verification QA: Recommendations of AAPM Task Group No. 218,» Medical Physics, nº 4, 2018.
J. McCulloch, J. Pawlowsky, N. Kirby, K. Rasmussen, Z. Shi, P. Myers, S. Stathakis, P. Niko y D. L. Saenz, «Patient-specific dose quality assurance of single-isocenter multiple brain metastasis stereotactic radiosurgery using PTW Octavius 4D,» Journal of Applied Clinical Medical Physics, vol. 21, nº 9, pp. 107-115, 2020.
Y. Xia, J. Adamson, Y. Zlateva y W. Giles, «Application of TG-218 action limits to SRS and SBRT pre-treatment patient specific QA,» Journal of Radiosurgery and SBRT, vol. 7, pp. 135-147, 2020.
PTW, [En línea]. Available: https://www.ptwdosimetry.com/fileadmin/user_upload/DETECTORS_Cat_en_16522900_12/blaetterkatalog/index.html#page_8. [Último acceso: 24 07 2021].
PTW, «www.ptwdosimetry.com,» [En línea]. Available: https://www.ptwdosimetry.com/en/products/mp3-water-phantom-system/. [Último acceso: 24 07 2021].
PTW, «ptwdosimetry.com,» 20 07 2021. [En línea]. Available: https://www.ptwdosimetry.com/en/products/octavius-4d/?type=3451&downloadfile=891&cHash=644b880d54783953b7a8dec440411d24.
PTW, «www.ptwdosimetry.com,» [En línea]. Available: https://www.ptwdosimetry.com/en/products/ruby/?type=3451&downloadfile=1665&cHash=851673c5278ef8853b55b324eace7362. [Último acceso: 23 07 2021].
PTW, «Small Field Dosimetry- Appliation Guide,» [En línea]. Available: https://www.ptwdosimetry.com/en/support/downloads/?type=3451&downloadfile=1836&cHash=f4027478a0444987243a730991d2ed1c. [Último acceso: 21 abril 2022].
R. Shende, G. Gupta, G. Patel y Kumar Senthil, «Commissioning of TrueBeamTM Medical Linear Accelerator: Quantitative and Qualitative Dosimetric Analysis and Comparison of Flattening Filter (FF) and Flattening Filter Free (FFF) Beam.,» International Journal of Medical Physics, vol. 5, pp. 51-69, 2016.
I. Masaru, A. Yuichi, M. Hirokazu, Yoshiro Tanaka, M. Norihisa y Y. Toshijiro, «Inter-unit variability of multi-leaf collimator parameters for IMRT and VMAT treatment planning: a multi-institutional survey,» Journal of Radiation Research, vol. 61, nº 2, pp. 307-313, 2020.
D. J. DiCostanzo y A. S. Ayan, «A novel methodology for the optimization of transmission and dosimetric leaf gap parameters,» RADIATION ONCOLOGY PHYSICS, vol. 23, nº 5, 2022.
Comisión Internacional de Unidades Radiologicas (ICRU), «ICRU REPORT 91: Prescribing, Recording, and Reporting of Stereotactic Treatments with Small Photon Beams,» Journal of the ICRU, vol. 14, nº 2, 2014.
J. D. Palmer, T. S. Nikhil, J. Chu, D. DiCostanzo, E. H. Bell, J. Grecula y J. McGregor, «Single-Isocenter Multitarget Stereotactic Radiosurgery Is Safe and Effective in the Treatment of Multiple Brain Metastases,» Advances in Radiation Oncology, vol. 5, nº 1, pp. 70-76, 2020.
J. Hofmaier, R. Bodensohn, S. Garny, I. Hadi, D. F, M. Eder, Y. Dinc, M. Reiner, S. Corradini y K. Parodi, «Single isocenter stereotactic radiosurgery for patients with multiple brain metastases: dosimetric comparison of VMAT and a dedicated DCAT planning tool,» Radiation Oncology, vol. 14, 2019.
G. J. Kim, E. D. Buckley, J. E. Herndon, S. R. Floyd, F.-F. Yin y J. P. Kirkpatrick, «Outcomes in Patients With 4 to 10 Brain Metastases Treated With Dose-Adapted Single-Isocenter Multitarget Stereotactic Radiosurgery: A Prospective Study,» Advances in radiation oncology, vol. 6, nº 6, 2021.
K. Johannes, J. E. Van Timmeren, M. Mayinger, S. Frei, K. Borsky, L. S. Stark, J. Krayenbuehl, M. A. Zamburlini, M. Guckenberger, S. Tanadini-Lang y N. Andratschke, «Distance to isocenter is not associated with an increased risk for local failure in LINAC-based single-isocenter SRS or SRT for multiple brain metastases,» Radiotherapy Oncology, vol. 159, pp. 169-175, 2021.
S. J. Gardner, S. Lu, C. Liu, N. Wen y I. J. Chetty , «Tuning of AcurosXB source size setting for small intracranial targets,» Appl Clin Med Phys, vol. 18, nº 3, pp. 170-181, 2017.
S. Diaz de Tuesta Rodriguez y J. R. Gomez Fervianza, «plataforma.congresosefmsepr,» 2 Junio 2021. [En línea]. Available: chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://plataforma.congresosefmsepr.es/event/4/contributions/2561/attachments/1395/1935/Metodos_Planificacion_Tecnicas_Avanzadas_SEFM_SD-JR.pdf. [Último acceso: 10 Agosto 2022].
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.license.spa.fl_str_mv Reconocimiento 4.0 Internacional
dc.rights.uri.spa.fl_str_mv http://creativecommons.org/licenses/by/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv Reconocimiento 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.extent.spa.fl_str_mv 126 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.coverage.city.none.fl_str_mv Valle del Cauca - Colombia
dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv Bogotá - Ciencias - Maestría en Física Médica
dc.publisher.faculty.spa.fl_str_mv Facultad de Ciencias
dc.publisher.place.spa.fl_str_mv Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá
institution Universidad Nacional de Colombia
bitstream.url.fl_str_mv https://repositorio.unal.edu.co/bitstream/unal/82567/1/license.txt
https://repositorio.unal.edu.co/bitstream/unal/82567/2/1075289111.2022.pdf
bitstream.checksum.fl_str_mv eb34b1cf90b7e1103fc9dfd26be24b4a
55a1dd88f25553d12f2a26eefa54e0bf
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
repository.mail.fl_str_mv repositorio_nal@unal.edu.co
_version_ 1806886646806740992
spelling Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Orejuela Mosquera, Diego Mauricio462cc118796bca35c23991ea09b2f204Plazas de Pinzon, Maria Cristinaf0881dc4c133b89730196b3918379074Herrera Alvarez , Sergio Esteban3ded66f4f55b0c65d1d5935743326f2d6002022-10-31T15:51:22Z2022-10-31T15:51:22Z2022-09https://repositorio.unal.edu.co/handle/unal/82567Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, fotografías a blanco y negro, fotografías a color, gráficasEn este trabajo final de maestría se realizó la implementación de tratamientos de radiocirugía intracraneal (SRS) en un hospital de mediana y alta complejidad. La primera parte fue el comisionamiento del CLINAC TrueBeam, para la validación del comisionamiento se aplicó el protocolo TG 119 usando los fantoma Octavius 4D, Ruby y el Portal Dosimetry. Para la técnica VMAT y las evaluaciones del índice gamma usando el Octavius 4D se encontraron valores del límite de confianza de 4.5, 4.7, 4.06, 5.30 y 4.5 para los haces de energía 6, 6 FFF, 10, 10 FFF y 16 MV, respectivamente, para esta misma técnica y la evaluación de dosis a punto se encontraron límites de confianza de 0.019, 0.026, 0.016, 0.026 y 0.018 para los haces de energía 6, 6 FFF, 10, 10 FFF y 16 MV, respectivamente. Posteriormente se desarrollo un protocolo para la implementación de radiocirugía intracraneal; desde las recomendaciones para la simulación hasta la evaluación de los planes de tratamiento. Para los controles de calidad usando el índice gamma se usaron las cantidades planteadas en el TG-218. La tercera parte se centró en la evaluación de la exactitud de la entrega de la dosis, se encontró que para las evaluaciones usando el Octavius 4D y para tratamientos de una única lesión con los criterios de diferencia de dosis y la distancia de 3%2mm se obtuvieron resultados con un promedio de 99.13 (IC 95%: 97.45-100). (Texto tomado de la fuente)In this final master's project, the implementation of intracranial radiosurgery (SRS) treatments was carried out in a medium and high complexity hospital. The first part was the commissioning of the CLINAC TrueBeam, for the validation of the commissioning the TG 119 protocol was applied using the Octavius ​​4D and Ruby phantoms and the Dosimetry Portal. For the VMAT technique and the gamma index evaluations using the Octavius ​​4D, confidence limit values ​​of 4.5, 4.7, 4.06, 5.30 and 4.5 were found for the energy beams 6, 6 FFF, 10, 10 FFF and 16 MV, respectively. , for this same technique and the point dose evaluation, confidence limits of 0.019, 0.026, 0.016, 0.026 and 0.018 were found for energy beams 6, 6 FFF, 10, 10 FFF and 16 MV, respectively. Subsequently, a protocol was developed for the implementation of intracranial radiosurgery; from recommendations for simulation to evaluation of treatment plans. For the quality controls using the gamma index, the amounts stated in the TG-218 were used. The third part focused on the evaluation of the accuracy of the dose delivery, it was found that for the evaluations using the Octavius ​​4D and for treatments of a single lesion with the criteria of dose difference and the distance of 3%2mm, obtained results with an average of 99.13 (95% CI: 97.45-100).MaestríaMaestría en Física Médica126 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Maestría en Física MédicaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y saludCancer - cirugíaCancer tratamientoCancer-surgeryCancer-treatmentRadioterapiaImplementaciónRadiocirugía estereotáxicaRadiotherapyStereotactic radiosurgeryImplementationImplementación de tratamientos de radiocirugía en un acelerador lineal clínico de un hospital público de mediana y alta complejidad en el Valle del Cauca, 2021Implementation of radiosurgery treatments in a clinical linear accelerator of a public hospital of medium and high complexity in Valle del Cauca, 2021Trabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMValle del Cauca - ColombiaRedColLaReferenciaInstituto Nacional del Cancer, «cancer.gov.co,» [En línea]. Available: https://www.cancer.gov/espanol/cancer/tratamiento/tipos. [Último acceso: 03 Septiembre 2021].A. Brosed Serrata y M. C. Lizuain Arroyo, Fundamentos de Fisica Medica, Volumen 3., 2012.Varian, [En línea]. Available: https://www.varian.com/es/products/radiotherapy/treatment-planning/eclipse. [Último acceso: 23 07 2021].Varian, «varian.com,» [En línea]. Available: https://varian.widen.net/view/pdf/xo1pmzdzjb/Acuros_ClinicalPerspectives_RAD10156A_April2015.pdf?u=wefire. [Último acceso: 23 07 2021]S. R. Cherry, «Multimodality Imaging: Beyond PET/CT and SPECT/CT,» Seminars in Nuclear Medicine, vol. 39, nº 5, pp. 348-353, 2009.j. A. Kennedy, O. Israel, A. Frenkel, R. Bar-Shalom y H. Azhari, «Improved Image Fusion in PET/CT Using Hybrid Image Reconstruction and Super-Resolution,» International Journal of Biomedical Imaging, p. 10, 2007.AAPM, «Accelerator beam data commissioning equipment and procedures: report of the TG-106 of the Therapy Physics Committee of the AAPM,» Medical Physcs, vol. 35, pp. 4186-4215, 2008.Ravinder Nath, P. J. Biggs, F. J. Bova, C. Ling, C, J. A. Purdy, J. van de Geijn y M. S. Weinhous, «AAPM code of practice for radiotherapy accelerators: Report of AAPM Radiation Therapy Task Group No. 45,» Medical Physics, 1994.INTERNATIONAL AGENCY ATOMIC ENERGY (IAEA), «Commissioning and comprehensive quality assurance of commercial 3D treatment planning system using IAEA Technical Report Series—430,» Vienna, 2008.P. P. Almond, P. J. Biggs, B. M. Coursey, W. F. Hanson, M. S. Huq, R. Nath y D. W. O. Rogers, «AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams,» Medical Physics, 1999INTERNATIONAL AGENCY ATOMIC ENERGY (IAEA), «Absorbed Dose Determination in External Beam Radiotherapy,» Vienna, 2001.INTERNATIONAL AGENCY ATOMIC ENERGY (IAEA), «Dosimetry of Small Static Fields Used in External Beam Radiotherapy. An International Code of Practice for Reference and Relative Dose Determination.,» Vienna, 2017.OMS, 2020. [En línea]. Available: https://www.who.int/es/news-room/fact-sheets/detail/cancer.L. E. Bravo y N. Muñoz, «Epidemiologia del cáncer en Colombia,» Colombia Médica, vol. 49, nº 1, 2018.L. M. Mayorga Fierro, «Factores de riesgo y detección precoz por pruebas de laboratorio de cáncer cervicouterino, en el Hospital Teodoro Maldonado Carbo durante el período 2010-2014,» Facultad de Ciencias Medicas, 2015.S. Mariacarmela, A. Liguori, A. D'Aveni, N. Karachaliou, M. Gonzales-Cao, M. Grazia Daffina, C. Lazarri, G. Altavilla y R. Rossel, «Liquid biopsy for lung cancer early detection,» Journal of Thoracic Disease, nº 10, 2018.E. Heitzer, S. Perakis, J. B. Geigl y M. R. Speicher, «The potential of liquid biopsies for the early detection of cancer,» Precision Oncology, nº 17, 2017.S. Kato y K. Honda, «Use of Biomarkers and Imaging for Early Detection of Pancreatic Cancer,» Cancers, vol. 12, nº 7, 2020.M. Perera, N. Papa, M. Roberts, M. Williams, C. Udovicich, I. Vela, D. Christiditis, D. Bolton, M. S. Hof,am, N. Lawrentschuk y D. Murphy, «Gallium-68 Prostate-specific Membrane Antigen Positron Emission Tomography in Advanced Prostate Cancer—Updated Diagnostic Utility, Sensitivity, Specificity, and Distribution of Prostate-specific Membrane Antigen-avid Lesions: A Systematic Review and Meta-,» European Urology, vol. 77, nº 4, pp. 403-417, 2020.P. Li y D. Sun, «Advanced diagnostic imaging of sentinel lymph node in early stage breast cancer,» Journal of clinical ultrasond, 2022.IAEA- AAPM, «Dosimetry of Small Static Fields Used in External Beam Radiotherapy- An International Code of Practice for Reference and Relative Dose Determination,» 2017.AAPM, «TG-119 IMRT Commissioning Tests Instructions for Planning, Measurement, and Analysis,» 2009.D. K. Mynampati, R. Yaparpalvi, L. Hong, . H.-C. Kuo y D. Mah, «Application of AAPM TG 119 to volumetric arc therapy (VMAT),» Radiation Oncology Physics, vol. 13, nº 5, pp. 108-116, 2012.C.-H. Yao, T.-H. Chang, C.-C. Lin, Y.-C. Lai, C.-H. Chen y Y.-J. Chang, «Three-dimensional dose comparison of flattening filter (FF) and flattening filter-free (FFF) radiation therapy by using NIPAM gel dosimetry,» Plos One, 2019.Y. Wang, M. K. Khan, J. Y. Ting y S. B. Easterling, «Surface dose investigation of the flattening filter free photon beams,» Int. J. Radiat. Oncol. Biol. Phys. , vol. 83, nº 2, pp. e281-e285, 2012.J. E. Lye, D. J. Butler, C. P. Oliver, A. Alves, J. Gibbons, F. P. Gibbons y I. M. Williams, «Comparison between the TRS-398 code of practice and the TG-51 dosimetry,» Phys. Med. Biol, vol. 61, nº 14, pp. 362-372, 2016.Y. Yan, P. Yadav, M. Bassetti, K. Du, D. Saenz, P. Harari y B. R. Paliwal, «Dosimetric differences in flattened and flattening filter-free beam treatment plans,» Journal Medical Physics, vol. 41, nº 2, pp. 92-99, 2016.C. Ma, M. Chen, T. Long, D. Parsons, X. Gu, S. Jiang, Q. Hou y W. Lu, «Flattening filter free in intensity-modulated radiotherapy (IMRT) – Theoretical modeling with delivery efficiency analysis,» Medical Physics, vol. 46, nº 1, pp. 34-44, 2018.G. Reggiori, P. Mancosu , S. Castiglioni, F. Alongi, C. Pellegrini, F. Lobefalo, M. Catalano y A. Fogliata , «Can volumetric modulated arc therapy with flattening filter free beams play a role in stereotactic body radiotherapy for liver lesions? A volume-based analysis,» Radiation Therapy Physics, vol. 39, nº 2, pp. 1112-1118, 2012.P. Navarria, A. M. Ascolese, P. Mancosu, L. Cozzi, E. Morenghi, M. Scorsetti, F. Alongi, E. Clerici, A. Tozzi, C. Iftode y G. Reggiori, «Volumetric modulated arc therapy with flattening filter free (FFF) beams for stereotactic body radiation therapy (SBRT) in patients with medically inoperable early stage non small cell lung cancer (NSCLC),» Radiotherapya & Oncology, vol. 107, nº 3, pp. 414-418, 2013.L. Vieillevigne, S. Bessieres, M. Quali y C. Lanaspeze, «Dosimetric comparison of flattened and unflattened beams for stereotactic body radiation therapy: Impact of the size of the PTV on dynamic conformal arc and volumetric modulated arc therapy,» European Journal of Medical Physics, vol. 32, nº 11, pp. 1405-1014, 2016.L. Irazola, B. Sanchez- Nieto, M. Garcia- Hernandez, J. A. Terron, J. Rosello, M. Ortiz- Seidel, M. Bejar, R. Linares , S. Velazquez y F. Sanchez Doblado, «10-MV SBRT FFF IRRADIATION TECHNIQUE IS ASSOCIATED TO THE LOWEST PERIPHERAL DOSE: THE OUTCOME OF 142 TREATMENT PLANS FOR THE 10 MOST COMMON TUMOUR LOCATIONS,» Radiation Protection Dosimetry, pp. 183-195, 2019.AAPM, «AAPM-RSS Medical Physics Practice Guideline 9.a. forSRS-SBRT,» AAPM REPORTS & DOCUMENTS, vol. 18, nº 5, pp. 10-21, 2017.G. Kim, J. Lawson, K. Murphy y T. Pawlicki, «Stereotactic Radiosurgery With FFF Mode Photon Beams,» Radiation Oncology Biology Physics, vol. 84, nº 3, 2012.Y. Lai, S. Chen, C. Xu, L. Shi, L. Fu, H. Ha, Q. Lin y Z. Zhang, « Dosimetric superiority of flattening filter free beams for single-fraction stereotactic radiosurgery in single brain metastasis,» Oncotarget, vol. 8, nº 21, pp. 35272-35279, 2017.S. Laoui, D. E. Roa, J. Kuo, M. Baldytchev, J. Gonzales y S. Dietrich, « Flattening filter free beam energy selection and its impact in multitarget intracranial stereotactic radiosurgery treatments,» Med Dosim, vol. 45, nº 4, pp. 363-367, 2020.AAPMA, «Tolerance Limits and Methodologies for IMRT Measurement-Based Verification QA: Recommendations of AAPM Task Group No. 218,» Medical Physics, 2018.Y. Xia, J. Adamson, Y. Zlateva y W. Giles, «Application of TG-218 action limits to SRS and SBRT pre-treatment patient specific QA,» Journal Radiosurgery SBRT, vol. 7, nº 2, pp. 135-147, 2020.Y. C. Lee y Y. Kim, «A patient-specific QA comparison between 2D and 3D diode arrays for single-lesion SRS and SBRT treatments,» Journal Radiosurgery SBRT, vol. 7, nº 4, pp. 295-307, 2021.J. C. Ramirez Giraldo, C. Arboleda Clavijo y C. H. McCollough, «Tomografía computarizada por rayos X: fundamentos y actualidad,» Revista Ingenieria Biomedica, 2008.INTERNATIONAL AGENCY ATOMIC ENERGY (IAEA), Radiation Oncology Physics: A Handbook for Teachers and Students, Vienna: IAEA Vienna, 2005.Varian , Eclipse Photon and Electron Algorithms Reference - EclipseAlgorithms13.6_RefGuide.pdf, Varian Medical Systems, 2015.H. E. Romejin, R. K. Ahuja, J. Dempsey y A. Kumar, «A Column Generation Approach to Radiation Therapy Treatment Planning Using Aperture Modulation,» SIAM Journal on Optimization, vol. 15, nº 3, pp. 838-862, 2005W. Parwaie, S. Refahi y B. Farhood, «Different Dosimeters/Detectors Used in Small-Field Dosimetry: Pros and Cons,» Journal of Medical Signals And Sensors, 2018.S. E. Order, «Radiation Therapy of Benign Diseases,» 1990.S. Mckewon, P. Haltfield, R. J. Prestwich, R. E. Shaffer y R. . E. Taylor, «Radiotherapy for benign disease; assessing the risk of radiation-induced cancer following exposure to intermediate dose radiation,» The british Journal of Radiology, vol. 88, nº 1056, 2015.M. Solans, C. Almazaán y J. Espinás, «La protonterapia en el tratamiento del cancer,» Agència de Qualitat i Avaluació Sanitàries de Catalunya; 2, Barcelona, 2014.L. N. Burigo, «Hadronterapia : simulações da contribuição de processos nucleares para o tratamento de tumores,» 2011.I. C. O. R. U. A. MEASUREMENTS, «Prescribing, Recording, and Reporting Photon-Beam Intensity- Modulated Radiation Therapy (IMRT),» OXFORD UNIVERSITY PRESS, 2010.S. N. Salva Camaño, «Historia de la estereotaxia, la braquiterapia y la radiocirugía en Cuba,» Revista Medica Electronica, vol. 33, 2011.S. H. Benedict, K. M. Yenice, D. Followill, J. M. Galvin, W. Hinson, B. Kavanagh, P. Keall, M. Lovelock, S. Meeks, L. Papiez, T. Purdie, R. Sadagopan, M. C. Schell y B. S. Salter, «Stereotactic body radiation therapy: The report of AAPM Task Group 101,» Medical Physics, nº 37, pp. 4078-4101, 2010.H. U. d. Valle, «HUV,» [En línea]. Available: https://huv.gov.co/index.php/quienes-somos/. [Último acceso: 11 02 2022].I. T. Castro, «PLAN OPERATIVO ANUAL Y EL PLAN OPERATIVO ANUAL DE INVERSIONES,» Santiago de Cali, 2021.M. d. S. y. P. Social, «GUÍA INSTRUCTIVA PARA LICENCIAMIENTO DE EQUIPOS GENERADORES DE RADIACIÓN IONIZANTE EN RADIOTERAPIA,» Bogota, 2018.P. Andreo, D. Burns, R. Kapsch, M. McEwen, S. Vatnitsky, C. Andersen y B. F, «Determination of consensus k Q values for megavoltage photon beams for the update of IAEA TRS-398,» Phys Med Biol, 2020.A. Fogliata, R. Garcia, T. Knoos, G. Nicolini, A. Clivio, E. Vanetti, C. Khampan y L. Cozzi, «Definition of parameters for quality assurance of flattening filter free (FFF) photon beams in radiation therapy,» Medical Physics, vol. 39, nº 10, pp. 6455-6464, 2012.A. Fogliata , J. Fleckensteina, F. Schneider, M. Pachoud, S. Ghandour, H. Frauss, G. Reggiori , Stravato Antonella, F. Lohr, L. Cozzi y M. Scorsetti, «Flattening filter free brams from TrueBeam and Versa HD units: Evaluation of the parameter for quality assurance,» Med Phys, vol. 1, 2016.M. Hussein, C. H. Clark y A. Nisbet, «Challenges in calculation of the gamma index in radiotherapy – Towards good practice,» Physica Medica, vol. 36, pp. 1-11, 2017.A. Farias, M. Martin-Landrove y R. Alfonso, «Puesta en Marcha de Sistema para la Garantía de Calidad Paciente Específico en Radioterapia de Intensidad Modulada,» 2017.A. Clivio, M. F. Belosi, L. Cozzi, N. Giorgia, E. Vanetti, G. Bolard, P. Fenoglietto, H. Krauss y A. Fogliata, «On the determination of reference levels for quality assurance of flattening filter free photon beams in radiation therapy,» Medical Physics, vol. 39, nº 10, pp. 6455-6464, 2014.M. Miften, A. Olch, D. Mihailidis, J. Moran, T. Pawlicki, A. Molineu, H. Li, K. Wijesooriya, J. Shi, P. Xia , N. Papanikolaou y D. A. Low, «Tolerance limits and methodologies for IMRT measurement-based verification QA: Recommendations of AAPM Task Group No. 218,» Medical Physics, nº 4, 2018.J. McCulloch, J. Pawlowsky, N. Kirby, K. Rasmussen, Z. Shi, P. Myers, S. Stathakis, P. Niko y D. L. Saenz, «Patient-specific dose quality assurance of single-isocenter multiple brain metastasis stereotactic radiosurgery using PTW Octavius 4D,» Journal of Applied Clinical Medical Physics, vol. 21, nº 9, pp. 107-115, 2020.Y. Xia, J. Adamson, Y. Zlateva y W. Giles, «Application of TG-218 action limits to SRS and SBRT pre-treatment patient specific QA,» Journal of Radiosurgery and SBRT, vol. 7, pp. 135-147, 2020.PTW, [En línea]. Available: https://www.ptwdosimetry.com/fileadmin/user_upload/DETECTORS_Cat_en_16522900_12/blaetterkatalog/index.html#page_8. [Último acceso: 24 07 2021].PTW, «www.ptwdosimetry.com,» [En línea]. Available: https://www.ptwdosimetry.com/en/products/mp3-water-phantom-system/. [Último acceso: 24 07 2021].PTW, «ptwdosimetry.com,» 20 07 2021. [En línea]. Available: https://www.ptwdosimetry.com/en/products/octavius-4d/?type=3451&downloadfile=891&cHash=644b880d54783953b7a8dec440411d24.PTW, «www.ptwdosimetry.com,» [En línea]. Available: https://www.ptwdosimetry.com/en/products/ruby/?type=3451&downloadfile=1665&cHash=851673c5278ef8853b55b324eace7362. [Último acceso: 23 07 2021].PTW, «Small Field Dosimetry- Appliation Guide,» [En línea]. Available: https://www.ptwdosimetry.com/en/support/downloads/?type=3451&downloadfile=1836&cHash=f4027478a0444987243a730991d2ed1c. [Último acceso: 21 abril 2022].R. Shende, G. Gupta, G. Patel y Kumar Senthil, «Commissioning of TrueBeamTM Medical Linear Accelerator: Quantitative and Qualitative Dosimetric Analysis and Comparison of Flattening Filter (FF) and Flattening Filter Free (FFF) Beam.,» International Journal of Medical Physics, vol. 5, pp. 51-69, 2016.I. Masaru, A. Yuichi, M. Hirokazu, Yoshiro Tanaka, M. Norihisa y Y. Toshijiro, «Inter-unit variability of multi-leaf collimator parameters for IMRT and VMAT treatment planning: a multi-institutional survey,» Journal of Radiation Research, vol. 61, nº 2, pp. 307-313, 2020.D. J. DiCostanzo y A. S. Ayan, «A novel methodology for the optimization of transmission and dosimetric leaf gap parameters,» RADIATION ONCOLOGY PHYSICS, vol. 23, nº 5, 2022.Comisión Internacional de Unidades Radiologicas (ICRU), «ICRU REPORT 91: Prescribing, Recording, and Reporting of Stereotactic Treatments with Small Photon Beams,» Journal of the ICRU, vol. 14, nº 2, 2014.J. D. Palmer, T. S. Nikhil, J. Chu, D. DiCostanzo, E. H. Bell, J. Grecula y J. McGregor, «Single-Isocenter Multitarget Stereotactic Radiosurgery Is Safe and Effective in the Treatment of Multiple Brain Metastases,» Advances in Radiation Oncology, vol. 5, nº 1, pp. 70-76, 2020.J. Hofmaier, R. Bodensohn, S. Garny, I. Hadi, D. F, M. Eder, Y. Dinc, M. Reiner, S. Corradini y K. Parodi, «Single isocenter stereotactic radiosurgery for patients with multiple brain metastases: dosimetric comparison of VMAT and a dedicated DCAT planning tool,» Radiation Oncology, vol. 14, 2019.G. J. Kim, E. D. Buckley, J. E. Herndon, S. R. Floyd, F.-F. Yin y J. P. Kirkpatrick, «Outcomes in Patients With 4 to 10 Brain Metastases Treated With Dose-Adapted Single-Isocenter Multitarget Stereotactic Radiosurgery: A Prospective Study,» Advances in radiation oncology, vol. 6, nº 6, 2021.K. Johannes, J. E. Van Timmeren, M. Mayinger, S. Frei, K. Borsky, L. S. Stark, J. Krayenbuehl, M. A. Zamburlini, M. Guckenberger, S. Tanadini-Lang y N. Andratschke, «Distance to isocenter is not associated with an increased risk for local failure in LINAC-based single-isocenter SRS or SRT for multiple brain metastases,» Radiotherapy Oncology, vol. 159, pp. 169-175, 2021.S. J. Gardner, S. Lu, C. Liu, N. Wen y I. J. Chetty , «Tuning of AcurosXB source size setting for small intracranial targets,» Appl Clin Med Phys, vol. 18, nº 3, pp. 170-181, 2017.S. Diaz de Tuesta Rodriguez y J. R. Gomez Fervianza, «plataforma.congresosefmsepr,» 2 Junio 2021. [En línea]. Available: chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://plataforma.congresosefmsepr.es/event/4/contributions/2561/attachments/1395/1935/Metodos_Planificacion_Tecnicas_Avanzadas_SEFM_SD-JR.pdf. [Último acceso: 10 Agosto 2022].EstudiantesInvestigadoresPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/82567/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1075289111.2022.pdf1075289111.2022.pdfTesis de Maestría en Física Médicaapplication/pdf8937128https://repositorio.unal.edu.co/bitstream/unal/82567/2/1075289111.2022.pdf55a1dd88f25553d12f2a26eefa54e0bfMD52unal/82567oai:repositorio.unal.edu.co:unal/825672022-10-31 10:52:57.705Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.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

Publicaciones similares