Conexiones moleculares y su implicación en psoriasis: Variaciones en la expresión génica y proteica a nivel de los queratinocitos de pacientes con psoriasis de moderada a severa que fueron tratados con anticuerpos monoclonales

ilustraciones, diagramas

Autores:
Carreño Jiménez, Leidy Johanna
Tipo de recurso:
Fecha de publicación:
2023
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/84429
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/84429
https://repositorio.unal.edu.co/
Palabra clave:
610 - Medicina y salud::616 - Enfermedades
Etanercept
Adalimumab
Anticuerpos Monoclonales
Antibodies, Monoclonal
Psoriasis
Anticuerpo monoclonal
Expresión génica
Expresión proteica
Correlación
Respondedores
No respondedores
Psoriasis
Monoclonal antibody
Gene Expression
Protein expression
Correlation
Responders
Non responders
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
id UNACIONAL2_b1b965b236aa25e54a7edcf407585123
oai_identifier_str oai:repositorio.unal.edu.co:unal/84429
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Conexiones moleculares y su implicación en psoriasis: Variaciones en la expresión génica y proteica a nivel de los queratinocitos de pacientes con psoriasis de moderada a severa que fueron tratados con anticuerpos monoclonales
dc.title.translated.eng.fl_str_mv Molecular Connections and their implication in Psoriasis: Variations in gene and protein expression at the level of the keratinocytes from patients with moderate to severe psoriasis who were treated with monoclonal antibodies.
title Conexiones moleculares y su implicación en psoriasis: Variaciones en la expresión génica y proteica a nivel de los queratinocitos de pacientes con psoriasis de moderada a severa que fueron tratados con anticuerpos monoclonales
spellingShingle Conexiones moleculares y su implicación en psoriasis: Variaciones en la expresión génica y proteica a nivel de los queratinocitos de pacientes con psoriasis de moderada a severa que fueron tratados con anticuerpos monoclonales
610 - Medicina y salud::616 - Enfermedades
Etanercept
Adalimumab
Anticuerpos Monoclonales
Antibodies, Monoclonal
Psoriasis
Anticuerpo monoclonal
Expresión génica
Expresión proteica
Correlación
Respondedores
No respondedores
Psoriasis
Monoclonal antibody
Gene Expression
Protein expression
Correlation
Responders
Non responders
title_short Conexiones moleculares y su implicación en psoriasis: Variaciones en la expresión génica y proteica a nivel de los queratinocitos de pacientes con psoriasis de moderada a severa que fueron tratados con anticuerpos monoclonales
title_full Conexiones moleculares y su implicación en psoriasis: Variaciones en la expresión génica y proteica a nivel de los queratinocitos de pacientes con psoriasis de moderada a severa que fueron tratados con anticuerpos monoclonales
title_fullStr Conexiones moleculares y su implicación en psoriasis: Variaciones en la expresión génica y proteica a nivel de los queratinocitos de pacientes con psoriasis de moderada a severa que fueron tratados con anticuerpos monoclonales
title_full_unstemmed Conexiones moleculares y su implicación en psoriasis: Variaciones en la expresión génica y proteica a nivel de los queratinocitos de pacientes con psoriasis de moderada a severa que fueron tratados con anticuerpos monoclonales
title_sort Conexiones moleculares y su implicación en psoriasis: Variaciones en la expresión génica y proteica a nivel de los queratinocitos de pacientes con psoriasis de moderada a severa que fueron tratados con anticuerpos monoclonales
dc.creator.fl_str_mv Carreño Jiménez, Leidy Johanna
dc.contributor.advisor.none.fl_str_mv Montilla, María del Pilar
Crosby, Milton Josué
dc.contributor.author.none.fl_str_mv Carreño Jiménez, Leidy Johanna
dc.subject.ddc.spa.fl_str_mv 610 - Medicina y salud::616 - Enfermedades
topic 610 - Medicina y salud::616 - Enfermedades
Etanercept
Adalimumab
Anticuerpos Monoclonales
Antibodies, Monoclonal
Psoriasis
Anticuerpo monoclonal
Expresión génica
Expresión proteica
Correlación
Respondedores
No respondedores
Psoriasis
Monoclonal antibody
Gene Expression
Protein expression
Correlation
Responders
Non responders
dc.subject.decs.none.fl_str_mv Etanercept
Adalimumab
Anticuerpos Monoclonales
dc.subject.decs.eng.fl_str_mv Antibodies, Monoclonal
dc.subject.proposal.spa.fl_str_mv Psoriasis
Anticuerpo monoclonal
Expresión génica
Expresión proteica
Correlación
Respondedores
No respondedores
dc.subject.proposal.eng.fl_str_mv Psoriasis
Monoclonal antibody
Gene Expression
Protein expression
Correlation
Responders
Non responders
description ilustraciones, diagramas
publishDate 2023
dc.date.accessioned.none.fl_str_mv 2023-08-03T14:14:26Z
dc.date.available.none.fl_str_mv 2023-08-03T14:14:26Z
dc.date.issued.none.fl_str_mv 2023-04-24
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/84429
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/84429
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
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94. Visvanathan S, Baum P, Vinisko R, Schmid R, Flack M, Fuentes-Duculan J, et al. IL-23 pathway inhibition by risankizumab differentially modulates the molecular and histopathological profile in psoriatic skin compared with ustekinumab. Exp Dermatol. 2016;25:25.
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dc.format.extent.spa.fl_str_mv iv, 59 páginas
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spelling Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Montilla, María del Pilarad072151961a372caf9c2143d405e2dbCrosby, Milton Josué053f3781291c7c8fae04830f285009e0600Carreño Jiménez, Leidy Johannab37bd6fcf80804834215f8b8451b2b442023-08-03T14:14:26Z2023-08-03T14:14:26Z2023-04-24https://repositorio.unal.edu.co/handle/unal/84429Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasDebido a al efecto pleiotrópico de algunas citocinas involucradas en el desarrollo de la respuesta inmune inflamatoria, el potencial efecto deletéreo en la fisiología celular inducido por la inflamación crónica y el moderado éxito de las terapias convencionales existentes (terapia alopática), la comprensión de los mecanismos inmunológicos en psoriasis y su efecto fisiopatológico se han convertido en la piedra angular para el desarrollo de nuevos y mejores medicamentos. Con la introducción de anticuerpos monoclonales y proteínas de fusión, sumado a las terapias químicas y físicas existentes, se ha incrementado el arsenal terapéutico disponible. Como consecuencia de la complejidad inmunológica de la enfermedad y su asociación con otras enfermedades ligadas a la respuesta inmune inflamatoria, surge la necesidad de ampliar el conocimiento acerca de la fisiopatología de la enfermedad y los mecanismos inmunológicos y moleculares de acción de los medicamentos empleados con el objeto de proporcionar la mejor asistencia a los pacientes. En la literatura se encuentra disponible abundante información respecto a datos clínicos de seguridad y eficacia de cada uno de los medicamentos utilizados en el tratamiento de la enfermedad, sin embargo, la información encontrada en la literatura respecto a las modificaciones en la expresión génica se encuentra fraccionada, situación que lleva a una pérdida de datos, que impide vislumbrar las implicaciones moleculares y bioquímicas de los diferentes tratamientos en el espectro de la enfermedad. Realizar una integración de esta información, permitirá una mejor comprensión de su rol en el manejo de la psoriasis y posibilitará el análisis de los aspectos diferenciales a nivel molecular de los múltiples mecanismos de acción de las terapias biológicas indicadas en esta patología. Objetivo Identificar las respuestas transcripcionales y de expresión proteica según los mecanismos de acción de los anticuerpos monoclonales que tienen como blanco directo e indirecto el eje IL-23/T17 en tratamiento de la psoriasis. (Texto tomado de la fuente)Due to the pleiotropic effect of some cytokines involved in the development of the inflammatory immune response, the potential deleterious effect on cell physiology induced by chronic inflammation and the moderate success of existing conventional therapies (allopathic therapy), understanding the mechanisms Immunological agents in psoriasis and their pathophysiological effect have become the cornerstone for the development of new and better medicines. With the introduction of monoclonal antibodies and fusion proteins, added to existing chemical and physical therapies, the available therapeutic arsenal has increased. Because of the immunological complexity of the disease and its association with other diseases linked to the inflammatory immune response, there is a need to broaden the knowledge about the pathophysiology of the disease and the immunological and molecular mechanisms of action of the medicines used to provide the best care to patients. Abundant information is available in the literature regarding clinical data on safety and efficacy of each of the medicines used in the treatment of the disease, however, the information found in the literature regarding the modifications in gene expression is fragmented, a situation that leads to a loss of data, which prevents a glimpse of the molecular and biochemical implications of the different treatments in the spectrum of the disease. Carrying out an integration of this information will allow a better understanding of its role in the management of psoriasis and will enable the analysis of the differential aspects at the molecular level of the multiple mechanisms of action of the biological therapies indicated in this pathology.MaestríaMagister en InmunologíaEl protocolo fue presentado y registrado en la plataforma de revisiones sistemáticas PROSPERO, con el registro: CRD42020222010. Se utilizaron las bases de datos de PUBMED/MEDLINE, Embase, LILACS y CENTRAL, para los idiomas español inglés, desde el 01/05/2005 hasta 20/08/2022. Se seleccionaron artículos originales observacionales de cohorte, casos y controles y ensayos clínicos con comparaciones antes y después, en los que se habían administrado anticuerpos monoclonales tipo anti-IL-23, anti-IL-17, anti-TNF- α y anti IL-12/23. Acorde con la metodología Cochrane, se sintetizaron los datos a través de descripciones cualitativas (narrativa) y cuantitativa a través de mapas de calor (Lasagna plot), forest plot y metaanálisis de efectos aleatorios debido a la heterogeneidad.*Revisión sistemática de la literaturaiv, 59 páginasapplication/pdfspa610 - Medicina y salud::616 - EnfermedadesEtanerceptAdalimumabAnticuerpos MonoclonalesAntibodies, MonoclonalPsoriasisAnticuerpo monoclonalExpresión génicaExpresión proteicaCorrelaciónRespondedoresNo respondedoresPsoriasisMonoclonal antibodyGene ExpressionProtein expressionCorrelationRespondersNon respondersConexiones moleculares y su implicación en psoriasis: Variaciones en la expresión génica y proteica a nivel de los queratinocitos de pacientes con psoriasis de moderada a severa que fueron tratados con anticuerpos monoclonalesMolecular Connections and their implication in Psoriasis: Variations in gene and protein expression at the level of the keratinocytes from patients with moderate to severe psoriasis who were treated with monoclonal antibodies.Trabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBogotá - Medicina - Maestría en InmunologíaFacultad de MedicinaUniversidad Nacional de Colombia - Sede Bogotá1. 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Curr Pharm Biotechnol. 2022;23(6):873-81.EstudiantesInvestigadoresMaestrosPúblico generalORIGINAL1032391142.2023.pdf1032391142.2023.pdfTesis de maestría Inmunologíaapplication/pdf1749427https://repositorio.unal.edu.co/bitstream/unal/84429/4/1032391142.2023.pdf987219a90b1c2eeafdc1b6eecf912561MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/84429/5/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD55THUMBNAIL1032391142.2023.pdf.jpg1032391142.2023.pdf.jpgGenerated Thumbnailimage/jpeg4954https://repositorio.unal.edu.co/bitstream/unal/84429/6/1032391142.2023.pdf.jpg2b38b74b19a1bc58b63c7627bf9dfd11MD56unal/84429oai:repositorio.unal.edu.co:unal/844292024-08-12 23:12:07.442Repositorio Institucional Universidad Nacional de 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