Estimación del número de unidades motoras del abductor corto del pulgar mediante el método exploración del potencial de acción muscular compuesto (MScanFit) en adultos sanos: valores de referencia
ilustraciones, gráficas, tablas
- Autores:
-
Parra Durán, Fabián Andrés
- Tipo de recurso:
- Fecha de publicación:
- 2022
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/81702
- Palabra clave:
- 610 - Medicina y salud::612 - Fisiología humana
Articulaciones de los Dedos
Músculos
Actividad Motora
Finger Joint
Muscles
Motor Activity
Unidades motoras
Excitabilidad axonal
Exploración del PAMC
MScanFit
MUNE
CMAP scan
Axonal excitability
Motor units
- Rights
- openAccess
- License
- Reconocimiento 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Estimación del número de unidades motoras del abductor corto del pulgar mediante el método exploración del potencial de acción muscular compuesto (MScanFit) en adultos sanos: valores de referencia |
| dc.title.translated.eng.fl_str_mv |
Motor unit number estimation of abductor pollicis brevis by the scan compound muscle action potential (MScanFit) method in healthy adults: reference values |
| title |
Estimación del número de unidades motoras del abductor corto del pulgar mediante el método exploración del potencial de acción muscular compuesto (MScanFit) en adultos sanos: valores de referencia |
| spellingShingle |
Estimación del número de unidades motoras del abductor corto del pulgar mediante el método exploración del potencial de acción muscular compuesto (MScanFit) en adultos sanos: valores de referencia 610 - Medicina y salud::612 - Fisiología humana Articulaciones de los Dedos Músculos Actividad Motora Finger Joint Muscles Motor Activity Unidades motoras Excitabilidad axonal Exploración del PAMC MScanFit MUNE CMAP scan Axonal excitability Motor units |
| title_short |
Estimación del número de unidades motoras del abductor corto del pulgar mediante el método exploración del potencial de acción muscular compuesto (MScanFit) en adultos sanos: valores de referencia |
| title_full |
Estimación del número de unidades motoras del abductor corto del pulgar mediante el método exploración del potencial de acción muscular compuesto (MScanFit) en adultos sanos: valores de referencia |
| title_fullStr |
Estimación del número de unidades motoras del abductor corto del pulgar mediante el método exploración del potencial de acción muscular compuesto (MScanFit) en adultos sanos: valores de referencia |
| title_full_unstemmed |
Estimación del número de unidades motoras del abductor corto del pulgar mediante el método exploración del potencial de acción muscular compuesto (MScanFit) en adultos sanos: valores de referencia |
| title_sort |
Estimación del número de unidades motoras del abductor corto del pulgar mediante el método exploración del potencial de acción muscular compuesto (MScanFit) en adultos sanos: valores de referencia |
| dc.creator.fl_str_mv |
Parra Durán, Fabián Andrés |
| dc.contributor.advisor.spa.fl_str_mv |
Ortiz Corredor, Fernando |
| dc.contributor.author.spa.fl_str_mv |
Parra Durán, Fabián Andrés |
| dc.contributor.other.spa.fl_str_mv |
Mendoza Pulido, Juan Camilo |
| dc.subject.ddc.spa.fl_str_mv |
610 - Medicina y salud::612 - Fisiología humana |
| topic |
610 - Medicina y salud::612 - Fisiología humana Articulaciones de los Dedos Músculos Actividad Motora Finger Joint Muscles Motor Activity Unidades motoras Excitabilidad axonal Exploración del PAMC MScanFit MUNE CMAP scan Axonal excitability Motor units |
| dc.subject.decs.spa.fl_str_mv |
Articulaciones de los Dedos Músculos Actividad Motora |
| dc.subject.decs.eng.fl_str_mv |
Finger Joint Muscles Motor Activity |
| dc.subject.proposal.spa.fl_str_mv |
Unidades motoras Excitabilidad axonal Exploración del PAMC |
| dc.subject.proposal.eng.fl_str_mv |
MScanFit MUNE CMAP scan Axonal excitability Motor units |
| description |
ilustraciones, gráficas, tablas |
| publishDate |
2022 |
| dc.date.accessioned.none.fl_str_mv |
2022-07-18T19:14:21Z |
| dc.date.available.none.fl_str_mv |
2022-07-18T19:14:21Z |
| dc.date.issued.none.fl_str_mv |
2022-07-09 |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Especialidad Médica |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/masterThesis |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/TM |
| status_str |
acceptedVersion |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.unal.edu.co/handle/unal/81702 |
| dc.identifier.instname.spa.fl_str_mv |
Universidad Nacional de Colombia |
| dc.identifier.reponame.spa.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
| dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.unal.edu.co/ |
| url |
https://repositorio.unal.edu.co/handle/unal/81702 https://repositorio.unal.edu.co/ |
| identifier_str_mv |
Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
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spa |
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spa |
| dc.relation.indexed.spa.fl_str_mv |
Bireme |
| dc.relation.references.spa.fl_str_mv |
Blok, J. H., Ruitenberg, A., Maathuis, E. M., & Visser, G. H. (2007). The electrophysiological muscle scan. Muscle and Nerve, 36(4), 436–446. https://doi.org/10.1002/mus.20838 Bostock, H. (2016). Estimating motor unit numbers from a CMAP scan. Muscle and Nerve, 53(6), 889–896. https://doi.org/10.1002/mus.24945 Bromberg, M. B. (1993). Motor unit estimation: Reproducibility of the spike‐triggered averaging technique in normal and ALS subjects. Muscle & Nerve, 16(5), 466–471. https://doi.org/10.1002/mus.880160506 Bromberg, M. B., & Brownell, A. A. (2008). Motor Unit Number Estimation in the Assessment of Performance and Function in Motor Neuron Disease. Physical Medicine and Rehabilitation Clinics of North America, 19(3), 509–532. https://doi.org/10.1016/j.pmr.2008.02.006 Burke, D., Kiernan, M. C., & Bostock, H. (2001). Excitability of human axons. Clinical Neurophysiology, 112(9), 1575–1585. https://doi.org/10.1016/S1388-2457(01)00595-8 Daube, J. R. (1995). Estimating the number of motor units in a muscle. Journal of Clinical Neurophysiology, 12(6), 585–594. https://doi.org/10.1097/00004691-199511000-00005 Daube, J. R. (2006). Motor unit number estimates - From A to Z. Journal of the Neurological Sciences, 242(1-2 SPEC. ISS.), 23–35. https://doi.org/10.1016/j.jns.2005.11.011 de Carvalho, M., Barkhaus, P. E., Nandedkar, S. D., & Swash, M. (2018). Motor unit number estimation (MUNE): Where are we now? Clinical Neurophysiology, 129(8), 1507–1516. https://doi.org/10.1016/j.clinph.2018.04.748 Dillingham, T., Chen, S., Andary, M., Buschbacher, R., Del Toro, D., Smith, B., Zimmermann, K., & Yuen, S. O. (2016). Establishing high-quality reference values for nerve conduction studies: A report from the normative data task force of the American Association Of Neuromuscular & Electrodiagnostic Medicine. Muscle and Nerve, 54(3), 366–370. https://doi.org/10.1002/mus.25204 Doherty, T. J., & Brown, W. F. (1993). The estimated numbers and relative sizes of thenar motor units as selected by multiple point stimulation in young and older adults. Muscle & Nerve, 16(4), 355–366. https://doi.org/10.1002/mus.880160404 Drenthen, J., Islam, B., Islam, Z., Mohammad, Q. D., Maathuis, E. M., Visser, G. H., van Doorn, P. A., Blok, J. H., Endtz, H. P., & Jacobs, B. C. (2021). Changes in motor nerve excitability in acute phase Guillain-Barré syndrome. Muscle and Nerve, 63(4), 546–552. https://doi.org/10.1002/mus.27172 Drenthen, J., Maathuis, E. M., Visser, G. H., van Doorn, P. A., Blok, J. H., & Jacobs, B. C. (2013). Limb motor nerve dysfunction in Miller Fisher syndrome. Journal of the Peripheral Nervous System : JPNS, 18(1), 25–29. https://doi.org/10.1111/jns5.12003 Eisen, A., & Kuwabara, S. (2012). The split hand syndrome in amyotrophic lateral sclerosis. In Journal of Neurology, Neurosurgery and Psychiatry (Vol. 83, Issue 4, pp. 399–403). BMJ Publishing Group. https://doi.org/10.1136/jnnp-2011-301456 Farschtschi, S., Gelderblom, M., Buschbaum, S., Bostock, H., Grafe, P., & Mautner, V. F. (2017). Muscle action potential scans and ultrasound imaging in neurofibromatosis type 2. Muscle and Nerve, 55(3), 350–358. https://doi.org/10.1002/mus.25256 Feldman, E. L., Callaghan, B. C., Pop-Busui, R., Zochodne, D. W., Wright, D. E., Bennett, D. L., Bril, V., Russell, J. W., & Viswanathan, V. (2019). Diabetic neuropathy. Nature Reviews. Disease Primers, 5(1), 42. https://doi.org/10.1038/s41572-019-0097-9 Galvez-Jimenez, N., Morren, J. A., & Soriano, A. (2021). Principles of Electrodiagnosis: Introduction. In Electrodiagnostic Medicine (pp. 1–24). Springer, Cham. https://doi.org/10.1007/978-3-030-74997-2_1 Garg, N., Howells, J., Yiannikas, C., Vucic, S., Krishnan, A. V., Spies, J., Bostock, H., Mathey, E. K., Pollard, J. D., Park, S. B., & Kiernan, M. C. (2017). Motor unit remodelling in multifocal motor neuropathy: The importance of axonal loss. Clinical Neurophysiology, 128(10), 2022–2028. https://doi.org/10.1016/j.clinph.2017.07.414 Gooch, C. L., Doherty, T. J., Chan, K. M., Bromberg, M. B., Lewis, R. A., Stashuk, D. W., Berger, M. J., Andary, M. T., & Daube, J. R. (2014). Motor unit number estimation: A technology and literature review. Muscle and Nerve, 50(6), 884–893. https://doi.org/10.1002/mus.24442 Gunes, T., Sirin, N. G., Sahin, S., Kose, E., & Isak, B. (2021). Use of CMAP, MScan fit-MUNE, and MUNIX in understanding neurodegeneration pattern of ALS and detection of early motor neuron loss in daily practice. Neuroscience Letters, 741(547), 135488. https://doi.org/10.1016/j.neulet.2020.135488 Habeych, M. E., Trinh, T., Issar, T., Kwai, N. C. G., & Krishnan, A. V. (2020). Motor unit number estimation of facial muscles using the M Scan-Fit method. Muscle and Nerve, 62(4), 555–558. https://doi.org/10.1002/mus.27010 Hales, J. P., Lin, C. S. Y., & Bostock, H. (2004). Variations in excitability of single human motor axons, related to stochastic properties of nodal sodium channels. Journal of Physiology, 559(3), 953–964. https://doi.org/10.1113/jphysiol.2004.068726 Henderson, R. D., Ridall, G. R., Pettitt, A. N., McCombe, P. A., & Daube, J. R. (2006). The stimulus-response curve and motor unit variability in normal subjects and subjects with amyotrophic lateral sclerosis. Muscle and Nerve, 34(1), 34–43. https://doi.org/10.1002/mus.20561 Henderson, Robert D., & McCombe, P. A. (2017). Assessment of Motor Units in Neuromuscular Disease. In Neurotherapeutics (Vol. 14, Issue 1, pp. 69–77). Springer. https://doi.org/10.1007/s13311-016-0473-z Henderson, Robert D., Ridall, P. G., Hutchinson, N. M., Pettitt, A. N., & McCombe, P. A. (2007). Bayesian statistical mune method. Muscle and Nerve, 36(2), 206–213. https://doi.org/10.1002/mus.20805 Henderson, Robert D, & McCombe, P. A. (2017). Assessment of Motor Units in Neuromuscular Disease. In Neurotherapeutics (Vol. 14, Issue 1, pp. 69–77). https://doi.org/10.1007/s13311-016-0473-z Hepple, R. T., & Rice, C. L. (2016). Innervation and neuromuscular control in ageing skeletal muscle. In Journal of Physiology (Vol. 594, Issue 8, pp. 1965–1978). John Wiley & Sons, Ltd. https://doi.org/10.1113/JP270561 Higashihara, M., Menon, P., van den Bos, M., Pavey, N., & Vucic, S. (2020). Reproducibility of motor unit number index and MScanFit motor unit number estimation across intrinsic hand muscles. Muscle and Nerve, 62(2), 192–200. https://doi.org/10.1002/mus.26839 Jacobsen, A. B., Bostock, H., Fuglsang-Frederiksen, A., Duez, L., Beniczky, S., Møller, A. T., Blicher, J. U., & Tankisi, H. (2017). Reproducibility, and sensitivity to motor unit loss in amyotrophic lateral sclerosis, of a novel MUNE method: MScanFit MUNE. Clinical Neurophysiology, 128(7), 1380–1388. https://doi.org/10.1016/j.clinph.2017.03.045 Jacobsen, A. B., Kristensen, R. S., Witt, A., Kristensen, A. G., Duez, L., Beniczky, S., Fuglsang-Frederiksen, A., & Tankisi, H. (2018). The utility of motor unit number estimation methods versus quantitative motor unit potential analysis in diagnosis of ALS. Clinical Neurophysiology, 129(3), 646–653. https://doi.org/10.1016/j.clinph.2018.01.002 Jacobsen, Anna B., Bostock, H., & Tankisi, H. (2018). Cmap scan mune (Mscan)-a novel motor unit number estimation (mune) method. Journal of Visualized Experiments, 2018(136), 1–7. https://doi.org/10.3791/56805 Jacobsen, Anna Bystrup, Bostock, H., & Tankisi, H. (2019). Following disease progression in motor neuron disorders with 3 motor unit number estimation methods. Muscle and Nerve, 59(1), 82–87. https://doi.org/10.1002/mus.26304 Kesim-Sahin, O., Sirin, N. G., Erbas, B., Artug, T., Oguz-Akarsu, E., Kocasoy-Orhan, E., Baslo, M. B., Mammadova, N., Emekli, U., & Oge, A. E. (2020). Compound muscle action potential scan and MScanFit motor unit number estimation during Wallerian degeneration after nerve transections. Muscle and Nerve, 62(2), 239–246. https://doi.org/10.1002/mus.26923 Kiernan, M. C., Burke, D., Andersen, K. V., & Bostock, H. (2000). Multiple measures of axonal excitability: A new approach in clinical testing. Muscle and Nerve, 23(3), 399–409. https://doi.org/10.1002/(SICI)1097-4598(200003)23:3<399::AID-MUS12>3.0.CO;2-G Kristensen, A. G., Bostock, H., Finnerup, N. B., Andersen, H., Jensen, T. S., Gylfadottir, S., Itani, M., Krøigård, T., Sindrup, S., & Tankisi, H. (2019). Detection of early motor involvement in diabetic polyneuropathy using a novel MUNE method – MScanFit MUNE. Clinical Neurophysiology, 130(10), 1981–1987. https://doi.org/10.1016/j.clinph.2019.08.003 Kristensen, A. G., Khan, K. S., Bostock, H., Khan, B. S., Gylfadottir, S., Andersen, H., Finnerup, N. B., Jensen, T. S., & Tankisi, H. (2020). MScanFit motor unit number estimation and muscle velocity recovery cycle recordings in diabetic polyneuropathy. Clinical Neurophysiology, 131(11), 2591–2599. https://doi.org/10.1016/j.clinph.2020.07.017 Kristensen, R. S., Bostock, H., Tan, S. V., Witt, A., Fuglsang-Frederiksen, A., Qerama, E., Andersen, H., & Tankisi, H. (2019). MScanFit motor unit number estimation (MScan)and muscle velocity recovery cycle recordings in amyotrophic lateral sclerosis patients. Clinical Neurophysiology, 130(8), 1280–1288. https://doi.org/10.1016/j.clinph.2019.04.713 Kuwabara, S., Sonoo, M., Komori, T., Shimizu, T., Hirashima, F., Inaba, A., Misawa, S., Hatanaka, Y., Kanai, K., Sawai, S., Isose, S., Hoshino, S., Kagamihara, Y., Kugio, Y., Awatsu, Y., Ichikawa, T., Yamada, H., Oishi, C., Ito, E., … Sawada, M. (2008). Dissociated small hand muscle atrophy in amyotrophic lateral sclerosis: Frequency, extent, and specificity. Muscle and Nerve, 37(4), 426–430. https://doi.org/10.1002/mus.20949 Li, X., Zong, Y., Klein, C. S., & Zhou, P. (2018). Motor unit number estimation of human abductor hallucis from a compound muscle action potential scan. Muscle and Nerve, 58(5), 735. https://doi.org/10.1002/mus.26295 Lomen-Hoerth, C., & Slawnych, M. P. (2003). Statistical motor unit number estimation: From theory to practice. Muscle and Nerve, 28(3), 263–272. https://doi.org/10.1002/mus.10351 Maathuis, E. M., Drenthen, J., Van Doorn, P. A., Visser, G. H., & Blok, J. H. (2013). The CMAP scan as a tool to monitor disease progression in ALS and PMA. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 14(3), 217–223. https://doi.org/10.3109/21678421.2012.732079 Maathuis, E. M., Drenthen, J., Visser, G. H., & Blok, J. H. (2011). Reproducibility of the CMAP scan. Journal of Electromyography and Kinesiology, 21(3), 433–437. https://doi.org/10.1016/j.jelekin.2010.11.007 Maathuis, E. M., Henderson, R. D., Drenthen, J., Hutchinson, N. M., Daube, J. R., Blok, J. H., & Visser, G. H. (2012). Optimal stimulation settings for CMAP scan registrations. Journal of Brachial Plexus and Peripheral Nerve Injury, 7, 1–7. https://doi.org/10.1186/1749-7221-7-4 McComas, A. J., Fawcett, P. R., Campbell, M. J., & Sica, R. E. (1971). Electrophysiological estimation of the number of motor units within a human muscle. Journal of Neurology, Neurosurgery, and Psychiatry, 34(2), 121–131. https://doi.org/10.1136/jnnp.34.2.121 McNeil, C. J., Doherty, T. J., Stashuk, D. W., & Rice, C. L. (2005). Motor unit number estimates in the tibialis anterior muscle of young, old, and very old men. Muscle and Nerve, 31(4), 461–467. https://doi.org/10.1002/mus.20276 Murtazina, A. F., Belyakova-Bodina, A. I., & Brutyan, A. G. (2018). Electrophysiological Techniques for Motor Unit Number Estimation. Human Physiology, 44(8), 827–837. https://doi.org/10.1134/S036211971808008X Nandedkar, B. S. D., & Ph, D. (n.d.). NEURODIAGNOSTICS CMAP Scan : Recording & Analysis. Nandedkar, S. D., Barkhaus, P. E., & Stålberg, E. V. (2010). Motor unit number index (MUNIX): Principle, method, and findings in healthy subjects and in patients with motor neuron disease. Muscle and Nerve, 42(5), 798–807. https://doi.org/10.1002/mus.21824 Nandedkar, S. D., Barkhaus, P. E., & Stålberg, E. V. (2011). Reproducibility of munix in patients with amyotrophic lateral sclerosis. Muscle and Nerve, 44(6), 919–922. https://doi.org/10.1002/mus.22204 Nandedkar, S. D., Barkhaus, P. E., & Stålberg, E. V. (2022). Clinical Neurophysiology Analysis of the compound muscle action potential scan : Step index ( STEPIX ) and amplitude index ( AMPIX ). Clinical Neurophysiology, xxxx. https://doi.org/10.1016/j.clinph.2022.04.011 Nandedkar, S. D., Nandedkar, D. S., Barkhaus, P. E., & Stalberg, E. V. (2004). Motor unit number index (MUNIX). IEEE Transactions on Biomedical Engineering, 51(12), 2209–2211. https://doi.org/10.1109/TBME.2004.834281 Neuwirth, C., Braun, N., Claeys, K. G., Bucelli, R., Fournier, C., Bromberg, M., Petri, S., Goedee, S., Lenglet, T., Leppanen, R., Canosa, A., Goodman, I., Al-Lozi, M., Ohkubo, T., Hübers, A., Atassi, N., Abrahao, A., Funke, A., Appelfeller, M., … Weber, M. (2018). Implementing Motor Unit Number Index (MUNIX) in a large clinical trial: Real world experience from 27 centres. Clinical Neurophysiology, 129(8), 1756–1762. https://doi.org/10.1016/j.clinph.2018.04.614 Neuwirth, C., Nandedkar, S., Stålberg, E., Barkhaus, P. E., Carvalho, M. de, Furtula, J., Dijk, J. P. va., Baldinger, R., Castro, J., Costa, J., Otto, M., Sandberg, A., & Weber, M. (2011). Motor Unit Number Index (MUNIX): A novel neurophysiological marker for neuromuscular disorders; test-retest reliability in healthy volunteers. Clinical Neurophysiology, 122(9), 1867–1872. https://doi.org/10.1016/j.clinph.2011.02.017 Neuwirth, C., Nandedkar, S., Stålberg, E., & Weber, M. (2010). Motor Unit Number Index (MUNIX): A novel neurophysiological technique to follow disease progression in amyotrophic lateral sclerosis. Muscle and Nerve, 42(3), 379–384. https://doi.org/10.1002/mus.21707 Okhovat, A. A., Advani, S., Moradi, K., Ziaadini, B., Panahi, A., Nafissi, S., Haghi Ashtiani, B., & Fatehi, F. (2021). Application of CMAP scan for the evaluation of patients with chronic inflammatory demyelinating polyneuropathy: a prospective study. Neurophysiologie Clinique, 51(2), 175–181. https://doi.org/10.1016/j.neucli.2020.12.005 Pagnini, F., Rossi, G., Lunetta, C., Banfi, P., Castelnuovo, G., Corbo, M., & Molinari, E. (2010). Burden, depression, and anxiety in caregivers of people with amyotrophic lateral sclerosis. Psychology, Health and Medicine, 15(6), 685–693. https://doi.org/10.1080/13548506.2010.507773 Quinn, C., & Elman, L. (2020). Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases. Continuum (Minneapolis, Minn.), 26(5), 1323–1347. https://doi.org/10.1212/CON.0000000000000911 Ridall, P. G., Pettitt, A. N., Henderson, R. D., & McCombe, P. A. (2006). Motor unit number estimation - A Bayesian approach. Biometrics, 62(4), 1235–1250. https://doi.org/10.1111/j.1541-0420.2006.00577.x Schneider, C., Wassermann, M. K., Grether, N. B., Fink, G. R., Wunderlich, G., & Lehmann, H. C. (2021). Motor unit number estimation in adult patients with spinal muscular atrophy treated with nusinersen. European Journal of Neurology, 28(9), 3022–3029. https://doi.org/10.1111/ene.15005 Sirin, N. G., Oguz Akarsu, E., Kocasoy Orhan, E., Erbas, B., Artug, T., Dede, H. O., Baslo, M. B., Idrisoglu, H. A., & Oge, A. E. (2019). Parameters derived from compound muscle action potential scan for discriminating amyotrophic lateral sclerosis-related denervation. Muscle and Nerve, 60(4), 400–408. https://doi.org/10.1002/mus.26644 Sleutjes, B. T.H.M., Montfoort, I., Maathuis, E. M., Drenthen, J., van Doorn, P. A., Visser, G. H., & Blok, J. H. (2014). CMAP scan discontinuities: Automated detection and relation to motor unit loss. Clinical Neurophysiology, 125(2), 388–395. https://doi.org/10.1016/j.clinph.2013.07.016 Sleutjes, Boudewijn T.H.M., Bystrup Jacobsen, A., Tankisi, H., Gorkem Sirin, N., Emre Oge, A., Henderson, R. D., van Doorn, P. A., van den Berg, L. H., & van Eijk, R. P. A. (2021). Advancing disease monitoring of amyotrophic lateral sclerosis with the compound muscle action potential scan. Clinical Neurophysiology, 132(12), 3152–3159. https://doi.org/10.1016/j.clinph.2021.09.014 Sleutjes, Boudewijn T.H.M., Ruisch, J., Nassi, T. E., Buitenweg, J. R., van Schelven, L. J., van den Berg, L. H., Franssen, H., & Stephan Goedee, H. (2021). Impact of stimulus duration on motor unit thresholds and alternation in compound muscle action potential scans. Clinical Neurophysiology, 132(2), 323–331. https://doi.org/10.1016/j.clinph.2020.10.026 Sleutjes, Boudewijn T.H.M., Wijngaarde, C. A., Wadman, R. I., Otto, L. A. M., Asselman, F. L., Cuppen, I., van den Berg, L. H., Ludo van der Pol, W., & Stephan Goedee, H. (2020). Assessment of motor unit loss in patients with spinal muscular atrophy. Clinical Neurophysiology, 131(6), 1280–1286. https://doi.org/10.1016/j.clinph.2020.01.018 Sørensen, D. M., Bostock, H., Ballegaard, M., Fuglsang-Frederiksen, A., Graffe, C. C., Grötting, A., Jones, K., Kallio, M., Krarup, C., Krøigård, T., Lupescu, T., Maitland, S., Moldovan, M., Nilsen, K. B., Pugdahl, K., Santos, M. O., Themistocleous, A. C., Zlateva, S. S., Ööpik, M., & Tankisi, H. (2022). Assessing inter-rater reproducibility in MScanFit MUNE in a 6-subject, 12-rater “Round Robin” setup. Neurophysiologie Clinique, 52(2), 157–169. https://doi.org/10.1016/j.neucli.2021.11.002 Stålberg, E., van Dijk, H., Falck, B., Kimura, J., Neuwirth, C., Pitt, M., Podnar, S., Rubin, D. I., Rutkove, S., Sanders, D. B., Sonoo, M., Tankisi, H., & Zwarts, M. (2019). Standards for quantification of EMG and neurography. In Clinical Neurophysiology (Vol. 130, Issue 9, pp. 1688–1729). Elsevier Ireland Ltd. https://doi.org/10.1016/j.clinph.2019.05.008 Stikvoort García, D. J. L., Kovalchuk, M. O., Goedee, H. S., van Schelven, L. J., van den Berg, L. H., Franssen, H., & Sleutjes, B. T. H. M. (2022). Motor unit integrity in multifocal motor neuropathy: A systematic evaluation with CMAP scans. Muscle and Nerve, 65(3), 317–325. https://doi.org/10.1002/mus.27469 Van Dijk, J. P., Schelhaas, H. J., Van Schaik, I. N., Janssen, H. M. H. A., Stegeman, D. F., & Zwarts, M. J. (2010). Monitoring disease progression using high-density motor unit number estimation in amyotrophic lateral sclerosis. Muscle and Nerve, 42(2), 239–244. https://doi.org/10.1002/mus.21680 Visser, G. H., & Blok, J. H. (2009). Chapter 6 The CMAP scan. In Supplements to Clinical Neurophysiology (Vol. 60, Issue C, pp. 65–77). Elsevier. https://doi.org/10.1016/S1567-424X(08)00006-8 Vucic, S., & Rutkove, S. B. (2018). Neurophysiological biomarkers in amyotrophic lateral sclerosis. In Current opinion in neurology (Vol. 31, Issue 5, pp. 640–647). NLM (Medline). https://doi.org/10.1097/WCO.0000000000000593 Wilbourn, A. J. (2000). The “split hand syndrome” [1]. In Muscle and Nerve (Vol. 23, Issue 1, p. 138). John Wiley and Sons Inc. https://doi.org/10.1002/(SICI)1097-4598(200001)23:1<138::AID-MUS22>3.0.CO;2-7 Witt, A., Fuglsang-Frederiksen, A., Finnerup, N. B., Kasch, H., & Tankisi, H. (2020). Detecting peripheral motor nervous system involvement in chronic spinal cord injury using two novel methods: MScanFit MUNE and muscle velocity recovery cycles. Clinical Neurophysiology, 131(10), 2383–2392. https://doi.org/10.1016/j.clinph.2020.06.032 Zong, Y., Lu, Z., Chen, M., Deng, L., Xie, Q., & Zhou, P. (2022). Motor Unit Number Estimation of the Second Lumbrical Muscle in Human Hand. Frontiers in Physiology, 13(February), 1–5. https://doi.org/10.3389/fphys.2022.854385 Zong, Y., Lu, Z., Chen, M., Li, X., Stampas, A., Deng, L., & Zhou, P. (2021). CMAP scan examination of the first dorsal interosseous muscle after spinal cord injury. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 29, 1199–1205. https://doi.org/10.1109/TNSRE.2021.3088061 Zong, Y., Lu, Z., Chen, M., Xie, Q., & Zhou, P. (2022). MScanFit motor unit number estimation of human anconeus muscle. Muscle and Nerve, 65(4), 460–463. https://doi.org/10.1002/mus.27487 Zong, Y., Lu, Z., Zhang, L., Li, X., & Zhou, P. (2020). Motor unit number of the first dorsal interosseous muscle estimated from CMAP scan with different pulse widths and steps. Journal of Neural Engineering, 17(1). https://doi.org/10.1088/1741-2552/ab57cc |
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Departamento de Medicina Física y Rehabilitacion |
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Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Ortiz Corredor, Fernando81b4b274e2c2e83d0bffd14631b9acb8600Parra Durán, Fabián Andréscac02f3ccacf2de735e8db9d9d8090f2Mendoza Pulido, Juan Camilo2022-07-18T19:14:21Z2022-07-18T19:14:21Z2022-07-09https://repositorio.unal.edu.co/handle/unal/81702Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, gráficas, tablasIntroducción: La exploración del PAMC MScanFit es un método MUNE novedoso que cuantifica el número de unidades motoras, es reproducible, sensible al cambio, preciso y toma un corto tiempo. Objetivo: estimar el número de unidades motoras en el musculo abductor corto del pulgar, usando el método MScanFit en personas adultos sanos de Colombia. Metodología: se realizaron registros en el abductor corto del pulgar en individuos sanos, se determinó la normalidad en la distribución de los datos con la técnica D'Agostino & Pearson. Para la presentación de la estadística descriptiva se calcularon valores mínimos, máximo, mediana, rango intercuartil, percentiles 3 y 97. Resultados: En total se evaluaron 109 individuos, la mediana de la edad fue 29 años (mínimo=18, máximo=49); el valor MUNE fue de (mediana: 103 UM) en el APB, con un error (mediana: 7,4%) y un porcentaje de paso máximo: 17% (mediana: 3,3%). Se encontraron correlaciones de la edad frente al número de UM y paso % sin significancia estadística. Conclusión: es el primer estudio que ofrece valores de corte y normalidad para la estimación del número de unidades motoras (MUNE), para la población adulta joven colombiana. (Texto tomado de la fuente).Introduction: The CMAP Scan MScanFit is a novel MUNE method that quantifies the number of motor units, is reproducible, sensitive to change, accurate, and takes a short time. Objective: to estimate the number of motor units in the abductor pollicis brevis muscle, using the MScanFit method in healthy adults from Colombia. Methodology: recordings were made in the abductor pollicis brevis in healthy individuals, normality in the distribution of the data was determined with the D'Agostino & Pearson technique. For the presentation of descriptive statistics, minimum, maximum, median, interquartile range, 3rd and 97th percentile values were calculated. Results: A total of 109 individuals were evaluated, the median age was 29 years (minimum=18, maximum=49).; the MUNE value was (median: 103 MU) in the APB, with an error (median: 7.4%) and a percentage of maximum passage: 17% (median: 3.3%). Correlations of age against the number of MU and step % were found without statistical significance. Conclusion: it is the first study that offers cut-off and normality values for the estimation of the number of motor units (MUNE), for the Colombian young adult population.Incluye anexosEspecialidades MédicasEspecialista en Medicina Física y RehabilitaciónElectrodiagnóstico y enfermedades neuromuscularesxv, 68 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Especialidad en Medicina Física y RehabilitaciónDepartamento de Medicina Física y RehabilitacionFacultad de MedicinaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::612 - Fisiología humanaArticulaciones de los DedosMúsculosActividad MotoraFinger JointMusclesMotor ActivityUnidades motorasExcitabilidad axonalExploración del PAMCMScanFitMUNECMAP scanAxonal excitabilityMotor unitsEstimación del número de unidades motoras del abductor corto del pulgar mediante el método exploración del potencial de acción muscular compuesto (MScanFit) en adultos sanos: valores de referenciaMotor unit number estimation of abductor pollicis brevis by the scan compound muscle action potential (MScanFit) method in healthy adults: reference valuesTrabajo de grado - Especialidad Médicainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBiremeBlok, J. H., Ruitenberg, A., Maathuis, E. M., & Visser, G. H. (2007). The electrophysiological muscle scan. Muscle and Nerve, 36(4), 436–446. https://doi.org/10.1002/mus.20838Bostock, H. (2016). Estimating motor unit numbers from a CMAP scan. Muscle and Nerve, 53(6), 889–896. https://doi.org/10.1002/mus.24945Bromberg, M. B. (1993). Motor unit estimation: Reproducibility of the spike‐triggered averaging technique in normal and ALS subjects. Muscle & Nerve, 16(5), 466–471. https://doi.org/10.1002/mus.880160506Bromberg, M. B., & Brownell, A. A. (2008). Motor Unit Number Estimation in the Assessment of Performance and Function in Motor Neuron Disease. Physical Medicine and Rehabilitation Clinics of North America, 19(3), 509–532. https://doi.org/10.1016/j.pmr.2008.02.006Burke, D., Kiernan, M. C., & Bostock, H. (2001). Excitability of human axons. Clinical Neurophysiology, 112(9), 1575–1585. https://doi.org/10.1016/S1388-2457(01)00595-8Daube, J. R. (1995). Estimating the number of motor units in a muscle. Journal of Clinical Neurophysiology, 12(6), 585–594. https://doi.org/10.1097/00004691-199511000-00005Daube, J. R. (2006). Motor unit number estimates - From A to Z. Journal of the Neurological Sciences, 242(1-2 SPEC. ISS.), 23–35. https://doi.org/10.1016/j.jns.2005.11.011de Carvalho, M., Barkhaus, P. E., Nandedkar, S. D., & Swash, M. (2018). Motor unit number estimation (MUNE): Where are we now? Clinical Neurophysiology, 129(8), 1507–1516. https://doi.org/10.1016/j.clinph.2018.04.748Dillingham, T., Chen, S., Andary, M., Buschbacher, R., Del Toro, D., Smith, B., Zimmermann, K., & Yuen, S. O. (2016). Establishing high-quality reference values for nerve conduction studies: A report from the normative data task force of the American Association Of Neuromuscular & Electrodiagnostic Medicine. Muscle and Nerve, 54(3), 366–370. https://doi.org/10.1002/mus.25204Doherty, T. J., & Brown, W. F. (1993). The estimated numbers and relative sizes of thenar motor units as selected by multiple point stimulation in young and older adults. Muscle & Nerve, 16(4), 355–366. https://doi.org/10.1002/mus.880160404Drenthen, J., Islam, B., Islam, Z., Mohammad, Q. D., Maathuis, E. M., Visser, G. H., van Doorn, P. A., Blok, J. H., Endtz, H. P., & Jacobs, B. C. (2021). Changes in motor nerve excitability in acute phase Guillain-Barré syndrome. Muscle and Nerve, 63(4), 546–552. https://doi.org/10.1002/mus.27172Drenthen, J., Maathuis, E. M., Visser, G. H., van Doorn, P. A., Blok, J. H., & Jacobs, B. C. (2013). Limb motor nerve dysfunction in Miller Fisher syndrome. Journal of the Peripheral Nervous System : JPNS, 18(1), 25–29. https://doi.org/10.1111/jns5.12003Eisen, A., & Kuwabara, S. (2012). The split hand syndrome in amyotrophic lateral sclerosis. In Journal of Neurology, Neurosurgery and Psychiatry (Vol. 83, Issue 4, pp. 399–403). BMJ Publishing Group. https://doi.org/10.1136/jnnp-2011-301456Farschtschi, S., Gelderblom, M., Buschbaum, S., Bostock, H., Grafe, P., & Mautner, V. F. (2017). Muscle action potential scans and ultrasound imaging in neurofibromatosis type 2. Muscle and Nerve, 55(3), 350–358. https://doi.org/10.1002/mus.25256Feldman, E. L., Callaghan, B. C., Pop-Busui, R., Zochodne, D. W., Wright, D. E., Bennett, D. L., Bril, V., Russell, J. W., & Viswanathan, V. (2019). Diabetic neuropathy. Nature Reviews. Disease Primers, 5(1), 42. https://doi.org/10.1038/s41572-019-0097-9Galvez-Jimenez, N., Morren, J. A., & Soriano, A. (2021). Principles of Electrodiagnosis: Introduction. In Electrodiagnostic Medicine (pp. 1–24). Springer, Cham. https://doi.org/10.1007/978-3-030-74997-2_1Garg, N., Howells, J., Yiannikas, C., Vucic, S., Krishnan, A. V., Spies, J., Bostock, H., Mathey, E. K., Pollard, J. D., Park, S. B., & Kiernan, M. C. (2017). Motor unit remodelling in multifocal motor neuropathy: The importance of axonal loss. Clinical Neurophysiology, 128(10), 2022–2028. https://doi.org/10.1016/j.clinph.2017.07.414Gooch, C. L., Doherty, T. J., Chan, K. M., Bromberg, M. B., Lewis, R. A., Stashuk, D. W., Berger, M. J., Andary, M. T., & Daube, J. R. (2014). Motor unit number estimation: A technology and literature review. Muscle and Nerve, 50(6), 884–893. https://doi.org/10.1002/mus.24442Gunes, T., Sirin, N. G., Sahin, S., Kose, E., & Isak, B. (2021). Use of CMAP, MScan fit-MUNE, and MUNIX in understanding neurodegeneration pattern of ALS and detection of early motor neuron loss in daily practice. Neuroscience Letters, 741(547), 135488. https://doi.org/10.1016/j.neulet.2020.135488Habeych, M. E., Trinh, T., Issar, T., Kwai, N. C. G., & Krishnan, A. V. (2020). Motor unit number estimation of facial muscles using the M Scan-Fit method. Muscle and Nerve, 62(4), 555–558. https://doi.org/10.1002/mus.27010Hales, J. P., Lin, C. S. Y., & Bostock, H. (2004). Variations in excitability of single human motor axons, related to stochastic properties of nodal sodium channels. Journal of Physiology, 559(3), 953–964. https://doi.org/10.1113/jphysiol.2004.068726Henderson, R. D., Ridall, G. R., Pettitt, A. N., McCombe, P. A., & Daube, J. R. (2006). The stimulus-response curve and motor unit variability in normal subjects and subjects with amyotrophic lateral sclerosis. Muscle and Nerve, 34(1), 34–43. https://doi.org/10.1002/mus.20561Henderson, Robert D., & McCombe, P. A. (2017). Assessment of Motor Units in Neuromuscular Disease. In Neurotherapeutics (Vol. 14, Issue 1, pp. 69–77). Springer. https://doi.org/10.1007/s13311-016-0473-zHenderson, Robert D., Ridall, P. G., Hutchinson, N. M., Pettitt, A. N., & McCombe, P. A. (2007). Bayesian statistical mune method. Muscle and Nerve, 36(2), 206–213. https://doi.org/10.1002/mus.20805Henderson, Robert D, & McCombe, P. A. (2017). Assessment of Motor Units in Neuromuscular Disease. In Neurotherapeutics (Vol. 14, Issue 1, pp. 69–77). https://doi.org/10.1007/s13311-016-0473-zHepple, R. T., & Rice, C. L. (2016). Innervation and neuromuscular control in ageing skeletal muscle. In Journal of Physiology (Vol. 594, Issue 8, pp. 1965–1978). John Wiley & Sons, Ltd. https://doi.org/10.1113/JP270561Higashihara, M., Menon, P., van den Bos, M., Pavey, N., & Vucic, S. (2020). Reproducibility of motor unit number index and MScanFit motor unit number estimation across intrinsic hand muscles. Muscle and Nerve, 62(2), 192–200. https://doi.org/10.1002/mus.26839Jacobsen, A. B., Bostock, H., Fuglsang-Frederiksen, A., Duez, L., Beniczky, S., Møller, A. T., Blicher, J. U., & Tankisi, H. (2017). Reproducibility, and sensitivity to motor unit loss in amyotrophic lateral sclerosis, of a novel MUNE method: MScanFit MUNE. Clinical Neurophysiology, 128(7), 1380–1388. https://doi.org/10.1016/j.clinph.2017.03.045Jacobsen, A. B., Kristensen, R. S., Witt, A., Kristensen, A. G., Duez, L., Beniczky, S., Fuglsang-Frederiksen, A., & Tankisi, H. (2018). The utility of motor unit number estimation methods versus quantitative motor unit potential analysis in diagnosis of ALS. Clinical Neurophysiology, 129(3), 646–653. https://doi.org/10.1016/j.clinph.2018.01.002Jacobsen, Anna B., Bostock, H., & Tankisi, H. (2018). Cmap scan mune (Mscan)-a novel motor unit number estimation (mune) method. Journal of Visualized Experiments, 2018(136), 1–7. https://doi.org/10.3791/56805Jacobsen, Anna Bystrup, Bostock, H., & Tankisi, H. (2019). Following disease progression in motor neuron disorders with 3 motor unit number estimation methods. Muscle and Nerve, 59(1), 82–87. https://doi.org/10.1002/mus.26304Kesim-Sahin, O., Sirin, N. G., Erbas, B., Artug, T., Oguz-Akarsu, E., Kocasoy-Orhan, E., Baslo, M. B., Mammadova, N., Emekli, U., & Oge, A. E. (2020). Compound muscle action potential scan and MScanFit motor unit number estimation during Wallerian degeneration after nerve transections. Muscle and Nerve, 62(2), 239–246. https://doi.org/10.1002/mus.26923Kiernan, M. C., Burke, D., Andersen, K. V., & Bostock, H. (2000). Multiple measures of axonal excitability: A new approach in clinical testing. Muscle and Nerve, 23(3), 399–409. https://doi.org/10.1002/(SICI)1097-4598(200003)23:3<399::AID-MUS12>3.0.CO;2-GKristensen, A. G., Bostock, H., Finnerup, N. B., Andersen, H., Jensen, T. S., Gylfadottir, S., Itani, M., Krøigård, T., Sindrup, S., & Tankisi, H. (2019). Detection of early motor involvement in diabetic polyneuropathy using a novel MUNE method – MScanFit MUNE. Clinical Neurophysiology, 130(10), 1981–1987. https://doi.org/10.1016/j.clinph.2019.08.003Kristensen, A. G., Khan, K. S., Bostock, H., Khan, B. S., Gylfadottir, S., Andersen, H., Finnerup, N. B., Jensen, T. S., & Tankisi, H. (2020). MScanFit motor unit number estimation and muscle velocity recovery cycle recordings in diabetic polyneuropathy. Clinical Neurophysiology, 131(11), 2591–2599. https://doi.org/10.1016/j.clinph.2020.07.017Kristensen, R. S., Bostock, H., Tan, S. V., Witt, A., Fuglsang-Frederiksen, A., Qerama, E., Andersen, H., & Tankisi, H. (2019). MScanFit motor unit number estimation (MScan)and muscle velocity recovery cycle recordings in amyotrophic lateral sclerosis patients. Clinical Neurophysiology, 130(8), 1280–1288. https://doi.org/10.1016/j.clinph.2019.04.713Kuwabara, S., Sonoo, M., Komori, T., Shimizu, T., Hirashima, F., Inaba, A., Misawa, S., Hatanaka, Y., Kanai, K., Sawai, S., Isose, S., Hoshino, S., Kagamihara, Y., Kugio, Y., Awatsu, Y., Ichikawa, T., Yamada, H., Oishi, C., Ito, E., … Sawada, M. (2008). Dissociated small hand muscle atrophy in amyotrophic lateral sclerosis: Frequency, extent, and specificity. Muscle and Nerve, 37(4), 426–430. https://doi.org/10.1002/mus.20949Li, X., Zong, Y., Klein, C. S., & Zhou, P. (2018). Motor unit number estimation of human abductor hallucis from a compound muscle action potential scan. Muscle and Nerve, 58(5), 735. https://doi.org/10.1002/mus.26295Lomen-Hoerth, C., & Slawnych, M. P. (2003). Statistical motor unit number estimation: From theory to practice. Muscle and Nerve, 28(3), 263–272. https://doi.org/10.1002/mus.10351Maathuis, E. M., Drenthen, J., Van Doorn, P. A., Visser, G. H., & Blok, J. H. (2013). The CMAP scan as a tool to monitor disease progression in ALS and PMA. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 14(3), 217–223. https://doi.org/10.3109/21678421.2012.732079Maathuis, E. M., Drenthen, J., Visser, G. H., & Blok, J. H. (2011). Reproducibility of the CMAP scan. Journal of Electromyography and Kinesiology, 21(3), 433–437. https://doi.org/10.1016/j.jelekin.2010.11.007Maathuis, E. M., Henderson, R. D., Drenthen, J., Hutchinson, N. M., Daube, J. R., Blok, J. H., & Visser, G. H. (2012). Optimal stimulation settings for CMAP scan registrations. Journal of Brachial Plexus and Peripheral Nerve Injury, 7, 1–7. https://doi.org/10.1186/1749-7221-7-4McComas, A. J., Fawcett, P. R., Campbell, M. J., & Sica, R. E. (1971). Electrophysiological estimation of the number of motor units within a human muscle. Journal of Neurology, Neurosurgery, and Psychiatry, 34(2), 121–131. https://doi.org/10.1136/jnnp.34.2.121McNeil, C. J., Doherty, T. J., Stashuk, D. W., & Rice, C. L. (2005). Motor unit number estimates in the tibialis anterior muscle of young, old, and very old men. Muscle and Nerve, 31(4), 461–467. https://doi.org/10.1002/mus.20276Murtazina, A. F., Belyakova-Bodina, A. I., & Brutyan, A. G. (2018). Electrophysiological Techniques for Motor Unit Number Estimation. Human Physiology, 44(8), 827–837. https://doi.org/10.1134/S036211971808008XNandedkar, B. S. D., & Ph, D. (n.d.). NEURODIAGNOSTICS CMAP Scan : Recording & Analysis.Nandedkar, S. D., Barkhaus, P. E., & Stålberg, E. V. (2010). Motor unit number index (MUNIX): Principle, method, and findings in healthy subjects and in patients with motor neuron disease. Muscle and Nerve, 42(5), 798–807. https://doi.org/10.1002/mus.21824Nandedkar, S. D., Barkhaus, P. E., & Stålberg, E. V. (2011). Reproducibility of munix in patients with amyotrophic lateral sclerosis. Muscle and Nerve, 44(6), 919–922. https://doi.org/10.1002/mus.22204Nandedkar, S. D., Barkhaus, P. E., & Stålberg, E. V. (2022). Clinical Neurophysiology Analysis of the compound muscle action potential scan : Step index ( STEPIX ) and amplitude index ( AMPIX ). Clinical Neurophysiology, xxxx. https://doi.org/10.1016/j.clinph.2022.04.011Nandedkar, S. D., Nandedkar, D. S., Barkhaus, P. E., & Stalberg, E. V. (2004). Motor unit number index (MUNIX). IEEE Transactions on Biomedical Engineering, 51(12), 2209–2211. https://doi.org/10.1109/TBME.2004.834281Neuwirth, C., Braun, N., Claeys, K. G., Bucelli, R., Fournier, C., Bromberg, M., Petri, S., Goedee, S., Lenglet, T., Leppanen, R., Canosa, A., Goodman, I., Al-Lozi, M., Ohkubo, T., Hübers, A., Atassi, N., Abrahao, A., Funke, A., Appelfeller, M., … Weber, M. (2018). Implementing Motor Unit Number Index (MUNIX) in a large clinical trial: Real world experience from 27 centres. Clinical Neurophysiology, 129(8), 1756–1762. https://doi.org/10.1016/j.clinph.2018.04.614Neuwirth, C., Nandedkar, S., Stålberg, E., Barkhaus, P. E., Carvalho, M. de, Furtula, J., Dijk, J. P. va., Baldinger, R., Castro, J., Costa, J., Otto, M., Sandberg, A., & Weber, M. (2011). Motor Unit Number Index (MUNIX): A novel neurophysiological marker for neuromuscular disorders; test-retest reliability in healthy volunteers. Clinical Neurophysiology, 122(9), 1867–1872. https://doi.org/10.1016/j.clinph.2011.02.017Neuwirth, C., Nandedkar, S., Stålberg, E., & Weber, M. (2010). Motor Unit Number Index (MUNIX): A novel neurophysiological technique to follow disease progression in amyotrophic lateral sclerosis. Muscle and Nerve, 42(3), 379–384. https://doi.org/10.1002/mus.21707Okhovat, A. A., Advani, S., Moradi, K., Ziaadini, B., Panahi, A., Nafissi, S., Haghi Ashtiani, B., & Fatehi, F. (2021). Application of CMAP scan for the evaluation of patients with chronic inflammatory demyelinating polyneuropathy: a prospective study. Neurophysiologie Clinique, 51(2), 175–181. https://doi.org/10.1016/j.neucli.2020.12.005Pagnini, F., Rossi, G., Lunetta, C., Banfi, P., Castelnuovo, G., Corbo, M., & Molinari, E. (2010). Burden, depression, and anxiety in caregivers of people with amyotrophic lateral sclerosis. Psychology, Health and Medicine, 15(6), 685–693. https://doi.org/10.1080/13548506.2010.507773Quinn, C., & Elman, L. (2020). Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases. Continuum (Minneapolis, Minn.), 26(5), 1323–1347. https://doi.org/10.1212/CON.0000000000000911Ridall, P. G., Pettitt, A. N., Henderson, R. D., & McCombe, P. A. (2006). Motor unit number estimation - A Bayesian approach. Biometrics, 62(4), 1235–1250. https://doi.org/10.1111/j.1541-0420.2006.00577.xSchneider, C., Wassermann, M. K., Grether, N. B., Fink, G. R., Wunderlich, G., & Lehmann, H. C. (2021). Motor unit number estimation in adult patients with spinal muscular atrophy treated with nusinersen. European Journal of Neurology, 28(9), 3022–3029. https://doi.org/10.1111/ene.15005Sirin, N. G., Oguz Akarsu, E., Kocasoy Orhan, E., Erbas, B., Artug, T., Dede, H. O., Baslo, M. B., Idrisoglu, H. A., & Oge, A. E. (2019). Parameters derived from compound muscle action potential scan for discriminating amyotrophic lateral sclerosis-related denervation. Muscle and Nerve, 60(4), 400–408. https://doi.org/10.1002/mus.26644Sleutjes, B. T.H.M., Montfoort, I., Maathuis, E. M., Drenthen, J., van Doorn, P. A., Visser, G. H., & Blok, J. H. (2014). CMAP scan discontinuities: Automated detection and relation to motor unit loss. Clinical Neurophysiology, 125(2), 388–395. https://doi.org/10.1016/j.clinph.2013.07.016Sleutjes, Boudewijn T.H.M., Bystrup Jacobsen, A., Tankisi, H., Gorkem Sirin, N., Emre Oge, A., Henderson, R. D., van Doorn, P. A., van den Berg, L. H., & van Eijk, R. P. A. (2021). Advancing disease monitoring of amyotrophic lateral sclerosis with the compound muscle action potential scan. Clinical Neurophysiology, 132(12), 3152–3159. https://doi.org/10.1016/j.clinph.2021.09.014Sleutjes, Boudewijn T.H.M., Ruisch, J., Nassi, T. E., Buitenweg, J. R., van Schelven, L. J., van den Berg, L. H., Franssen, H., & Stephan Goedee, H. (2021). Impact of stimulus duration on motor unit thresholds and alternation in compound muscle action potential scans. Clinical Neurophysiology, 132(2), 323–331. https://doi.org/10.1016/j.clinph.2020.10.026Sleutjes, Boudewijn T.H.M., Wijngaarde, C. A., Wadman, R. I., Otto, L. A. M., Asselman, F. L., Cuppen, I., van den Berg, L. H., Ludo van der Pol, W., & Stephan Goedee, H. (2020). Assessment of motor unit loss in patients with spinal muscular atrophy. Clinical Neurophysiology, 131(6), 1280–1286. https://doi.org/10.1016/j.clinph.2020.01.018Sørensen, D. M., Bostock, H., Ballegaard, M., Fuglsang-Frederiksen, A., Graffe, C. C., Grötting, A., Jones, K., Kallio, M., Krarup, C., Krøigård, T., Lupescu, T., Maitland, S., Moldovan, M., Nilsen, K. B., Pugdahl, K., Santos, M. O., Themistocleous, A. C., Zlateva, S. S., Ööpik, M., & Tankisi, H. (2022). Assessing inter-rater reproducibility in MScanFit MUNE in a 6-subject, 12-rater “Round Robin” setup. Neurophysiologie Clinique, 52(2), 157–169. https://doi.org/10.1016/j.neucli.2021.11.002Stålberg, E., van Dijk, H., Falck, B., Kimura, J., Neuwirth, C., Pitt, M., Podnar, S., Rubin, D. I., Rutkove, S., Sanders, D. B., Sonoo, M., Tankisi, H., & Zwarts, M. (2019). Standards for quantification of EMG and neurography. In Clinical Neurophysiology (Vol. 130, Issue 9, pp. 1688–1729). Elsevier Ireland Ltd. https://doi.org/10.1016/j.clinph.2019.05.008Stikvoort García, D. J. L., Kovalchuk, M. O., Goedee, H. S., van Schelven, L. J., van den Berg, L. H., Franssen, H., & Sleutjes, B. T. H. M. (2022). Motor unit integrity in multifocal motor neuropathy: A systematic evaluation with CMAP scans. Muscle and Nerve, 65(3), 317–325. https://doi.org/10.1002/mus.27469Van Dijk, J. P., Schelhaas, H. J., Van Schaik, I. N., Janssen, H. M. H. A., Stegeman, D. F., & Zwarts, M. J. (2010). Monitoring disease progression using high-density motor unit number estimation in amyotrophic lateral sclerosis. Muscle and Nerve, 42(2), 239–244. https://doi.org/10.1002/mus.21680Visser, G. H., & Blok, J. H. (2009). Chapter 6 The CMAP scan. In Supplements to Clinical Neurophysiology (Vol. 60, Issue C, pp. 65–77). Elsevier. https://doi.org/10.1016/S1567-424X(08)00006-8Vucic, S., & Rutkove, S. B. (2018). Neurophysiological biomarkers in amyotrophic lateral sclerosis. In Current opinion in neurology (Vol. 31, Issue 5, pp. 640–647). NLM (Medline). https://doi.org/10.1097/WCO.0000000000000593Wilbourn, A. J. (2000). The “split hand syndrome” [1]. In Muscle and Nerve (Vol. 23, Issue 1, p. 138). John Wiley and Sons Inc. https://doi.org/10.1002/(SICI)1097-4598(200001)23:1<138::AID-MUS22>3.0.CO;2-7Witt, A., Fuglsang-Frederiksen, A., Finnerup, N. B., Kasch, H., & Tankisi, H. (2020). Detecting peripheral motor nervous system involvement in chronic spinal cord injury using two novel methods: MScanFit MUNE and muscle velocity recovery cycles. Clinical Neurophysiology, 131(10), 2383–2392. https://doi.org/10.1016/j.clinph.2020.06.032Zong, Y., Lu, Z., Chen, M., Deng, L., Xie, Q., & Zhou, P. (2022). Motor Unit Number Estimation of the Second Lumbrical Muscle in Human Hand. Frontiers in Physiology, 13(February), 1–5. https://doi.org/10.3389/fphys.2022.854385Zong, Y., Lu, Z., Chen, M., Li, X., Stampas, A., Deng, L., & Zhou, P. (2021). CMAP scan examination of the first dorsal interosseous muscle after spinal cord injury. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 29, 1199–1205. https://doi.org/10.1109/TNSRE.2021.3088061Zong, Y., Lu, Z., Chen, M., Xie, Q., & Zhou, P. (2022). MScanFit motor unit number estimation of human anconeus muscle. Muscle and Nerve, 65(4), 460–463. https://doi.org/10.1002/mus.27487Zong, Y., Lu, Z., Zhang, L., Li, X., & Zhou, P. (2020). Motor unit number of the first dorsal interosseous muscle estimated from CMAP scan with different pulse widths and steps. 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EVESURBIFBPUiBMQSBTRUNSRVRBUsONQSBHRU5FUkFMLiAqTEEgVEVTSVMgQSBQVUJMSUNBUiBERUJFIFNFUiBMQSBWRVJTScOTTiBGSU5BTCBBUFJPQkFEQS4gCgpBbCBoYWNlciBjbGljIGVuIGVsIHNpZ3VpZW50ZSBib3TDs24sIHVzdGVkIGluZGljYSBxdWUgZXN0w6EgZGUgYWN1ZXJkbyBjb24gZXN0b3MgdMOpcm1pbm9zLiBTaSB0aWVuZSBhbGd1bmEgZHVkYSBzb2JyZSBsYSBsaWNlbmNpYSwgcG9yIGZhdm9yLCBjb250YWN0ZSBjb24gZWwgYWRtaW5pc3RyYWRvciBkZWwgc2lzdGVtYS4KClVOSVZFUlNJREFEIE5BQ0lPTkFMIERFIENPTE9NQklBIC0gw5psdGltYSBtb2RpZmljYWNpw7NuIDE5LzEwLzIwMjEK 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