Efectos del fitocannabinoide cannabidiol sobre la excreción de sodio en ratas Wistar

ilustraciones, diagramas, fotografías

Autores:
Yepes Gómez, Heidy Viviana
Tipo de recurso:
Fecha de publicación:
2024
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/86056
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/86056
https://repositorio.unal.edu.co/
Palabra clave:
610 - Medicina y salud::615 - Farmacología y terapéutica
590 - Animales::599 - Mamíferos
Cannabidiol/metabolismo
Urinálisis/veterinaria
Reabsorción Renal/efectos de los fármacos
Cannabidiol/metabolism
Urinalysis/veterinary
Renal Reabsorption/drug effects
Reabsorción de sodio a nivel renal
Endocannabinoidoma
Filtración glomerular
Receptor CB1
CBD
Renal sodium reabsorption
Endocannabinoidome
Glomerular filtration
CB1 receptor
CBD
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openAccess
License
Reconocimiento 4.0 Internacional
id UNACIONAL2_ad8f5bcf28a5e0ec29c8d9ecc1417b9b
oai_identifier_str oai:repositorio.unal.edu.co:unal/86056
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Efectos del fitocannabinoide cannabidiol sobre la excreción de sodio en ratas Wistar
dc.title.translated.eng.fl_str_mv Effects of the phytocannabinoid cannabidiol on sodium excretion in Wistar rats
title Efectos del fitocannabinoide cannabidiol sobre la excreción de sodio en ratas Wistar
spellingShingle Efectos del fitocannabinoide cannabidiol sobre la excreción de sodio en ratas Wistar
610 - Medicina y salud::615 - Farmacología y terapéutica
590 - Animales::599 - Mamíferos
Cannabidiol/metabolismo
Urinálisis/veterinaria
Reabsorción Renal/efectos de los fármacos
Cannabidiol/metabolism
Urinalysis/veterinary
Renal Reabsorption/drug effects
Reabsorción de sodio a nivel renal
Endocannabinoidoma
Filtración glomerular
Receptor CB1
CBD
Renal sodium reabsorption
Endocannabinoidome
Glomerular filtration
CB1 receptor
CBD
title_short Efectos del fitocannabinoide cannabidiol sobre la excreción de sodio en ratas Wistar
title_full Efectos del fitocannabinoide cannabidiol sobre la excreción de sodio en ratas Wistar
title_fullStr Efectos del fitocannabinoide cannabidiol sobre la excreción de sodio en ratas Wistar
title_full_unstemmed Efectos del fitocannabinoide cannabidiol sobre la excreción de sodio en ratas Wistar
title_sort Efectos del fitocannabinoide cannabidiol sobre la excreción de sodio en ratas Wistar
dc.creator.fl_str_mv Yepes Gómez, Heidy Viviana
dc.contributor.advisor.spa.fl_str_mv Dueñas Gomez, Zulma Janeth
Betancurt Rendón, Jhon
dc.contributor.author.spa.fl_str_mv Yepes Gómez, Heidy Viviana
dc.contributor.researchgroup.spa.fl_str_mv Neurobiología y Comportamiento
dc.subject.ddc.spa.fl_str_mv 610 - Medicina y salud::615 - Farmacología y terapéutica
590 - Animales::599 - Mamíferos
topic 610 - Medicina y salud::615 - Farmacología y terapéutica
590 - Animales::599 - Mamíferos
Cannabidiol/metabolismo
Urinálisis/veterinaria
Reabsorción Renal/efectos de los fármacos
Cannabidiol/metabolism
Urinalysis/veterinary
Renal Reabsorption/drug effects
Reabsorción de sodio a nivel renal
Endocannabinoidoma
Filtración glomerular
Receptor CB1
CBD
Renal sodium reabsorption
Endocannabinoidome
Glomerular filtration
CB1 receptor
CBD
dc.subject.decs.spa.fl_str_mv Cannabidiol/metabolismo
Urinálisis/veterinaria
Reabsorción Renal/efectos de los fármacos
dc.subject.decs.eng.fl_str_mv Cannabidiol/metabolism
Urinalysis/veterinary
Renal Reabsorption/drug effects
dc.subject.proposal.spa.fl_str_mv Reabsorción de sodio a nivel renal
Endocannabinoidoma
Filtración glomerular
Receptor CB1
CBD
dc.subject.proposal.eng.fl_str_mv Renal sodium reabsorption
Endocannabinoidome
Glomerular filtration
CB1 receptor
CBD
description ilustraciones, diagramas, fotografías
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-05-08T20:44:26Z
dc.date.available.none.fl_str_mv 2024-05-08T20:44:26Z
dc.date.issued.none.fl_str_mv 2024-05
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/86056
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/86056
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.indexed.spa.fl_str_mv Bireme
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spelling Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Dueñas Gomez, Zulma Janethddf6ccc29fb0eb2a962c31ef7d7bb79d600Betancurt Rendón, Jhon48812f0d18f6468dbb2412e88bcd7daeYepes Gómez, Heidy Viviana870e45a2c3069c0e7e3a83de34ede655Neurobiología y Comportamiento2024-05-08T20:44:26Z2024-05-08T20:44:26Z2024-05https://repositorio.unal.edu.co/handle/unal/86056Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramas, fotografíasLa excreción de sodio a nivel renal en modelo murino, inducida por el CBD, está mediada por la unión del ligando en este caso el fitocannabinoide con los receptores para cannabis. Esta interacción modula el Endocannabinoidoma a nivel renal, específicamente en la reabsorción de sodio, modificando en cierta medida la tasa de filtración glomerular. En referencia a lo previamente explicado, este trabajo tuvo como objetivo identificar los efectos del fitocannabinoide cannabidiol a diferentes dosis, sobre la reabsorción de sodio a nivel renal. Metodología: Se están utilizaron 30 ratas macho Wistar, adultas (3 meses de edad), distribuidos en 4 grupos, grupo control, grupo vehículo, grupo al os que se les aplicó vía intraperitoneal CBD disuelto en acetite de oliva extra virgen a diferentes dosis (15, 30 y 50 mg/Kg) 48 horas previo a la toma de la muestra. El método utilizado para tomar la orina fue recolección directa puntual, que consiste en realizar un estímulo táctil sobre la espalda del animal, colocando un vaso precipitado de 5ml cerca de la zona perineal. Las muestras se almacenaron a -20°C, hasta su análisis por espectrometría de masas y análisis estadístico (ANOVA unifactorial; software spss, p=0.05). Resultados: los datos obtenidos indican que al aumentar la dosis de cannabidiol, 48 horas después de su aplicación, se evidencia un incremento de la excreción de sodio, Probablemente por una disminución de la actividad de la bomba Na+/K+ATPasa a nivel del túbulo proximal. Conclusión: Estos resultados apoyan la hipótesis que sugiere que el CBD es un antagonista de los receptores CB1 y agonista de los receptores TRPV1 a nivel renal, aumentando la excreción de sodio a nivel renal. (Texto tomado de la fuente).The excretion of sodium at the renal level in the murine model, induced by CBD, is mediated by binding of the ligand in this case the phytocannabinoid to the receptors for cannabis. This interaction modulates the Endocannabinoidome at the renal level, specifically in sodium reabsorption, modifying to some extent the glomerular filtration rate. In reference to the previously explained, this study aimed to identify the effects of the phytocannabinoid cannabidiol at different doses, on sodium reabsorption at the renal level. Methodology: Thirty adult male Wistar rats (3 months of age) were used, distributed in 4 groups, control group, vehicle group, to which were administered intraperitoneally CBD dissolved in extra virgin olive oil at different doses (15, 30 and 50 mg/Kg) 48 hours prior to sampling. The method used to collect urine was direct collection, which consists of performing a tactile stimulus on the back of the animal, placing a 5ml precipitated vessel near the perineal area. Samples were stored at -20°C until analysis by mass spectrometry and statistical analysis (single-factorial ANOVA; spss software, p=0. 05). Results: the data obtained indicate that when increasing the dose of cannabidiol, 48 hours after its application, there is evidence of an increase in sodium excretion, probably due to a decrease in the activity of the Na+/K+ATPase pump at the level of the proximal tubule. Conclusion: These results support the hypothesis that CBD is an antagonist of CB1 receptors and agonist of TRPV1 receptors at the renal level, increasing sodium excretion at the renal level.MaestríaMagíster en FisiologíaPara llevar a cabo este trabajo, se realizó un estudio de tipo experimental completo, donde se utilizaron ratas Wistar a las que se les aplicó el fitocannabinoide cannabidiol (CBD) full espectrum (donado por la empresa ICAN de la Ciudad de México) a dosis de15- 50mg/Kg ; estas dosis se estandarizaron de esta manera de acuerdo con la metodología utilizada en el estudio de Hložek y colaboradores en el 2017 donde evaluaron el perfil farmacocinético de diferentes fitocannabinoides entre ellos el CBD administrados por vía subcutánea en ratas Wistar con el objetivo de determinar cambios comportamentales . Posteriormente, se midieron los niveles de excreción de sodio en orina, obteniendo esta, mediante el método de recolección directa puntual en vaso precipitado , 40 horas post administración del CBD. El estudio que se llevó a cabo es un estudio experimental con casos y controles.Modelos animales; estrés y comportamiento; vínculo materno; neurobiología del estrésXIII, 74 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Maestría en FisiologíaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::615 - Farmacología y terapéutica590 - Animales::599 - MamíferosCannabidiol/metabolismoUrinálisis/veterinariaReabsorción Renal/efectos de los fármacosCannabidiol/metabolismUrinalysis/veterinaryRenal Reabsorption/drug effectsReabsorción de sodio a nivel renalEndocannabinoidomaFiltración glomerularReceptor CB1CBDRenal sodium reabsorptionEndocannabinoidomeGlomerular filtrationCB1 receptorCBDEfectos del fitocannabinoide cannabidiol sobre la excreción de sodio en ratas WistarEffects of the phytocannabinoid cannabidiol on sodium excretion in Wistar ratsTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBiremeFrancisca Medina Pontigo D, Daya Dra Sylvia Arrau Barra F, Marczuk Dyurich Flor Ortiz Rios Mish Castillo Vázquez M, Santisteban-Arenas RR, Andrés Cifuentes Sanabria Sara Lorena Rojas Jeidy Yuranny Valcárcel Peña C, EDITORIAL MVZ Cert Luis Fernando Martínez Cornejo D, et al. 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EXCRECIÓN DE SODIO EN RATAS WISTAR FINAL.pdf.jpgEFECTOS DEL FITOCANNABNOIDE CANNABIDIOL SOBRE LA EXCRECIÓN DE SODIO EN RATAS WISTAR FINAL.pdf.jpgGenerated Thumbnailimage/jpeg4467https://repositorio.unal.edu.co/bitstream/unal/86056/3/EFECTOS%20DEL%20FITOCANNABNOIDE%20CANNABIDIOL%20SOBRE%20LA%20EXCRECI%c3%93N%20DE%20SODIO%20EN%20RATAS%20WISTAR%20FINAL.pdf.jpg3ce1e8edd30296650d6c6bd70a6f84fcMD53unal/86056oai:repositorio.unal.edu.co:unal/860562024-08-24 23:13:53.572Repositorio Institucional Universidad Nacional de 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