Efecto del reemplazo de antibióticos promotores de crecimiento por una butirina esterificada en dietas de preiniciación en el rendimiento productivo y algunos parámetros de salud intestinal de lechones destetados a 21 días
ilustraciones a color, diagramas
- Autores:
-
González Castiblanco, Johana Katerine
- Tipo de recurso:
- Fecha de publicación:
- 2023
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/85679
- Palabra clave:
- 630 - Agricultura y tecnologías relacionadas::636 - Producción animal
610 - Medicina y salud::615 - Farmacología y terapéutica
Sulfato de Butirosina
Antibacterianos
Biomarcadores farmacológicos
Butirosin Sulfate
Anti-Bacterial agents
Biomarkers, pharmacological
Producción animal
Lechones lactantes - Salud
Etapas del desarrollo animal
Animal husbandry
Baby pigs - Health
Animal developmental stages
Antibióticos promotores de crecimiento
Butirinas
Biomarcadores
Citoquinas
Escherichia coli
Vellosidad
Lechones destetos
Growth promoting antibiotics
Tributyrin
Biomarkers
Cytokines
Escherichia coli
Villus
Weaned pigs
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Efecto del reemplazo de antibióticos promotores de crecimiento por una butirina esterificada en dietas de preiniciación en el rendimiento productivo y algunos parámetros de salud intestinal de lechones destetados a 21 días |
| dc.title.translated.eng.fl_str_mv |
Effect of replacing antibiotic growth promoters with tributyrin in pre-starter diets on growth performance and some intestinal health parameters of weaned piglets |
| title |
Efecto del reemplazo de antibióticos promotores de crecimiento por una butirina esterificada en dietas de preiniciación en el rendimiento productivo y algunos parámetros de salud intestinal de lechones destetados a 21 días |
| spellingShingle |
Efecto del reemplazo de antibióticos promotores de crecimiento por una butirina esterificada en dietas de preiniciación en el rendimiento productivo y algunos parámetros de salud intestinal de lechones destetados a 21 días 630 - Agricultura y tecnologías relacionadas::636 - Producción animal 610 - Medicina y salud::615 - Farmacología y terapéutica Sulfato de Butirosina Antibacterianos Biomarcadores farmacológicos Butirosin Sulfate Anti-Bacterial agents Biomarkers, pharmacological Producción animal Lechones lactantes - Salud Etapas del desarrollo animal Animal husbandry Baby pigs - Health Animal developmental stages Antibióticos promotores de crecimiento Butirinas Biomarcadores Citoquinas Escherichia coli Vellosidad Lechones destetos Growth promoting antibiotics Tributyrin Biomarkers Cytokines Escherichia coli Villus Weaned pigs |
| title_short |
Efecto del reemplazo de antibióticos promotores de crecimiento por una butirina esterificada en dietas de preiniciación en el rendimiento productivo y algunos parámetros de salud intestinal de lechones destetados a 21 días |
| title_full |
Efecto del reemplazo de antibióticos promotores de crecimiento por una butirina esterificada en dietas de preiniciación en el rendimiento productivo y algunos parámetros de salud intestinal de lechones destetados a 21 días |
| title_fullStr |
Efecto del reemplazo de antibióticos promotores de crecimiento por una butirina esterificada en dietas de preiniciación en el rendimiento productivo y algunos parámetros de salud intestinal de lechones destetados a 21 días |
| title_full_unstemmed |
Efecto del reemplazo de antibióticos promotores de crecimiento por una butirina esterificada en dietas de preiniciación en el rendimiento productivo y algunos parámetros de salud intestinal de lechones destetados a 21 días |
| title_sort |
Efecto del reemplazo de antibióticos promotores de crecimiento por una butirina esterificada en dietas de preiniciación en el rendimiento productivo y algunos parámetros de salud intestinal de lechones destetados a 21 días |
| dc.creator.fl_str_mv |
González Castiblanco, Johana Katerine |
| dc.contributor.advisor.spa.fl_str_mv |
Casas Bedoya, Gloria Amparo Galvis Mogollón, José Darío |
| dc.contributor.author.spa.fl_str_mv |
González Castiblanco, Johana Katerine |
| dc.subject.ddc.spa.fl_str_mv |
630 - Agricultura y tecnologías relacionadas::636 - Producción animal 610 - Medicina y salud::615 - Farmacología y terapéutica |
| topic |
630 - Agricultura y tecnologías relacionadas::636 - Producción animal 610 - Medicina y salud::615 - Farmacología y terapéutica Sulfato de Butirosina Antibacterianos Biomarcadores farmacológicos Butirosin Sulfate Anti-Bacterial agents Biomarkers, pharmacological Producción animal Lechones lactantes - Salud Etapas del desarrollo animal Animal husbandry Baby pigs - Health Animal developmental stages Antibióticos promotores de crecimiento Butirinas Biomarcadores Citoquinas Escherichia coli Vellosidad Lechones destetos Growth promoting antibiotics Tributyrin Biomarkers Cytokines Escherichia coli Villus Weaned pigs |
| dc.subject.decs.spa.fl_str_mv |
Sulfato de Butirosina Antibacterianos Biomarcadores farmacológicos |
| dc.subject.decs.eng.fl_str_mv |
Butirosin Sulfate Anti-Bacterial agents Biomarkers, pharmacological |
| dc.subject.lemb.spa.fl_str_mv |
Producción animal Lechones lactantes - Salud Etapas del desarrollo animal |
| dc.subject.lemb.eng.fl_str_mv |
Animal husbandry Baby pigs - Health Animal developmental stages |
| dc.subject.proposal.spa.fl_str_mv |
Antibióticos promotores de crecimiento Butirinas Biomarcadores Citoquinas Escherichia coli Vellosidad Lechones destetos |
| dc.subject.proposal.eng.fl_str_mv |
Growth promoting antibiotics Tributyrin Biomarkers Cytokines Escherichia coli Villus Weaned pigs |
| description |
ilustraciones a color, diagramas |
| publishDate |
2023 |
| dc.date.issued.none.fl_str_mv |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2024-02-09T20:10:44Z |
| dc.date.available.none.fl_str_mv |
2024-02-09T20:10:44Z |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Maestría |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/masterThesis |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
| dc.type.content.spa.fl_str_mv |
Text |
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http://purl.org/redcol/resource_type/TM |
| status_str |
acceptedVersion |
| dc.identifier.uri.none.fl_str_mv |
https://repositorio.unal.edu.co/handle/unal/85679 |
| dc.identifier.instname.spa.fl_str_mv |
Universidad Nacional de Colombia |
| dc.identifier.reponame.spa.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
| dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.unal.edu.co/ |
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https://repositorio.unal.edu.co/handle/unal/85679 https://repositorio.unal.edu.co/ |
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Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
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spa |
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Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Casas Bedoya, Gloria Amparo5c6fb123ce812075a2f0188b0d32173aGalvis Mogollón, José Darío307d8d1ce83ef8e9016c40d366dfd301González Castiblanco, Johana Katerineeec05e6cb9f62ff532f016e27163de6b2024-02-09T20:10:44Z2024-02-09T20:10:44Z2023https://repositorio.unal.edu.co/handle/unal/85679Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones a color, diagramasLos antibióticos promotores de crecimiento (APC) han sido usados por años para mejorar los parámetros productivos y la salud intestinal en los animales, sin embargo, su uso desmedido ha contribuido al aumento de la resistencia antimicrobiana tanto en animales como en humanos, siendo un problema relevante de salud pública. En consecuencia, se ha impulsado tendencia de buscar nuevas alternativas como las tributirinas o butirinas esterificadas que alcanzan a tener un mayor efecto en la parte distal del intestino, mejorando los parámetros productivos y la salud intestinal de lechones destetos. El objetivo del proyecto fue evaluar el efecto de la inclusión de una butirina esterificada como alternativa a los antibióticos promotores de crecimiento en lechones destetos, en algunos parámetros productivos y de salud intestinal. En este estudio se seleccionaron 96 lechones de 21 días de edad y fueron asignados a tres tratamientos: un control negativo (CN) sin APC, ácidos orgánicos u óxido de zinc, un control positivo (CP), en el que se incluyó un antibiótico promotor de crecimiento (avilamicina 0,3kg/Ton) y el tratamiento de evaluación que consistió en adicionar una butirina esterificada (2kg/Ton) (CN+B), al control negativo. Los lechones fueron alimentados por 14 días. No se observaron diferencias estadísticamente significativas entre los tratamientos en los parámetros productivos. Sin embargo, el score de consistencia de las heces en los lechones tratados con butirinas esterificadas fue menor que en CP o el CN (p<0.05). El uso de butirinas esterificadas incrementó (p<0.05) la altura de la vellosidad en yeyuno e íleon, así como la relación altura de la vellosidad: profundidad de la cripta en íleon. Así mismo, la expresión de TNF-α en yeyuno fue mayor, mientras que la expresión de IL-6 disminuyó en íleon (p<0.05) en lechones alimentados con dietas suplementadas con butirinas. Se concluyó que las butirinas esterificadas pueden mejorar la función intestinal por su efecto en la morfología intestinal y la consistencia fecal. (Texto tomado de la fuente)Antibiotic growth promoters have been used for years to improve growth performance and gut health, however, their excessive use has contributed to the increase in antimicrobial resistance in animals and humans, being a problem relevant to health. Consequently, there has been a tendency to look for new alternatives such as tributyrin or esterified butyrin that have a greater effect on the distal part of the intestine, improving the growth performance and gut health of weaned piglets. The objective of the project was to evaluate the effect of the inclusion of esterified butyrate as an alternative to antibiotic growth promoters in weaned piglets on some growth performance and gut health parameters. In this study, 96 piglets of 21 days of age were selected and allowed three treatments: a negative control (NC) without APC, organic acid, or zinc oxide, a positive control (PC), in which an antibiotic growth promoter was included (avilamycin 0.3kg/Ton), and the evaluation treatment which consisted of adding an esterified butyrate (2kg/Ton) (NC+B), to the negative control. The piglets were fed for 14 days. No statistically significant differences were observed between treatments in growth performance. However, the fecal consistency score in piglets treated with esterified butyrates was lower than in PC or NC (p<0.05). The use of esterified butyrines increased (p<0.05) the height of the villus in the jejunum and ileum, as well as the ratio of villus height: to crypt depth of the ileum. Likewise, the expression of TNF-α in the jejunum was higher, while the expression of IL-6 decreased in the ileum. Overall, esterified butyrates can improve intestinal function due to their effect on intestinal morphology and fecal consistency.MaestríaMagíster en Salud Animal o Magíster en Producción AnimalNutrición Animal106 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina Veterinaria y de Zootecnia - Maestría en Salud y Producción AnimalFacultad de Medicina Veterinaria y de ZootecniaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá630 - Agricultura y tecnologías relacionadas::636 - Producción animal610 - Medicina y salud::615 - Farmacología y terapéuticaSulfato de ButirosinaAntibacterianosBiomarcadores farmacológicosButirosin SulfateAnti-Bacterial agentsBiomarkers, pharmacologicalProducción animalLechones lactantes - SaludEtapas del desarrollo animalAnimal husbandryBaby pigs - HealthAnimal developmental stagesAntibióticos promotores de crecimientoButirinasBiomarcadoresCitoquinasEscherichia coliVellosidadLechones destetosGrowth promoting antibioticsTributyrinBiomarkersCytokinesEscherichia coliVillusWeaned pigsEfecto del reemplazo de antibióticos promotores de crecimiento por una butirina esterificada en dietas de preiniciación en el rendimiento productivo y algunos parámetros de salud intestinal de lechones destetados a 21 díasEffect of replacing antibiotic growth promoters with tributyrin in pre-starter diets on growth performance and some intestinal health parameters of weaned pigletsTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMAarestrup, F. 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Frontiers in Microbiology, 10(JAN), 1–18. https://doi.org/10.3389/fmicb.2018.03335Efecto del reemplazo de antibióticos promotores de crecimiento por una butirina esterificada en dietas de preiniciación en el rendimiento productivo y algunos parámetros de salud intestinal de lechones destetados a 21 díasEstudiantesInvestigadoresLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/85679/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1020783128.2023.pdf1020783128.2023.pdfTesis de Maestría en Salud y Producción Animalapplication/pdf2150246https://repositorio.unal.edu.co/bitstream/unal/85679/2/1020783128.2023.pdff5b147118b9b0b6a0dff9bf20a8b7705MD52THUMBNAIL1020783128.2023.pdf.jpg1020783128.2023.pdf.jpgGenerated Thumbnailimage/jpeg5452https://repositorio.unal.edu.co/bitstream/unal/85679/3/1020783128.2023.pdf.jpg8e5b513624c9c917a60200bfb7a2329cMD53unal/85679oai:repositorio.unal.edu.co:unal/856792024-02-09 23:07:10.09Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.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