Identificación de microorganismos intrabdominales asociados a colección intrabdominal postoperatoria en niños con apendicitis perforada
ilustraciones, gráficas, tablas
- Autores:
-
Garzón González, Luz Nélida Marina
- Tipo de recurso:
- Fecha de publicación:
- 2022
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/81097
- Palabra clave:
- 610 - Medicina y salud::617 - Cirugía, medicina regional, odontología, oftalmología, otología, audiología
Appendicitis/parasitology
Cecal Diseases
Intraabdominal Infections
Apendicitis/parasitología
Enfermedades del Ciego
Infecciones Intraabdominales
Apendicitis
Resistencia bacteriana
Alto riesgo
Absceso intraabdominal
Appendicitis
Bacterial resistance
High-risk patients
Intra-abdominal abscess
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Identificación de microorganismos intrabdominales asociados a colección intrabdominal postoperatoria en niños con apendicitis perforada |
| dc.title.translated.eng.fl_str_mv |
Identification of intra-abdominal bacteria and association with intra-abdominal abscess in pediatric patients with perforated appendicitis |
| title |
Identificación de microorganismos intrabdominales asociados a colección intrabdominal postoperatoria en niños con apendicitis perforada |
| spellingShingle |
Identificación de microorganismos intrabdominales asociados a colección intrabdominal postoperatoria en niños con apendicitis perforada 610 - Medicina y salud::617 - Cirugía, medicina regional, odontología, oftalmología, otología, audiología Appendicitis/parasitology Cecal Diseases Intraabdominal Infections Apendicitis/parasitología Enfermedades del Ciego Infecciones Intraabdominales Apendicitis Resistencia bacteriana Alto riesgo Absceso intraabdominal Appendicitis Bacterial resistance High-risk patients Intra-abdominal abscess |
| title_short |
Identificación de microorganismos intrabdominales asociados a colección intrabdominal postoperatoria en niños con apendicitis perforada |
| title_full |
Identificación de microorganismos intrabdominales asociados a colección intrabdominal postoperatoria en niños con apendicitis perforada |
| title_fullStr |
Identificación de microorganismos intrabdominales asociados a colección intrabdominal postoperatoria en niños con apendicitis perforada |
| title_full_unstemmed |
Identificación de microorganismos intrabdominales asociados a colección intrabdominal postoperatoria en niños con apendicitis perforada |
| title_sort |
Identificación de microorganismos intrabdominales asociados a colección intrabdominal postoperatoria en niños con apendicitis perforada |
| dc.creator.fl_str_mv |
Garzón González, Luz Nélida Marina |
| dc.contributor.advisor.spa.fl_str_mv |
Valero Halaby, Juan Javier |
| dc.contributor.author.spa.fl_str_mv |
Garzón González, Luz Nélida Marina |
| dc.contributor.financer.spa.fl_str_mv |
HOMI - Fundación Hospital Pediátrico La Misericordia |
| dc.contributor.researchgroup.spa.fl_str_mv |
Unidad de Cirugía Pediátrica de la Universidad Nacional de Colombia |
| dc.subject.ddc.spa.fl_str_mv |
610 - Medicina y salud::617 - Cirugía, medicina regional, odontología, oftalmología, otología, audiología |
| topic |
610 - Medicina y salud::617 - Cirugía, medicina regional, odontología, oftalmología, otología, audiología Appendicitis/parasitology Cecal Diseases Intraabdominal Infections Apendicitis/parasitología Enfermedades del Ciego Infecciones Intraabdominales Apendicitis Resistencia bacteriana Alto riesgo Absceso intraabdominal Appendicitis Bacterial resistance High-risk patients Intra-abdominal abscess |
| dc.subject.decs.eng.fl_str_mv |
Appendicitis/parasitology Cecal Diseases Intraabdominal Infections |
| dc.subject.decs.spa.fl_str_mv |
Apendicitis/parasitología Enfermedades del Ciego Infecciones Intraabdominales |
| dc.subject.proposal.spa.fl_str_mv |
Apendicitis Resistencia bacteriana Alto riesgo Absceso intraabdominal |
| dc.subject.proposal.eng.fl_str_mv |
Appendicitis Bacterial resistance High-risk patients Intra-abdominal abscess |
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ilustraciones, gráficas, tablas |
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2022 |
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2022-03-01T17:06:00Z |
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2022-03-01T17:06:00Z |
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2022-02-17 |
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Trabajo de grado - Especialidad Médica |
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info:eu-repo/semantics/masterThesis |
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Text |
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http://purl.org/redcol/resource_type/TM |
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Universidad Nacional de Colombia |
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Repositorio Institucional Universidad Nacional de Colombia |
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Di Saverio, S. et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J. Emerg. Surg. 15, 1–42 (2020). Rentea, R. M., Peter, S. D. S. & Snyder, C. L. Pediatric appendicitis_ state of the art review. Pediatric Surgery International vol. 33 269–283 (2017). Peter, S. D. S. et al. An evidence-based definition for perforated appendicitis derived from a prospective randomized trial. J. Pediatr. Surg. 43, 2242–2245 (2008). Castañeda-Espinosa, S. D. et al. Cambio en la clasificación macroscópica de la apendicitis. ¿Tiene algún impacto? Estudio retrospectivo en un Hospital Universitario Pediátrico. Rev. la Fac. Med. 63, 243–250 (2015). Vallejo, M. et al. Características clínicas y microbiológicas de la infección intra-abdominal complicada en Colombia: un estudio multicéntrico. Rev. Chil. infectología 33, 261–267 (2016). Lob, S. H., Badal, R. E., Hackel, M. A. & Sahm, D. F. Epidemiology and antimicrobial susceptibility of gram-negative pathogens causing intra-abdominal infections in pediatric patients in Europe—SMART 2011–2014. J. Pediatric Infect. Dis. Soc. 6, 72–79 (2017). Somers, K. K., Eastwood, D., Liu, Y. & Arca, M. J. Splitting hairs and challenging guidelines: Defining the role of perioperative antibiotics in pediatric appendicitis patients. J. Pediatr. Surg. 55, 406–413 (2020). Pennell, C. et al. A Standardized Protocol for the Management of Appendicitis in Children Reduces Resource Utilization. Pediatr. Qual. Saf. 5, e357 (2020). Bansal, S., Banever, G. T., Karrer, F. M. & Partrick, D. A. Appendicitis in children less than 5 years old: influence of age on presentation and outcome. Am. J. Surg. 204, 1031–1035 (2012). Witt, C. E., Goldin, A. B., Vavilala, M. S. & Rivara, F. P. Effect of body mass index percentile on pediatric gastrointestinal surgery outcomes. J. Pediatr. Surg. 51, 1473–1479 (2016). Kasatpibal, N. et al. Risk of surgical site infection and efficacy of antibiotic prophylaxis: a cohort study of appendectomy patients in Thailand. BMC Infect. Dis. 6, 1–7 (2006). Levin, D. E. & Pegoli, W. Abscess After Appendectomy: Predisposing Factors. Adv. Surg. 49, 263–280 (2015). Gómez, D. R., Alberto, J., Buriticá, A. & Clemencia, O. Riesgo anestésico y tipo de herida asociados a infección intrahospitalaria en pacientes quirúrgicos. Modelo logístic. Rev. Colomb. Anestesiol. 30, 17–21 (2002). Holguín-Sanabria, D. A. et al. Prevalence of organ-space surgical site infections after appendectomy for ruptured appendix in children. Rev. la Fac. Med. 67, 639–643 (2019). Glass, C. C. & Rangel, S. J. Overview and diagnosis of acute appendicitis in children. Semin. Pediatr. Surg. 25, 198–203 (2016). Rentea, R. M. & St. Peter, S. D. Pediatric Appendicitis. Surg. Clin. North Am. 97, 93–112 (2017). Samuel, M. Pediatric appendicitis score. J. Pediatr. Surg. 37, 877–881 (2002). Rentea, R. M., Peter, S. D. S. S. & Snyder, C. L. Pediatric appendicitis: state of the art review. Pediatr. Surg. Int. 33, 269–283 (2017). Caruso, A. M. et al. Acute appendicitis in children: not only surgical treatment. J. Pediatr. Surg. 52, 444–448 (2017). Mazuski, J. E. et al. The surgical infection society revised guidelines on the management of intra-abdominal infection. Surg. Infect. (Larchmt). 18, 1–76 (2017). Association, W. M. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 310, 2191–2194 (2013). Lee, Y. R., McMahan, D., McCall, C. & Perry, G. K. Complicated intra-abdominal infections: the old antimicrobials and the new players. Drugs 75, 2097–2117 (2015). Solomkin, J. S. et al. Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Complicated Intra-abdominal Infection Guidelines • CID vol. 2010 133–64 (2010). Blot, S., De Waele, J. J. & Vogelaers, D. Essentials for selecting antimicrobial therapy for intra-abdominal infections. Drugs 72, e17–e32 (2012). Jiménez, A., Sánchez, A., Rey, A. & Fajardo, C. Recuperación de bacterias aerobias y anaerobias de pacientes con apendicitis aguda mediante botellas de hemocultivo. Biomedica 39, 699–706 (2019). Miller, J. M. et al. A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2018 update by the Infectious Diseases Society of America and the American Society for Microbiology. Clin. Infect. Dis. 67, e1–e94 (2018). Weiss, S. L. et al. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Medicine vol. 46 (2020). Arguedas, A. et al. An open, multicenter clinical trial of piperacillin/tazobactam in the treatment of pediatric patients with intra-abdominal infections. J. Chemother. 8, 130–136 (1996). Hamdy, R. F. et al. Comparative effectiveness of ceftriaxone plus metronidazole versus anti-pseudomonal antibiotics for perforated appendicitis in children. Surg. Infect. (Larchmt). 20, 399–405 (2019). Roque, F. M. C. B. et al. Antibiotics for appendicectomy in children and adolescents during the perioperative period: an integrative review. Rev. Paul. Pediatr. 37, 494–502 (2019). Catena, F. et al. TEA Study: three-day ertapenem versus three-day Ampicillin-Sulbactam. BMC Gastroenterol. 13, 1–6 (2013). Hassinger, T. E. et al. Longer-duration antimicrobial therapy does not prevent treatment failure in high-risk patients with complicated intra-abdominal infections. Surg. Infect. (Larchmt). 18, 659–663 (2017). Fernández Ibieta, M. et al. Estudio de la flora patógena y resistencias en apendicitis pediátricas. Cir Pediatr 27, 16–20 (2014). Coccolini, F. et al. Antibiotic resistance evaluation and clinical analysis of acute appendicitis; report of 1431 consecutive worldwide patients: A cohort study. Int. J. Surg. 26, 6–11 (2016). Schmitt, F. et al. Bacterial studies of complicated appendicitis over a 20-year period and their impact on empirical antibiotic treatment. J. Pediatr. Surg. 47, 2055–2062 (2012). Tartar, T. et al. Does microbial resistance profile change in community-based intra-abdominal infections? Evaluation of the culture results of patients with appendicitis. Turk. J. Pediatr. 60, 520–526 (2018). Kwok, C. P. D., Tsui, S. Y. B. & Chan, K. W. E. Updates on bacterial resistance and empirical antibiotics treatment of complicated acute appendicitis in children. J. Pediatr. Surg. (2021) doi:10.1016/j.jpedsurg.2021.03.027. Obinwa, O., Casidy, M. & Flynn, J. The microbiology of bacterial peritonitis due to appendicitis in children. Ir. J. Med. Sci. 183, 585–591 (2014). Andrey, V., Crisinel, P.-A. A., Prod’hom, G., Croxatto, A. & Joseph, J.-M. M. Impact of co-amoxicillin-resistant Escherichia coli and Pseudomonas aeruginosa on the rate of infectious complications in paediatric complicated appendicitis. Swiss Med. Wkly. 149, w20055 (2019). Sun, L., Liu, S., Wang, J. & Wang, L. Analysis of Risk Factors for Multiantibiotic-Resistant Infections Among Surgical Patients at a Children’s Hospital. Microb. Drug Resist. 25, 297–303 (2019). Chan, K. W. E. et al. Evidence-based adjustment of antibiotic in pediatric complicated appendicitis in the era of antibiotic resistance. Pediatr. Surg. Int. 26, 157–160 (2010). Sartelli, M. et al. Complicated intra-abdominal infections worldwide : the definitive data of the CIAOW Study. 1–10 (2014). Abdulhamid, A. K. & Sarker, S.-J. J. Is abdominal drainage after open emergency appendectomy for complicated appendicitis beneficial or waste of money? A single centre retrospective cohort study. Ann. Med. Surg. 36, 168–172 (2018). |
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Universidad Nacional de Colombia |
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Bogotá - Medicina - Especialidad en Cirugía Pediátrica |
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Departamento de Cirugía |
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Facultad de Medicina |
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Bogotá, Colombia |
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Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Valero Halaby, Juan Javiera9f60a6385dd1dc3c32b29794a0df44c600Garzón González, Luz Nélida Marina0b55217c2c0d53b6cdfb95add762c72dHOMI - Fundación Hospital Pediátrico La MisericordiaUnidad de Cirugía Pediátrica de la Universidad Nacional de Colombia2022-03-01T17:06:00Z2022-03-01T17:06:00Z2022-02-17https://repositorio.unal.edu.co/handle/unal/81097Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, gráficas, tablasIntroducción La apendicitis aguda es la urgencia quirúrgica abdominal más frecuente en niños. Los patógenos más comúnmente asociados son las enterobacterias y los anaerobios, existiendo diferencias entre la sensibilidad bacteriana en los distintos hospitales. El objetivo del estudio es determinar la asociación entre la presencia de un microorganismo resistente al antibiótico empírico y el desarrollo de colecciones en pacientes con apendicitis perforada. Metodología Se realizó un estudio prospectivo de cohortes en pacientes menores de 18 años llevados a apendicectomía por laparoscopia con documentación intraoperatoria de apendicitis perforada entre el 1 noviembre del 2019 al 30 septiembre 2020, se tomó muestra de líquido peritoneal para cultivo y se procesaron en botellas de hemocultivo aerobio, anaerobio y tubo seco. Se recolectaron datos clínicos y microbiológicos de todos los pacientes. Resultados Se incluyeron 232 pacientes, la edad promedio fue 10.10 años (DE 3.74). Los microorganismos más comúnmente aislados fueron Escherichia coli (E. coli) (80.14%) y Pseudomona aeruginosa (7.45%). El 5.31% de E coli fueron catalogadas como BLEE. P aeruginosa no presentó resistencia al meropenem. Se documentaron 50 cultivos con gérmenes resistentes al antibiótico iniciado empíricamente, siendo necesario el cambio de antibiótico en 5 casos, sin encontrar una asociación entre esta resistencia y la aparición de absceso intrabdominal postoperatorio. En el análisis multivariado los factores asociados a presentar colección intrabdominal fueron el alto riesgo al ingreso OR 2.89 (p=0.01) y el requerimiento de dren OR 4.78 (p<0.01). Conclusiones E. coli fue el microorganismo más comúnmente aislado, con una baja tasa de aislamientos BLEE. El presentar un microorganismo resistente al antibiótico empírico no se asoció con aumento en la tasa de colección postoperatoria. Los factores asociados a presentar absceso intrabdominal fueron el alto riesgo al ingreso y el requerimiento de dren en el postoperatorio. (Texto tomado de la fuente).Introduction Acute appendicitis is the most common surgical emergency in children. Enterobacteria and anaerobes are the pathogens most frequently associated with its occurrence and the sensitivity of bacteria to antibiotics differs from one hospital to another. The objective of this study was to determine the association between the presence of a microorganism resistant to the antibiotic used in empirical therapy and the development of intra-abdominal abscess in patients with perforated appendicitis. Methodology A prospective cohort study was conducted in patients under 18 years of age who underwent laparoscopic appendectomy between November 1, 2019 and September 30, 2020 and in which perforated appendicitis was documented intraoperatively; peritoneal fluid samples were taken for bacteria culture purposes; samples were processed in aerobic and anaerobic blood culture bottles and dry tubes. Clinical and microbiological data from all patients were collected. Results A total of 232 patients were included and the mean age was 10.10 years (SD 3.74). Escherichia coli (E. coli) (80.14%) and Pseudomona aeruginosa (7.45%) were the most isolated microorganism. Besides, 5.31% of E coli isolates were classified as ESBL-producing organism. None of the P aeruginosa isolates were resistant to meropenem. Germs resistant to the antibiotic used in the empirical antimicrobial therapy were documented in 50 cultures, and changing the antibiotic was necessary in 5 cases, without finding an association between this resistance and the appearance of a postoperative intra-abdominal abscess. In the multivariate analysis, being a high risk patient on admission (OR 2.89 (p=0.01)) and the requirement of postoperative drain, (OR 4.78 (p<0.01)) were associated with having intra-abdominal abscess postoperatively. Conclusions E. coli was the most commonly isolated microorganism, with a low rate of ESBL-producing isolates. Having a microorganism resistant to the antibiotic used in empirical antimicrobial therapy was not associated with an increased risk of postoperative intra-abdominal collections. The following factors were associated with the development of intra-abdominal abscess: being a high-risk patient on admission and requiring postoperative drain.Incluye anexosEspecialidades MédicasEspecialista en Cirugía Pediátricaxvi, 53 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Especialidad en Cirugía PediátricaDepartamento de CirugíaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::617 - Cirugía, medicina regional, odontología, oftalmología, otología, audiologíaAppendicitis/parasitologyCecal DiseasesIntraabdominal InfectionsApendicitis/parasitologíaEnfermedades del CiegoInfecciones IntraabdominalesApendicitisResistencia bacterianaAlto riesgoAbsceso intraabdominalAppendicitisBacterial resistanceHigh-risk patientsIntra-abdominal abscessIdentificación de microorganismos intrabdominales asociados a colección intrabdominal postoperatoria en niños con apendicitis perforadaIdentification of intra-abdominal bacteria and association with intra-abdominal abscess in pediatric patients with perforated appendicitisTrabajo de grado - Especialidad Médicainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBiremeDi Saverio, S. et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J. Emerg. Surg. 15, 1–42 (2020).Rentea, R. M., Peter, S. D. S. & Snyder, C. L. Pediatric appendicitis_ state of the art review. Pediatric Surgery International vol. 33 269–283 (2017).Peter, S. D. S. et al. An evidence-based definition for perforated appendicitis derived from a prospective randomized trial. J. Pediatr. Surg. 43, 2242–2245 (2008).Castañeda-Espinosa, S. D. et al. Cambio en la clasificación macroscópica de la apendicitis. ¿Tiene algún impacto? Estudio retrospectivo en un Hospital Universitario Pediátrico. Rev. la Fac. Med. 63, 243–250 (2015).Vallejo, M. et al. Características clínicas y microbiológicas de la infección intra-abdominal complicada en Colombia: un estudio multicéntrico. Rev. Chil. infectología 33, 261–267 (2016).Lob, S. H., Badal, R. E., Hackel, M. A. & Sahm, D. F. Epidemiology and antimicrobial susceptibility of gram-negative pathogens causing intra-abdominal infections in pediatric patients in Europe—SMART 2011–2014. J. Pediatric Infect. Dis. Soc. 6, 72–79 (2017).Somers, K. K., Eastwood, D., Liu, Y. & Arca, M. J. Splitting hairs and challenging guidelines: Defining the role of perioperative antibiotics in pediatric appendicitis patients. J. Pediatr. Surg. 55, 406–413 (2020).Pennell, C. et al. A Standardized Protocol for the Management of Appendicitis in Children Reduces Resource Utilization. Pediatr. Qual. Saf. 5, e357 (2020).Bansal, S., Banever, G. T., Karrer, F. M. & Partrick, D. A. Appendicitis in children less than 5 years old: influence of age on presentation and outcome. Am. J. Surg. 204, 1031–1035 (2012).Witt, C. E., Goldin, A. B., Vavilala, M. S. & Rivara, F. P. Effect of body mass index percentile on pediatric gastrointestinal surgery outcomes. J. Pediatr. Surg. 51, 1473–1479 (2016).Kasatpibal, N. et al. Risk of surgical site infection and efficacy of antibiotic prophylaxis: a cohort study of appendectomy patients in Thailand. BMC Infect. Dis. 6, 1–7 (2006).Levin, D. E. & Pegoli, W. Abscess After Appendectomy: Predisposing Factors. Adv. Surg. 49, 263–280 (2015).Gómez, D. R., Alberto, J., Buriticá, A. & Clemencia, O. Riesgo anestésico y tipo de herida asociados a infección intrahospitalaria en pacientes quirúrgicos. Modelo logístic. Rev. Colomb. Anestesiol. 30, 17–21 (2002).Holguín-Sanabria, D. A. et al. Prevalence of organ-space surgical site infections after appendectomy for ruptured appendix in children. Rev. la Fac. Med. 67, 639–643 (2019).Glass, C. C. & Rangel, S. J. Overview and diagnosis of acute appendicitis in children. Semin. Pediatr. Surg. 25, 198–203 (2016).Rentea, R. M. & St. Peter, S. D. Pediatric Appendicitis. Surg. Clin. North Am. 97, 93–112 (2017).Samuel, M. Pediatric appendicitis score. J. Pediatr. Surg. 37, 877–881 (2002).Rentea, R. M., Peter, S. D. S. S. & Snyder, C. L. Pediatric appendicitis: state of the art review. Pediatr. Surg. Int. 33, 269–283 (2017).Caruso, A. M. et al. Acute appendicitis in children: not only surgical treatment. J. Pediatr. Surg. 52, 444–448 (2017).Mazuski, J. E. et al. The surgical infection society revised guidelines on the management of intra-abdominal infection. Surg. Infect. (Larchmt). 18, 1–76 (2017).Association, W. M. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 310, 2191–2194 (2013).Lee, Y. R., McMahan, D., McCall, C. & Perry, G. K. Complicated intra-abdominal infections: the old antimicrobials and the new players. Drugs 75, 2097–2117 (2015).Solomkin, J. S. et al. Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. 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