Dímero d y ultrasonografía de miembros inferiores como factores pronósticos de trombosis venosa profunda y embolismo pulmonar recurrente: revisión sistemática y metaanálisis

ilustraciones a color, diagramas

Autores:: Salinas Mendoza, Sebastian

Tipo de recurso:

Fecha de publicación:: 2023

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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repository_id_str
dc.title.spa.fl_str_mv	Dímero d y ultrasonografía de miembros inferiores como factores pronósticos de trombosis venosa profunda y embolismo pulmonar recurrente: revisión sistemática y metaanálisis
dc.title.translated.eng.fl_str_mv	D-dimer and lower limb ultrasound as prognostic factors for recurrent deep vein thrombosis and pulmonary embolism: systematic review and meta-analysis.
title	Dímero d y ultrasonografía de miembros inferiores como factores pronósticos de trombosis venosa profunda y embolismo pulmonar recurrente: revisión sistemática y metaanálisis
spellingShingle	Dímero d y ultrasonografía de miembros inferiores como factores pronósticos de trombosis venosa profunda y embolismo pulmonar recurrente: revisión sistemática y metaanálisis 610 - Medicina y salud 610 - Medicina y salud::616 - Enfermedades Tromboembolia - Diagnóstico por imagen Extremidad inferior - Fisiopatología Ultrasonografía Revisión sistemática Thromboembolism - Diagnostic imaging Lower extremity - Physiopathology Ultrasonography Systematic review Dimero D Ultrasonografía de miembros inferiores Trombosis venosa profunda Tromboembolismo pulmonar D-dimer Lower limb ultrasonography Deep vein thrombosis Pulmonary thromboembolism
title_short	Dímero d y ultrasonografía de miembros inferiores como factores pronósticos de trombosis venosa profunda y embolismo pulmonar recurrente: revisión sistemática y metaanálisis
title_full	Dímero d y ultrasonografía de miembros inferiores como factores pronósticos de trombosis venosa profunda y embolismo pulmonar recurrente: revisión sistemática y metaanálisis
title_fullStr	Dímero d y ultrasonografía de miembros inferiores como factores pronósticos de trombosis venosa profunda y embolismo pulmonar recurrente: revisión sistemática y metaanálisis
title_full_unstemmed	Dímero d y ultrasonografía de miembros inferiores como factores pronósticos de trombosis venosa profunda y embolismo pulmonar recurrente: revisión sistemática y metaanálisis
title_sort	Dímero d y ultrasonografía de miembros inferiores como factores pronósticos de trombosis venosa profunda y embolismo pulmonar recurrente: revisión sistemática y metaanálisis
dc.creator.fl_str_mv	Salinas Mendoza, Sebastian
dc.contributor.advisor.spa.fl_str_mv	Meléndez Rhenals, Sugeich del Mar Burgos Cárdenas, Álvaro Javier
dc.contributor.author.spa.fl_str_mv	Salinas Mendoza, Sebastian
dc.contributor.orcid.spa.fl_str_mv	Salinas Mendoza, Sebastian [0000-0002-7517-1643]
dc.subject.ddc.spa.fl_str_mv	610 - Medicina y salud 610 - Medicina y salud::616 - Enfermedades
topic	610 - Medicina y salud 610 - Medicina y salud::616 - Enfermedades Tromboembolia - Diagnóstico por imagen Extremidad inferior - Fisiopatología Ultrasonografía Revisión sistemática Thromboembolism - Diagnostic imaging Lower extremity - Physiopathology Ultrasonography Systematic review Dimero D Ultrasonografía de miembros inferiores Trombosis venosa profunda Tromboembolismo pulmonar D-dimer Lower limb ultrasonography Deep vein thrombosis Pulmonary thromboembolism
dc.subject.decs.spa.fl_str_mv	Tromboembolia - Diagnóstico por imagen Extremidad inferior - Fisiopatología Ultrasonografía Revisión sistemática
dc.subject.decs.eng.fl_str_mv	Thromboembolism - Diagnostic imaging Lower extremity - Physiopathology Ultrasonography Systematic review
dc.subject.proposal.spa.fl_str_mv	Dimero D Ultrasonografía de miembros inferiores Trombosis venosa profunda Tromboembolismo pulmonar
dc.subject.proposal.eng.fl_str_mv	D-dimer Lower limb ultrasonography Deep vein thrombosis Pulmonary thromboembolism
description	ilustraciones a color, diagramas
publishDate	2023
dc.date.issued.none.fl_str_mv	2023-09-18
dc.date.accessioned.none.fl_str_mv	2024-02-06T20:13:44Z
dc.date.available.none.fl_str_mv	2024-02-06T20:13:44Z
dc.type.spa.fl_str_mv	Trabajo de grado - Especialidad Médica
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/85635
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/85635 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.references.spa.fl_str_mv	Stevens H, Peter K, Tran H, McFadyen J. Predicting the risk of recurrent venous thromboembolism: Current challenges and future opportunities. J Clin Med. 2020;9(5). Parakh RS, Sabath DE. Venous Thromboembolism: Role of the Clinical Laboratory in Diagnosis and Management. Vol. 3, The journal of applied laboratory medicine. 2019. Serhal M, Barnes GD. Venous thromboembolism: A clinician update. Vascular Medicine (United Kingdom). 2019;24(2). Turetz M, Sideris AT, Friedman OA, Triphathi N, Horowitz JM. Epidemiology, Pathophysiology, and Natural History of Pulmonary Embolism. Semin Intervent Radiol. 2018;35(2). Heit JA, Spencer FA, White RH. The epidemiology of venous thromboembolism. J Thromb Thrombolysis. 2016;41(1). Winter MP, Schernthaner GH, Lang IM. Chronic complications of venous thromboembolism. Journal of Thrombosis and Haemostasis. 2017;15(8). Mazzolai L, Aboyans V, Ageno W, Agnelli G, Alatri A, Bauersachs R, et al. Diagnosis and management of acute deep vein thrombosis: A joint consensus document from the European Society of Cardiology working groups of aorta and peripheral vascular diseases and pulmonary circulation and right ventricular function. Vol. 39, European Heart Journal. 2018. Lang I. Chronic thromboembolic pulmonary hypertension: A distinct disease entity. Vol. 24, European Respiratory Review. 2015. Medrek S, Safdar Z. Epidemiology and Pathophysiology of Chronic Thromboembolic Pulmonary Hypertension: Risk Factors and Mechanisms. Vol. 12, Methodist DeBakey cardiovascular journal. 2016. Liederman Z, Chan N, Bhagirath V. Current challenges in diagnosis of venous thromboembolism. Vol. 9, Journal of Clinical Medicine. 2020. Grosse SD, Nelson RE, Nyarko KA, Richardson LC, Raskob GE. The economic burden of incident venous thromboembolism in the United States: A review of estimated attributable healthcare costs. Vol. 137, Thrombosis Research. 2016. Cross MB, Boettner F. Pathophysiology of Venous Thromboembolic Disease. Seminars in Arthroplasty JSES. 2009;20(4). Palareti G. Recurrent Venous Thromboembolism: What Is the Risk and How to Prevent It. Scientifica (Cairo). 2012;2012. Khan F, Rahman A, Carrier M, Kearon C, Weitz JI, Schulman S, et al. Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event: Systematic review and meta-analysis. The BMJ. 2019;366. Fahrni J, Husmann M, Gretener SB, Keo HH. Assessing the risk of recurrent venous thromboembolism – A practical approach. Vasc Health Risk Manag. 2015;11. Steinbrecher O, Šinkovec H, Eischer L, Kyrle PA, Eichinger S. D-dimer levels over time after anticoagulation and the association with recurrent venous thromboembolism. Thromb Res. 2021;197. Kearon C, Ginsberg JS, Hirsh J. The role of venous ultrasonography in the diagnosis of suspected deep venous thrombosis and pulmonary embolism. Vol. 129, Annals of Internal Medicine. 1998. Tan M, Huisman M V. High percentage of non-diagnostic compression ultrasonography results and the diagnosis of ipsilateral recurrent proximal deep vein thrombosis: Reply to a rebuttal. Vol. 9, Journal of Thrombosis and Haemostasis. 2011. Hamadah A, Alwasaidi T, Le Gal G, Carrier M, Wells PS, Scarvelis D, et al. Baseline imaging after therapy for unprovoked venous thromboembolism: A randomized controlled comparison of baseline imaging for diagnosis of suspected recurrence. Journal of Thrombosis and Haemostasis. 2011;9(12). Needleman L, Cronan JJ, Lilly MP, Merli GJ, Adhikari S, Hertzberg BS, et al. Ultrasound for Lower Extremity Deep Venous Thrombosis. Circulation. 2018;137(14). Steinbrecher O, Šinkovec H, Eischer L, Kyrle PA, Eichinger S. D-dimer levels over time after anticoagulation and the association with recurrent venous thromboembolism. Thromb Res. 2021;197. Palareti G, Cosmi B, Legnani C, Tosetto A, Brusi C, Iorio A, et al. d -Dimer Testing to Determine the Duration of Anticoagulation Therapy . New England Journal of Medicine. 2006;355(17). Rodger MA, Kahn SR, Wells PS, Anderson DA, Chagnon I, Le Gal G, et al. Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy. CMAJ. 2008;179(5). Kearon C, Spencer FA, O’Keeffe D, Parpia S, Schulman S, Baglin T, et al. D-Dimer testing to select patients with a first unprovoked venous thromboembolism who can stop anticoagulant therapy: A cohort study. Ann Intern Med. 2015;162(1). Young L, Ockelford P, Milne D, Rolfe-Vyson V, Mckelvie S, Harper P. Post-treatment residual thrombus increases the risk of recurrent deep vein thrombosis and mortality. Vol. 4, Journal of Thrombosis and Haemostasis. 2006. An J, Sun B, Ji Y, Zhang Z, Zhai Z, Wang C. d-dimer is a predictor of clot resolution in patients with pulmonary thromboembolism: A retrospective cohort study. Clinical Respiratory Journal. 2020 Jun 1;14(6):549–56. Avnery O, Martin M, Bura-Riviere A, Barillari G, Mazzolai L, Mahé I, et al. D-dimer levels and risk of recurrence following provoked venous thromboembolism: findings from the RIETE registry. J Intern Med. 2020;287:32–41. Baglin T, Palmer CR, Luddington R, Baglin C. Unprovoked recurrent venous thrombosis: Prediction by D-dimer and clinical risk factors. Journal of Thrombosis and Haemostasis. 2008 Apr;6(4):577–82. Bradbury C, Fletcher K, Sun Y, Heneghan C, Gardiner C, Roalfe A, et al. A randomised controlled trial of extended anticoagulation treatment versus standard treatment for the prevention of recurrent venous thromboembolism (VTE) and post-thrombotic syndrome in patients being treated for a first episode of unprovoked VTE (the ExACT study). Br J Haematol. 2020 Mar 1;188(6):962–75. Brighton T, Bosco A, Robedo K, Mister R, Hague W, Kirby A, et al. PB 400 \| Residual Vein Thrombus Does Not Predict for Recurrent Vein Thrombosis in the ASPIRE Study. Cosmi B, Legnani C, Cini M, Guazzaloca G, Palareti G. D-dimer levels in combination with residual venous obstruction and the risk of recurrence after anticoagulation withdrawal for a first idiopathic deep vein thrombosis. Thromb Haemost. 2005 Nov;94(5):969–74. Cosmi B, Legnani C, Cini M, Favaretto E, Palareti G. D-dimer and factor VIII are independent risk factors for recurrence after anticoagulation withdrawal for a first idiopathic deep vein thrombosis. Thromb Res. 2008;122(5):610–7. Cosmi B, Legnani C, Tosetto A, Pengo V, Ghirarduzzi A, Testa S, et al. Usefulness of repeated D-dimer testing after stopping anticoagulation for a first episode of unprovoked venous thromboembolism: The PROLONG II prospective study. Blood. 2010 Jan 21;115(3):481–8. Cosmi B, Legnani C, Iorio A, Pengo V, Ghirarduzzi A, Testa S, et al. Residual Venous Obstruction, alone and in Combination with D-Dimer, as a Risk Factor for Recurrence after Anticoagulation Withdrawal following a First Idiopathic Deep Vein Thrombosis in the Prolong Study. European Journal of Vascular and Endovascular Surgery. 2010 Mar;39(3):356–65. Couturaud F, Sanchez O, Pernod G, Mismetti P, Jego P, Duhamel E, et al. Six Months vs Extended Oral Anticoagulation After a First Episode of Pulmonary Embolism The PADIS-PE Randomized Clinical Trial. JAMA. 2015;314(1):31–40. Eichinger S, Minar E, Bialonczyk C, Hirschl M, Quehenberger P, Schneider B, et al. D-Dimer Levels and Risk of Recurrent Venous Thromboembolism [Internet]. Available from: https://jamanetwork.com/ Eichinger S, Heinze G, Jandeck LM, Kyrle PA. Risk assessment of recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism: The vienna prediction model. Circulation. 2010 Apr;121(14):1630–6. Franco Moreno AI, García Navarro MJ, Ortiz Sánchez J, Martín Díaz RM, Madroñal Cerezo E, De Ancos Aracil CL, et al. A risk score for prediction of recurrence in patients with unprovoked venous thromboembolism (DAMOVES). Eur J Intern Med. 2016 Apr 1;29:59–64. Kearon C, Gent M, Hrish J, Weitz J, Kovacs MJ, Anderson DR, et al. A comparasion fo three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism. New England Journal of Medicine. 1999;340(12):901–7. Kearon C, Spencer FA, O’Keeffe D, Parpia S, Schulman S, Baglin T, et al. D-Dimer testing to select patients with a first unprovoked venous thromboembolism who can stop anticoagulant therapy: A cohort study. Ann Intern Med. 2015 Jan 6;162(1):27–34. Kearon C, Parpia S, Spencer FA, Baglin T, Stevens SM, Bauer KA, et al. D-dimer levels and recurrence in patients with unprovoked VTE and a negative qualitative D-dimer test after treatment. Thromb Res. 2016 Oct 1;146:119–25 Kearon C, Parpia S, Spencer FA, Schulman S, Stevens SM, Shah V, et al. Long-term risk of recurrence in patients with a first unprovoked venous thromboembolism managed according to d-dimer results; A cohort study. Journal of Thrombosis and Haemostasis. 2019 Jul 1;17(7):1144–52. Kijrattanakul P, Thippayanuruksakul P, Akkawat B, Rojnuckarin P. Recurrences after stopping anticoagulant therapy inThai patients with non cancer-related venousthromboembolism. 2015. Le Gal G, Carrier M, Kovacs MJ, Betancourt MT, Kahn SR, Wells PS, et al. Residual vein obstruction as a predictor for recurrent thromboembolic events after a first unprovoked episode: Data from the REVERSE cohort study. Journal of Thrombosis and Haemostasis. 2011 Jun;9(6):1126–32 Mazetto BM, Orsi FL de A, Silveira SAF, Zapponi KCS, Colella MP, de Paula EV, et al. Lower Echogenicity of the Residual Venous Thrombosis at Ultrasound Examination Is Associated to Recurrent Thrombosis Events. Blood. 2014 Dec 6;124(21):4251–4251. Mazetto BM, Orsi FLA, Silveira SAF, Bittar LF, Flores-Nascimento MMC, Zapponi KCS, et al. Residual Vein Thrombosis Echogenicity Is Associated to the Risk of DVT Recurrence: A Cohort Study. Clinical and Applied Thrombosis/Hemostasis. 2018 Apr 1;24(3):477–82. Mrozińska S, Cieslik J, Broniatowska E, Undas A. Unfavorably altered plasma clot properties in women with a HERDOO2 score equal to or greater than 2 and prediction of recurrent venous thromboembolism. Pol Arch Intern Med. 2018;128(10):572–9. Palareti G, Cosmi B, Legnani C, Tosetto A, Brusi C, Lorio A, et al. D-Dimer Testing to Determine the Duration of Anticoagulation Therapy. New England Journal Of Medicine. 2006;355:1780–9 Palareti G, Cosmi B, Legnani C, Antonucci E, De Micheli V, Ghirarduzzi A, et al. D-dimer to guide the duration of anticoagulation in patients with venous thromboembolism: A management study. Blood. 2014 Jul 10;124(2):196–203. Poli D, Antonucci E, Ciuti G, Abbate R, Prisco D. Combination of D-dimer, F1+2 and residual vein obstruction as predictors of VTE recurrence in patients with first VTE episode after OAT withdrawal [4]. Vol. 6, Journal of Thrombosis and Haemostasis. 2008. p. 708–10. Posadas-Martínez ML, Torres Gómez F, Mezzarobba D, Schutz N, Ruberto J, Dovasio F, et al. Predictores de recurrencia de enfermedad tromboembólica venosa post suspensión de anticoagulación: estudio de cohorte prospectiva. Medwave. 2021 Dec 28;21(11):e8504. Prandoni P, Anthonie ;, Lensing WA, Prins MH, Bernardi E, Marchiori A, et al. Residual Venous Thrombosis as a Predictive Factor of Recurrent Venous Thromboembolism Background: The optimum duration of anticoagulant therapy [Internet]. 2002. Available from: www.annals.org Prandoni P, Prins MH, Lensing AWA. Residual Thrombosis on Ultrasonography to Guide the Duration of Anticoagulation in Patients With Deep Venous Thrombosis: A Randomized Trial. J Vasc Surg [Internet]. 2009 Oct;50(4):960. Available from: https://linkinghub.elsevier.com/retrieve/pii/S074152140901667X Prandoni P, Lensing AWA, Prins MH, Pesavento R, Piccioli A, Sartori MT, et al. The impact of residual thrombosis on the long-term outcome of patients with deep venous thrombosis treated with conventional anticoagulation. Semin Thromb Hemost. 2015;41(2):133–40. Prandoni P. OC 25.4 \| Residual Vein Thrombosis and Serial D-Dimer for the Long-term Management of Patients with Deep Venous Thrombosis Background: The optimal long-term strategy for preventing recurrent. Rodger MA, Kahn SR, Wells PS, Anderson DA, Chagnon I, Le Gal G, et al. Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy. CMAJ Canadian Medical Association Journal. 2008 Aug 26;179(5):417–26. Shrivastava S, Ridker PM, Glynn RJ, Goldhaber SZ, Moll S, Bounameaux H, et al. D-dimer, factor VIII coagulant activity, low-intensity warfarin and the risk of recurrent venous thromboembolism. Journal of Thrombosis and Haemostasis. 2006;4:1208–14. Siragusa S, Malato A, Anastasio R, Cigna V, Milio G, Amato C, et al. Residual vein thrombosis to establish duration of anticoagulation after a first episode of deep vein thrombosis: the Duration of Anticoagulation based on Compression UltraSonography (DACUS) study. 2008; Steinbrecher O, Šinkovec H, Eischer L, Kyrle PA, Eichinger S. D-dimer levels over time after anticoagulation and the association with recurrent venous thromboembolism. Thromb Res. 2021 Jan 1;197:160–4. Tamizifar B, Oghab P, Esfahani MA. The prediction role of D-dimer in recurrence of venous thromboembolism 1-year after anticoagulation discontinuing following idiopathic deep vein thrombosis. Journal of Research in Medical Sciences. 2014 ten Cate-Hoek A, Erkens P, Hamulyak K, Verhezen P, ten Cate H. Is the predictive quality of D-dimer for the recurrence of thrombosis time dependent? International Society on Thrombosis and Haemostasis. 2011;9(2):1–970. Timp JF, Braekkan SK, Lijfering WM, Van Hylckama Vlieg A, Hansen JB, Rosendaal FR, et al. Prediction of recurrent venous thrombosis in all patients with a first venous thrombotic event: The Leiden Thrombosis Recurrence Risk Prediction model (L-TRRiP). PLoS Med. 2019;16(10). Tritschler T, Limacher A, Méan M, Rodondi N, Aujesky D. Usefulness of D-Dimer Testing in Predicting Recurrence in Elderly Patients with Unprovoked Venous Thromboembolism. American Journal of Medicine. 2017 Oct 1;130(10):1221–4. van Hylckama Vlieg A, Baglin CA, Luddington R, Macdonald S, Rosendaal FR, Baglin TP. The risk of a first and a recurrent venous thrombosis associated with an elevated D-dimer level and an elevated thrombin potential: Results of the THE-VTE study. Journal of Thrombosis and Haemostasis. 2015 Sep 1;13(9):1642–52 Vorobyeva NM, Dobrovolsky AB, Panchenko EP, Titaeva E V, Karabasheva MB, Yarovoy SY, et al. Elevated D-dimer level after 1 month anticoagulant therapy as a predictor for adverse outcomes in patients with venous thromboembolism: 10-year follow-up results [Internet]. Available from: https://academic.oup.com/eurheartj/article/40/Supplement_1/ehz746.0531/5596100 Yang YL, Yuan P, Wang CY, Pudasaini B, Li Y, Yu YZ, et al. Variable predictors of acute pulmonary embolism recurrence with duration of follow-up. J Thorac Dis. 2020 Mar 1;12(3):403–13. Zabczyk M, Plens K, Wojtowicz W, Undas A. Prothrombotic fibrin clot phenotype is associated with recurrent pulmonary embolism after discontinuation of anticoagulant therapy. Arterioscler Thromb Vasc Biol. 2017 Feb 1;37(2):365–73. Eichinger S, Hron G, Kollars M, Kyrle PA. Prediction of recurrent venous thromboembolism by endogenous thrombin potential and D-dimer. Clin Chem. 2008 Dec 1;54(12):2042–8. Mronzinska S, Cieslik J, Broniatowska E, Undas A. Unfavorably altered plasma clot properties in women with a HERDOO2 score equal to or greater than 2 and prediction of recurrent venous thromboembolism. Pol Arch Intern Med. 2018;128(10):572–9. Avnery O, Martin M, Bura-Riviere A, Barillari G, Mazzolai L, Mahé I, et al. D-dimer levels and risk of recurrence following provoked venous thromboembolism: findings from the RIETE registry. J Intern Med. 2020 Jan 1;287(1):32–41. Hayden JA, Côté P, Bombardier C. Evaluation of the quality of prognosis studies in systematic reviews. Ann Intern Med. 2006;144(6). Tosetto A, Testa S, Martinelli I, Poli D, Cosmi B, Lodigiani C, et al. External validation of the DASH prediction rule: a retrospective cohort study. Journal of Thrombosis and Haemostasis. 2017 Oct 1;15(10):1963–70.
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dc.coverage.city.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
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spelling	Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Meléndez Rhenals, Sugeich del Mar8f8c43472cf092cbc296b6ff1abc8172Burgos Cárdenas, Álvaro Javier3ad010cec8ed5c40003bb9ee2480a609Salinas Mendoza, Sebastiancf5e22739b6358a70fdba73d16b633b4Salinas Mendoza, Sebastian [0000-0002-7517-1643]2024-02-06T20:13:44Z2024-02-06T20:13:44Z2023-09-18https://repositorio.unal.edu.co/handle/unal/85635Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones a color, diagramasLa enfermedad tromboembólica venosa (ETV) es una afección crónica y recurrente. Si bien la anticoagulación es efectiva, conlleva un alto riesgo de complicaciones. La duración óptima de esta terapia sigue siendo desconocida. Objetivo: Evaluar el uso del D-dímero y la ecografía de miembros inferiores como estrategias pronósticas para la recurrencia de la ETV. Se realizó una búsqueda el 28 de mayo de 2022 en las bases de datos de Medline, EMBASE y Cochrane. (PROSPERO CRD42022341082) Se incluyeron estudios de cohorte, estudios de casos y controles, y ensayos clínicos. La búsqueda inicial arrojó 4027 títulos y resúmenes. Después de eliminar 705 duplicados y revisar 3262 títulos y resúmenes, finalmente se incluyeron 43 artículos que proporcionaban información sobre el D-dímero y/o la ecografía de miembros inferiores como factores pronósticos. Encontramos que la persistencia de Trombosis residual y Dimero d Anormal se asociaron con mayor riesgo de ETV recurrente (OR1.49, 95%IC 1.17 a 1.90), (OR 2.25, 95% IC 1.85 a 2.74; 6008 participantes I2= 25%, intervalos predictivos 1.36 a 3.71), respectivamente. Sin embargo no hay certeza sobre el valor pronostico y por ende de su utilidad clínica (HR : 2.63 0.94 a 7.34 I2: 86% 6 estudios ). Esta revisión sistemática informa con muy baja calidad de la evidencia de que el resultado anormal del dímero D o de la trombosis residual en la ecografía se asocia con un mayor riesgo de TVP recurrente; sin embargo, existe incertidumbre sobre su valor pronóstico y aplicación clínica. (Texto tomado de la fuente)Venous thromboembolic disease (VTE) is a chronic and recurrent condition. While anticoagulation is effective, it carries a high risk of complications. The optimal duration of this therapy remains unknown. Objective: To evaluate the use of D-dimer and lower limb ultrasonography as prognostic strategies for VTE recurrence. A search was conducted on May 28, 2022, across the Medline, Embase, and Cochrane databases. (PROSPERO CRD42022341082) Selection Criteria: Cohort studies, case-control studies, and clinical trials were included. Studies were independently analyzed for inclusion criteria, exclusion criteria, and risk of bias. The initial search yielded 4027 titles and abstracts. After removing 705 duplicates and reviewing 3262 titles and abstracts, 43 articles were finally included, providing information on D-dimer and/or lower limb ultrasonography as prognostic factors. Lowquality evidence suggests that the persistence of residual thrombosis measured through CUS is associated with a higher risk of recurrent DVT (OR 1.49, 95% CI 1.17 to 1.90). Abnormal D-dimer levels are also associated with a higher risk of recurrence (OR 2.25, 95% CI 1.85 to 2.74; 6,008 participants, I2 = 25%, predictive intervals 1.36 to 3.71). However, there is uncertainty regarding the prognostic value and thus its clinical utility (HR: 2.63, 95% CI 0.94 to 7.34, I2: 86%, 6 studies). This systematic review informs with very low quality of the evidence that abnormal result of D-dimer or residual thrombosis in US is associated with a higher risk of recurrent DVT; however, there is uncertainty about its prognostic value and clinical applicationEspecialidades MédicasEspecialista en Medicina Interna71 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Especialidad en Medicina InternaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud610 - Medicina y salud::616 - EnfermedadesTromboembolia - Diagnóstico por imagenExtremidad inferior - FisiopatologíaUltrasonografíaRevisión sistemáticaThromboembolism - Diagnostic imagingLower extremity - PhysiopathologyUltrasonographySystematic reviewDimero DUltrasonografía de miembros inferioresTrombosis venosa profundaTromboembolismo pulmonarD-dimerLower limb ultrasonographyDeep vein thrombosisPulmonary thromboembolismDímero d y ultrasonografía de miembros inferiores como factores pronósticos de trombosis venosa profunda y embolismo pulmonar recurrente: revisión sistemática y metaanálisisD-dimer and lower limb ultrasound as prognostic factors for recurrent deep vein thrombosis and pulmonary embolism: systematic review and meta-analysis.Trabajo de grado - Especialidad Médicainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBogotá, ColombiaStevens H, Peter K, Tran H, McFadyen J. Predicting the risk of recurrent venous thromboembolism: Current challenges and future opportunities. J Clin Med. 2020;9(5).Parakh RS, Sabath DE. Venous Thromboembolism: Role of the Clinical Laboratory in Diagnosis and Management. Vol. 3, The journal of applied laboratory medicine. 2019.Serhal M, Barnes GD. Venous thromboembolism: A clinician update. Vascular Medicine (United Kingdom). 2019;24(2).Turetz M, Sideris AT, Friedman OA, Triphathi N, Horowitz JM. Epidemiology, Pathophysiology, and Natural History of Pulmonary Embolism. Semin Intervent Radiol. 2018;35(2).Heit JA, Spencer FA, White RH. The epidemiology of venous thromboembolism. J Thromb Thrombolysis. 2016;41(1).Winter MP, Schernthaner GH, Lang IM. Chronic complications of venous thromboembolism. Journal of Thrombosis and Haemostasis. 2017;15(8).Mazzolai L, Aboyans V, Ageno W, Agnelli G, Alatri A, Bauersachs R, et al. Diagnosis and management of acute deep vein thrombosis: A joint consensus document from the European Society of Cardiology working groups of aorta and peripheral vascular diseases and pulmonary circulation and right ventricular function. Vol. 39, European Heart Journal. 2018.Lang I. Chronic thromboembolic pulmonary hypertension: A distinct disease entity. Vol. 24, European Respiratory Review. 2015.Medrek S, Safdar Z. Epidemiology and Pathophysiology of Chronic Thromboembolic Pulmonary Hypertension: Risk Factors and Mechanisms. Vol. 12, Methodist DeBakey cardiovascular journal. 2016.Liederman Z, Chan N, Bhagirath V. Current challenges in diagnosis of venous thromboembolism. Vol. 9, Journal of Clinical Medicine. 2020.Grosse SD, Nelson RE, Nyarko KA, Richardson LC, Raskob GE. The economic burden of incident venous thromboembolism in the United States: A review of estimated attributable healthcare costs. Vol. 137, Thrombosis Research. 2016.Cross MB, Boettner F. Pathophysiology of Venous Thromboembolic Disease. Seminars in Arthroplasty JSES. 2009;20(4).Palareti G. Recurrent Venous Thromboembolism: What Is the Risk and How to Prevent It. Scientifica (Cairo). 2012;2012.Khan F, Rahman A, Carrier M, Kearon C, Weitz JI, Schulman S, et al. Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event: Systematic review and meta-analysis. The BMJ. 2019;366.Fahrni J, Husmann M, Gretener SB, Keo HH. Assessing the risk of recurrent venous thromboembolism – A practical approach. Vasc Health Risk Manag. 2015;11.Steinbrecher O, Šinkovec H, Eischer L, Kyrle PA, Eichinger S. D-dimer levels over time after anticoagulation and the association with recurrent venous thromboembolism. Thromb Res. 2021;197.Kearon C, Ginsberg JS, Hirsh J. The role of venous ultrasonography in the diagnosis of suspected deep venous thrombosis and pulmonary embolism. Vol. 129, Annals of Internal Medicine. 1998.Tan M, Huisman M V. High percentage of non-diagnostic compression ultrasonography results and the diagnosis of ipsilateral recurrent proximal deep vein thrombosis: Reply to a rebuttal. Vol. 9, Journal of Thrombosis and Haemostasis. 2011.Hamadah A, Alwasaidi T, Le Gal G, Carrier M, Wells PS, Scarvelis D, et al. Baseline imaging after therapy for unprovoked venous thromboembolism: A randomized controlled comparison of baseline imaging for diagnosis of suspected recurrence. Journal of Thrombosis and Haemostasis. 2011;9(12).Needleman L, Cronan JJ, Lilly MP, Merli GJ, Adhikari S, Hertzberg BS, et al. Ultrasound for Lower Extremity Deep Venous Thrombosis. Circulation. 2018;137(14).Steinbrecher O, Šinkovec H, Eischer L, Kyrle PA, Eichinger S. D-dimer levels over time after anticoagulation and the association with recurrent venous thromboembolism. Thromb Res. 2021;197.Palareti G, Cosmi B, Legnani C, Tosetto A, Brusi C, Iorio A, et al. d -Dimer Testing to Determine the Duration of Anticoagulation Therapy . New England Journal of Medicine. 2006;355(17).Rodger MA, Kahn SR, Wells PS, Anderson DA, Chagnon I, Le Gal G, et al. Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy. CMAJ. 2008;179(5).Kearon C, Spencer FA, O’Keeffe D, Parpia S, Schulman S, Baglin T, et al. D-Dimer testing to select patients with a first unprovoked venous thromboembolism who can stop anticoagulant therapy: A cohort study. Ann Intern Med. 2015;162(1).Young L, Ockelford P, Milne D, Rolfe-Vyson V, Mckelvie S, Harper P. Post-treatment residual thrombus increases the risk of recurrent deep vein thrombosis and mortality. Vol. 4, Journal of Thrombosis and Haemostasis. 2006.An J, Sun B, Ji Y, Zhang Z, Zhai Z, Wang C. d-dimer is a predictor of clot resolution in patients with pulmonary thromboembolism: A retrospective cohort study. Clinical Respiratory Journal. 2020 Jun 1;14(6):549–56.Avnery O, Martin M, Bura-Riviere A, Barillari G, Mazzolai L, Mahé I, et al. D-dimer levels and risk of recurrence following provoked venous thromboembolism: findings from the RIETE registry. J Intern Med. 2020;287:32–41.Baglin T, Palmer CR, Luddington R, Baglin C. Unprovoked recurrent venous thrombosis: Prediction by D-dimer and clinical risk factors. Journal of Thrombosis and Haemostasis. 2008 Apr;6(4):577–82.Bradbury C, Fletcher K, Sun Y, Heneghan C, Gardiner C, Roalfe A, et al. A randomised controlled trial of extended anticoagulation treatment versus standard treatment for the prevention of recurrent venous thromboembolism (VTE) and post-thrombotic syndrome in patients being treated for a first episode of unprovoked VTE (the ExACT study). Br J Haematol. 2020 Mar 1;188(6):962–75.Brighton T, Bosco A, Robedo K, Mister R, Hague W, Kirby A, et al. PB 400 \| Residual Vein Thrombus Does Not Predict for Recurrent Vein Thrombosis in the ASPIRE Study.Cosmi B, Legnani C, Cini M, Guazzaloca G, Palareti G. D-dimer levels in combination with residual venous obstruction and the risk of recurrence after anticoagulation withdrawal for a first idiopathic deep vein thrombosis. Thromb Haemost. 2005 Nov;94(5):969–74.Cosmi B, Legnani C, Cini M, Favaretto E, Palareti G. D-dimer and factor VIII are independent risk factors for recurrence after anticoagulation withdrawal for a first idiopathic deep vein thrombosis. Thromb Res. 2008;122(5):610–7.Cosmi B, Legnani C, Tosetto A, Pengo V, Ghirarduzzi A, Testa S, et al. Usefulness of repeated D-dimer testing after stopping anticoagulation for a first episode of unprovoked venous thromboembolism: The PROLONG II prospective study. Blood. 2010 Jan 21;115(3):481–8.Cosmi B, Legnani C, Iorio A, Pengo V, Ghirarduzzi A, Testa S, et al. Residual Venous Obstruction, alone and in Combination with D-Dimer, as a Risk Factor for Recurrence after Anticoagulation Withdrawal following a First Idiopathic Deep Vein Thrombosis in the Prolong Study. European Journal of Vascular and Endovascular Surgery. 2010 Mar;39(3):356–65.Couturaud F, Sanchez O, Pernod G, Mismetti P, Jego P, Duhamel E, et al. Six Months vs Extended Oral Anticoagulation After a First Episode of Pulmonary Embolism The PADIS-PE Randomized Clinical Trial. JAMA. 2015;314(1):31–40.Eichinger S, Minar E, Bialonczyk C, Hirschl M, Quehenberger P, Schneider B, et al. D-Dimer Levels and Risk of Recurrent Venous Thromboembolism [Internet]. Available from: https://jamanetwork.com/Eichinger S, Heinze G, Jandeck LM, Kyrle PA. Risk assessment of recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism: The vienna prediction model. Circulation. 2010 Apr;121(14):1630–6.Franco Moreno AI, García Navarro MJ, Ortiz Sánchez J, Martín Díaz RM, Madroñal Cerezo E, De Ancos Aracil CL, et al. A risk score for prediction of recurrence in patients with unprovoked venous thromboembolism (DAMOVES). Eur J Intern Med. 2016 Apr 1;29:59–64.Kearon C, Gent M, Hrish J, Weitz J, Kovacs MJ, Anderson DR, et al. A comparasion fo three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism. New England Journal of Medicine. 1999;340(12):901–7.Kearon C, Spencer FA, O’Keeffe D, Parpia S, Schulman S, Baglin T, et al. D-Dimer testing to select patients with a first unprovoked venous thromboembolism who can stop anticoagulant therapy: A cohort study. Ann Intern Med. 2015 Jan 6;162(1):27–34.Kearon C, Parpia S, Spencer FA, Baglin T, Stevens SM, Bauer KA, et al. D-dimer levels and recurrence in patients with unprovoked VTE and a negative qualitative D-dimer test after treatment. Thromb Res. 2016 Oct 1;146:119–25Kearon C, Parpia S, Spencer FA, Schulman S, Stevens SM, Shah V, et al. Long-term risk of recurrence in patients with a first unprovoked venous thromboembolism managed according to d-dimer results; A cohort study. Journal of Thrombosis and Haemostasis. 2019 Jul 1;17(7):1144–52.Kijrattanakul P, Thippayanuruksakul P, Akkawat B, Rojnuckarin P. Recurrences after stopping anticoagulant therapy inThai patients with non cancer-related venousthromboembolism. 2015.Le Gal G, Carrier M, Kovacs MJ, Betancourt MT, Kahn SR, Wells PS, et al. Residual vein obstruction as a predictor for recurrent thromboembolic events after a first unprovoked episode: Data from the REVERSE cohort study. Journal of Thrombosis and Haemostasis. 2011 Jun;9(6):1126–32Mazetto BM, Orsi FL de A, Silveira SAF, Zapponi KCS, Colella MP, de Paula EV, et al. Lower Echogenicity of the Residual Venous Thrombosis at Ultrasound Examination Is Associated to Recurrent Thrombosis Events. Blood. 2014 Dec 6;124(21):4251–4251.Mazetto BM, Orsi FLA, Silveira SAF, Bittar LF, Flores-Nascimento MMC, Zapponi KCS, et al. Residual Vein Thrombosis Echogenicity Is Associated to the Risk of DVT Recurrence: A Cohort Study. Clinical and Applied Thrombosis/Hemostasis. 2018 Apr 1;24(3):477–82.Mrozińska S, Cieslik J, Broniatowska E, Undas A. Unfavorably altered plasma clot properties in women with a HERDOO2 score equal to or greater than 2 and prediction of recurrent venous thromboembolism. Pol Arch Intern Med. 2018;128(10):572–9.Palareti G, Cosmi B, Legnani C, Tosetto A, Brusi C, Lorio A, et al. D-Dimer Testing to Determine the Duration of Anticoagulation Therapy. New England Journal Of Medicine. 2006;355:1780–9Palareti G, Cosmi B, Legnani C, Antonucci E, De Micheli V, Ghirarduzzi A, et al. D-dimer to guide the duration of anticoagulation in patients with venous thromboembolism: A management study. Blood. 2014 Jul 10;124(2):196–203.Poli D, Antonucci E, Ciuti G, Abbate R, Prisco D. Combination of D-dimer, F1+2 and residual vein obstruction as predictors of VTE recurrence in patients with first VTE episode after OAT withdrawal [4]. Vol. 6, Journal of Thrombosis and Haemostasis. 2008. p. 708–10.Posadas-Martínez ML, Torres Gómez F, Mezzarobba D, Schutz N, Ruberto J, Dovasio F, et al. Predictores de recurrencia de enfermedad tromboembólica venosa post suspensión de anticoagulación: estudio de cohorte prospectiva. Medwave. 2021 Dec 28;21(11):e8504.Prandoni P, Anthonie ;, Lensing WA, Prins MH, Bernardi E, Marchiori A, et al. Residual Venous Thrombosis as a Predictive Factor of Recurrent Venous Thromboembolism Background: The optimum duration of anticoagulant therapy [Internet]. 2002. Available from: www.annals.orgPrandoni P, Prins MH, Lensing AWA. Residual Thrombosis on Ultrasonography to Guide the Duration of Anticoagulation in Patients With Deep Venous Thrombosis: A Randomized Trial. J Vasc Surg [Internet]. 2009 Oct;50(4):960. Available from: https://linkinghub.elsevier.com/retrieve/pii/S074152140901667XPrandoni P, Lensing AWA, Prins MH, Pesavento R, Piccioli A, Sartori MT, et al. The impact of residual thrombosis on the long-term outcome of patients with deep venous thrombosis treated with conventional anticoagulation. Semin Thromb Hemost. 2015;41(2):133–40.Prandoni P. OC 25.4 \| Residual Vein Thrombosis and Serial D-Dimer for the Long-term Management of Patients with Deep Venous Thrombosis Background: The optimal long-term strategy for preventing recurrent.Rodger MA, Kahn SR, Wells PS, Anderson DA, Chagnon I, Le Gal G, et al. Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy. CMAJ Canadian Medical Association Journal. 2008 Aug 26;179(5):417–26.Shrivastava S, Ridker PM, Glynn RJ, Goldhaber SZ, Moll S, Bounameaux H, et al. D-dimer, factor VIII coagulant activity, low-intensity warfarin and the risk of recurrent venous thromboembolism. Journal of Thrombosis and Haemostasis. 2006;4:1208–14.Siragusa S, Malato A, Anastasio R, Cigna V, Milio G, Amato C, et al. Residual vein thrombosis to establish duration of anticoagulation after a first episode of deep vein thrombosis: the Duration of Anticoagulation based on Compression UltraSonography (DACUS) study. 2008;Steinbrecher O, Šinkovec H, Eischer L, Kyrle PA, Eichinger S. D-dimer levels over time after anticoagulation and the association with recurrent venous thromboembolism. Thromb Res. 2021 Jan 1;197:160–4.Tamizifar B, Oghab P, Esfahani MA. The prediction role of D-dimer in recurrence of venous thromboembolism 1-year after anticoagulation discontinuing following idiopathic deep vein thrombosis. Journal of Research in Medical Sciences. 2014ten Cate-Hoek A, Erkens P, Hamulyak K, Verhezen P, ten Cate H. Is the predictive quality of D-dimer for the recurrence of thrombosis time dependent? International Society on Thrombosis and Haemostasis. 2011;9(2):1–970.Timp JF, Braekkan SK, Lijfering WM, Van Hylckama Vlieg A, Hansen JB, Rosendaal FR, et al. Prediction of recurrent venous thrombosis in all patients with a first venous thrombotic event: The Leiden Thrombosis Recurrence Risk Prediction model (L-TRRiP). PLoS Med. 2019;16(10).Tritschler T, Limacher A, Méan M, Rodondi N, Aujesky D. Usefulness of D-Dimer Testing in Predicting Recurrence in Elderly Patients with Unprovoked Venous Thromboembolism. American Journal of Medicine. 2017 Oct 1;130(10):1221–4.van Hylckama Vlieg A, Baglin CA, Luddington R, Macdonald S, Rosendaal FR, Baglin TP. The risk of a first and a recurrent venous thrombosis associated with an elevated D-dimer level and an elevated thrombin potential: Results of the THE-VTE study. Journal of Thrombosis and Haemostasis. 2015 Sep 1;13(9):1642–52Vorobyeva NM, Dobrovolsky AB, Panchenko EP, Titaeva E V, Karabasheva MB, Yarovoy SY, et al. Elevated D-dimer level after 1 month anticoagulant therapy as a predictor for adverse outcomes in patients with venous thromboembolism: 10-year follow-up results [Internet]. Available from: https://academic.oup.com/eurheartj/article/40/Supplement_1/ehz746.0531/5596100Yang YL, Yuan P, Wang CY, Pudasaini B, Li Y, Yu YZ, et al. Variable predictors of acute pulmonary embolism recurrence with duration of follow-up. J Thorac Dis. 2020 Mar 1;12(3):403–13.Zabczyk M, Plens K, Wojtowicz W, Undas A. Prothrombotic fibrin clot phenotype is associated with recurrent pulmonary embolism after discontinuation of anticoagulant therapy. Arterioscler Thromb Vasc Biol. 2017 Feb 1;37(2):365–73.Eichinger S, Hron G, Kollars M, Kyrle PA. Prediction of recurrent venous thromboembolism by endogenous thrombin potential and D-dimer. Clin Chem. 2008 Dec 1;54(12):2042–8.Mronzinska S, Cieslik J, Broniatowska E, Undas A. Unfavorably altered plasma clot properties in women with a HERDOO2 score equal to or greater than 2 and prediction of recurrent venous thromboembolism. Pol Arch Intern Med. 2018;128(10):572–9.Avnery O, Martin M, Bura-Riviere A, Barillari G, Mazzolai L, Mahé I, et al. D-dimer levels and risk of recurrence following provoked venous thromboembolism: findings from the RIETE registry. J Intern Med. 2020 Jan 1;287(1):32–41.Hayden JA, Côté P, Bombardier C. Evaluation of the quality of prognosis studies in systematic reviews. Ann Intern Med. 2006;144(6).Tosetto A, Testa S, Martinelli I, Poli D, Cosmi B, Lodigiani C, et al. External validation of the DASH prediction rule: a retrospective cohort study. Journal of Thrombosis and Haemostasis. 2017 Oct 1;15(10):1963–70.EstudiantesInvestigadoresLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/85635/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL10191116262023.pdf10191116262023.pdfTesis de Especialización Medicina Internaapplication/pdf1821996https://repositorio.unal.edu.co/bitstream/unal/85635/2/10191116262023.pdf837ace4dd6a3f7b2dcec15cd74f7d532MD52THUMBNAIL10191116262023.pdf.jpg10191116262023.pdf.jpgGenerated Thumbnailimage/jpeg5561https://repositorio.unal.edu.co/bitstream/unal/85635/3/10191116262023.pdf.jpgaaee7cfd8a094dee604b1e2182b62f4eMD53unal/85635oai:repositorio.unal.edu.co:unal/856352024-02-06 23:03:46.764Repositorio Institucional Universidad Nacional de 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Dímero d y ultrasonografía de miembros inferiores como factores pronósticos de trombosis venosa profunda y embolismo pulmonar recurrente: revisión sistemática y metaanálisis

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