Development and optimization of analitical methodology to evaluate oleic acid, ethanolamine, pharmaceuticals used for the manufacturing of triethanolamine oleate injection

In this paper we present the results obtained during standarization of the separation systems for the assement of oleic acid and ethanolamine, pharmaceuticals used for the manufacturing of triethanolamine oleate injection BP. For the HPLC assay of oleic acid we used a Free Fatty Acids Waters® column...

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Autores:
Sierra, Noralba
Bolivar, Andrea Cristina
Rojas, Jaime
Tipo de recurso:
Article of journal
Fecha de publicación:
1999
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/23771
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/23771
http://bdigital.unal.edu.co/14808/
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openAccess
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Atribución-NoComercial 4.0 Internacional
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spelling Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Sierra, Noralbab0452c93-cd2a-4a35-a3bf-9dd3c078ab5f300Bolivar, Andrea Cristina5f3814be-936c-4b5d-841e-1c23a8d5e0a6300Rojas, Jaime2a00be03-4ada-44de-bca7-32d4720a142e3002019-06-25T21:18:29Z2019-06-25T21:18:29Z1999https://repositorio.unal.edu.co/handle/unal/23771http://bdigital.unal.edu.co/14808/In this paper we present the results obtained during standarization of the separation systems for the assement of oleic acid and ethanolamine, pharmaceuticals used for the manufacturing of triethanolamine oleate injection BP. For the HPLC assay of oleic acid we used a Free Fatty Acids Waters® column and acetonitrile – water (46 : 54) as mobile phase; the detection was performed at 201nm. Finally, a SE-30 glass column and a flame ionization detector (FID) was used for the gas chromatographic assay of ethanolamine.El presente artículo presenta los resultados obtenidos durante el desarrollo y optimización de dos metodologías analíticas, cromatografía líquida y de gases, para valorar respectivamente ácido oleico y etanolamina, materias primas empleadas en la fabricación de la solución inyectable de oleato de etanolamina BP(1). El ácido oleico se determinó por HPLC, empleando una columna WatersÃ’ para ácidos grasos, una mezcla de acetonitrilo:agua ( 46:54) como fase móvil y detección a 201 nm. Para la etanolamina se desarrolló un método por cromatografía de gases (CGL), para lo cual se preparó el derivado imínico a partir de la amina y benzaldehido, empleando metilparabeno como patrón interno, una columna de vidrio con metilsilicona como fase estacionaria (SE-30) y detector de ionización de llama (FID).application/pdfspaRevista Colombiana de Ciencias Químico Farmacéuticashttp://revistas.unal.edu.co/index.php/rccquifa/article/view/9164Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico Farmacéuticas; Vol. 28, núm. 1 (1999) 0034-7418 1909-6356Sierra, Noralba and Bolivar, Andrea Cristina and Rojas, Jaime (1999) Development and optimization of analitical methodology to evaluate oleic acid, ethanolamine, pharmaceuticals used for the manufacturing of triethanolamine oleate injection. Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 28, núm. 1 (1999) 0034-7418 1909-6356 .Development and optimization of analitical methodology to evaluate oleic acid, ethanolamine, pharmaceuticals used for the manufacturing of triethanolamine oleate injectionArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL9164-15359-1-PB.pdfapplication/pdf253060https://repositorio.unal.edu.co/bitstream/unal/23771/1/9164-15359-1-PB.pdf1caa403a9b21b47e48d6674b225cfda5MD51THUMBNAIL9164-15359-1-PB.pdf.jpg9164-15359-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg2314https://repositorio.unal.edu.co/bitstream/unal/23771/2/9164-15359-1-PB.pdf.jpg459f7a232109f087205ce08c8ff4bbb2MD52unal/23771oai:repositorio.unal.edu.co:unal/237712022-10-21 23:02:37.0Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co
dc.title.spa.fl_str_mv Development and optimization of analitical methodology to evaluate oleic acid, ethanolamine, pharmaceuticals used for the manufacturing of triethanolamine oleate injection
title Development and optimization of analitical methodology to evaluate oleic acid, ethanolamine, pharmaceuticals used for the manufacturing of triethanolamine oleate injection
spellingShingle Development and optimization of analitical methodology to evaluate oleic acid, ethanolamine, pharmaceuticals used for the manufacturing of triethanolamine oleate injection
title_short Development and optimization of analitical methodology to evaluate oleic acid, ethanolamine, pharmaceuticals used for the manufacturing of triethanolamine oleate injection
title_full Development and optimization of analitical methodology to evaluate oleic acid, ethanolamine, pharmaceuticals used for the manufacturing of triethanolamine oleate injection
title_fullStr Development and optimization of analitical methodology to evaluate oleic acid, ethanolamine, pharmaceuticals used for the manufacturing of triethanolamine oleate injection
title_full_unstemmed Development and optimization of analitical methodology to evaluate oleic acid, ethanolamine, pharmaceuticals used for the manufacturing of triethanolamine oleate injection
title_sort Development and optimization of analitical methodology to evaluate oleic acid, ethanolamine, pharmaceuticals used for the manufacturing of triethanolamine oleate injection
dc.creator.fl_str_mv Sierra, Noralba
Bolivar, Andrea Cristina
Rojas, Jaime
dc.contributor.author.spa.fl_str_mv Sierra, Noralba
Bolivar, Andrea Cristina
Rojas, Jaime
description In this paper we present the results obtained during standarization of the separation systems for the assement of oleic acid and ethanolamine, pharmaceuticals used for the manufacturing of triethanolamine oleate injection BP. For the HPLC assay of oleic acid we used a Free Fatty Acids Waters® column and acetonitrile – water (46 : 54) as mobile phase; the detection was performed at 201nm. Finally, a SE-30 glass column and a flame ionization detector (FID) was used for the gas chromatographic assay of ethanolamine.
publishDate 1999
dc.date.issued.spa.fl_str_mv 1999
dc.date.accessioned.spa.fl_str_mv 2019-06-25T21:18:29Z
dc.date.available.spa.fl_str_mv 2019-06-25T21:18:29Z
dc.type.spa.fl_str_mv Artículo de revista
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dc.identifier.eprints.spa.fl_str_mv http://bdigital.unal.edu.co/14808/
url https://repositorio.unal.edu.co/handle/unal/23771
http://bdigital.unal.edu.co/14808/
dc.language.iso.spa.fl_str_mv spa
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dc.relation.spa.fl_str_mv http://revistas.unal.edu.co/index.php/rccquifa/article/view/9164
dc.relation.ispartof.spa.fl_str_mv Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico Farmacéuticas
Revista Colombiana de Ciencias Químico Farmacéuticas
dc.relation.ispartofseries.none.fl_str_mv Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 28, núm. 1 (1999) 0034-7418 1909-6356
dc.relation.references.spa.fl_str_mv Sierra, Noralba and Bolivar, Andrea Cristina and Rojas, Jaime (1999) Development and optimization of analitical methodology to evaluate oleic acid, ethanolamine, pharmaceuticals used for the manufacturing of triethanolamine oleate injection. Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 28, núm. 1 (1999) 0034-7418 1909-6356 .
dc.rights.spa.fl_str_mv Derechos reservados - Universidad Nacional de Colombia
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.license.spa.fl_str_mv Atribución-NoComercial 4.0 Internacional
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dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial 4.0 Internacional
Derechos reservados - Universidad Nacional de Colombia
http://creativecommons.org/licenses/by-nc/4.0/
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
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dc.publisher.spa.fl_str_mv Revista Colombiana de Ciencias Químico Farmacéuticas
institution Universidad Nacional de Colombia
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