Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics

The kinetic and thermodynamic selectivity of acylhydrazone formation in dynamic combinatorial libraries (DCL) is described. Competition reactions were generated from hydrazides: isoniazid, 4-nitro-benzohydrazide, 4-dimethylamino-benzohydrazide, and nicotinic hydrazide; as well as the aldehyde deriva...

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Autores:
Gordillo Varela, Mónica Andrea
Zuluaga, Fabio
Chaur Valencia, Manuel Noé
Tipo de recurso:
Article of journal
Fecha de publicación:
2016
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/66282
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/66282
http://bdigital.unal.edu.co/67306/
Palabra clave:
54 Química y ciencias afines / Chemistry
dynamic combinatorial chemistry
acylhydrazones
coordination and configurational dynamics
librerías combinatorias dinámicas
acil-hidrazonas
dinámicas de coordinación y configuración
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
id UNACIONAL2_a9b8067ef4dde4019fe89f3e519aca5e
oai_identifier_str oai:repositorio.unal.edu.co:unal/66282
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics
title Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics
spellingShingle Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics
54 Química y ciencias afines / Chemistry
dynamic combinatorial chemistry
acylhydrazones
coordination and configurational dynamics
librerías combinatorias dinámicas
acil-hidrazonas
dinámicas de coordinación y configuración
title_short Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics
title_full Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics
title_fullStr Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics
title_full_unstemmed Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics
title_sort Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics
dc.creator.fl_str_mv Gordillo Varela, Mónica Andrea
Zuluaga, Fabio
Chaur Valencia, Manuel Noé
dc.contributor.author.spa.fl_str_mv Gordillo Varela, Mónica Andrea
Zuluaga, Fabio
Chaur Valencia, Manuel Noé
dc.subject.ddc.spa.fl_str_mv 54 Química y ciencias afines / Chemistry
topic 54 Química y ciencias afines / Chemistry
dynamic combinatorial chemistry
acylhydrazones
coordination and configurational dynamics
librerías combinatorias dinámicas
acil-hidrazonas
dinámicas de coordinación y configuración
dc.subject.proposal.spa.fl_str_mv dynamic combinatorial chemistry
acylhydrazones
coordination and configurational dynamics
librerías combinatorias dinámicas
acil-hidrazonas
dinámicas de coordinación y configuración
description The kinetic and thermodynamic selectivity of acylhydrazone formation in dynamic combinatorial libraries (DCL) is described. Competition reactions were generated from hydrazides: isoniazid, 4-nitro-benzohydrazide, 4-dimethylamino-benzohydrazide, and nicotinic hydrazide; as well as the aldehyde derivatives: benzaldehyde and 2-pyridine-carboxaldehyde. The obtained species and the distribution of the DCLs were monitored by 1H-NMR spectroscopy finding that those acylhydrazones containing the 4-dimethylamino-benzohydrazide are both the kinetic and thermodynamic product of their respective libraries. Configurational and coordination dynamics for some of these libraries were also investigated. The obtained results allowed the study of the redistribution of components and the amplification of one or more products using light and metal ions as physical and chemical templates, respectively.
publishDate 2016
dc.date.issued.spa.fl_str_mv 2016-09-01
dc.date.accessioned.spa.fl_str_mv 2019-07-03T01:49:51Z
dc.date.available.spa.fl_str_mv 2019-07-03T01:49:51Z
dc.type.spa.fl_str_mv Artículo de revista
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dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/article
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dc.type.content.spa.fl_str_mv Text
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format http://purl.org/coar/resource_type/c_6501
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dc.identifier.issn.spa.fl_str_mv ISSN: 2357-3791
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/66282
dc.identifier.eprints.spa.fl_str_mv http://bdigital.unal.edu.co/67306/
identifier_str_mv ISSN: 2357-3791
url https://repositorio.unal.edu.co/handle/unal/66282
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dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.spa.fl_str_mv https://revistas.unal.edu.co/index.php/rcolquim/article/view/61408
dc.relation.ispartof.spa.fl_str_mv Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Química
Revista Colombiana de Química
dc.relation.references.spa.fl_str_mv Gordillo Varela, Mónica Andrea and Zuluaga, Fabio and Chaur Valencia, Manuel Noé (2016) Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics. Revista Colombiana de Química, 45 (3). pp. 39-50. ISSN 2357-3791
dc.rights.spa.fl_str_mv Derechos reservados - Universidad Nacional de Colombia
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.license.spa.fl_str_mv Atribución-NoComercial 4.0 Internacional
dc.rights.uri.spa.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial 4.0 Internacional
Derechos reservados - Universidad Nacional de Colombia
http://creativecommons.org/licenses/by-nc/4.0/
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá - Facultad de Ciencias - Departamento de Química
institution Universidad Nacional de Colombia
bitstream.url.fl_str_mv https://repositorio.unal.edu.co/bitstream/unal/66282/1/61408-318174-1-PB.pdf
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repository.name.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
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spelling Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Gordillo Varela, Mónica Andrea22e0a9cb-5811-4494-9c2c-107f54fc9623300Zuluaga, Fabio6057ad0d-7a2c-473b-9e89-5e82d3acdc6a300Chaur Valencia, Manuel Noé6233669e-538c-4dfb-9659-d67b72007ff33002019-07-03T01:49:51Z2019-07-03T01:49:51Z2016-09-01ISSN: 2357-3791https://repositorio.unal.edu.co/handle/unal/66282http://bdigital.unal.edu.co/67306/The kinetic and thermodynamic selectivity of acylhydrazone formation in dynamic combinatorial libraries (DCL) is described. Competition reactions were generated from hydrazides: isoniazid, 4-nitro-benzohydrazide, 4-dimethylamino-benzohydrazide, and nicotinic hydrazide; as well as the aldehyde derivatives: benzaldehyde and 2-pyridine-carboxaldehyde. The obtained species and the distribution of the DCLs were monitored by 1H-NMR spectroscopy finding that those acylhydrazones containing the 4-dimethylamino-benzohydrazide are both the kinetic and thermodynamic product of their respective libraries. Configurational and coordination dynamics for some of these libraries were also investigated. The obtained results allowed the study of the redistribution of components and the amplification of one or more products using light and metal ions as physical and chemical templates, respectively.Se describe la selectividad cinética y termodinámica de la formación de acil-hidrazona en librerías combinatorias dinámicas (DCL). Se generaron reacciones competitivas a partir de hidrazidas: isoniazida, 4-nitro-benzohidrazida, 4-dimetilamino-benzohidrazida y hidrazida nicotínica; así como a partir de los derivados de aldehído: benzaldehído y 2-piridin-carboxaldehido. Las especies obtenidas y la distribución de los DCLs fueron monitoreados mediante espectroscopia 1H-NMR, encontrándose que las acil-hidrazonas que contenían la 4-dimetilamino-benzohidrazida son tanto el producto cinético, como el termodinámico de sus respectivas librerías. También se investigaron las dinámicas de configuración y de coordinación para algunas de estas librerías. Los resultados obtenidos permitieron estudiar la redistribución de los componentes y la amplificación de uno o más productos usando luz e iones metálicos como plantillas físicas y químicas, respectivamente.application/pdfspaUniversidad Nacional de Colombia - Sede Bogotá - Facultad de Ciencias - Departamento de Químicahttps://revistas.unal.edu.co/index.php/rcolquim/article/view/61408Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de QuímicaRevista Colombiana de QuímicaGordillo Varela, Mónica Andrea and Zuluaga, Fabio and Chaur Valencia, Manuel Noé (2016) Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics. Revista Colombiana de Química, 45 (3). pp. 39-50. ISSN 2357-379154 Química y ciencias afines / Chemistrydynamic combinatorial chemistryacylhydrazonescoordination and configurational dynamicslibrerías combinatorias dinámicasacil-hidrazonasdinámicas de coordinación y configuraciónAcylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamicsArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL61408-318174-1-PB.pdfapplication/pdf4060892https://repositorio.unal.edu.co/bitstream/unal/66282/1/61408-318174-1-PB.pdfa37e439e4e524e67884e969c62f4829bMD51THUMBNAIL61408-318174-1-PB.pdf.jpg61408-318174-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg9235https://repositorio.unal.edu.co/bitstream/unal/66282/2/61408-318174-1-PB.pdf.jpg4b98f82da594ba5dabc3aae204afea93MD52unal/66282oai:repositorio.unal.edu.co:unal/662822023-05-24 23:02:59.95Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co

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