Desarrollo de útiles génicos para la obtención de un doble mutante de Mycobacterium tuberculosis defectivo en proteínas de membrana MMPL7 y ATPasas tipo P

ilustraciones, fotografías, gráficas, tablas

Autores:: Vásquez Godoy, Vanessa

Tipo de recurso:

Fecha de publicación:: 2021

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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network_acronym_str	UNACIONAL2
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dc.title.spa.fl_str_mv	Desarrollo de útiles génicos para la obtención de un doble mutante de Mycobacterium tuberculosis defectivo en proteínas de membrana MMPL7 y ATPasas tipo P
dc.title.translated.eng.fl_str_mv	Development of gene tools to obtain a Mycobacterium tuberculosis double mutant defective in membrane proteins MMPL7 and P-type ATPases
title	Desarrollo de útiles génicos para la obtención de un doble mutante de Mycobacterium tuberculosis defectivo en proteínas de membrana MMPL7 y ATPasas tipo P
spellingShingle	Desarrollo de útiles génicos para la obtención de un doble mutante de Mycobacterium tuberculosis defectivo en proteínas de membrana MMPL7 y ATPasas tipo P 540 - Química y ciencias afines Mycobacterium tuberculosis Potencia de la Vacuna Enzimas Mycobacterium tuberculosis Vaccine Potency Enzymes Mycobacterium tuberculosis Potencial vacunal Atenuación ATTPasa tipo P Vaccine potential Attenuation MMPL7 P-type ATPase
title_short	Desarrollo de útiles génicos para la obtención de un doble mutante de Mycobacterium tuberculosis defectivo en proteínas de membrana MMPL7 y ATPasas tipo P
title_full	Desarrollo de útiles génicos para la obtención de un doble mutante de Mycobacterium tuberculosis defectivo en proteínas de membrana MMPL7 y ATPasas tipo P
title_fullStr	Desarrollo de útiles génicos para la obtención de un doble mutante de Mycobacterium tuberculosis defectivo en proteínas de membrana MMPL7 y ATPasas tipo P
title_full_unstemmed	Desarrollo de útiles génicos para la obtención de un doble mutante de Mycobacterium tuberculosis defectivo en proteínas de membrana MMPL7 y ATPasas tipo P
title_sort	Desarrollo de útiles génicos para la obtención de un doble mutante de Mycobacterium tuberculosis defectivo en proteínas de membrana MMPL7 y ATPasas tipo P
dc.creator.fl_str_mv	Vásquez Godoy, Vanessa
dc.contributor.advisor.spa.fl_str_mv	Soto Ospina, Carlos Yesid
dc.contributor.author.spa.fl_str_mv	Vásquez Godoy, Vanessa
dc.contributor.researchgroup.spa.fl_str_mv	Bioquímica y Biología Molecular de las Micobacterias
dc.subject.ddc.spa.fl_str_mv	540 - Química y ciencias afines
topic	540 - Química y ciencias afines Mycobacterium tuberculosis Potencia de la Vacuna Enzimas Mycobacterium tuberculosis Vaccine Potency Enzymes Mycobacterium tuberculosis Potencial vacunal Atenuación ATTPasa tipo P Vaccine potential Attenuation MMPL7 P-type ATPase
dc.subject.decs.spa.fl_str_mv	Mycobacterium tuberculosis Potencia de la Vacuna Enzimas
dc.subject.decs.eng.fl_str_mv	Mycobacterium tuberculosis Vaccine Potency Enzymes
dc.subject.proposal.spa.fl_str_mv	Mycobacterium tuberculosis Potencial vacunal Atenuación ATTPasa tipo P
dc.subject.proposal.eng.fl_str_mv	Vaccine potential Attenuation MMPL7 P-type ATPase
description	ilustraciones, fotografías, gráficas, tablas
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-10-28T13:45:19Z
dc.date.available.none.fl_str_mv	2021-10-28T13:45:19Z
dc.date.issued.none.fl_str_mv	2021
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/80627
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/80627 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
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dc.publisher.faculty.spa.fl_str_mv	Facultad de Ciencias
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
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spelling	Atribución-NoComercial-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Soto Ospina, Carlos Yesid90f333e0838e289f724edbb356042e46600Vásquez Godoy, Vanessa295834dcab41fb1a8013ed1a7250c860Bioquímica y Biología Molecular de las Micobacterias2021-10-28T13:45:19Z2021-10-28T13:45:19Z2021https://repositorio.unal.edu.co/handle/unal/80627Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, fotografías, gráficas, tablasEl documento presenta la investigación realizada sobre Mycobacterium tuberculosis, en cuanto a los transportadores de metales como lo son las ATPasas tipo P y los lípidos presentes en la membrana externa de la pared y que están relacionados con la virulencia de la bacteria; por otro lado muestra la metodología de obtención de mutantes delecionados en genes específicos de la micobacteria y la obtención de cepas mutantes desmarcadas de marcadores de selección antibiótica tanto en Mycobacterium tuberculosis como en Mycobacterium smegmatis. (Texto tomado de la fuente).The document presents the research carried out on Mycobacterium tuberculosis, in terms of metal transporters such as P-type ATPases and lipids present in the outer membrane of the wall and which are related to the virulence of the bacterium; on the other hand, it shows the methodology for obtaining deletion mutants in specific genes of the mycobacterium and the obtaining of mutant strains unmarked for antibiotic selection markers in both Mycobacterium tuberculosis and Mycobacterium smegmatis.Incluye anexosMaestríaMagíster en Ciencias - BioquímicaInteracción hospedero-patógenoxxi, 145 páginasapplication/pdfspa540 - Química y ciencias afinesMycobacterium tuberculosisPotencia de la VacunaEnzimasMycobacterium tuberculosisVaccine PotencyEnzymesMycobacterium tuberculosisPotencial vacunalAtenuaciónATTPasa tipo PVaccine potentialAttenuationMMPL7P-type ATPaseDesarrollo de útiles génicos para la obtención de un doble mutante de Mycobacterium tuberculosis defectivo en proteínas de membrana MMPL7 y ATPasas tipo PDevelopment of gene tools to obtain a Mycobacterium tuberculosis double mutant defective in membrane proteins MMPL7 and P-type ATPasesTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBogotá - Ciencias - Maestría en Ciencias - BioquímicaDepartamento de QuímicaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede BogotáWorld Health Organization, “Informe mundial sobre la tuberculosis 2017,” 2017. doi: ISBN 978 92 4 156539 4.R. 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Torres, “Respuesta de las ATPasas tipo P1B a las condiciones de estrés en Mycobacterium tuberculosis,” Universidad Nacional de Colombia, 2018.InvestigadoresPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-84074https://repositorio.unal.edu.co/bitstream/unal/80627/5/license.txt8153f7789df02f0a4c9e079953658ab2MD55ORIGINAL1073687714.2021.pdf1073687714.2021.pdfTesis de Maestría en Ciencias - Bioquímicaapplication/pdf3242188https://repositorio.unal.edu.co/bitstream/unal/80627/6/1073687714.2021.pdf10725f42a91cca1262321ccda87c166cMD56THUMBNAIL1073687714.2021.pdf.jpg1073687714.2021.pdf.jpgGenerated Thumbnailimage/jpeg4275https://repositorio.unal.edu.co/bitstream/unal/80627/7/1073687714.2021.pdf.jpg80fd411e18e835cf2b8f2bbeeb385a5bMD57unal/80627oai:repositorio.unal.edu.co:unal/806272023-07-28 23:04:55.843Repositorio Institucional Universidad Nacional de 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EVESURBIFBPUiBMQSBTRUNSRVRBUsONQSBHRU5FUkFMLiAqTEEgVEVTSVMgQSBQVUJMSUNBUiBERUJFIFNFUiBMQSBWRVJTScOTTiBGSU5BTCBBUFJPQkFEQS4gCgpBbCBoYWNlciBjbGljIGVuIGVsIHNpZ3VpZW50ZSBib3TDs24sIHVzdGVkIGluZGljYSBxdWUgZXN0w6EgZGUgYWN1ZXJkbyBjb24gZXN0b3MgdMOpcm1pbm9zLiBTaSB0aWVuZSBhbGd1bmEgZHVkYSBzb2JyZSBsYSBsaWNlbmNpYSwgcG9yIGZhdm9yLCBjb250YWN0ZSBjb24gZWwgYWRtaW5pc3RyYWRvciBkZWwgc2lzdGVtYS4KClVOSVZFUlNJREFEIE5BQ0lPTkFMIERFIENPTE9NQklBIC0gw5psdGltYSBtb2RpZmljYWNpw7NuIDE5LzEwLzIwMjEK

Desarrollo de útiles génicos para la obtención de un doble mutante de Mycobacterium tuberculosis defectivo en proteínas de membrana MMPL7 y ATPasas tipo P

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