Validation of a chromatographic method for the assay of sulphamethoxazol and trimethoprinm in tablets
The results obtained during the standarization of a methodology by reverse high performance liquid chromatography for the assay of sulfamethoxazol and trimethoprim in tablets are present. For the assay we used a C18 reversed phase column and a mobile phase composed by methanol: phosphoric acid 0.01M...
- Autores:
-
Morales, Liliana
Rojas, Jaime
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 1999
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/23770
- Acceso en línea:
- https://repositorio.unal.edu.co/handle/unal/23770
http://bdigital.unal.edu.co/14807/
- Palabra clave:
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Morales, Liliana520cc366-0f0f-4f27-bfeb-9495fd2a63ff300Rojas, Jaime2a00be03-4ada-44de-bca7-32d4720a142e3002019-06-25T21:18:28Z2019-06-25T21:18:28Z1999https://repositorio.unal.edu.co/handle/unal/23770http://bdigital.unal.edu.co/14807/The results obtained during the standarization of a methodology by reverse high performance liquid chromatography for the assay of sulfamethoxazol and trimethoprim in tablets are present. For the assay we used a C18 reversed phase column and a mobile phase composed by methanol: phosphoric acid 0.01M (23:73). The wavelength for UV detection was fixed at 227 nm. Linearity was achieved between 20 and 140 mcg/mL and between 3 and 28 mcg/mL for sulfamethoxazol and trimethoprim repectively. The accuracy, precision and robutness were demostratedEn el presente artículo se publican los resultados obtenidos durante el proceso de desarrollo y optimización de una metodología analítica por cromatografía líquida para la determinación cuantitativa de sulfametoxazol y trimetoprim en tabletas. El método utiliza una columna con octadecilsilano como fase estacionaria y una fase móvil compuesta por metanol: ácido fosfórico 0.01M ( 23:73 ) como fase móvil y detección espectrofotométrica a 227nm. El método luego de su validación demostró ser exacto, lineal y preciso dentro de un intervalo de concentraciones entre 20 y 140 mcg/mL para sulfametoxazol y entre 4 y 28 mcg/mL para trimetoprim.application/pdfspaRevista Colombiana de Ciencias Químico Farmacéuticashttp://revistas.unal.edu.co/index.php/rccquifa/article/view/9163Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico Farmacéuticas; Vol. 28, núm. 1 (1999) 0034-7418 1909-6356Morales, Liliana and Rojas, Jaime (1999) Validation of a chromatographic method for the assay of sulphamethoxazol and trimethoprinm in tablets. Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 28, núm. 1 (1999) 0034-7418 1909-6356 .Validation of a chromatographic method for the assay of sulphamethoxazol and trimethoprinm in tabletsArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL9163-15358-1-PB.pdfapplication/pdf208723https://repositorio.unal.edu.co/bitstream/unal/23770/1/9163-15358-1-PB.pdf2ece73e8ed888f3fd83c97fd86384deeMD51THUMBNAIL9163-15358-1-PB.pdf.jpg9163-15358-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg2314https://repositorio.unal.edu.co/bitstream/unal/23770/2/9163-15358-1-PB.pdf.jpg459f7a232109f087205ce08c8ff4bbb2MD52unal/23770oai:repositorio.unal.edu.co:unal/237702022-10-21 23:02:36.738Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co |
| dc.title.spa.fl_str_mv |
Validation of a chromatographic method for the assay of sulphamethoxazol and trimethoprinm in tablets |
| title |
Validation of a chromatographic method for the assay of sulphamethoxazol and trimethoprinm in tablets |
| spellingShingle |
Validation of a chromatographic method for the assay of sulphamethoxazol and trimethoprinm in tablets |
| title_short |
Validation of a chromatographic method for the assay of sulphamethoxazol and trimethoprinm in tablets |
| title_full |
Validation of a chromatographic method for the assay of sulphamethoxazol and trimethoprinm in tablets |
| title_fullStr |
Validation of a chromatographic method for the assay of sulphamethoxazol and trimethoprinm in tablets |
| title_full_unstemmed |
Validation of a chromatographic method for the assay of sulphamethoxazol and trimethoprinm in tablets |
| title_sort |
Validation of a chromatographic method for the assay of sulphamethoxazol and trimethoprinm in tablets |
| dc.creator.fl_str_mv |
Morales, Liliana Rojas, Jaime |
| dc.contributor.author.spa.fl_str_mv |
Morales, Liliana Rojas, Jaime |
| description |
The results obtained during the standarization of a methodology by reverse high performance liquid chromatography for the assay of sulfamethoxazol and trimethoprim in tablets are present. For the assay we used a C18 reversed phase column and a mobile phase composed by methanol: phosphoric acid 0.01M (23:73). The wavelength for UV detection was fixed at 227 nm. Linearity was achieved between 20 and 140 mcg/mL and between 3 and 28 mcg/mL for sulfamethoxazol and trimethoprim repectively. The accuracy, precision and robutness were demostrated |
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1999 |
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1999 |
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2019-06-25T21:18:28Z |
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2019-06-25T21:18:28Z |
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Artículo de revista |
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spa |
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http://revistas.unal.edu.co/index.php/rccquifa/article/view/9163 |
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Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico Farmacéuticas Revista Colombiana de Ciencias Químico Farmacéuticas |
| dc.relation.ispartofseries.none.fl_str_mv |
Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 28, núm. 1 (1999) 0034-7418 1909-6356 |
| dc.relation.references.spa.fl_str_mv |
Morales, Liliana and Rojas, Jaime (1999) Validation of a chromatographic method for the assay of sulphamethoxazol and trimethoprinm in tablets. Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 28, núm. 1 (1999) 0034-7418 1909-6356 . |
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Derechos reservados - Universidad Nacional de Colombia |
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