Efecto inhibitorio de sustancias provenientes de especies del género Piper sobre Quorum Sensing de Pseudomonas aeruginosa

ilustraciones, graficas

Autores:: Hernández Moreno, Lida Vanessa

Tipo de recurso:

Fecha de publicación:: 2022

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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network_acronym_str	UNACIONAL2
network_name_str	Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv	Efecto inhibitorio de sustancias provenientes de especies del género Piper sobre Quorum Sensing de Pseudomonas aeruginosa
dc.title.translated.eng.fl_str_mv	Inhibitory effect of substances from Piper species on Quorum Sensing of Pseudomonas aeruginosa
title	Efecto inhibitorio de sustancias provenientes de especies del género Piper sobre Quorum Sensing de Pseudomonas aeruginosa
spellingShingle	Efecto inhibitorio de sustancias provenientes de especies del género Piper sobre Quorum Sensing de Pseudomonas aeruginosa 540 - Química y ciencias afines::547 - Química orgánica Pseudomonas aeruginosa Piper pertomentellum Piperamidas Pseudomonas aeruginosa Quorum Sensing Piper Factores de virulencia Piper pertomentellum Piperamides Pseudomonas aeruginosa Quorum Sensing Piper virulence factors
title_short	Efecto inhibitorio de sustancias provenientes de especies del género Piper sobre Quorum Sensing de Pseudomonas aeruginosa
title_full	Efecto inhibitorio de sustancias provenientes de especies del género Piper sobre Quorum Sensing de Pseudomonas aeruginosa
title_fullStr	Efecto inhibitorio de sustancias provenientes de especies del género Piper sobre Quorum Sensing de Pseudomonas aeruginosa
title_full_unstemmed	Efecto inhibitorio de sustancias provenientes de especies del género Piper sobre Quorum Sensing de Pseudomonas aeruginosa
title_sort	Efecto inhibitorio de sustancias provenientes de especies del género Piper sobre Quorum Sensing de Pseudomonas aeruginosa
dc.creator.fl_str_mv	Hernández Moreno, Lida Vanessa
dc.contributor.advisor.none.fl_str_mv	Patiño Ladino, Oscar Javier Pabón Baquero, Ludy Cristina
dc.contributor.author.none.fl_str_mv	Hernández Moreno, Lida Vanessa
dc.contributor.researchgroup.spa.fl_str_mv	Grupo de Investigación en Química de Productos Naturales Vegetales Bioactivos (Quipronab)
dc.contributor.orcid.spa.fl_str_mv	0000-0001-5427-4398
dc.contributor.cvlac.spa.fl_str_mv	https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000013937
dc.subject.ddc.spa.fl_str_mv	540 - Química y ciencias afines::547 - Química orgánica
topic	540 - Química y ciencias afines::547 - Química orgánica Pseudomonas aeruginosa Piper pertomentellum Piperamidas Pseudomonas aeruginosa Quorum Sensing Piper Factores de virulencia Piper pertomentellum Piperamides Pseudomonas aeruginosa Quorum Sensing Piper virulence factors
dc.subject.decs.none.fl_str_mv	Pseudomonas aeruginosa
dc.subject.proposal.spa.fl_str_mv	Piper pertomentellum Piperamidas Pseudomonas aeruginosa Quorum Sensing Piper Factores de virulencia
dc.subject.proposal.eng.fl_str_mv	Piper pertomentellum Piperamides Pseudomonas aeruginosa Quorum Sensing Piper virulence factors
description	ilustraciones, graficas
publishDate	2022
dc.date.issued.none.fl_str_mv	2022-10-07
dc.date.accessioned.none.fl_str_mv	2023-05-25T18:48:27Z
dc.date.available.none.fl_str_mv	2023-05-25T18:48:27Z
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/83870
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/83870 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
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spelling	Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Patiño Ladino, Oscar Javierf66888847f55b0bd44a6f89b80f89996Pabón Baquero, Ludy Cristinad4bdc0a04765992e92cade8c33486ddbHernández Moreno, Lida Vanessa79a6bcebea9fb5d40d7b7c86b0be551dGrupo de Investigación en Química de Productos Naturales Vegetales Bioactivos (Quipronab)0000-0001-5427-4398https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=00000139372023-05-25T18:48:27Z2023-05-25T18:48:27Z2022-10-07https://repositorio.unal.edu.co/handle/unal/83870Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, graficasPseudomonas aeruginosa es una bacteria oportunista catalogada como de prioridad critica por la OMS y está asociada a una amplia gama de infecciones principalmente en las unidades de cuidados intensivos (UCI). La patogenicidad de esta bacteria está regulada principalmente por el sistema de comunicación denominado Quorum Sensing (QS) que le permite controlar sus factores de virulencia. Este sistema ha sido relacionado con la resistencia a los antibióticos y por ende se ha planteado su inhibición a partir de sustancias provenientes de plantas como una estrategia para el control de microorganismos resistentes. Las plantas del género Piper se han caracterizado por tener propiedades antibacterianas, antifúngicas, insecticidas, antioxidantes y citotóxicas, sin embargo, son pocos los estudios enfocados a la inhibición del QS. Por lo tanto, en el presente estudio se determinó el potencial de las sustancias provenientes de especies del género Piper como inhibidores del QS de P. aeruginosa. La metodología que se llevó a cabo comprendió la identificación de algunas especies pertenecientes al género Piper con potencial de inhibición de QS y la formación de biopelícula. Posteriormente se realizó el estudio fitoquímico sobre una de las especies con mayor potencial de inhibición de QS (P. pertomentellum) para aislar e identificar algunos constituyentes químicos bioactivos. Finalmente, se determinó la acción de constituyentes químicos presentes en especies del género Piper sobre la formación de biopelículas y la producción de algunos factores de virulencia (elastasas, proteasas y piocianina) asociados al QS de P. aeruginosa. Los resultados obtenidos permitieron identificar especies pertenecientes al género Piper con potencial de inhibición de QS, destacándose P. asperiusculum, P. cumanense, P. pertomentellum, P. bogotense, P. sucrense y P. grande por presentar porcentajes de producción menores o igual al 50% en los ensayos de formación de biopelícula o producción de violaceína. El estudio fitoquímico realizado sobre la parte aérea de P. pertomentellum permitió aislar e identificar una nueva piperamida (etiltembamida (C1)), junto con cuatro amidas conocidas (tembamida (C2), cefaradiona B (C3), benzamida (C4) y tembamida (C5)). Los compuestos identificados se reportan por primera vez para la especie y sus estructuras están de acuerdo con la quimiotaxonomía del género Piper. Por último, en este estudio se destaca el potencial inhibitorio de los factores de virulencia y en la formación de biopelícula de los compuestos con potencial multidiana que correspondieron a amidas (C9 y C10), hidroquinonas (C8, C18 y C19) y derivados de ácido benzoico (C16). presentes en especies del género Piper. Adicionalmente, con los resultados obtenidos se establecieron algunas relaciones de estructura-actividad preliminar sobre los compuestos más activos. Esta investigación contribuye a la búsqueda de inhibidores de origen natural que pueden servir como alternativa de control del QS en P. aeruginosa para reducir la resistencia bacteriana, mediante la caracterización del potencial inhibitorio de sustancias provenientes de algunas especies del género Piper. (Texto tomado de la fuente)Pseudomonas aeruginosa is an opportunistic bacterium classified as a critical priority by the WHO and is associated with a wide range of infections mainly in intensive care units (ICU). The pathogenicity of this bacterium is mainly regulated by a communication system called Quorum Sensing (QS) that allows it to control its virulence factors. This system has been related to antibiotic resistance and therefore its inhibition by plant-derived substances has been proposed as a strategy for the control of resistant microorganisms. Plants of the genus Piper have been characterized for having antibacterial, antifungal, insecticidal, antioxidant and cytotoxic properties, however, few studies have focused on the inhibition of the QS. Therefore, in the present study, the potential of substances from Piper species as QS inhibitors of P. aeruginosa was determined. The methodology carried out involved the identification of some species belonging to the genus Piper with potential for QS inhibition and biofilm formation. Subsequently, a phytochemical study was carried out on one of the species with the greatest potential for QS inhibition (P. pertomentellum) to isolate and identify some bioactive chemical constituents. Finally, the action of chemical constituents presents in Piper species on biofilm formation and the production of some virulence factors (elastases, proteases and pyocyanin) associated with QS of P. aeruginosa was determined. The results obtained allowed the identification of species belonging to the genus Piper with QS inhibition potential, with P. asperiusculum, P. cumanense, P. pertomentellum, P. bogotense, P. sucrense and P. grande standing out for presenting production percentages of less than or equal to 50% in the biofilm formation or violacein production assays. The phytochemical study carried out on the aerial part of P. pertomentellum allowed the isolation and identification of a new piperamide (ethyltembamide (C1)), together with four known amides (tembamide (C2), cefaradione B (C3), benzamide (C4) and tembamide (C5)). The identified compounds are reported for the first time for the species and their structures are in agreement with the chemotaxonomy of the genus Piper. Finally, this study highlights the inhibitory potential on virulence factors and biofilm formation of compounds with multidiana potential that corresponded to amides (C9 and C10), hydroquinones (C8, C18 and C19) and benzoic acid derivatives (C16). present in species of the genus Piper. Additionally, with the results obtained, some preliminary structure-activity relationships on the most active compounds were established. This research contributes to the search for inhibitors of natural origin that can serve as an alternative for the control of QS in P. aeruginosa to reduce bacterial resistance, through the characterization of the inhibitory potential of substances from some species of the Piper genus.MinicienciasUniversidad de La SalleUniversidad Nacional de ColombiaMinisterio de Medio Ambiente y Desarrollo SostenibleMaestríaMagister en Ciencias FarmacéuticasQuímica de Productos Naturales167 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias FarmacéuticasFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá540 - Química y ciencias afines::547 - Química orgánicaPseudomonas aeruginosaPiper pertomentellumPiperamidasPseudomonas aeruginosaQuorum SensingPiperFactores de virulenciaPiper pertomentellumPiperamidesPseudomonas aeruginosaQuorum SensingPipervirulence factorsEfecto inhibitorio de sustancias provenientes de especies del género Piper sobre Quorum Sensing de Pseudomonas aeruginosaInhibitory effect of substances from Piper species on Quorum Sensing of Pseudomonas aeruginosaTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMAdonizio, A. 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Revista Latinoamericana de Infectología Pediátrica, 30(4), 147–150. www.medigraphic.org.mxFinanciamiento:Ninguno.Conflictodeintereses:Ninguno.Esteartículopuedeserconsultadoenversióncompletaenhttp://www.medigraphic.com/rlipMincienciasEstudiantesInvestigadoresMaestrosMedios de comunicaciónPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/83870/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1022403783.2022.pdf1022403783.2022.pdfTesis de Maestría en Ciencias Farmacéuticasapplication/pdf3595745https://repositorio.unal.edu.co/bitstream/unal/83870/2/1022403783.2022.pdf2f4cdc1fd5d7a048dbc240ff006c42ddMD52THUMBNAIL1022403783.2022.pdf.jpg1022403783.2022.pdf.jpgGenerated Thumbnailimage/jpeg5278https://repositorio.unal.edu.co/bitstream/unal/83870/3/1022403783.2022.pdf.jpg4843b08ddcddc32113cecf3da047d23eMD53unal/83870oai:repositorio.unal.edu.co:unal/838702024-08-06 23:10:39.01Repositorio Institucional Universidad 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