Validation of a uv spectrophotometric and a reverse high performance methods for the assay of codeine phosphate in tablets
In this paper we present the results obtained during the validation of a UV spectrometric meted for the assay of codeine phosphate in tablets and in uniformity of content test. Also we report the results obtained in the validation of a reverse high performance method developed for the determination...
- Autores:
-
Romero, Diego
Gil, Andrés
Rojas, Jaime
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2000
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/23760
- Acceso en línea:
- https://repositorio.unal.edu.co/handle/unal/23760
http://bdigital.unal.edu.co/14797/
- Palabra clave:
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Romero, Diego71beaf52-6592-4820-b8e5-3b503a0c19df300Gil, Andrés80392404-e5d0-49b5-8393-25d9a037e6ad300Rojas, Jaime2a00be03-4ada-44de-bca7-32d4720a142e3002019-06-25T21:18:18Z2019-06-25T21:18:18Z2000https://repositorio.unal.edu.co/handle/unal/23760http://bdigital.unal.edu.co/14797/In this paper we present the results obtained during the validation of a UV spectrometric meted for the assay of codeine phosphate in tablets and in uniformity of content test. Also we report the results obtained in the validation of a reverse high performance method developed for the determination of codeine phosphate in the dissolution test and in the quality control with release purpose. As stationary bounded phase we used octadecylsilane and a mobile phase composed of acetonitrile-water-triethylamine (4,0: 95,9 : 0,1). The detection was performed at 230 nm.Presentamos en este artículo los resultados del desarrollo de dos métodos analíticos para la determinación de fosfato de codeína en tabletas al igual que los obtenidos en el proceso de validación de los mismos. El primer método destinado a la prueba de uniformidad de contenido se fundamenta en la absorción a 287 nm de soluciones de fosfato de codeína en ácido clorhídrico 0.1 N, mientras que el segundo método consiste en una separación por cromatografía líquida de alta eficiencia empleando como fase móvil de acetonitrilo-agua-trietilamina en proporción 4.0 : 95.9 : 0.1, una columna de octadecilsilano y detección a 230 nm. Este último método se aplicó para la determinación del fosfato de codeína en los ensayos de disolución y de contenido en tabletas.application/pdfspaRevista Colombiana de Ciencias Químico Farmacéuticashttp://revistas.unal.edu.co/index.php/rccquifa/article/view/9153Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico FarmacéuticasRevista Colombiana de Ciencias Químico Farmacéuticas; Vol. 29, núm. 1 (2000) 0034-7418 1909-6356Romero, Diego and Gil, Andrés and Rojas, Jaime (2000) Validation of a uv spectrophotometric and a reverse high performance methods for the assay of codeine phosphate in tablets. Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 29, núm. 1 (2000) 0034-7418 1909-6356 .Validation of a uv spectrophotometric and a reverse high performance methods for the assay of codeine phosphate in tabletsArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL9153-15325-1-PB.pdfapplication/pdf298713https://repositorio.unal.edu.co/bitstream/unal/23760/1/9153-15325-1-PB.pdfee2fc0751890b2f73db25e84c3827781MD51THUMBNAIL9153-15325-1-PB.pdf.jpg9153-15325-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg2089https://repositorio.unal.edu.co/bitstream/unal/23760/2/9153-15325-1-PB.pdf.jpg045c41d27a78fa77febbb772a8ad97e7MD52unal/23760oai:repositorio.unal.edu.co:unal/237602023-10-13 23:06:14.396Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co |
| dc.title.spa.fl_str_mv |
Validation of a uv spectrophotometric and a reverse high performance methods for the assay of codeine phosphate in tablets |
| title |
Validation of a uv spectrophotometric and a reverse high performance methods for the assay of codeine phosphate in tablets |
| spellingShingle |
Validation of a uv spectrophotometric and a reverse high performance methods for the assay of codeine phosphate in tablets |
| title_short |
Validation of a uv spectrophotometric and a reverse high performance methods for the assay of codeine phosphate in tablets |
| title_full |
Validation of a uv spectrophotometric and a reverse high performance methods for the assay of codeine phosphate in tablets |
| title_fullStr |
Validation of a uv spectrophotometric and a reverse high performance methods for the assay of codeine phosphate in tablets |
| title_full_unstemmed |
Validation of a uv spectrophotometric and a reverse high performance methods for the assay of codeine phosphate in tablets |
| title_sort |
Validation of a uv spectrophotometric and a reverse high performance methods for the assay of codeine phosphate in tablets |
| dc.creator.fl_str_mv |
Romero, Diego Gil, Andrés Rojas, Jaime |
| dc.contributor.author.spa.fl_str_mv |
Romero, Diego Gil, Andrés Rojas, Jaime |
| description |
In this paper we present the results obtained during the validation of a UV spectrometric meted for the assay of codeine phosphate in tablets and in uniformity of content test. Also we report the results obtained in the validation of a reverse high performance method developed for the determination of codeine phosphate in the dissolution test and in the quality control with release purpose. As stationary bounded phase we used octadecylsilane and a mobile phase composed of acetonitrile-water-triethylamine (4,0: 95,9 : 0,1). The detection was performed at 230 nm. |
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2000 |
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2000 |
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2019-06-25T21:18:18Z |
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2019-06-25T21:18:18Z |
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spa |
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http://revistas.unal.edu.co/index.php/rccquifa/article/view/9153 |
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Universidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico Farmacéuticas Revista Colombiana de Ciencias Químico Farmacéuticas |
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Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 29, núm. 1 (2000) 0034-7418 1909-6356 |
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Romero, Diego and Gil, Andrés and Rojas, Jaime (2000) Validation of a uv spectrophotometric and a reverse high performance methods for the assay of codeine phosphate in tablets. Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 29, núm. 1 (2000) 0034-7418 1909-6356 . |
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Derechos reservados - Universidad Nacional de Colombia |
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