Evaluación y análisis antigénico de virus de campo como candidatos para la actualización del diagnóstico serológico de Influenza en cerdos en Colombia

ilustraciones, diagramas

Autores:
Ospina Jimenez, Andres Felipe
Tipo de recurso:
Fecha de publicación:
2024
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/86351
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/86351
https://repositorio.unal.edu.co/
Palabra clave:
630 - Agricultura y tecnologías relacionadas::632 - Lesiones, enfermedades, plagas vegetales
Virus de la influenza porcina
Swine influenzavirus
Virus/clasificación
Antígenos/análisis
Virus/classification
Antigens/analysis
Influenzavirus
Antigenicidad
Bioinformática
Influenza porcina
Cartografia antigénica
Swine Influenza
Antigenic characterization
Antigenic cluster
Bioinformatics
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
id UNACIONAL2_a0b0fdc691810942760ecba450db216a
oai_identifier_str oai:repositorio.unal.edu.co:unal/86351
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.none.fl_str_mv Evaluación y análisis antigénico de virus de campo como candidatos para la actualización del diagnóstico serológico de Influenza en cerdos en Colombia
dc.title.translated.eng.fl_str_mv Antigenic analysis of field viruses as candidates for the update of serological diagnosis of Influenza in swine in Colombia
title Evaluación y análisis antigénico de virus de campo como candidatos para la actualización del diagnóstico serológico de Influenza en cerdos en Colombia
spellingShingle Evaluación y análisis antigénico de virus de campo como candidatos para la actualización del diagnóstico serológico de Influenza en cerdos en Colombia
630 - Agricultura y tecnologías relacionadas::632 - Lesiones, enfermedades, plagas vegetales
Virus de la influenza porcina
Swine influenzavirus
Virus/clasificación
Antígenos/análisis
Virus/classification
Antigens/analysis
Influenzavirus
Antigenicidad
Bioinformática
Influenza porcina
Cartografia antigénica
Swine Influenza
Antigenic characterization
Antigenic cluster
Bioinformatics
title_short Evaluación y análisis antigénico de virus de campo como candidatos para la actualización del diagnóstico serológico de Influenza en cerdos en Colombia
title_full Evaluación y análisis antigénico de virus de campo como candidatos para la actualización del diagnóstico serológico de Influenza en cerdos en Colombia
title_fullStr Evaluación y análisis antigénico de virus de campo como candidatos para la actualización del diagnóstico serológico de Influenza en cerdos en Colombia
title_full_unstemmed Evaluación y análisis antigénico de virus de campo como candidatos para la actualización del diagnóstico serológico de Influenza en cerdos en Colombia
title_sort Evaluación y análisis antigénico de virus de campo como candidatos para la actualización del diagnóstico serológico de Influenza en cerdos en Colombia
dc.creator.fl_str_mv Ospina Jimenez, Andres Felipe
dc.contributor.advisor.spa.fl_str_mv Ramírez Nieto, Gloria Consuelo
Rincón Monroy, Maria Antonia
dc.contributor.author.spa.fl_str_mv Ospina Jimenez, Andres Felipe
dc.contributor.researchgroup.spa.fl_str_mv Microbiología y Epidemiología
dc.contributor.orcid.spa.fl_str_mv 0000-0003-2836-7923
dc.contributor.cvlac.spa.fl_str_mv Andres Felipe Ospina [0001884053]
dc.subject.ddc.spa.fl_str_mv 630 - Agricultura y tecnologías relacionadas::632 - Lesiones, enfermedades, plagas vegetales
topic 630 - Agricultura y tecnologías relacionadas::632 - Lesiones, enfermedades, plagas vegetales
Virus de la influenza porcina
Swine influenzavirus
Virus/clasificación
Antígenos/análisis
Virus/classification
Antigens/analysis
Influenzavirus
Antigenicidad
Bioinformática
Influenza porcina
Cartografia antigénica
Swine Influenza
Antigenic characterization
Antigenic cluster
Bioinformatics
dc.subject.agrovoc.spa.fl_str_mv Virus de la influenza porcina
dc.subject.agrovoc.eng.fl_str_mv Swine influenzavirus
dc.subject.decs.spa.fl_str_mv Virus/clasificación
Antígenos/análisis
dc.subject.decs.eng.fl_str_mv Virus/classification
Antigens/analysis
dc.subject.proposal.spa.fl_str_mv Influenzavirus
Antigenicidad
Bioinformática
Influenza porcina
Cartografia antigénica
dc.subject.proposal.eng.fl_str_mv Swine Influenza
Antigenic characterization
Antigenic cluster
Bioinformatics
description ilustraciones, diagramas
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-07-02T20:47:06Z
dc.date.available.none.fl_str_mv 2024-07-02T20:47:06Z
dc.date.issued.none.fl_str_mv 2024
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/86351
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/86351
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.indexed.spa.fl_str_mv Agrosavia
Agrovoc
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dc.publisher.faculty.spa.fl_str_mv Facultad de Medicina Veterinaria y de Zootecnia
dc.publisher.place.spa.fl_str_mv Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá
institution Universidad Nacional de Colombia
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spelling Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Ramírez Nieto, Gloria Consuelo4826613b06a65b088940e0eb7ed6844dRincón Monroy, Maria Antoniaadf677b1c806c702f21f8ef0cecc186dOspina Jimenez, Andres Felipe83bd4069b2264e18188d49d30861f059600Microbiología y Epidemiología0000-0003-2836-7923Andres Felipe Ospina [0001884053]2024-07-02T20:47:06Z2024-07-02T20:47:06Z2024https://repositorio.unal.edu.co/handle/unal/86351Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasEl Virus de Influenza A (VIA) en cerdos ocasiona infección respiratoria y se asocia al Complejo Respiratorio Porcino, generando impacto económico y sanitario. En Colombia, la limitada información sobre el VIA en cerdos ha llevado al uso de cepas de referencia internacional en pruebas de diagnóstico serológico. La representatividad de dichas cepas en el contexto colombiano es incierta, lo que afecta la precisión del diagnóstico nacional. Por lo tanto, el objetivo del presente estudio fue caracterizar molecular y antigénicamente VIA porcinos presentes en el país, elegir cepas representativas y verificar su utilidad como antígenos en pruebas serológicas. A través de aproximaciones basadas en secuencia y diversas metodologías moleculares, se caracterizaron 38 VIA provenientes de ocho regiones del país, detectados entre 2008 – 2021. Se eligieron siete candidatos virales, los cuales fueron evaluados mediante pruebas de Inhibición de Hemaglutinación (HI). Los resultados obtenidos muestran que en el país existe diversidad filogenética, lo que se evidencia por la identificación del subtipo H1N1 (clados 1A.3.3.2 y 1A.1) y con el reporte por primera vez de virus de los subtipos H1N2 y H3N2. Adicionalmente, se encontraron cinco clústeres antigénicos en el VIA H1 y se reconoció el H3 como una nueva variante genética y antigénica. Los siete candidatos elegidos permitieron una mejor detección de anticuerpos con respecto a las cepas de referencia utilizadas hasta el momento en el país, mostrando buena repetibilidad en la ejecución de la prueba de HI. A través de asociaciones estadísticas se logró reducir el número de candidatos propuestos a cuatro, los cuales pueden ser potencialmente usados como antígenos de referencia en las pruebas serológicas para VIA en cerdos en el país. (Texto tomado de la fuente).Influenza A Virus (IAV) in pigs causes respiratory infections and is associated to the Porcine Respiratory Disease Complex, accounting for economical loses and sanitary issues. In Colombia, knowledge about swine IAV is scarce. This has led to the implementation of international reference strains for serological assays. Representativity of these strains in the Colombian context is unknown affecting the national diagnostic capacity. Therefore, this study aimed the molecular and antigenic characterization of swine IAV in the county, the selection of representative strains, and the assessment of their value as antigens for serological assays. 38 IAV from eight regions of the country detected between 2008 – 2021 were characterized through sequence-based approaches. Seven candidates were selected for serological evaluation using the Hemagglutination Assay (HI). The results showed that there is a significant phylogenetic diversity in the country. This is supported by the recognition of the H1N1 subtype (clades: 1A.3.3.2 and 1A.1) and the identification for the first time of the H1N2 and H3N2 virus subtypes. Five antigenic clusters were recognized in the IAV H1 subtype as well as one in the H3 subtype representing a novel genetic and phylogenetic variant. The seven selected candidates allowed a higher antibody detection than the reference strains used until now in the country and they exhibited good repeatability among performs of the HI assay. Based on statistical associations the number of proposed candidates could be reduced to four. These candidates can potentially be included in serological assays in the country.Texto en inglés y españolMaestríaMagíster en Salud Animal o Magíster en Producción AnimalMicrobiología e inmunologíaxviii, 189 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina Veterinaria y de Zootecnia - Maestría en Salud y Producción AnimalFacultad de Medicina Veterinaria y de ZootecniaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá630 - Agricultura y tecnologías relacionadas::632 - Lesiones, enfermedades, plagas vegetalesVirus de la influenza porcinaSwine influenzavirusVirus/clasificaciónAntígenos/análisisVirus/classificationAntigens/analysisInfluenzavirusAntigenicidadBioinformáticaInfluenza porcinaCartografia antigénicaSwine InfluenzaAntigenic characterizationAntigenic clusterBioinformaticsEvaluación y análisis antigénico de virus de campo como candidatos para la actualización del diagnóstico serológico de Influenza en cerdos en ColombiaAntigenic analysis of field viruses as candidates for the update of serological diagnosis of Influenza in swine in ColombiaTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMColombiahttp://vocab.getty.edu/page/tgn/1000050AgrosaviaAgrovocOspina-Jimenez, A. 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Journal of Visualized Experiments : JoVE, 2016(115), 54573. https://doi.org/10.3791/54573PorkcolombiaEstudiantesInvestigadoresPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/86351/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINALTESIS_AFOJ.pdfTESIS_AFOJ.pdfTesis de Maestría en Salud y Producción Animalapplication/pdf4150221https://repositorio.unal.edu.co/bitstream/unal/86351/2/TESIS_AFOJ.pdf7e3ac7441c3f466335c24f24109e5eeeMD52THUMBNAILTESIS_AFOJ.pdf.jpgTESIS_AFOJ.pdf.jpgGenerated Thumbnailimage/jpeg5498https://repositorio.unal.edu.co/bitstream/unal/86351/3/TESIS_AFOJ.pdf.jpg52f03ad2f8997b4ae73e1e2b5abcb6ceMD53unal/86351oai:repositorio.unal.edu.co:unal/863512024-08-25 23:12:02.801Repositorio Institucional Universidad Nacional de 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