Obtención y caracterización de dos scaffolds poliméricos, cargados con compuesto con potencial bioactivo, utilizando la técnica de electrospinning
ilustraciones, fotografías, diagramas
- Autores:
-
Quiroga Vergel, Ángela Viviana
- Tipo de recurso:
- Fecha de publicación:
- 2023
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/84497
- Palabra clave:
- 620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
COMPUESTOS POLIMERICOS
Polymeric composites
Electrospinning
Solution Blow Spinning
Ibuprofeno
Policaprolactona
Esterilización UV
Ibuprofen
Polycaprolactone
UV Sterilization
- Rights
- openAccess
- License
- Reconocimiento 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Obtención y caracterización de dos scaffolds poliméricos, cargados con compuesto con potencial bioactivo, utilizando la técnica de electrospinning |
| dc.title.translated.eng.fl_str_mv |
Fabrication and characterization of two polymeric scaffolds, loaded with potentially bioactive compound, using the electrospinning technique |
| title |
Obtención y caracterización de dos scaffolds poliméricos, cargados con compuesto con potencial bioactivo, utilizando la técnica de electrospinning |
| spellingShingle |
Obtención y caracterización de dos scaffolds poliméricos, cargados con compuesto con potencial bioactivo, utilizando la técnica de electrospinning 620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería COMPUESTOS POLIMERICOS Polymeric composites Electrospinning Solution Blow Spinning Ibuprofeno Policaprolactona Esterilización UV Ibuprofen Polycaprolactone UV Sterilization |
| title_short |
Obtención y caracterización de dos scaffolds poliméricos, cargados con compuesto con potencial bioactivo, utilizando la técnica de electrospinning |
| title_full |
Obtención y caracterización de dos scaffolds poliméricos, cargados con compuesto con potencial bioactivo, utilizando la técnica de electrospinning |
| title_fullStr |
Obtención y caracterización de dos scaffolds poliméricos, cargados con compuesto con potencial bioactivo, utilizando la técnica de electrospinning |
| title_full_unstemmed |
Obtención y caracterización de dos scaffolds poliméricos, cargados con compuesto con potencial bioactivo, utilizando la técnica de electrospinning |
| title_sort |
Obtención y caracterización de dos scaffolds poliméricos, cargados con compuesto con potencial bioactivo, utilizando la técnica de electrospinning |
| dc.creator.fl_str_mv |
Quiroga Vergel, Ángela Viviana |
| dc.contributor.advisor.none.fl_str_mv |
Clavijo-Grimaldo, Dianney Lancheros, Ruth |
| dc.contributor.author.none.fl_str_mv |
Quiroga Vergel, Ángela Viviana |
| dc.contributor.orcid.spa.fl_str_mv |
Ángela Quiroga [0000000349127451] |
| dc.subject.ddc.spa.fl_str_mv |
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería |
| topic |
620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería COMPUESTOS POLIMERICOS Polymeric composites Electrospinning Solution Blow Spinning Ibuprofeno Policaprolactona Esterilización UV Ibuprofen Polycaprolactone UV Sterilization |
| dc.subject.lemb.spa.fl_str_mv |
COMPUESTOS POLIMERICOS |
| dc.subject.lemb.eng.fl_str_mv |
Polymeric composites |
| dc.subject.proposal.spa.fl_str_mv |
Electrospinning Solution Blow Spinning Ibuprofeno Policaprolactona Esterilización UV |
| dc.subject.proposal.eng.fl_str_mv |
Ibuprofen Polycaprolactone UV Sterilization |
| description |
ilustraciones, fotografías, diagramas |
| publishDate |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2023-08-08T20:05:04Z |
| dc.date.available.none.fl_str_mv |
2023-08-08T20:05:04Z |
| dc.date.issued.none.fl_str_mv |
2023 |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Maestría |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/masterThesis |
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info:eu-repo/semantics/acceptedVersion |
| dc.type.content.spa.fl_str_mv |
Text |
| dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/TM |
| status_str |
acceptedVersion |
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https://repositorio.unal.edu.co/handle/unal/84497 |
| dc.identifier.instname.spa.fl_str_mv |
Universidad Nacional de Colombia |
| dc.identifier.reponame.spa.fl_str_mv |
Repositorio Institucional Universidad Nacional de Colombia |
| dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.unal.edu.co/ |
| url |
https://repositorio.unal.edu.co/handle/unal/84497 https://repositorio.unal.edu.co/ |
| identifier_str_mv |
Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
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spa |
| language |
spa |
| dc.relation.references.spa.fl_str_mv |
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Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Clavijo-Grimaldo, Dianney57bf7d1e03e2a7e3c2ac8a45df1a68f0Lancheros, Ruth156ee63f628309463773b9f2910f4538Quiroga Vergel, Ángela Vivianaffd8d83d197420d1a0a6abbe984c4808Ángela Quiroga [0000000349127451]2023-08-08T20:05:04Z2023-08-08T20:05:04Z2023https://repositorio.unal.edu.co/handle/unal/84497Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, fotografías, diagramasAntiinflamatorios no esteroideos como el ibuprofeno (IBU), suelen ser administrados por vía oral para tratar enfermedades articulares. Sin embargo, presentan efectos secundarios a largo plazo como riesgo de infarto, accidente cerebrovascular, insuficiencia renal, sangrado gastrointestinal, entre otros. En etapas avanzadas se presentan daños en el cartílago, por lo que las últimas investigaciones se han orientado a dispositivos (scaffold) que puedan reparar este tejido. Esta tesis pretende contribuir a estos nuevos métodos, con scaffolds que tengan el poder de coadyuvar en el tratamiento de estas enfermedades, disminuir el dolor y reducir los efectos segundarios. Para esto se elaboran dos scaffold de PCL cargados con 10% de IBU y se evalúa la influencia de la técnica de fabricación del scaffold, electrospinning (SE) y solution blow spinning (SBS). Se caracterizaron por microscopía SEM, FTIR, tensión, ángulo de contacto, isoterma-BET y DSC. También fue analizada la cinética de liberación de IBU, donde se obtuvo una liberación rápida del fármaco, debido al pequeño tamaño de la molécula a liberar y la porosidad interna de las fibras. Los resultados de la caracterización mostraron que, con la incorporación de IBU se obtienen fibras de menor diámetro y scaffold con mayor resistencia a la tensión y fragilidad. Por otro lado, el proceso de esterilización genera cambios morfológicos en las fibras, aumentando la cristalinidad y suprimiendo la hidrofobicidad de PCL, lo que favorecería la biocompatibilidad del scaffold. SBS se destacó por presentar una liberación más controlada y SE por producir fibras más homogéneas y con mejores propiedades mecánicas. (Texto tomado de la fuente)Non-steroidal anti-inflammatory drugs such as ibuprofen (IBU) are usually administered orally to treat joint diseases. However, they have long-term side effects such as the risk of heart attack, stroke, kidney failure, gastrointestinal bleeding, among others. In advanced stages, cartilage damage occurs, so the latest research has focused on devices (scaffolds) that can repair this tissue. This thesis aims to contribute to these new methods, with scaffolds that be able to assist in the treatment of these diseases, reduce pain and side effects. Hence, two PCL scaffolds loaded with 10% IBU are made and the influence of the scaffold manufacturing technique, electrospinning (SE) and solution blow spinning (SBS), is evaluated. They were characterized by SEM microscopy, FTIR, strain, contact angle, isotherm-BET, and DSC. The release kinetics of IBU was also analyzed, where a rapid release of the drug was obtained, due to the small size of the molecule to be released and the internal porosity of the fibers. The results of the characterization reveal that with the incorporation of IBU fibers of smaller diameter and scaffold with higher resistance to tension and brittleness are obtained. On the other hand, the sterilization process generates morphological changes in the fibers, increasing the crystallinity and suppressing the hydrophobicity of PCL, creasing the biocompatibility of the scaffold. SBS stands out for a more controlled release and SE for producing more homogeneous fibers with better mechanical properties.MaestríaMagíster en Ingeniería - Materiales y ProcesosMateriales Poliméricosxix, 114 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ingeniería - Maestría en Ingeniería - Materiales y ProcesosFacultad de IngenieríaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingenieríaCOMPUESTOS POLIMERICOSPolymeric compositesElectrospinningSolution Blow SpinningIbuprofenoPolicaprolactonaEsterilización UVIbuprofenPolycaprolactoneUV SterilizationObtención y caracterización de dos scaffolds poliméricos, cargados con compuesto con potencial bioactivo, utilizando la técnica de electrospinningFabrication and characterization of two polymeric scaffolds, loaded with potentially bioactive compound, using the electrospinning techniqueTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TM[1] J. 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Ramakrishna, «A review on polymer nanofibers by electrospinning and their applications in nanocomposites», Composites Science and Technology, vol. 63, n.o 15, pp. 2223-2253, nov. 2003, doi: 10.1016/S0266-3538(03)00178-7.InvestigadoresMaestrosPúblico generalORIGINALTesis de Maestria - Ángela Quiroga - 1032466395.pdfTesis de Maestria - Ángela Quiroga - 1032466395.pdfTesis de Maestría en Ingeniería - Materiales y Procesosapplication/pdf5960254https://repositorio.unal.edu.co/bitstream/unal/84497/2/Tesis%20de%20Maestria%20-%20%c3%81ngela%20Quiroga%20-%201032466395.pdff2205ef541b828144b5189e4d5806697MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/84497/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51THUMBNAILTesis de Maestria - Ángela Quiroga - 1032466395.pdf.jpgTesis de Maestria - Ángela Quiroga - 1032466395.pdf.jpgGenerated 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