Factores asociados a la supervivencia a 5 años y los costos en la atención de pacientes con trasplante renal en Colombia
ilustraciones, graficas, mapas
- Autores:
-
Espinel Pachón, Cristian Felipe
- Tipo de recurso:
- Fecha de publicación:
- 2022
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/81992
- Palabra clave:
- 610 - Medicina y salud::616 - Enfermedades
Trasplante de Riñón
Costo de Enfermedad
Kidney Transplantation
Cost of Illness
Colombia
Trasplante renal
Supervivencia
Costos
Factores de riesgo
Colombia
Kidney transplantation
Survival
Costs
Risk factors
- Rights
- openAccess
- License
- Atribución-NoComercial-SinDerivadas 4.0 Internacional
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| dc.title.spa.fl_str_mv |
Factores asociados a la supervivencia a 5 años y los costos en la atención de pacientes con trasplante renal en Colombia |
| dc.title.translated.eng.fl_str_mv |
5-year patient survival, health care costs, and related factors in patients with renal transplant in Colombia |
| title |
Factores asociados a la supervivencia a 5 años y los costos en la atención de pacientes con trasplante renal en Colombia |
| spellingShingle |
Factores asociados a la supervivencia a 5 años y los costos en la atención de pacientes con trasplante renal en Colombia 610 - Medicina y salud::616 - Enfermedades Trasplante de Riñón Costo de Enfermedad Kidney Transplantation Cost of Illness Colombia Trasplante renal Supervivencia Costos Factores de riesgo Colombia Kidney transplantation Survival Costs Risk factors |
| title_short |
Factores asociados a la supervivencia a 5 años y los costos en la atención de pacientes con trasplante renal en Colombia |
| title_full |
Factores asociados a la supervivencia a 5 años y los costos en la atención de pacientes con trasplante renal en Colombia |
| title_fullStr |
Factores asociados a la supervivencia a 5 años y los costos en la atención de pacientes con trasplante renal en Colombia |
| title_full_unstemmed |
Factores asociados a la supervivencia a 5 años y los costos en la atención de pacientes con trasplante renal en Colombia |
| title_sort |
Factores asociados a la supervivencia a 5 años y los costos en la atención de pacientes con trasplante renal en Colombia |
| dc.creator.fl_str_mv |
Espinel Pachón, Cristian Felipe |
| dc.contributor.advisor.none.fl_str_mv |
Contreras Villamizar, Kateir Mariel Buitrago Gutiérrez, Giancarlo |
| dc.contributor.author.none.fl_str_mv |
Espinel Pachón, Cristian Felipe |
| dc.contributor.researchgroup.spa.fl_str_mv |
Instituto de Investigaciones Clínicas – Facultad de Medicina |
| dc.subject.ddc.spa.fl_str_mv |
610 - Medicina y salud::616 - Enfermedades |
| topic |
610 - Medicina y salud::616 - Enfermedades Trasplante de Riñón Costo de Enfermedad Kidney Transplantation Cost of Illness Colombia Trasplante renal Supervivencia Costos Factores de riesgo Colombia Kidney transplantation Survival Costs Risk factors |
| dc.subject.other.spa.fl_str_mv |
Trasplante de Riñón Costo de Enfermedad |
| dc.subject.other.eng.fl_str_mv |
Kidney Transplantation Cost of Illness |
| dc.subject.proposal.spa.fl_str_mv |
Colombia Trasplante renal Supervivencia Costos Factores de riesgo |
| dc.subject.proposal.eng.fl_str_mv |
Colombia Kidney transplantation Survival Costs Risk factors |
| description |
ilustraciones, graficas, mapas |
| publishDate |
2022 |
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2022-08-22T19:25:38Z |
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2022-08-22T19:25:38Z |
| dc.date.issued.none.fl_str_mv |
2022-08-16 |
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Trabajo de grado - Especialidad Médica |
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info:eu-repo/semantics/masterThesis |
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http://purl.org/redcol/resource_type/TM |
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https://repositorio.unal.edu.co/handle/unal/81992 |
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Universidad Nacional de Colombia |
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Repositorio Institucional Universidad Nacional de Colombia |
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https://repositorio.unal.edu.co/ |
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https://repositorio.unal.edu.co/handle/unal/81992 https://repositorio.unal.edu.co/ |
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Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia |
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Jankowski J, Floege J, Fliser D, Böhm M, Marx N. Cardiovascular Disease in Chronic Kidney Disease: Pathophysiological Insights and Therapeutic Options. Circulation [Internet]. 2021 Mar 16 [cited 2022 Jul 27];143(11):1157–72. Available from: https://pubmed.ncbi.nlm.nih.gov/33720773/ Bikbov B, Purcell CA, Levey AS, Smith M, Abdoli A, Abebe M, et al. Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet (London, England) [Internet]. 2020 Feb 29 [cited 2022 Jul 27];395(10225):709–33. Available from: https://pubmed.ncbi.nlm.nih.gov/32061315/ Wolfe RA, Ashby VB, Milford EL, Ojo AO, Ettenger RE, Agodoa LYC, et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med [Internet]. 1999 Dec 2 [cited 2022 Jul 27];341(23):1725–30. Available from: https://pubmed.ncbi.nlm.nih.gov/10580071/ Hariharan S, Israni AK, Danovitch G. Long-Term Survival after Kidney Transplantation. N Engl J Med [Internet]. 2021 Aug 19 [cited 2022 Jul 27];385(8):729–43. Available from: https://pubmed.ncbi.nlm.nih.gov/34407344/ Elshahat S, Cockwell P, Maxwell AP, Griffin M, O’Brien T, O’Neill C. The impact of chronic kidney disease on developed countries from a health economics perspective: A systematic scoping review. PLoS One [Internet]. 2020 [cited 2022 Jul 27];15(3). Available from: https://pubmed.ncbi.nlm.nih.gov/32208435/ ERC | Cuenta de Alto Costo [Internet]. [cited 2022 Jul 27]. Available from: https://cuentadealtocosto.org/site/erc/ CKD Evaluation and Management – KDIGO [Internet]. [cited 2022 Jul 27]. Available from: https://kdigo.org/guidelines/ckd-evaluation-and-management/ Vadakedath S, Kandi V. Dialysis: A Review of the Mechanisms Underlying Complications in the Management of Chronic Renal Failure. Cureus [Internet]. 2017 Aug 24 [cited 2022 Jul 27];9(8). Available from: https://pubmed.ncbi.nlm.nih.gov/29067226/ Rak A, Raina R, Suh TT, Krishnappa V, Darusz J, Sidoti CW, et al. Palliative care for patients with end-stage renal disease: approach to treatment that aims to improve quality of life and relieve suffering for patients (and families) with chronic illnesses. Clin Kidney J [Internet]. 2017 Feb 1 [cited 2022 Jul 27];10(1):68–73. Available from: https://pubmed.ncbi.nlm.nih.gov/28638606/ Teitelbaum I. Peritoneal Dialysis. Ingelfinger JR, editor. N Engl J Med [Internet]. 2021 Nov 4 [cited 2022 Jul 27];385(19):1786–95. Available from: https://pubmed.ncbi.nlm.nih.gov/34731538/ Criterios de Asignación para Trasplante Renal en Colombia. Chadban SJ, Ahn C, Axelrod DA, Foster BJ, Kasiske BL, Kher V, et al. KDIGO Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation. Transplantation [Internet]. 2020 Apr 1 [cited 2022 Jul 27];104(4S1 Suppl 1):S11–103. Available from: https://pubmed.ncbi.nlm.nih.gov/32301874/ Why living-donor renal transplant yields better outcomes than cadaver renal transplant? | Nefrología [Internet]. [cited 2022 Jul 27]. Available from: https://revistanefrologia.com/en-why-living-donor-renal-transplant-yields-articulo-X2013251408032916 Arnol M, Naumovic R, Dimitrov EP, Racki S, Bucsa CA, Covic A, et al. Immunosuppressive regimens following kidney transplantation in five European countries: The observational RECORD study. Transplant Reports [Internet]. 2020 Sep 1 [cited 2022 Jul 27];5(3). Available from: https://www.bib.irb.hr/1107507 CHAPTER 7 Reporting the incidence and prevalence of renal transplantation in Australia and New Zealand; summarizing immunosuppression regimens, rejection episodes, graft survival and patient survival. [cited 2022 Jul 27]; Available from: http://www.anzdata.org.au Shabaka A, Cases-Corona C, Fernandez-Juarez G. Therapeutic Insights in Chronic Kidney Disease Progression. Front Med [Internet]. 2021 Feb 23 [cited 2022 Jul 27];8. Available from: https://pubmed.ncbi.nlm.nih.gov/33708784/ REGISTROS - SLANH [Internet]. [cited 2022 Jul 27]. Available from: https://www.slanh.net/registros/ Situación de la enfermedad renal crónica, la hipertensión arterial y diabetes mellitus en Colombia 2020 | Cuenta de Alto Costo [Internet]. [cited 2022 Jul 27]. Available from: https://cuentadealtocosto.org/site/publicaciones/situacion-de-la-enfermedad-renal-cronica-la-hipertension-arterial-y-diabetes-mellitus-en-colombia-2020/ Miskulin D, Bragg-Gresham J, Gillespie BW, Tentori F, Pisoni RL, Tighiouart H, et al. Key comorbid conditions that are predictive of survival among hemodialysis patients. Clin J Am Soc Nephrol [Internet]. 2009 [cited 2022 Jul 27];4(11):1818–26. Available from: https://pubmed.ncbi.nlm.nih.gov/19808231/ Influence of initial nutritional status on continuous ambulatory peritoneal dialysis patient survival - PubMed [Internet]. [cited 2022 Jul 27]. Available from: https://pubmed.ncbi.nlm.nih.gov/10716579/ Shafi T, Jaar BG, Plantinga LC, Fink NE, Sadler JH, Parekh RS, et al. Association of residual urine output with mortality, quality of life, and inflammation in incident hemodialysis patients: the Choices for Healthy Outcomes in Caring for End-Stage Renal Disease (CHOICE) Study. Am J Kidney Dis [Internet]. 2010 [cited 2022 Jul 27];56(2):348–58. Available from: https://pubmed.ncbi.nlm.nih.gov/20605303/ Annual Data Report | USRDS [Internet]. [cited 2022 Jul 27]. Available from: https://www.usrds.org/annual-data-report/ Wang V, Vilme H, Maciejewski ML, Boulware LE. The Economic Burden of Chronic Kidney Disease and End-Stage Renal Disease. Semin Nephrol [Internet]. 2016 Jul 1 [cited 2022 Jul 27];36(4):319–30. Available from: https://pubmed.ncbi.nlm.nih.gov/27475662/ Liyanage T, Ninomiya T, Jha V, Neal B, Patrice HM, Okpechi I, et al. Worldwide access to treatment for end-stage kidney disease: a systematic review. Lancet (London, England) [Internet]. 2015 May 16 [cited 2022 Jul 27];385(9981):1975–82. Available from: https://pubmed.ncbi.nlm.nih.gov/25777665/ Yang F, Liao M, Wang P, Yang Z, Liu Y. The Cost-Effectiveness of Kidney Replacement Therapy Modalities: A Systematic Review of Full Economic Evaluations. Appl Health Econ Health Policy [Internet]. 2021 Mar 1 [cited 2022 Jul 27];19(2):163–80. Available from: https://pubmed.ncbi.nlm.nih.gov/33047212/ Rosselli D, Rueda J-D, Diaz C. Cost-effectiveness of kidney transplantation compared with chronic dialysis in end-stage renal disease. Saudi J Kidney Dis Transpl [Internet]. 2015 [cited 2022 Jul 27];26(4):733. Available from: https://pubmed.ncbi.nlm.nih.gov/26178546/ Situación del Trasplante Renal en Colombia 2015 | Cuenta de Alto Costo [Internet]. [cited 2022 Jul 28]. Available from: https://cuentadealtocosto.org/site/publicaciones/situacion-del-trasplante-renal-en-colombia-2015/ Supervivencia y mortalidad por tipo de terapia de reemplazo renal, en pacientes con enfermedad renal crónica terminal, en una cohorte de pacientes asegurados en Colombia [Internet]. [cited 2022 Jul 28]. Available from: https://repository.urosario.edu.co/handle/10336/12115 Pinto-Ramirez J, Garcia-Lopez A, Salcedo-Herrera S, Patino-Jaramillo N, Garcia-Lopez J, Barbosa-Salinas J, et al. Risk factors for graft loss and death among kidney transplant recipients: A competing risk analysis. Gołębiewska J, editor. PLoS One [Internet]. 2022 Jul 14 [cited 2022 Jul 28];17(7):e0269990. Available from: https://pubmed.ncbi.nlm.nih.gov/35834500/ Hart A, Smith JM, Skeans MA, Gustafson SK, Stewart DE, Cherikh WS, et al. OPTN/SRTR 2014 ANNUAL DATA REPORT: KIDNEY. Am J Transplant [Internet]. 2016 Jan 1 [cited 2022 Jul 28];16(Suppl 2):11. Available from: /pmc/articles/PMC5541687/ Annual reports - ERA Registry | ERA [Internet]. [cited 2022 Jul 28]. Available from: https://www.era-online.org/en/registry/publications/annual-reports/#2013 ANZDATA 38th Annual Report 2015 (Data to 2014) - ANZDATA [Internet]. [cited 2022 Jul 28]. Available from: https://www.anzdata.org.au/report/anzdata-38th-annual-report-2015/ Chinese medical association Healthcare in China Report On Organ Transplantation Developement in China(2015–2018) [Internet]. [cited 2022 Jul 28]. Available from: https://en.cma.org.cn/art/2020/5/14/art_692_34498.html Yagisawa T, Mieno M, Yoshimura N, Yuzawa K, Takahara S. Current status of kidney transplantation in Japan in 2015: The data of the Kidney Transplant Registry Committee, Japanese Society for Clinical Renal Transplantation and the Japan Society for Transplantation. Ren Replace Ther [Internet]. 2016 Dec 7 [cited 2022 Jul 28];2(1):1–7. Available from: https://rrtjournal.biomedcentral.com/articles/10.1186/s41100-016-0080-9 Ghelichi-Ghojogh M, Ghaem H, Mohammadizadeh F, Vali M, Ahmed F, Hassanipour S, et al. Graft and Patient Survival Rates in Kidney Transplantation, and Their Associated Factors: A Systematic Review and Meta-Analysis. Iran J Public Health [Internet]. 2021 Jul 22 [cited 2022 Jul 28];50(8):1555–63. Available from: https://pubmed.ncbi.nlm.nih.gov/34917526/ Javeson C. Tam M, B. Cabanayan-Casasola C, A.Danguilan R. Long term graft and recipient outcome of deceased donor renal transplantation at the National Kidney and Transplant Institute. Trends Transplant. 2017;10(3). Larpparisuth N, Cheungpasitporn W, Lumpaopong A. Global Perspective on Kidney Transplantation: Thailand. Kidney360 [Internet]. 2021 Jul 29 [cited 2022 Jul 28];2(7):1163–5. Available from: https://pubmed.ncbi.nlm.nih.gov/35368352/ Hassan S, Ndonga A. Patient and alograft survival after transplantation with a living donor kidney: 14 years experience. East Cent African J Surg [Internet]. 2016 Jun 2 [cited 2022 Jul 28];8(1). Available from: https://www.ajol.info/index.php/ecajs/article/view/136778 IRODaT - International Registry on Organ Donation and Transplantation [Internet]. [cited 2022 Jul 28]. Available from: https://www.irodat.org/ Dimensionamento dos Transplantes no Brasil e em cada estado (2013-2020) [Internet]. [cited 2022 Jul 28]. Available from: https://site.abto.org.br/publicacao/xxvi-no-4-anual/ Registro Argentino de Diálisis Crónica [Internet]. [cited 2022 Jul 28]. Available from: https://www.cadradialisis.org.ar/registro.php Arend SM, Mallat MJK, Westendorp RJW, Van Der Woude FJ, Van Es LA. Patient survival after renal transplantation; more than 25 years follow-up. Nephrol Dial Transplant [Internet]. 1997 Aug [cited 2022 Jul 28];12(8):1672–9. Available from: https://pubmed.ncbi.nlm.nih.gov/9269647/ Abeling T, Scheffner I, Karch A, Broecker V, Koch A, Haller H, et al. Risk factors for death in kidney transplant patients: analysis from a large protocol biopsy registry. Nephrol Dial Transplant [Internet]. 2019 Jul 1 [cited 2022 Jul 28];34(7):1171–81. Available from: https://pubmed.ncbi.nlm.nih.gov/29860340/ Wyld MLR, De La Mata NL, Masson P, O’Lone E, Kelly PJ, Webster AC. Cardiac Mortality in Kidney Transplant Patients: A Population-based Cohort Study 1988-2013 in Australia and New Zealand. Transplantation [Internet]. 2021 [cited 2022 Jul 28];105(2):413–22. Available from: https://pubmed.ncbi.nlm.nih.gov/32168042/ Woo YM, Jardine AG, Clark AF, MacGregor MS, Bowman AW, Macpherson SG, et al. Early graft function and patient survival following cadaveric renal transplantation. Kidney Int [Internet]. 1999 [cited 2022 Jul 28];55(2):692–9. Available from: https://pubmed.ncbi.nlm.nih.gov/9987094/ Jay CL, Washburn K, Dean PG, Helmick RA, Pugh JA, Stegall MD. Survival Benefit in Older Patients Associated With Earlier Transplant With High KDPI Kidneys. Transplantation [Internet]. 2017 Apr 1 [cited 2022 Jul 28];101(4):867–72. Available from: https://pubmed.ncbi.nlm.nih.gov/27495758/ Ojo AO. Cardiovascular complications after renal transplantation and their prevention. Transplantation [Internet]. 2006 Sep [cited 2022 Jul 28];82(5):603–11. Available from: https://pubmed.ncbi.nlm.nih.gov/16969281/ Wu C, Evans I, Joseph R, Shapiro R, Tan H, Basu A, et al. Comorbid conditions in kidney transplantation: association with graft and patient survival. J Am Soc Nephrol [Internet]. 2005 [cited 2022 Jul 28];16(11):3437–44. Available from: https://pubmed.ncbi.nlm.nih.gov/16176999/ Erlandsson H, Qureshi AR, Scholz T, Lundgren T, Bruchfeld A, Stenvinkel P, et al. Observational study of risk factors associated with clinical outcome among elderly kidney transplant recipients in Sweden - a decade of follow-up. Transpl Int [Internet]. 2021 Nov 1 [cited 2022 Jul 28];34(11):2363–70. Available from: https://pubmed.ncbi.nlm.nih.gov/34346109/ Rubin RH. Infectious disease complications of renal transplantation. Kidney Int [Internet]. 1993 [cited 2022 Jul 28];44(1):221–36. Available from: https://pubmed.ncbi.nlm.nih.gov/8394951/ Carga económica de la enfermedad renal crónica en Colombia, 2015-2016 | Salud UNINORTE;35(1): 84-100, ene.-abr. 2019. tab, graf | LILACS [Internet]. [cited 2022 Jul 28]. Available from: https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1099300 Koto P, Tennankore K, Vinson A, Krmpotic K, Weiss MJ, Theriault C, et al. What are the short-term annual cost savings associated with kidney transplantation? Cost Eff Resour Alloc [Internet]. 2022 Dec 1 [cited 2022 Jul 28];20(1). Available from: https://pubmed.ncbi.nlm.nih.gov/35505433/ 2014 U.S. organ and tissue transplant cost estimates and discussion [Internet]. [cited 2022 Jul 28]. Available from: https://us.milliman.com/en/insight/2014-usorgan-and-tissue-transplant-cost-estimates-and-discussion Salamzadeh J, Foroutan N, Jamshidi HR, Rasekh HR, Ghatari AR, Foroutan A, et al. Costs of Treatment after Renal Transplantation: Is it Worth to Pay More? Iran J Pharm Res IJPR [Internet]. 2014 [cited 2022 Jul 28];13(1):271. Available from: /pmc/articles/PMC3985242/ Younis M, Jabr S, Al-Khatib A, Forgione D, Hartmann M, Kisa A. A cost analysis of kidney replacement therapy options in Palestine. Inquiry [Internet]. 2015 [cited 2022 Jul 28];52. Available from: https://pubmed.ncbi.nlm.nih.gov/25765018/ Torales S, Berardo J, Hasdeu S, Esquivel MP, Rosales A, Azofeifa C, et al. Comparative economic evaluation of renal replacement therapies in Argentina, Costa Rica, and Uruguay. Rev Panam Salud Publica/Pan Am J Public Heal. 2021;45. Helanterä I, Isola T, Lehtonen TK, Åberg F, Lempinen M, Isoniemi H. Association of Clinical Factors with the Costs of Kidney Transplantation in the Current Era. Ann Transplant [Internet]. 2019 [cited 2022 Jul 28];24:393–400. Available from: https://pubmed.ncbi.nlm.nih.gov/31263093/ Chamberlain G, Baboolal K, Bennett H, Pockett RD, McEwan P, Sabater J, et al. The economic burden of posttransplant events in renal transplant recipients in Europe. Transplantation [Internet]. 2014 Apr 27 [cited 2022 Jul 28];97(8):854–61. Available from: https://pubmed.ncbi.nlm.nih.gov/24732898/ KaborÉ R, Haller MC, Harambat J, Heinze G, LeffondrÉ K. Risk prediction models for graft failure in kidney transplantation: a systematic review. Nephrol Dial Transplant [Internet]. 2017 Apr 1 [cited 2022 Jul 28];32(suppl_2):ii68–76. Available from: https://pubmed.ncbi.nlm.nih.gov/28206633/ Hart A, Zaun D, Itzler R, Schladt D, Israni A, Kasiske B. Cost, healthcare utilization, and outcomes of antibody-mediated rejection in kidney transplant recipients in the US. J Med Econ [Internet]. 2021 [cited 2022 Jul 28];24(1):1011–7. Available from: https://pubmed.ncbi.nlm.nih.gov/34348559/ Cooper M, Schnitzler M, Nilubol C, Wang W, Wu Z, Nordyke RJ. Costs in the Year Following Deceased Donor Kidney Transplantation: Relationships With Renal Function and Graft Failure. Transpl Int [Internet]. 2022 May 27 [cited 2022 Jul 28];35. Available from: https://pubmed.ncbi.nlm.nih.gov/35692736/ Sussell J, Silverstein AR, Goutam P, Incerti D, Kee R, Chen CX, et al. The economic burden of kidney graft failure in the United States. Am J Transplant [Internet]. 2020 May 1 [cited 2022 Jul 28];20(5):1323–33. Available from: https://pubmed.ncbi.nlm.nih.gov/32020739/ Wu DA, Robb ML, Forsythe JLR, Bradley C, Cairns J, Draper H, et al. Recipient Comorbidity and Survival Outcomes After Kidney Transplantation: A UK-wide Prospective Cohort Study. Transplantation [Internet]. 2020 [cited 2022 Jul 28];104(6):1246–55. Available from: https://pubmed.ncbi.nlm.nih.gov/31449188/ Machnicki G, Lentine KL, Salvalaggio PR, Burroughs TE, Brennan DC, Schnitzler MA. Kidney transplant Medicare payments and length of stay: associations with comorbidities and organ quality. Arch Med Sci [Internet]. 2011 Apr [cited 2022 Jul 28];7(2):278–86. Available from: https://pubmed.ncbi.nlm.nih.gov/22291768/ Pourfarziani V, Rafati-Shaldehi H, Assari S, Naghizadeh MM, Amini M, Hollisaaz MT, et al. Hospitalization databases: a tool for transplantation monitoring. Transplant Proc [Internet]. 2007 May [cited 2022 Jul 28];39(4):981–3. Available from: https://pubmed.ncbi.nlm.nih.gov/17524868/ |
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Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Contreras Villamizar, Kateir Marield64b76574c82b169414022f9608fe9e8600Buitrago Gutiérrez, Giancarloc304fd7c64c44ef2ca0d627075cbb8cfEspinel Pachón, Cristian Felipe8366e8d634f4841b9da4da39fc5c8642Instituto de Investigaciones Clínicas – Facultad de Medicina2022-08-22T19:25:38Z2022-08-22T19:25:38Z2022-08-16https://repositorio.unal.edu.co/handle/unal/81992Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, graficas, mapasIntroducción: El trasplante renal es la terapia de reemplazo renal ideal para la enfermedad renal crónica avanzada, dado su impacto en la reducción de mortalidad y costos comparado con diálisis. En Colombia es necesario establecer registros propios sobre supervivencia del paciente, costos y factores pronósticos a largo plazo en pacientes post-trasplante renal. Objetivo: Determinar la tasa de supervivencia del paciente, los costos en la atención en salud y sus factores asociados a 5 años en pacientes post-trasplante renal pertenecientes al régimen contributivo en Colombia. Materiales y métodos: Estudio de cohorte retrospectivo utilizando registros administrativos en salud, incluyó 1437 pacientes trasplantados renales pertenecientes al régimen contributivo, desde 1 enero de 2013 hasta 31 diciembre de 2014. Se realizaron análisis para determinar a 5 años: 1) supervivencia del paciente, 2) costos directos desde la perspectiva del tercer pagador y 3) factores asociados; mediante regresiones de Poisson, regresiones lineales y modelos de regresión multivariada multinivel, respectivamente. Resultados y conclusiones: La tasa de supervivencia del paciente a 1 año fue 95.2% y a 5 años 79.82%. Los factores asociados a mayor mortalidad a 5 años fueron la edad (comparado con 18-29): 60-69 años (HR 4.15, [IC 95% 2.39; 7.20], p<0.001), ≥70 años (HR 6.79, [IC 95% 3.51; 13.12], p<0.001); y el índice de comorbilidad de Charlson (ICC) (comparado con ≤3): 4-5 puntos (HR 2.04, [IC 95% 1.56; 2.67], p<0.001), 6-7 puntos (HR 1.54, [IC 95% 1.04; 2.27], p=0.02) y ≥8 puntos (HR 2.25, [IC 95% 1.35; 3.76], p=0.002). La mediana de costos a 5 años postrasplante renal fue 122,059 millones de COP (promedio anual de 24,412 millones de COP). El ICC ≥4 y pertenecer a las regiones geográficas Atlántica, Oriental y Pacífica se asociaron a mayores costos; mientras que ser trasplantado en el 2014 se asoció a menores costos a 5 años en comparación con el año previo. (Texto tomado de la fuente)Introduction: Kidney transplantation is the optimal renal replacement therapy for end-stage chronic kidney disease, improving both mortality and costs compared with dialysis. In Colombia, data covering long-term patient survival, health care costs, and related factors are needed in kidney transplant recipients. Objective: Determine patient survival rates, health care costs, and related factors at 5 years in patients with kidney transplant in Colombia. Materials y methods: Retrospective cohort study using administrative health care records, including 1,437 kidney transplant recipient patients from 1 January 2013 to 31 December 2014 included in Colombia´s contributory regime. Analysis were done to determine at 5 years: 1) patient survival, 2) direct health care costs from a third-payer perspective and 3) related factors; using Poisson regressions, linear regressions, and multilevel multivariate regression models, respectively. Results and conclusions: Patient survival rates were 95.2% and 79.82% at 1-year and 5 years, respectively. Mortality-related factors at 5 years were age (reference 18-29 years): 60-69 (HR 4.15, [IC 95% 2.39; 7.20], p<0.001), ≥70 (HR 6.79, [IC 95% 3.51; 13.12], p<0.001); and comorbidity Charlson index (CCI) (reference ≤3 points): 4-5 (HR 2.04, [IC 95% 1.56; 2.67], p<0.001), 6-7 (HR 1.54, [IC 95% 1.04; 2.27], p=0.02) and ≥8 (HR 2.25, [IC 95% 1.35; 3.76], p=0.002). The Median 5 years cost was COP 122,059 million (annual average COP 24,413 million). CCI ≥8 and Atlantic, Oriental and Pacific geographic regions were related to higher costs; while kidney transplantation in 2014 was related to lower costs.Especialidades MédicasEspecialista en Medicina InternaTrasplante renalxiii, 65 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Especialidad en Medicina InternaDepartamento de Medicina InternaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::616 - EnfermedadesTrasplante de RiñónCosto de EnfermedadKidney TransplantationCost of IllnessColombiaTrasplante renalSupervivenciaCostosFactores de riesgoColombiaKidney transplantationSurvivalCostsRisk factorsFactores asociados a la supervivencia a 5 años y los costos en la atención de pacientes con trasplante renal en Colombia5-year patient survival, health care costs, and related factors in patients with renal transplant in ColombiaTrabajo de grado - Especialidad Médicainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMRedColLaReferenciaJankowski J, Floege J, Fliser D, Böhm M, Marx N. 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Available from: https://pubmed.ncbi.nlm.nih.gov/17524868/EstudiantesInvestigadoresMaestrosMedios de comunicaciónPadres y familiasPúblico generalReceptores de fondos federales y solicitantesResponsables políticosORIGINAL1016065177.2022.pdf1016065177.2022.pdfTesis de especialidad médica - Medicina Internaapplication/pdf1254525https://repositorio.unal.edu.co/bitstream/unal/81992/1/1016065177.2022.pdfb69b6677d519bb27ee0be16861d4b3acMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-84074https://repositorio.unal.edu.co/bitstream/unal/81992/6/license.txt8153f7789df02f0a4c9e079953658ab2MD56THUMBNAIL1016065177.2022.pdf.jpg1016065177.2022.pdf.jpgGenerated Thumbnailimage/jpeg4952https://repositorio.unal.edu.co/bitstream/unal/81992/7/1016065177.2022.pdf.jpg27461c9a78e6b34153e352b5127e6671MD57unal/81992oai:repositorio.unal.edu.co:unal/819922023-08-07 23:03:45.208Repositorio Institucional Universidad Nacional de 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