Estudio de la respuesta de levaduras transformadoras de xilosa a condiciones de estrés en hidrolizados de bagazo de caña de azúcar

ilustraciones, diagramas

Autores:
Garcia Acero, Angela Maria
Tipo de recurso:
Doctoral thesis
Fecha de publicación:
2022
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/85881
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/85881
https://repositorio.unal.edu.co/
Palabra clave:
660 - Ingeniería química::668 - Tecnología de otros productos orgánicos
570 - Biología::572 - Bioquímica
Levadura
yeasts
Levaduras no-convencionales
Fermentación
Inhibidores
Adaptación
Protección cruzada
Non-conventional yeasts
Fermentation
Inhibitors
Adaptation
Cross-protection
Investigación química
Azúcar
Chemical research
Sugar
Rights
openAccess
License
Atribución-NoComercial-SinDerivadas 4.0 Internacional
id UNACIONAL2_97186c5c7f73e9ce780aa72d4a16b31f
oai_identifier_str oai:repositorio.unal.edu.co:unal/85881
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Estudio de la respuesta de levaduras transformadoras de xilosa a condiciones de estrés en hidrolizados de bagazo de caña de azúcar
dc.title.translated.eng.fl_str_mv Study of the response of xylose-transforming yeasts to stress conditions in sugarcane bagasse hydrolysate
dc.title.translated.por.fl_str_mv Estudo da resposta de leveduras transformadoras de xilose a condições de estresse em hidrolisado de bagaço de cana de açúcar
title Estudio de la respuesta de levaduras transformadoras de xilosa a condiciones de estrés en hidrolizados de bagazo de caña de azúcar
spellingShingle Estudio de la respuesta de levaduras transformadoras de xilosa a condiciones de estrés en hidrolizados de bagazo de caña de azúcar
660 - Ingeniería química::668 - Tecnología de otros productos orgánicos
570 - Biología::572 - Bioquímica
Levadura
yeasts
Levaduras no-convencionales
Fermentación
Inhibidores
Adaptación
Protección cruzada
Non-conventional yeasts
Fermentation
Inhibitors
Adaptation
Cross-protection
Investigación química
Azúcar
Chemical research
Sugar
title_short Estudio de la respuesta de levaduras transformadoras de xilosa a condiciones de estrés en hidrolizados de bagazo de caña de azúcar
title_full Estudio de la respuesta de levaduras transformadoras de xilosa a condiciones de estrés en hidrolizados de bagazo de caña de azúcar
title_fullStr Estudio de la respuesta de levaduras transformadoras de xilosa a condiciones de estrés en hidrolizados de bagazo de caña de azúcar
title_full_unstemmed Estudio de la respuesta de levaduras transformadoras de xilosa a condiciones de estrés en hidrolizados de bagazo de caña de azúcar
title_sort Estudio de la respuesta de levaduras transformadoras de xilosa a condiciones de estrés en hidrolizados de bagazo de caña de azúcar
dc.creator.fl_str_mv Garcia Acero, Angela Maria
dc.contributor.advisor.spa.fl_str_mv Velasquez Lozano, Mario Enrique
Rosa, Carlos Augusto
dc.contributor.author.spa.fl_str_mv Garcia Acero, Angela Maria
dc.contributor.researchgroup.spa.fl_str_mv Grupo de Investigación en Procesos Químicos y Bioquímicos
Taxonomia, Biodiversidade e Biotecnologia de Fungos
dc.contributor.orcid.spa.fl_str_mv Garcia Acero, Angela Maria [0000-0002-2241-9465]
dc.contributor.cvlac.spa.fl_str_mv Garcia Acero, Angela Maria [https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001468893]
dc.contributor.researchgate.spa.fl_str_mv Garcia Acero, Angela Maria [https://www.researchgate.net/profile/Angela-Garcia-Acero]
dc.subject.ddc.spa.fl_str_mv 660 - Ingeniería química::668 - Tecnología de otros productos orgánicos
570 - Biología::572 - Bioquímica
topic 660 - Ingeniería química::668 - Tecnología de otros productos orgánicos
570 - Biología::572 - Bioquímica
Levadura
yeasts
Levaduras no-convencionales
Fermentación
Inhibidores
Adaptación
Protección cruzada
Non-conventional yeasts
Fermentation
Inhibitors
Adaptation
Cross-protection
Investigación química
Azúcar
Chemical research
Sugar
dc.subject.agrovoc.spa.fl_str_mv Levadura
dc.subject.agrovoc.eng.fl_str_mv yeasts
dc.subject.proposal.spa.fl_str_mv Levaduras no-convencionales
Fermentación
Inhibidores
Adaptación
Protección cruzada
dc.subject.proposal.eng.fl_str_mv Non-conventional yeasts
Fermentation
Inhibitors
Adaptation
Cross-protection
dc.subject.unesco.spa.fl_str_mv Investigación química
Azúcar
dc.subject.unesco.eng.fl_str_mv Chemical research
Sugar
description ilustraciones, diagramas
publishDate 2022
dc.date.issued.none.fl_str_mv 2022-09-27
dc.date.accessioned.none.fl_str_mv 2024-04-08T19:32:45Z
dc.date.available.none.fl_str_mv 2024-04-08T19:32:45Z
dc.type.spa.fl_str_mv Trabajo de grado - Doctorado
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/doctoralThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_db06
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TD
format http://purl.org/coar/resource_type/c_db06
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/85881
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/85881
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.indexed.spa.fl_str_mv Agrosavia
Agrovoc
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spelling Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Velasquez Lozano, Mario Enrique329ea40d5f707973fde8a14204c75808Rosa, Carlos Augustobb85de8686ca4fae00f3a99d39f91f55Garcia Acero, Angela Mariaf35e006ae559d2f54028f4835d2b846bGrupo de Investigación en Procesos Químicos y BioquímicosTaxonomia, Biodiversidade e Biotecnologia de FungosGarcia Acero, Angela Maria [0000-0002-2241-9465]Garcia Acero, Angela Maria [https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001468893]Garcia Acero, Angela Maria [https://www.researchgate.net/profile/Angela-Garcia-Acero]2024-04-08T19:32:45Z2024-04-08T19:32:45Z2022-09-27https://repositorio.unal.edu.co/handle/unal/85881Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramasLa transición hacia los sistemas de producción de base biológica implica no solo la adaptación de tecnologías existentes sino la búsqueda de procesos eficientes y sostenibles. El uso de microorganismos como biocatalizadores para la transformación de biomasa residual ha sido estudiado en las últimas décadas. Sin embargo, dentro de los parámetros de selección de estos microorganismos la capacidad de tolerar y adaptarse a condiciones estresantes es una de las mayores limitantes para su empleo en escala industrial. Este trabajo tiene como objetivo describir la diversidad de la comunidad de levaduras transformadoras de D-xilosa asociadas a bosques de robles en los Andes Colombianos y estudiar la respuesta fenotípica a condiciones de estrés de levaduras no-convencionales, aisladas en ambientes naturales y fermentativos en Colombia capaces de metabolizar la D-xilosa, para su implementación en la fermentación de hidrolizados hemicelulósicos de bagazo de caña de azúcar. Para esto se realizó el aislamiento e identificación taxonómica de 175 levaduras asimiladoras de D-xilosa de bosques de robles de la región central de la cordillera oriental de los Andes en Colombia pertenecientes a 35 especies previamente conocidas y 15 posibles especies nuevas. Se observó que 75 aislados en los bosques de robles presentaron capacidad metabólica para la transformación de la D-xilosa hasta etanol o xilitol. También se evaluaron 50 levaduras de la colección Biológica Banco de Cepas y Genes del IBUN-UNAL, aislados en ambientes fermentativos en el municipio de Puerto López (Meta) y Paipa (Boyacá) de los cuales 12 presentaron capacidad para transformar D-xilosa y producir xilitol como producto principal. Se evaluó la implementación de condiciones de estrés térmico como estrategia para la preparación del inóculo en dos especies de levaduras asociadas a ambientes fermentativos, Meyerozyma caribbica y Candida tropicalis, para la fermentación de D-xilosa en medios suplementados con ácido acético. M. caribbica evidenció la adquisición de protección cruzada a estrés en las levaduras expuestas a 10 °C con un aumento del 29 % en la producción de xilitol frente a las células crecidas a 30 °C en la fermentación de la D-xilosa en presencia del ácido acético (6 g/L). La exposición a estrés ácido, oxidativo y térmico previo a la fermentación de hidrolizado hemicelulósico de bagazo de caña de azúcar fue aplicado para dos levaduras aisladas en ambientes naturales, Debaryomyeces nepalensis y Scheffersomyces cryptocercus/Sc. virginianus, para la producción de xilitol y etanol, respectivamente. La respuesta fenotípica a las diferentes condiciones de estrés fue específica para cada especie y relacionada con el direccionamiento metabólico para la transformación de la pentosa. D. nepalensis presentó un aumento del 32% en la producción de xilitol en comparación con las células sin tratar en fermentación del hidrolizado hemicelulósico de bagazo de caña de azúcar (75% v/v). La estrategia de preparación del inóculo con exposición previa al estrés sumado a la fermentación en serie mejora la aptitud en Scheffersomyces cryptocercus/Sc. virginianus logrando fermentar la D-xilosa presente en el hidrolizado hemicelulósico de bagazo de caña sin diluir. Este es el primer trabajo realizado en la bioprospección de la diversidad de levaduras de bosques de robles en la cordillera oriental de Los Andes (Colombia) y los resultados demuestran el potencial para la exploración de servicios ecosistémicos no maderables presentes en estos hábitats forestales. (Texto tomado de la fuente).The transition to biological-based production systems implies not only the adaptation of existing technologies but the search for efficient and sustainable processes. The use of microorganisms as biocatalysts for the transformation of residual biomass has been studied in the last decades. However, within the parameters for the selection of these microorganisms, the ability to tolerate and adapt to stressful conditions is one of the greatest limitations for its use on an industrial scale. The aim of this work is to describe the diversity of the community of D-xylose-transforming yeasts associated with oak forests in the Colombian Andes and to study the phenotypic response to stress conditions of non-conventional yeasts, isolated in natural and fermentative environments in Colombia capable of D-xylose metabolism, for its implementation in the fermentation of sugarcane bagasse hemicellulosic hydrolysates. For this, the isolation and taxonomic identification of 175 D-xylose-assimilating yeasts from oak forests of the central region of the eastern Andes Mountain range in Colombia was carried out belonging to 35 species previously known and 15 possible new species. It was observed that 75 isolates presented the metabolic capacity for the transformation of D-xylose to ethanol or xylitol. We also evaluated 50 yeasts from the biological collection Bank of Strain and Genes of IBUN-UNAL, isolated in the municipality of Puerto López (Meta, Colombia) and Paipa (Boyacá, Colombia), of which 12 have the capacity to ferment xylose and produce xylitol as the main product. The implementation of thermal stress conditions was evaluated as a strategy for the preparation of the inoculum in two yeast species associated with fermentative environments, Meyerozyma caribbica and Candida tropicalis, for the fermentation of D-xylose in media supplemented with acetic acid. M. caribbica showed the acquisition of cross-stress protection in yeasts exposed to 10 °C with a 29 % increase in xylitol production compared to cells grown at 30 °C in the fermentation of D-xylose in the presence of the acetic acid (6 g/L). Exposure to acid, oxidative, and thermal stress prior to fermentation of hemicellulosic hydrolysate from sugarcane bagasse was applied to two yeasts isolated in natural environments, Debaryomyeces nepalensis and Scheffersomyces cryptocercus/Sc. virginianus, to produce xylitol and ethanol, respectively. The phenotypic response to the different stress conditions was species-specific and related to metabolic wiring for pentose transformation. D. nepalensis showed a 32% increase in xylitol production compared to untreated cells in fermentation of diluted sugarcane bagasse hemicellulosic hydrolysate (75% v/v). The inoculum preparation strategy with prior stress exposure coupled with serial fermentation improves fitness in Scheffersomyces cryptocercus/Sc. virginianus, achieving fermenting the D-xylose present in the sugarcane bagasse hemicellulosic hydrolysate undiluted. This is the first work carried out on the bioprospecting of the yeast diversity from oak forests in the eastern Andes Mountain range (Colombia) and the results demonstrate the potential for the exploration of non-timber ecosystem services present in these forest habitats.DoctoradoDoctor en IngenieríaBioprocesosxiv, 181 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ingeniería - Doctorado en Ingeniería - Ingeniería QuímicaFacultad de IngenieríaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá660 - Ingeniería química::668 - Tecnología de otros productos orgánicos570 - Biología::572 - BioquímicaLevadurayeastsLevaduras no-convencionalesFermentaciónInhibidoresAdaptaciónProtección cruzadaNon-conventional yeastsFermentationInhibitorsAdaptationCross-protectionInvestigación químicaAzúcarChemical researchSugarEstudio de la respuesta de levaduras transformadoras de xilosa a condiciones de estrés en hidrolizados de bagazo de caña de azúcarStudy of the response of xylose-transforming yeasts to stress conditions in sugarcane bagasse hydrolysateEstudo da resposta de leveduras transformadoras de xilose a condições de estresse em hidrolisado de bagaço de cana de açúcarTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_db06Texthttp://purl.org/redcol/resource_type/TDAgrosaviaAgrovocAdeboye, P. 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Frontiers in microbiology, 8, 1927.InvestigadoresPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/85881/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL53161689.2022.pdf53161689.2022.pdfTesis de Doctorado en Ingeniería - Ingeniería Químicaapplication/pdf3669803https://repositorio.unal.edu.co/bitstream/unal/85881/2/53161689.2022.pdf49c06c3c51d628fddb9ce0d4863d7543MD52THUMBNAIL53161689.2022.pdf.jpg53161689.2022.pdf.jpgGenerated Thumbnailimage/jpeg4941https://repositorio.unal.edu.co/bitstream/unal/85881/3/53161689.2022.pdf.jpga430926e7350720c7f3c9805425d197aMD53unal/85881oai:repositorio.unal.edu.co:unal/858812024-08-23 23:11:35.948Repositorio Institucional Universidad Nacional de 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