Application of latent variable models to autoimmune diseases clinimetry

Abstract: Clinical manifestations of autoimmune diseases often are presented as presence or absence of certain symptoms, which in the clinical context can be associated with disease severity. Classical measures like number of symptoms present have been used to assess the severity of disease, neverth...

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Autores:
Molano González, Nicolás
Tipo de recurso:
Fecha de publicación:
2015
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/55431
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/55431
http://bdigital.unal.edu.co/50840/
Palabra clave:
31 Colecciones de estadística general / Statistics
51 Matemáticas / Mathematics
61 Ciencias médicas; Medicina / Medicine and health
Latent Variable
Nonlinear models
Bayesian estimation
Clinimetry
Variables latentes
Modelos No lineales
Estimacion Bayesiana
Clinimetria
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
Description
Summary:Abstract: Clinical manifestations of autoimmune diseases often are presented as presence or absence of certain symptoms, which in the clinical context can be associated with disease severity. Classical measures like number of symptoms present have been used to assess the severity of disease, nevertheless this score does not reflect particular aspects of each symptom in the severity manifestation. In this setting latent variable models are a natural choice to address the problem of characterize the disease severity in function of the presence or absence of symptoms in a given patient. On the other hand, we seek associations of this latent trait (i.e severity) with other clinical and demographical information, in order to identify risk factors which can be used in the future for personalized diagnostic and treatment. Having this in mind we investigate extension to the 2pl IRT models, as proposed by Ogasawara (1995), where the individuals latent trait can be modeled by person covariates, and as result of our research, we propose a novel Bayesian algorithm based on working variables for the classical 1pl, 2pl an the extended models involving subject level covariates. This novel algorithm is based on the works of Gamerman (1997), Cepeda-Cuervo (2001), Cepeda-Cuervo and Achcar (2010) and Gutierrez (2015)