Method for the segmentation of brain magnetic resonance images using a neural network architecture based on attention models

ilustraciones, diagramas, tablas

Autores:
Laiton Bonadiez, Camilo Andres
Tipo de recurso:
Fecha de publicación:
2022
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
eng
OAI Identifier:
oai:repositorio.unal.edu.co:unal/82378
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/82378
https://repositorio.unal.edu.co/
Palabra clave:
000 - Ciencias de la computación, información y obras generales::003 - Sistemas
000 - Ciencias de la computación, información y obras generales::004 - Procesamiento de datos Ciencia de los computadores
000 - Ciencias de la computación, información y obras generales::005 - Programación, programas, datos de computación
610 - Medicina y salud::611 - Anatomía humana, citología, histología
Magnetic resonance imaging
Diagnostic imaging
Resonancia magnética en imágenes
Diagnóstico por imágenes
Medical image segmentation
Deep learning
Transformers
Convolutional neural networks
Brain structures
Segmentación de imágenes médicas
Aprendizaje profundo
Redes neuronales convolucionales
Transformers
Estructuras cerebrales
Rights
openAccess
License
Atribución-NoComercial-SinDerivadas 4.0 Internacional
id UNACIONAL2_932a8b0410be44bd6d394d38b7af1872
oai_identifier_str oai:repositorio.unal.edu.co:unal/82378
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.eng.fl_str_mv Method for the segmentation of brain magnetic resonance images using a neural network architecture based on attention models
dc.title.translated.spa.fl_str_mv Método para la segmentación de imágenes de resonancia magnética cerebrales usando una arquitectura de red neuronal basada en modelos de atención
title Method for the segmentation of brain magnetic resonance images using a neural network architecture based on attention models
spellingShingle Method for the segmentation of brain magnetic resonance images using a neural network architecture based on attention models
000 - Ciencias de la computación, información y obras generales::003 - Sistemas
000 - Ciencias de la computación, información y obras generales::004 - Procesamiento de datos Ciencia de los computadores
000 - Ciencias de la computación, información y obras generales::005 - Programación, programas, datos de computación
610 - Medicina y salud::611 - Anatomía humana, citología, histología
Magnetic resonance imaging
Diagnostic imaging
Resonancia magnética en imágenes
Diagnóstico por imágenes
Medical image segmentation
Deep learning
Transformers
Convolutional neural networks
Brain structures
Segmentación de imágenes médicas
Aprendizaje profundo
Redes neuronales convolucionales
Transformers
Estructuras cerebrales
title_short Method for the segmentation of brain magnetic resonance images using a neural network architecture based on attention models
title_full Method for the segmentation of brain magnetic resonance images using a neural network architecture based on attention models
title_fullStr Method for the segmentation of brain magnetic resonance images using a neural network architecture based on attention models
title_full_unstemmed Method for the segmentation of brain magnetic resonance images using a neural network architecture based on attention models
title_sort Method for the segmentation of brain magnetic resonance images using a neural network architecture based on attention models
dc.creator.fl_str_mv Laiton Bonadiez, Camilo Andres
dc.contributor.advisor.none.fl_str_mv Sanchez Torres, German
Branch Bedoya, John Willian
dc.contributor.author.none.fl_str_mv Laiton Bonadiez, Camilo Andres
dc.contributor.researchgroup.spa.fl_str_mv Gidia: Grupo de Investigación YyDesarrollo en Inteligencia Artificial
dc.subject.ddc.spa.fl_str_mv 000 - Ciencias de la computación, información y obras generales::003 - Sistemas
000 - Ciencias de la computación, información y obras generales::004 - Procesamiento de datos Ciencia de los computadores
000 - Ciencias de la computación, información y obras generales::005 - Programación, programas, datos de computación
610 - Medicina y salud::611 - Anatomía humana, citología, histología
topic 000 - Ciencias de la computación, información y obras generales::003 - Sistemas
000 - Ciencias de la computación, información y obras generales::004 - Procesamiento de datos Ciencia de los computadores
000 - Ciencias de la computación, información y obras generales::005 - Programación, programas, datos de computación
610 - Medicina y salud::611 - Anatomía humana, citología, histología
Magnetic resonance imaging
Diagnostic imaging
Resonancia magnética en imágenes
Diagnóstico por imágenes
Medical image segmentation
Deep learning
Transformers
Convolutional neural networks
Brain structures
Segmentación de imágenes médicas
Aprendizaje profundo
Redes neuronales convolucionales
Transformers
Estructuras cerebrales
dc.subject.lemb.eng.fl_str_mv Magnetic resonance imaging
Diagnostic imaging
dc.subject.lemb.spa.fl_str_mv Resonancia magnética en imágenes
Diagnóstico por imágenes
dc.subject.proposal.eng.fl_str_mv Medical image segmentation
Deep learning
Transformers
Convolutional neural networks
Brain structures
dc.subject.proposal.spa.fl_str_mv Segmentación de imágenes médicas
Aprendizaje profundo
Redes neuronales convolucionales
Transformers
Estructuras cerebrales
description ilustraciones, diagramas, tablas
publishDate 2022
dc.date.accessioned.none.fl_str_mv 2022-10-19T15:23:04Z
dc.date.available.none.fl_str_mv 2022-10-19T15:23:04Z
dc.date.issued.none.fl_str_mv 2022-07-31
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/82378
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/82378
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.references.spa.fl_str_mv M. M. Miller-Thomas and T. L. Benzinger, “Neurologic applications of pet/mr imaging,” Magnetic Resonance Imaging Clinics of North America, vol. 25, no. 2, pp. 297–313, 2017. Hybrid PET/MR Imaging.
W. Mier and D. Mier, “Advantages in functional imaging of the brain,” Frontiers in Human Neuroscience, vol. 9, 2015.
H. Neeb, K. Zilles, and N. J. Shah, “Fully-automated detection of cerebral water content changes: Study of age- and gender-related h2o patterns with quantitative mri,” NeuroImage, vol. 29, no. 3, pp. 910–922, 2006.
M. E. Shenton, C. C. Dickey, M. Frumin, and R. W. McCarley, “A review of mri findings in schizophrenia,” Schizophrenia Research, vol. 49, no. 1, pp. 1–52, 2001.
G. Widmann, B. Henninger, C. Kremser, and W. Jaschke, “Sequences in head & neck radiology – state of the art mri,” 2017.
H. Yu, L. T. Yang, Q. Zhang, D. Armstrong, and M. J. Deen, “Convolutional neural networks for medical image analysis: State-of-the-art, comparisons, improvement and perspectives,” Neurocomputing, vol. 444, pp. 92–110, 2021.
X. Xie, J. Niu, X. Liu, Z. Chen, S. Tang, and S. Yu, “A survey on incorporating domain knowledge into deep learning for medical image analysis,” Medical Image Analysis, vol. 69, p. 101985, 2021.
U. Ilhan and A. Ilhan, “Brain tumor segmentation based on a new threshold ap- proach,” Procedia Computer Science, vol. 120, pp. 580–587, 2017. 9th International Conference on Theory and Application of Soft Computing, Computing with Words and Perception, ICSCCW 2017, 22-23 August 2017, Budapest, Hungary.
W. Deng, W. Xiao, H. Deng, and J. Liu, “Mri brain tumor segmentation with region growing method based on the gradients and variances along and inside of the boundary curve,” in 2010 3rd International Conference on Biomedical Engineering and Informatics, vol. 1, pp. 393–396, 2010.
J. Ashburner and K. J. Friston, “Unified segmentation,” NeuroImage, vol. 26, no. 3, pp. 839–851, 2005.
J. Liu and L. Guo, “A new brain mri image segmentation strategy based on k- means clustering and svm,” in 2015 7th International Conference on Intelligent Human-Machine Systems and Cybernetics, vol. 2, pp. 270–273, 2015.
X. Zhao and X.-M. Zhao, “Deep learning of brain magnetic resonance images: A brief review,” Methods, vol. 192, pp. 131–140, 2021. Deep networks and network representation in bioinformatics.
W. T. Le, F. Maleki, F. P. Romero, R. Forghani, and S. Kadoury, “Overview of machine learning: Part 2: Deep learning for medical image analysis,” Neuroimaging Clinics of North America, vol. 30, no. 4, pp. 417–431, 2020. Machine Learning and Other Artificial Intelligence Applications.
X. Liu, H. Wang, Z. Li, and L. Qin, “Deep learning in ecg diagnosis: A review,” Knowledge-Based Systems, vol. 227, p. 107187, 2021.
A. Nogales, A ́lvaro J. Garc ́ıa-Tejedor, D. Monge, J. S. Vara, and C. Anto ́n, “A survey of deep learning models in medical therapeutic areas,” Artificial Intelligence in Medicine, vol. 112, p. 102020, 2021.
J. Gu, Z. Wang, J. Kuen, L. Ma, A. Shahroudy, B. Shuai, T. Liu, X. Wang, G. Wang, J. Cai, and T. Chen, “Recent advances in convolutional neural networks,” Pattern Recognition, vol. 77, pp. 354–377, 2018.
L. Alzubaidi, J. Zhang, A. J. Humaidi, A. Al-Dujaili, Y. Duan, O. Al-Shamma, J. Santamar ́ıa, M. A. Fadhel, M. Al-Amidie, and L. Farhan, “Review of deep lear- ning: concepts, cnn architectures, challenges, applications, future directions,” Jour- nal of Big Data, vol. 8, p. 53, Mar 2021.
M. Kwabena Patrick, A. Felix Adekoya, A. Abra Mighty, and B. Y. Edward, “Cap- sule networks – a survey,” Journal of King Saud University - Computer and Infor- mation Sciences, vol. 34, no. 1, pp. 1295–1310, 2022.
S. Sabour, N. Frosst, and G. E. Hinton, “Dynamic routing between capsules,” in Proceedings of the 31st International Conference on Neural Information Processing Systems, NIPS’17, (Red Hook, NY, USA), p. 3859–3869, Curran Associates Inc., 2017.
A. Vaswani, N. Shazeer, N. Parmar, J. Uszkoreit, L. Jones, A. N. Gomez, L. Kaiser, and I. Polosukhin, “Attention is all you need,” 2017.
A. Dosovitskiy, L. Beyer, A. Kolesnikov, D. Weissenborn, X. Zhai, T. Unterthiner, M. Dehghani, M. Minderer, G. Heigold, S. Gelly, J. Uszkoreit, and N. Houlsby, “An image is worth 16x16 words: Transformers for image recognition at scale,” 2020.
J. Chen, Y. Lu, Q. Yu, X. Luo, E. Adeli, Y. Wang, L. Lu, A. L. Yuille, and Y. Zhou, “Transunet: Transformers make strong encoders for medical image segmentation,” 2021.
B. Fischl, D. H. Salat, E. Busa, M. Albert, M. Dieterich, C. Haselgrove, A. van der Kouwe, R. Killiany, D. Kennedy, S. Klaveness, A. Montillo, N. Makris, B. Rosen, and A. M. Dale, “Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain,” Neuron, vol. 33, pp. 341–355, Jan. 2002.
D. W. Shattuck and R. M. Leahy, “Brainsuite: An automated cortical surface iden- tification tool,” Medical Image Analysis, vol. 6, no. 2, pp. 129–142, 2002.
M. Jenkinson, C. F. Beckmann, T. E. Behrens, M. W. Woolrich, and S. M. Smith, “Fsl,” NeuroImage, vol. 62, no. 2, pp. 782–790, 2012. 20 YEARS OF fMRI.
O. Ronneberger, P. Fischer, and T. Brox, “U-net: Convolutional networks for bio- medical image segmentation,” in Medical Image Computing and Computer-Assisted Intervention – MICCAI 2015 (N. Navab, J. Hornegger, W. M. Wells, and A. F. Frangi, eds.), (Cham), pp. 234–241, Springer International Publishing, 2015.
I. Despotovi ́c, B. Goossens, and W. Philips, “Mri segmentation of the human brain: Challenges, methods, and applications,” Computational and Mathematical Methods in Medicine, vol. 2015, p. 450341, Mar 2015.
P. A. Yushkevich, Y. Gao, and G. Gerig, “ITK-SNAP: An interactive tool for semi-automatic segmentation of multi-modality biomedical images,” Annu Int Conf IEEE Eng Med Biol Soc, vol. 2016, pp. 3342–3345, Aug. 2016.
S. Pieper, M. Halle, and R. Kikinis, “3d slicer,” in 2004 2nd IEEE International Symposium on Biomedical Imaging: Nano to Macro (IEEE Cat No. 04EX821), pp. 632–635 Vol. 1, 2004.
C. Qin, Y. Wu, W. Liao, J. Zeng, S. Liang, and X. Zhang, “Improved u-net3+ with stage residual for brain tumor segmentation,” BMC Medical Imaging, vol. 22, p. 14, Jan 2022.
J. Sun, Y. Peng, Y. Guo, and D. Li, “Segmentation of the multimodal brain tumor image used the multi-pathway architecture method based on 3d fcn,” Neurocompu- ting, vol. 423, pp. 34–45, 2021.
W. Dai, B. Woo, S. Liu, M. Marques, F. Tang, S. Crozier, C. Engstrom, and S. Chan- dra, “Can3d: Fast 3d knee mri segmentation via compact context aggregation,” in 2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI), pp. 1505– 1508, 2021.
T. S. Deepthi Murthy and G. Sadashivappa, “Brain tumor segmentation using th- resholding, morphological operations and extraction of features of tumor,” in 2014 International Conference on Advances in Electronics Computers and Communica- tions, pp. 1–6, 2014.
W. Polakowski, D. Cournoyer, S. Rogers, M. DeSimio, D. Ruck, J. Hoffmeister, and R. Raines, “Computer-aided breast cancer detection and diagnosis of masses using difference of gaussians and derivative-based feature saliency,” IEEE Transactions on Medical Imaging, vol. 16, no. 6, pp. 811–819, 1997.
M. Wani and B. Batchelor, “Edge-region-based segmentation of range images,” IEEE Transactions on Pattern Analysis and Machine Intelligence, vol. 16, no. 3, pp. 314–319, 1994.
J. Wu, F. Ye, J.-L. Ma, X.-P. Sun, J. Xu, and Z.-M. Cui, “The segmentation and visualization of human organs based on adaptive region growing method,” in 2008 IEEE 8th International Conference on Computer and Information Technology Workshops, pp. 439–443, 2008.
N. Passat, C. Ronse, J. Baruthio, J.-P. Armspach, C. Maillot, and C. Jahn, “Region- growing segmentation of brain vessels: An atlas-based automatic approach,” Journal of Magnetic Resonance Imaging, vol. 21, no. 6, pp. 715–725, 2005.
P. Gibbs, D. L. Buckley, S. J. Blackband, and A. Horsman, “Tumour volume de- termination from MR images by morphological segmentation,” Physics in Medicine and Biology, vol. 41, pp. 2437–2446, nov 1996.
S. Pohlman, K. A. Powell, N. A. Obuchowski, W. A. Chilcote, and S. Grundfest- Broniatowski, “Quantitative classification of breast tumors in digitized mammo- grams,” Medical Physics, vol. 23, no. 8, pp. 1337–1345, 1996.
E. A. A. Maksoud, M. Elmogy, and R. M. Al-Awadi, “Mri brain tumor segmenta- tion system based on hybrid clustering techniques,” in Advanced Machine Learning Technologies and Applications (A. E. Hassanien, M. F. Tolba, and A. Taher Azar, eds.), (Cham), pp. 401–412, Springer International Publishing, 2014.
X. Artaechevarria, A. Munoz-Barrutia, and C. Ortiz-de Solorzano, “Combination strategies in multi-atlas image segmentation: Application to brain mr data,” IEEE Transactions on Medical Imaging, vol. 28, no. 8, pp. 1266–1277, 2009.
P. Coupe, J. V. Manjon, V. Fonov, J. Pruessner, M. Robles, and D. L. Collins, “Patch-based segmentation using expert priors: Application to hippocampus and ventricle segmentation,” NeuroImage, vol. 54, no. 2, pp. 940–954, 2011.
H. Wang, J. W. Suh, S. R. Das, J. B. Pluta, C. Craige, and P. A. Yushkevich, “Multi-atlas segmentation with joint label fusion,” IEEE Transactions on Pattern Analysis and Machine Intelligence, vol. 35, no. 3, pp. 611–623, 2013.
G. Wu, Q. Wang, D. Zhang, F. Nie, H. Huang, and D. Shen, “A generative proba- bility model of joint label fusion for multi-atlas based brain segmentation,” Medical Image Analysis, vol. 18, no. 6, pp. 881–890, 2014. Sparse Methods for Signal Re- construction and Medical Image Analysis.
M. Kass, A. Witkin, and D. Terzopoulos, “Snakes: Active contour models,” Inter- national Journal of Computer Vision, vol. 1, pp. 321–331, Jan 1988.
Z. Wu, Y. Guo, S. H. Park, Y. Gao, P. Dong, S.-W. Lee, and D. Shen, “Robust brain roi segmentation by deformation regression and deformable shape model,” Medical Image Analysis, vol. 43, pp. 198–213, 2018.
A.Rajendran and R. Dhanasekaran, “Fuzzy clustering and deformable model for tumor segmentation on mri brain image: A combined approach,” Procedia Engineering, vol. 30, pp. 327–333, 2012. International Conference on Communication Technology and System Design 2011.
H. Khotanlou, J. Atif, O. Colliot, and I. Bloch, “3d brain tumor segmentation using fuzzy classification and deformable models,” in Fuzzy Logic and Applications (I. Bloch, A. Petrosino, and A. G. B. Tettamanzi, eds.), (Berlin, Heidelberg), pp. 312–318, Springer Berlin Heidelberg, 2006.
S. S. Tng, N. Q. K. Le, H.-Y. Yeh, and M. C. H. Chua, “Improved prediction model of protein lysine crotonylation sites using bidirectional recurrent neural networks,” Journal of Proteome Research, vol. 21, pp. 265–273, Jan 2022.
N. Q. K. Le and Q.-T. Ho, “Deep transformers and convolutional neural network in identifying dna n6-methyladenine sites in cross-species genomes,” Methods, 2021.
D. Bank, N. Koenigstein, and R. Giryes, “Autoencoders,” 2020.
G. Montufar, “Restricted boltzmann machines: Introduction and review,” 2018.
A. Sherstinsky, “Fundamentals of recurrent neural network (rnn) and long short-term memory (lstm) network,” Physica D: Nonlinear Phenomena, vol. 404, p. 132306, 2020.
Y. LeCun, B. Boser, J. S. Denker, D. Henderson, R. E. Howard, W. Hubbard, and L. D. Jackel, “Backpropagation Applied to Handwritten Zip Code Recognition,” Neural Computation, vol. 1, pp. 541–551, 12 1989.
K. Fukushima, “Neocognitron: A self-organizing neural network model for a mechanism of pattern recognition unaffected by shift in position,” Biological Cybernetics, vol. 36, pp. 193–202, Apr 1980.
D. Nie, L. Wang, Y. Gao, and D. Shen, “Fully convolutional networks for multi-modality isointense infant brain image segmentation,” in 2016 IEEE 13th Interna- tional Symposium on Biomedical Imaging (ISBI), pp. 1342–1345, 2016.
S. Bao and A. C. S. Chung, “Multi-scale structured cnn with label consistency for brain mr image segmentation,” Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, vol. 6, no. 1, pp. 113–117, 2018.
L. Henschel, S. Conjeti, S. Estrada, K. Diers, B. Fischl, and M. Reuter, “Fastsurfer - a fast and accurate deep learning based neuroimaging pipeline,” NeuroImage, vol. 219, p. 117012, 2020.
T. Brosch, L. Y. W. Tang, Y. Yoo, D. K. B. Li, A. Traboulsee, and R. Tam, “Deep 3d convolutional encoder networks with shortcuts for multiscale feature integration applied to multiple sclerosis lesion segmentation,” IEEE Transactions on Medical Imaging, vol. 35, no. 5, pp. 1229–1239, 2016.
S. Valverde, M. Cabezas, E. Roura, S. Gonzalez-Villa, D. Pareto, J. C. Vilanova, L. Ramio-Torrenta, Alex Rovira, A. Oliver, and X. Llado , “Improving automated multiple sclerosis lesion segmentation with a cascaded 3d convolutional neural net- work approach,” NeuroImage, vol. 155, pp. 159–168, 2017.
R. E. Gabr, I. Coronado, M. Robinson, S. J. Sujit, S. Datta, X. Sun, W. J. Allen, F. D. Lublin, J. S. Wolinsky, and P. A. Narayana, “Brain and lesion segmentation in multiple sclerosis using fully convolutional neural networks: A large-scale study,” Multiple Sclerosis Journal, vol. 26, no. 10, pp. 1217–1226, 2020. PMID: 31190607.
M. Havaei, A. Davy, D. Warde-Farley, A. Biard, A. Courville, Y. Bengio, C. Pal, P.-M. Jodoin, and H. Larochelle, “Brain tumor segmentation with deep neural networks,” Medical Image Analysis, vol. 35, pp. 18–31, 2017.
M. Havaei, F. Dutil, C. Pal, H. Larochelle, and P.-M. Jodoin, “A convolutional neural network approach to brain tumor segmentation,” in Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries (A. Crimi, B. Menze, O. Maier, M. Reyes, and H. Handels, eds.), (Cham), pp. 195–208, Springer International Pu- blishing, 2016.
L. Chen, P. Bentley, and D. Rueckert, “Fully automatic acute ischemic lesion segmentation in dwi using convolutional neural networks,” NeuroImage: Clinical, vol. 15, pp. 633–643, 2017.
Z. Akkus, I. Ali, J. Sedlar, T. L. Kline, J. P. Agrawal, I. F. Parney, C. Giannini, and B. J. Erickson, “Predicting 1p19q chromosomal deletion of low-grade gliomas from mr images using deep learning,” 2016.
P. Kumar, P. Nagar, C. Arora, and A. Gupta, “U-segnet: Fully convolutional neural network based automated brain tissue segmentation tool,” in 2018 25th IEEE International Conference on Image Processing (ICIP), pp. 3503–3507, 2018.
Z. Zhou, M. M. R. Siddiquee, N. Tajbakhsh, and J. Liang, “Unet++: Redesigning skip connections to exploit multiscale features in image segmentation,” IEEE Transactions on Medical Imaging, vol. 39, no. 6, pp. 1856–1867, 2020.
N. Ibtehaz and M. S. Rahman, “Multiresunet : Rethinking the u-net architecture for multimodal biomedical image segmentation,” Neural Networks, vol. 121, pp. 74–87, 2020.
H. Salehinejad, S. Sankar, J. Barfett, E. Colak, and S. Valaee, “Recent advances in recurrent neural networks,” 2018.
J. Devlin, M.-W. Chang, K. Lee, and K. Toutanova, “Bert: Pre-training of deep bidirectional transformers for language understanding,” 2018.
S. Zheng, J. Lu, H. Zhao, X. Zhu, Z. Luo, Y. Wang, Y. Fu, J. Feng, T. Xiang, P. H. S. Torr, and L. Zhang, “Rethinking semantic segmentation from a sequence-to-sequence perspective with transformers,” 2020.
J. M. J. Valanarasu, P. Oza, I. Hacihaliloglu, and V. M. Patel, “Medical transformer: Gated axial-attention for medical image segmentation,” 2021.
A. Klein and J. Tourville, “101 labeled brain images and a consistent human cortical labeling protocol,” Frontiers in Neuroscience, vol. 6, 2012.
H. Z. U. Rehman, H. Hwang, and S. Lee, “Conventional and deep learning methods for skull stripping in brain mri,” Applied Sciences, vol. 10, no. 5, 2020.
G. Fein, B. Landman, H. Tran, J. Barakos, K. Moon, V. Di Sclafani, and R. Shumway, “Statistical parametric mapping of brain morphology: Sensitivity is dramatically increased by using brain-extracted images as inputs,” NeuroImage, vol. 30, no. 4, pp. 1187–1195, 2006.
J. Acosta-Cabronero, G. B. Williams, J. M. Pereira, G. Pengas, and P. J. Nestor, “The impact of skull-stripping and radio-frequency bias correction on grey-matter segmentation for voxel-based morphometry,” NeuroImage, vol. 39, no. 4, pp. 1654– 1665, 2008.
P. A. Taylor, G. Chen, D. R. Glen, J. K. Rajendra, R. C. Reynolds, and R. W. Cox, “Fmri processing with afni: Some comments and corrections on “exploring the impact of analysis software on task fmri results”,” bioRxiv, 2018.
B. B. Avants, N. J. Tustison, G. Song, P. A. Cook, A. Klein, and J. C. Gee, “A reproducible evaluation of ants similarity metric performance in brain image registration,” NeuroImage, vol. 54, pp. 2033–2044, Feb 2011. 20851191[pmid].
D. W. Shattuck, S. R. Sandor-Leahy, K. A. Schaper, D. A. Rottenberg, and R. M. Leahy, “Magnetic resonance image tissue classification using a partial volume model,” Neuroimage, vol. 13, pp. 856–876, May 2001.
S. M. Smith, “Fast robust automated brain extraction,” Human Brain Mapping, vol. 17, no. 3, pp. 143–155, 2002.
B. Puccio, J. P. Pooley, J. S. Pellman, E. C. Taverna, and R. C. Craddock, “The preprocessed connectomes project repository of manually corrected skull-stripped T1-weighted anatomical MRI data,” GigaScience, vol. 5, 10 2016. s13742-016-0150- 5.
M. Yi-de, L. Qing, and Q. Zhi-bai, “Automated image segmentation using improved pcnn model based on cross-entropy,” in Proceedings of 2004 International Symposium on Intelligent Multimedia, Video and Speech Processing, 2004., pp. 743–746, 2004.
S. Jadon, “A survey of loss functions for semantic segmentation,” in 2020 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB), IEEE, oct 2020.
T. Sugino, T. Kawase, S. Onogi, T. Kin, N. Saito, and Y. Nakajima, “Loss weigh- tings for improving imbalanced brain structure segmentation using fully convolutional networks,” Healthcare, vol. 9, no. 8, 2021.
C.H.Sudre,W.Li,T.Vercauteren,S.Ourselin,andM.JorgeCardoso,“Generalised dice overlap as a deep learning loss function for highly unbalanced segmentations,” in Deep Learning in Medical Image Analysis and Multimodal Learning for Clinical Decision Support (M. J. Cardoso, T. Arbel, G. Carneiro, T. Syeda-Mahmood, J. M. R. Tavares, M. Moradi, A. Bradley, H. Greenspan, J. P. Papa, A. Madabhushi, J. C. Nascimento, J. S. Cardoso, V. Belagiannis, and Z. Lu, eds.), (Cham), pp. 240– 248, Springer International Publishing, 2017.
T.-Y. Lin, P. Goyal, R. Girshick, K. He, and P. Dolla ́r, “Focal loss for dense object detection,” 2017.
E. Castro, J. S. Cardoso, and J. C. Pereira, “Elastic deformations for data augmentation in breast cancer mass detection,” in 2018 IEEE EMBS International Conference on Biomedical Health Informatics (BHI), pp. 230–234, 2018.
G. Valvano, N. Martini, A. Leo, G. Santini, D. Della Latta, E. Ricciardi, and D. Chiappino, “Training of a skull-stripping neural network with efficient data augmentation,” 2018.
A. L. Maas, “Rectifier nonlinearities improve neural network acoustic models,” 2013.
K. He, X. Zhang, S. Ren, and J. Sun, “Delving deep into rectifiers: Surpassing human-level performance on imagenet classification,” 2015.
C. Wachinger, M. Reuter, and T. Klein, “Deepnat: Deep convolutional neural network for segmenting neuroanatomy,” NeuroImage, vol. 170, pp. 434–445, 2018. Segmenting the Brain.
A. Guha Roy, S. Conjeti, N. Navab, and C. Wachinger, “Quicknat: A fully convolutional network for quick and accurate segmentation of neuroanatomy,” NeuroImage, vol. 186, pp. 713–727, 2019.
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dc.publisher.spa.fl_str_mv Universidad Nacional de Colombia
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dc.publisher.department.spa.fl_str_mv Departamento de la Computación y la Decisión
dc.publisher.faculty.spa.fl_str_mv Facultad de Minas
dc.publisher.place.spa.fl_str_mv Medellín, Colombia
dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Medellín
institution Universidad Nacional de Colombia
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spelling Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Sanchez Torres, German4b698f4e03454cea5a4cc7c24825b47a600Branch Bedoya, John Willian8373bc4285cc9e2e59e8f540f737e1db600Laiton Bonadiez, Camilo Andres7cc1768e9ff944533283233db2664234600Gidia: Grupo de Investigación YyDesarrollo en Inteligencia Artificial2022-10-19T15:23:04Z2022-10-19T15:23:04Z2022-07-31https://repositorio.unal.edu.co/handle/unal/82378Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramas, tablasIn recent years, the use of deep learning-based models for developing advanced healthcare systems has been growing due to the results they can achieve. However, the majority of the proposed deep learning-models largely use convolutional and pooling operations, causing a loss in valuable data and focusing on local information. In this thesis, we propose a deep learning-based approach that uses global and local features which are of importance in the medical image segmentation process. In order to train the architecture, we used extracted three-dimensional (3D) blocks from the full magnetic resonance image resolution, which were sent through a set of successive convolutional neural network (CNN) layers free of pooling operations to extract local information. Later, we sent the resulting feature maps to successive layers of self-attention modules to obtain the global context, whose output was later dispatched to the decoder pipeline composed mostly of upsampling layers. The model was trained using the Mindboggle-101 dataset. The experimental results showed that the self-attention modules allow segmentation with a higher Mean Dice Score of 0.90 ± 0.036 compared with other UNet-based approaches. The average segmentation time was approximately 0.032 s per brain structure. The proposed model allows tackling the brain structure segmentation task properly. Exploiting the global context that the self-attention modules incorporate allows for more precise and faster segmentation. We segmented 37 brain structures and, to the best of our knowledge, it is the largest number of structures under a 3D approach using attention mechanisms.En los últimos años, el uso de modelos basados en aprendizaje profundo para el desarrollo de sistemas de salud avanzados ha ido en aumento debido a los excelentes resultados que pueden alcanzar. Sin embargo, la mayoría de los modelos de aprendizaje profundo propuestos utilizan, en gran medida, operaciones convolucionales y de pooling, lo que provoca una pérdida de datos valiosos centrándose principalmente en la información local. En esta tesis, proponemos un enfoque basado en el aprendizaje profundo que utiliza características globales y locales que son importantes en el proceso de segmentación de imágenes médicas. Para entrenar la arquitectura, utilizamos bloques tridimensionales (3D) extraídos de la resolución completa de la imagen de resonancia magnética. Estas se enviaron a través de un conjunto de capas sucesivas de redes neuronales convolucionales (CNN) libres de operaciones de pooling para extraer información local. Luego, enviamos los mapas de características resultantes a capas sucesivas de módulos de autoatención para obtener el contexto global, cuya salida se envió más tarde a la canalización del decodificador compuesta principalmente por capas de upsampling. El modelo fue entrenado usando el conjunto de datos Mindboggle-101. Los resultados experimentales mostraron que los módulos de autoatención permiten la segmentación con un Mean Dice Score 0,90 ± 0,036 la cual es mayor en comparación con otros enfoques basados en UNet. El tiempo medio de segmentación fue de aproximadamente 0,032 s por estructura cerebral. El modelo propuesto permite abordar adecuadamente la tarea de segmentación de estructuras cerebrales. Así mismo, permite aprovechar el contexto global que incorporan los módulos de autoatención logrando una segmentación más precisa y rápida. En este trabajo segmentamos 37 estructuras cerebrales y, según nuestro conocimiento, es el mayor número de estructuras bajo un enfoque 3D utilizando mecanismos de atención. (Texto tomado de la fuente)MaestríaMagíster en Ingeniería - Ingeniería de SistemasLa metodología constó de 4 fases. La primera se concentró en Determinar el conjunto de imágenes de resonancia magnética que fueron parte del conjunto de datos y seleccionar el conjunto de estructuras anatómicas a segmentar. La segunda fase estuvo dirigida a Definir el conjunto de técnicas a emplear en el preprocesamiento de las imágenes de resonancia magnética definidas. La tercera fase se concentró en Diseñar la arquitectura de red neuronal para la segmentación de las estructuras anatómicas cerebrales y por último, la cuarta fase estuvo dirigida a evaluar y comparar el modelo de red neuronal implementado con aquellos existentes en el estado del arte.Visión artificial y aprendizaje automáticoÁrea Curricular de Ingeniería de Sistemas e Informáticaxi, 54 páginasapplication/pdfengUniversidad Nacional de ColombiaMedellín - Minas - Maestría en Ingeniería - Ingeniería de SistemasDepartamento de la Computación y la DecisiónFacultad de MinasMedellín, ColombiaUniversidad Nacional de Colombia - Sede Medellín000 - Ciencias de la computación, información y obras generales::003 - Sistemas000 - Ciencias de la computación, información y obras generales::004 - Procesamiento de datos Ciencia de los computadores000 - Ciencias de la computación, información y obras generales::005 - Programación, programas, datos de computación610 - Medicina y salud::611 - Anatomía humana, citología, histologíaMagnetic resonance imagingDiagnostic imagingResonancia magnética en imágenesDiagnóstico por imágenesMedical image segmentationDeep learningTransformersConvolutional neural networksBrain structuresSegmentación de imágenes médicasAprendizaje profundoRedes neuronales convolucionalesTransformersEstructuras cerebralesMethod for the segmentation of brain magnetic resonance images using a neural network architecture based on attention modelsMétodo para la segmentación de imágenes de resonancia magnética cerebrales usando una arquitectura de red neuronal basada en modelos de atenciónTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMM. M. Miller-Thomas and T. L. Benzinger, “Neurologic applications of pet/mr imaging,” Magnetic Resonance Imaging Clinics of North America, vol. 25, no. 2, pp. 297–313, 2017. Hybrid PET/MR Imaging.W. Mier and D. Mier, “Advantages in functional imaging of the brain,” Frontiers in Human Neuroscience, vol. 9, 2015.H. Neeb, K. Zilles, and N. J. Shah, “Fully-automated detection of cerebral water content changes: Study of age- and gender-related h2o patterns with quantitative mri,” NeuroImage, vol. 29, no. 3, pp. 910–922, 2006.M. E. Shenton, C. C. Dickey, M. Frumin, and R. W. McCarley, “A review of mri findings in schizophrenia,” Schizophrenia Research, vol. 49, no. 1, pp. 1–52, 2001.G. Widmann, B. Henninger, C. Kremser, and W. Jaschke, “Sequences in head & neck radiology – state of the art mri,” 2017.H. Yu, L. T. Yang, Q. Zhang, D. Armstrong, and M. J. Deen, “Convolutional neural networks for medical image analysis: State-of-the-art, comparisons, improvement and perspectives,” Neurocomputing, vol. 444, pp. 92–110, 2021.X. Xie, J. Niu, X. Liu, Z. Chen, S. Tang, and S. Yu, “A survey on incorporating domain knowledge into deep learning for medical image analysis,” Medical Image Analysis, vol. 69, p. 101985, 2021.U. Ilhan and A. Ilhan, “Brain tumor segmentation based on a new threshold ap- proach,” Procedia Computer Science, vol. 120, pp. 580–587, 2017. 9th International Conference on Theory and Application of Soft Computing, Computing with Words and Perception, ICSCCW 2017, 22-23 August 2017, Budapest, Hungary.W. Deng, W. Xiao, H. Deng, and J. Liu, “Mri brain tumor segmentation with region growing method based on the gradients and variances along and inside of the boundary curve,” in 2010 3rd International Conference on Biomedical Engineering and Informatics, vol. 1, pp. 393–396, 2010.J. Ashburner and K. J. Friston, “Unified segmentation,” NeuroImage, vol. 26, no. 3, pp. 839–851, 2005.J. Liu and L. Guo, “A new brain mri image segmentation strategy based on k- means clustering and svm,” in 2015 7th International Conference on Intelligent Human-Machine Systems and Cybernetics, vol. 2, pp. 270–273, 2015.X. Zhao and X.-M. Zhao, “Deep learning of brain magnetic resonance images: A brief review,” Methods, vol. 192, pp. 131–140, 2021. Deep networks and network representation in bioinformatics.W. T. Le, F. Maleki, F. P. Romero, R. Forghani, and S. Kadoury, “Overview of machine learning: Part 2: Deep learning for medical image analysis,” Neuroimaging Clinics of North America, vol. 30, no. 4, pp. 417–431, 2020. Machine Learning and Other Artificial Intelligence Applications.X. Liu, H. Wang, Z. Li, and L. Qin, “Deep learning in ecg diagnosis: A review,” Knowledge-Based Systems, vol. 227, p. 107187, 2021.A. Nogales, A ́lvaro J. Garc ́ıa-Tejedor, D. Monge, J. S. Vara, and C. Anto ́n, “A survey of deep learning models in medical therapeutic areas,” Artificial Intelligence in Medicine, vol. 112, p. 102020, 2021.J. Gu, Z. Wang, J. Kuen, L. Ma, A. Shahroudy, B. Shuai, T. Liu, X. Wang, G. Wang, J. Cai, and T. Chen, “Recent advances in convolutional neural networks,” Pattern Recognition, vol. 77, pp. 354–377, 2018.L. Alzubaidi, J. Zhang, A. J. Humaidi, A. Al-Dujaili, Y. Duan, O. Al-Shamma, J. Santamar ́ıa, M. A. Fadhel, M. Al-Amidie, and L. Farhan, “Review of deep lear- ning: concepts, cnn architectures, challenges, applications, future directions,” Jour- nal of Big Data, vol. 8, p. 53, Mar 2021.M. Kwabena Patrick, A. Felix Adekoya, A. Abra Mighty, and B. Y. Edward, “Cap- sule networks – a survey,” Journal of King Saud University - Computer and Infor- mation Sciences, vol. 34, no. 1, pp. 1295–1310, 2022.S. Sabour, N. Frosst, and G. E. Hinton, “Dynamic routing between capsules,” in Proceedings of the 31st International Conference on Neural Information Processing Systems, NIPS’17, (Red Hook, NY, USA), p. 3859–3869, Curran Associates Inc., 2017.A. Vaswani, N. Shazeer, N. Parmar, J. Uszkoreit, L. Jones, A. N. Gomez, L. Kaiser, and I. Polosukhin, “Attention is all you need,” 2017.A. Dosovitskiy, L. Beyer, A. Kolesnikov, D. Weissenborn, X. Zhai, T. Unterthiner, M. Dehghani, M. Minderer, G. Heigold, S. Gelly, J. Uszkoreit, and N. Houlsby, “An image is worth 16x16 words: Transformers for image recognition at scale,” 2020.J. Chen, Y. Lu, Q. Yu, X. Luo, E. Adeli, Y. Wang, L. Lu, A. L. Yuille, and Y. Zhou, “Transunet: Transformers make strong encoders for medical image segmentation,” 2021.B. Fischl, D. H. Salat, E. Busa, M. Albert, M. Dieterich, C. Haselgrove, A. van der Kouwe, R. Killiany, D. Kennedy, S. Klaveness, A. Montillo, N. Makris, B. Rosen, and A. M. Dale, “Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain,” Neuron, vol. 33, pp. 341–355, Jan. 2002.D. W. Shattuck and R. M. Leahy, “Brainsuite: An automated cortical surface iden- tification tool,” Medical Image Analysis, vol. 6, no. 2, pp. 129–142, 2002.M. Jenkinson, C. F. Beckmann, T. E. Behrens, M. W. Woolrich, and S. M. Smith, “Fsl,” NeuroImage, vol. 62, no. 2, pp. 782–790, 2012. 20 YEARS OF fMRI.O. Ronneberger, P. Fischer, and T. Brox, “U-net: Convolutional networks for bio- medical image segmentation,” in Medical Image Computing and Computer-Assisted Intervention – MICCAI 2015 (N. Navab, J. Hornegger, W. M. Wells, and A. F. Frangi, eds.), (Cham), pp. 234–241, Springer International Publishing, 2015.I. Despotovi ́c, B. Goossens, and W. Philips, “Mri segmentation of the human brain: Challenges, methods, and applications,” Computational and Mathematical Methods in Medicine, vol. 2015, p. 450341, Mar 2015.P. A. Yushkevich, Y. Gao, and G. Gerig, “ITK-SNAP: An interactive tool for semi-automatic segmentation of multi-modality biomedical images,” Annu Int Conf IEEE Eng Med Biol Soc, vol. 2016, pp. 3342–3345, Aug. 2016.S. Pieper, M. Halle, and R. Kikinis, “3d slicer,” in 2004 2nd IEEE International Symposium on Biomedical Imaging: Nano to Macro (IEEE Cat No. 04EX821), pp. 632–635 Vol. 1, 2004.C. Qin, Y. Wu, W. Liao, J. Zeng, S. Liang, and X. Zhang, “Improved u-net3+ with stage residual for brain tumor segmentation,” BMC Medical Imaging, vol. 22, p. 14, Jan 2022.J. Sun, Y. Peng, Y. Guo, and D. Li, “Segmentation of the multimodal brain tumor image used the multi-pathway architecture method based on 3d fcn,” Neurocompu- ting, vol. 423, pp. 34–45, 2021.W. Dai, B. Woo, S. Liu, M. Marques, F. Tang, S. Crozier, C. Engstrom, and S. Chan- dra, “Can3d: Fast 3d knee mri segmentation via compact context aggregation,” in 2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI), pp. 1505– 1508, 2021.T. S. Deepthi Murthy and G. Sadashivappa, “Brain tumor segmentation using th- resholding, morphological operations and extraction of features of tumor,” in 2014 International Conference on Advances in Electronics Computers and Communica- tions, pp. 1–6, 2014.W. Polakowski, D. Cournoyer, S. Rogers, M. DeSimio, D. Ruck, J. Hoffmeister, and R. Raines, “Computer-aided breast cancer detection and diagnosis of masses using difference of gaussians and derivative-based feature saliency,” IEEE Transactions on Medical Imaging, vol. 16, no. 6, pp. 811–819, 1997.M. Wani and B. Batchelor, “Edge-region-based segmentation of range images,” IEEE Transactions on Pattern Analysis and Machine Intelligence, vol. 16, no. 3, pp. 314–319, 1994.J. Wu, F. Ye, J.-L. Ma, X.-P. Sun, J. Xu, and Z.-M. Cui, “The segmentation and visualization of human organs based on adaptive region growing method,” in 2008 IEEE 8th International Conference on Computer and Information Technology Workshops, pp. 439–443, 2008.N. Passat, C. Ronse, J. Baruthio, J.-P. Armspach, C. Maillot, and C. Jahn, “Region- growing segmentation of brain vessels: An atlas-based automatic approach,” Journal of Magnetic Resonance Imaging, vol. 21, no. 6, pp. 715–725, 2005.P. Gibbs, D. L. Buckley, S. J. Blackband, and A. Horsman, “Tumour volume de- termination from MR images by morphological segmentation,” Physics in Medicine and Biology, vol. 41, pp. 2437–2446, nov 1996.S. Pohlman, K. A. Powell, N. A. Obuchowski, W. A. Chilcote, and S. Grundfest- Broniatowski, “Quantitative classification of breast tumors in digitized mammo- grams,” Medical Physics, vol. 23, no. 8, pp. 1337–1345, 1996.E. A. A. Maksoud, M. Elmogy, and R. M. Al-Awadi, “Mri brain tumor segmenta- tion system based on hybrid clustering techniques,” in Advanced Machine Learning Technologies and Applications (A. E. Hassanien, M. F. Tolba, and A. Taher Azar, eds.), (Cham), pp. 401–412, Springer International Publishing, 2014.X. Artaechevarria, A. Munoz-Barrutia, and C. Ortiz-de Solorzano, “Combination strategies in multi-atlas image segmentation: Application to brain mr data,” IEEE Transactions on Medical Imaging, vol. 28, no. 8, pp. 1266–1277, 2009.P. Coupe, J. V. Manjon, V. Fonov, J. Pruessner, M. Robles, and D. L. Collins, “Patch-based segmentation using expert priors: Application to hippocampus and ventricle segmentation,” NeuroImage, vol. 54, no. 2, pp. 940–954, 2011.H. Wang, J. W. Suh, S. R. Das, J. B. Pluta, C. Craige, and P. A. Yushkevich, “Multi-atlas segmentation with joint label fusion,” IEEE Transactions on Pattern Analysis and Machine Intelligence, vol. 35, no. 3, pp. 611–623, 2013.G. Wu, Q. Wang, D. Zhang, F. Nie, H. Huang, and D. Shen, “A generative proba- bility model of joint label fusion for multi-atlas based brain segmentation,” Medical Image Analysis, vol. 18, no. 6, pp. 881–890, 2014. Sparse Methods for Signal Re- construction and Medical Image Analysis.M. Kass, A. Witkin, and D. Terzopoulos, “Snakes: Active contour models,” Inter- national Journal of Computer Vision, vol. 1, pp. 321–331, Jan 1988.Z. Wu, Y. Guo, S. H. Park, Y. Gao, P. Dong, S.-W. Lee, and D. Shen, “Robust brain roi segmentation by deformation regression and deformable shape model,” Medical Image Analysis, vol. 43, pp. 198–213, 2018.A.Rajendran and R. Dhanasekaran, “Fuzzy clustering and deformable model for tumor segmentation on mri brain image: A combined approach,” Procedia Engineering, vol. 30, pp. 327–333, 2012. International Conference on Communication Technology and System Design 2011.H. Khotanlou, J. Atif, O. Colliot, and I. Bloch, “3d brain tumor segmentation using fuzzy classification and deformable models,” in Fuzzy Logic and Applications (I. Bloch, A. Petrosino, and A. G. B. Tettamanzi, eds.), (Berlin, Heidelberg), pp. 312–318, Springer Berlin Heidelberg, 2006.S. S. Tng, N. Q. K. Le, H.-Y. Yeh, and M. C. H. Chua, “Improved prediction model of protein lysine crotonylation sites using bidirectional recurrent neural networks,” Journal of Proteome Research, vol. 21, pp. 265–273, Jan 2022.N. Q. K. Le and Q.-T. Ho, “Deep transformers and convolutional neural network in identifying dna n6-methyladenine sites in cross-species genomes,” Methods, 2021.D. Bank, N. Koenigstein, and R. Giryes, “Autoencoders,” 2020.G. Montufar, “Restricted boltzmann machines: Introduction and review,” 2018.A. Sherstinsky, “Fundamentals of recurrent neural network (rnn) and long short-term memory (lstm) network,” Physica D: Nonlinear Phenomena, vol. 404, p. 132306, 2020.Y. LeCun, B. Boser, J. S. Denker, D. Henderson, R. E. Howard, W. Hubbard, and L. D. Jackel, “Backpropagation Applied to Handwritten Zip Code Recognition,” Neural Computation, vol. 1, pp. 541–551, 12 1989.K. Fukushima, “Neocognitron: A self-organizing neural network model for a mechanism of pattern recognition unaffected by shift in position,” Biological Cybernetics, vol. 36, pp. 193–202, Apr 1980.D. Nie, L. Wang, Y. Gao, and D. Shen, “Fully convolutional networks for multi-modality isointense infant brain image segmentation,” in 2016 IEEE 13th Interna- tional Symposium on Biomedical Imaging (ISBI), pp. 1342–1345, 2016.S. Bao and A. C. S. Chung, “Multi-scale structured cnn with label consistency for brain mr image segmentation,” Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, vol. 6, no. 1, pp. 113–117, 2018.L. Henschel, S. Conjeti, S. Estrada, K. Diers, B. Fischl, and M. Reuter, “Fastsurfer - a fast and accurate deep learning based neuroimaging pipeline,” NeuroImage, vol. 219, p. 117012, 2020.T. Brosch, L. Y. W. Tang, Y. Yoo, D. K. B. Li, A. Traboulsee, and R. Tam, “Deep 3d convolutional encoder networks with shortcuts for multiscale feature integration applied to multiple sclerosis lesion segmentation,” IEEE Transactions on Medical Imaging, vol. 35, no. 5, pp. 1229–1239, 2016.S. Valverde, M. Cabezas, E. Roura, S. Gonzalez-Villa, D. Pareto, J. C. Vilanova, L. Ramio-Torrenta, Alex Rovira, A. Oliver, and X. Llado , “Improving automated multiple sclerosis lesion segmentation with a cascaded 3d convolutional neural net- work approach,” NeuroImage, vol. 155, pp. 159–168, 2017.R. E. Gabr, I. Coronado, M. Robinson, S. J. Sujit, S. Datta, X. Sun, W. J. Allen, F. D. Lublin, J. S. Wolinsky, and P. A. Narayana, “Brain and lesion segmentation in multiple sclerosis using fully convolutional neural networks: A large-scale study,” Multiple Sclerosis Journal, vol. 26, no. 10, pp. 1217–1226, 2020. PMID: 31190607.M. Havaei, A. Davy, D. Warde-Farley, A. Biard, A. Courville, Y. Bengio, C. Pal, P.-M. Jodoin, and H. Larochelle, “Brain tumor segmentation with deep neural networks,” Medical Image Analysis, vol. 35, pp. 18–31, 2017.M. Havaei, F. Dutil, C. Pal, H. Larochelle, and P.-M. Jodoin, “A convolutional neural network approach to brain tumor segmentation,” in Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries (A. Crimi, B. Menze, O. Maier, M. Reyes, and H. Handels, eds.), (Cham), pp. 195–208, Springer International Pu- blishing, 2016.L. Chen, P. Bentley, and D. Rueckert, “Fully automatic acute ischemic lesion segmentation in dwi using convolutional neural networks,” NeuroImage: Clinical, vol. 15, pp. 633–643, 2017.Z. Akkus, I. Ali, J. Sedlar, T. L. Kline, J. P. Agrawal, I. F. Parney, C. Giannini, and B. J. Erickson, “Predicting 1p19q chromosomal deletion of low-grade gliomas from mr images using deep learning,” 2016.P. Kumar, P. Nagar, C. Arora, and A. Gupta, “U-segnet: Fully convolutional neural network based automated brain tissue segmentation tool,” in 2018 25th IEEE International Conference on Image Processing (ICIP), pp. 3503–3507, 2018.Z. Zhou, M. M. R. Siddiquee, N. Tajbakhsh, and J. Liang, “Unet++: Redesigning skip connections to exploit multiscale features in image segmentation,” IEEE Transactions on Medical Imaging, vol. 39, no. 6, pp. 1856–1867, 2020.N. Ibtehaz and M. S. Rahman, “Multiresunet : Rethinking the u-net architecture for multimodal biomedical image segmentation,” Neural Networks, vol. 121, pp. 74–87, 2020.H. Salehinejad, S. Sankar, J. Barfett, E. Colak, and S. Valaee, “Recent advances in recurrent neural networks,” 2018.J. Devlin, M.-W. Chang, K. Lee, and K. Toutanova, “Bert: Pre-training of deep bidirectional transformers for language understanding,” 2018.S. Zheng, J. Lu, H. Zhao, X. Zhu, Z. Luo, Y. Wang, Y. Fu, J. Feng, T. Xiang, P. H. S. Torr, and L. Zhang, “Rethinking semantic segmentation from a sequence-to-sequence perspective with transformers,” 2020.J. M. J. Valanarasu, P. Oza, I. Hacihaliloglu, and V. M. Patel, “Medical transformer: Gated axial-attention for medical image segmentation,” 2021.A. Klein and J. Tourville, “101 labeled brain images and a consistent human cortical labeling protocol,” Frontiers in Neuroscience, vol. 6, 2012.H. Z. U. Rehman, H. Hwang, and S. Lee, “Conventional and deep learning methods for skull stripping in brain mri,” Applied Sciences, vol. 10, no. 5, 2020.G. Fein, B. Landman, H. Tran, J. Barakos, K. Moon, V. Di Sclafani, and R. Shumway, “Statistical parametric mapping of brain morphology: Sensitivity is dramatically increased by using brain-extracted images as inputs,” NeuroImage, vol. 30, no. 4, pp. 1187–1195, 2006.J. Acosta-Cabronero, G. B. Williams, J. M. Pereira, G. Pengas, and P. J. Nestor, “The impact of skull-stripping and radio-frequency bias correction on grey-matter segmentation for voxel-based morphometry,” NeuroImage, vol. 39, no. 4, pp. 1654– 1665, 2008.P. A. Taylor, G. Chen, D. R. Glen, J. K. Rajendra, R. C. Reynolds, and R. W. Cox, “Fmri processing with afni: Some comments and corrections on “exploring the impact of analysis software on task fmri results”,” bioRxiv, 2018.B. B. Avants, N. J. Tustison, G. Song, P. A. Cook, A. Klein, and J. C. Gee, “A reproducible evaluation of ants similarity metric performance in brain image registration,” NeuroImage, vol. 54, pp. 2033–2044, Feb 2011. 20851191[pmid].D. W. Shattuck, S. R. Sandor-Leahy, K. A. Schaper, D. A. Rottenberg, and R. M. Leahy, “Magnetic resonance image tissue classification using a partial volume model,” Neuroimage, vol. 13, pp. 856–876, May 2001.S. M. Smith, “Fast robust automated brain extraction,” Human Brain Mapping, vol. 17, no. 3, pp. 143–155, 2002.B. Puccio, J. P. Pooley, J. S. Pellman, E. C. Taverna, and R. C. Craddock, “The preprocessed connectomes project repository of manually corrected skull-stripped T1-weighted anatomical MRI data,” GigaScience, vol. 5, 10 2016. s13742-016-0150- 5.M. Yi-de, L. Qing, and Q. Zhi-bai, “Automated image segmentation using improved pcnn model based on cross-entropy,” in Proceedings of 2004 International Symposium on Intelligent Multimedia, Video and Speech Processing, 2004., pp. 743–746, 2004.S. Jadon, “A survey of loss functions for semantic segmentation,” in 2020 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB), IEEE, oct 2020.T. Sugino, T. Kawase, S. Onogi, T. Kin, N. Saito, and Y. Nakajima, “Loss weigh- tings for improving imbalanced brain structure segmentation using fully convolutional networks,” Healthcare, vol. 9, no. 8, 2021.C.H.Sudre,W.Li,T.Vercauteren,S.Ourselin,andM.JorgeCardoso,“Generalised dice overlap as a deep learning loss function for highly unbalanced segmentations,” in Deep Learning in Medical Image Analysis and Multimodal Learning for Clinical Decision Support (M. J. Cardoso, T. Arbel, G. Carneiro, T. Syeda-Mahmood, J. M. R. Tavares, M. Moradi, A. Bradley, H. Greenspan, J. P. Papa, A. Madabhushi, J. C. Nascimento, J. S. Cardoso, V. Belagiannis, and Z. Lu, eds.), (Cham), pp. 240– 248, Springer International Publishing, 2017.T.-Y. Lin, P. Goyal, R. Girshick, K. He, and P. Dolla ́r, “Focal loss for dense object detection,” 2017.E. Castro, J. S. Cardoso, and J. C. Pereira, “Elastic deformations for data augmentation in breast cancer mass detection,” in 2018 IEEE EMBS International Conference on Biomedical Health Informatics (BHI), pp. 230–234, 2018.G. Valvano, N. Martini, A. Leo, G. Santini, D. Della Latta, E. Ricciardi, and D. Chiappino, “Training of a skull-stripping neural network with efficient data augmentation,” 2018.A. L. Maas, “Rectifier nonlinearities improve neural network acoustic models,” 2013.K. He, X. Zhang, S. Ren, and J. Sun, “Delving deep into rectifiers: Surpassing human-level performance on imagenet classification,” 2015.C. Wachinger, M. Reuter, and T. Klein, “Deepnat: Deep convolutional neural network for segmenting neuroanatomy,” NeuroImage, vol. 170, pp. 434–445, 2018. Segmenting the Brain.A. Guha Roy, S. Conjeti, N. Navab, and C. Wachinger, “Quicknat: A fully convolutional network for quick and accurate segmentation of neuroanatomy,” NeuroImage, vol. 186, pp. 713–727, 2019.EstudiantesInvestigadoresMaestrosLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/82378/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1016093055.2022.pdf1016093055.2022.pdfTesis de Maestría en Ingeniería - Ingeniería de Sistemasapplication/pdf14112182https://repositorio.unal.edu.co/bitstream/unal/82378/2/1016093055.2022.pdfe5acc38401dd7d55eee8c85f9915efe8MD52THUMBNAIL1016093055.2022.pdf.jpg1016093055.2022.pdf.jpgGenerated Thumbnailimage/jpeg4549https://repositorio.unal.edu.co/bitstream/unal/82378/3/1016093055.2022.pdf.jpg11ef968d33573033a449d8bd184aedb7MD53unal/82378oai:repositorio.unal.edu.co:unal/823782023-10-06 18:05:28.237Repositorio Institucional Universidad Nacional de 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